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2-Dimethylaminoethanol (+)-Bitartrate Salt

    • Product Name 2-Dimethylaminoethanol (+)-Bitartrate Salt
    • Alias DMAE Bitartrate
    • Einecs 245-366-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    499302

    Chemical Name 2-Dimethylaminoethanol (+)-Bitartrate Salt
    Cas Number 5988-51-2
    Molecular Formula C6H15NO • C4H6O6
    Molecular Weight 255.27 g/mol
    Appearance White to off-white crystalline powder
    Solubility Soluble in water
    Melting Point 168-172 °C (decomposition)
    Storage Temperature 2-8 °C (refrigerated)
    Ph In Water 4.0-5.0 (1% solution)
    Synonyms DMAE bitartrate, Dimethylethanolamine (+)-bitartrate
    Ec Number 209-640-4

    As an accredited 2-Dimethylaminoethanol (+)-Bitartrate Salt factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White HDPE bottle containing 100 grams of 2-Dimethylaminoethanol (+)-Bitartrate Salt, tamper-evident cap, labeled with hazard and handling information.
    Shipping 2-Dimethylaminoethanol (+)-Bitartrate Salt is shipped in tightly sealed, chemical-resistant containers to prevent moisture ingress and contamination. The packaging complies with hazardous material transport regulations, ensuring safe handling and transit. Appropriate labeling and documentation accompany the shipment, and temperature conditions are maintained as recommended to preserve product integrity during delivery.
    Storage 2-Dimethylaminoethanol (+)-Bitartrate Salt should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from incompatible substances like strong oxidizers and acids. Avoid exposure to moisture and direct sunlight. Recommended storage temperature is between 2–8°C (refrigerated). Properly label the container and keep it out of reach of unauthorized personnel.
    Application of 2-Dimethylaminoethanol (+)-Bitartrate Salt

    Applications of 2-Dimethylaminoethanol (+)-Bitartrate Salt in Industrial Manufacturing

    2-Dimethylaminoethanol (+)-Bitartrate Salt is a specialized intermediate widely adopted in pharmaceutical, agrochemical, and performance materials manufacturing. As the original producer, we supply this raw material in controlled batches geared for multiple downstream processes where chiral purity and quality system traceability are mandatory. Our production supports clients operating advanced synthesis routes, demanding consistent integration into regulated production workflows.

    1. Chiral Intermediate for CNS-Active Pharmaceutical Ingredient Synthesis

    Many pharmaceutical API manufacturers utilize this salt as a resolving agent or building block when synthesizing enantiomerically pure intermediates for central nervous system drugs. The compound’s chiral nature supports selective synthesis, reducing racemic impurities during key coupling or derivatization steps. Process engineers introduce it at critical stages in synthesis to comply with stringent regulatory purity demands. Each batch meets or exceeds ICH guidelines to ensure downstream APIs remain GMP-compliant from initial route development through commercial production.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • USP/NF and EP monographs for chiral auxiliaries, as applicable
    • FDA 21 CFR Part 211 – Pharmaceutical Current Good Manufacturing Practice
    • EDQM CEP requirements for pharmaceutical starting materials

    Typical usage ratio

    • 0.15–0.75 molar equivalents relative to targeted API precursor, tailored after route scouting based on target enantiomeric excess and downstream yield

    Downstream process integration

    • Batchwise addition during asymmetric synthesis reactions, resolution protocols, or preparative chiral chromatography steps
    • Removed or cleaved during late-stage purification, leaving no residual in final API

    Final product types

    • Active pharmaceutical ingredients for CNS indications (e.g., antidepressants, antipsychotics, Alzheimer’s therapies)
    • Advanced chiral intermediates sold to CDMOs under supply agreements

    2. Resolving Agent for Agrochemical Synthesis (Enantiopure Pesticides & Herbicides)

    Research-led agrochemical companies employ this salt as a resolution agent during synthesis of enantioselective active substances where regulatory requirements permit only the optically pure isomer. High selectivity in splitting racemates ensures that process streams meet purity specifications demanded under regional agrochemical approvals. Production teams control its dosage per reaction scale, allowing for cost-effective conversion while ensuring full removal post-reaction to mitigate environmental trace issues.

    Industry compliance standards

    • FAO/WHO Specifications and Evaluations for Agricultural Pesticides
    • ISO 9001:2015 Quality Systems for synthesis and supply chain traceability
    • EU Regulation (EC) No 1107/2009 (Plant Protection Products)
    • REACH Registration for industrial substances

    Typical usage ratio

    • 0.12–0.38 molar equivalents per batch, defined after small-scale optimization based on pesticide structural class and regulatory requirements on enantiomeric purity

    Downstream process integration

    • Dosed during the enantiomeric resolution of racemic intermediates prior to further transformation into biological actives
    • Salt removed post-resolution during aqueous or solvent extraction, ensuring non-detectable levels in finished concentrate

    Final product types

    • Registered chiral agrochemicals (herbicides, insecticides, fungicides) with improved biological selectivity
    • Technical grades for formulating commercial crop protection products

    3. Intermediate for Optical Materials Manufacturing (Chiral Ligands and Modifiers)

    High-performance material producers incorporate this compound as a chiral template or resolving additive in the controlled synthesis of specialty ligands and optical modifiers used for advanced display and imaging systems. Its integration supports precision control over optical activity, crucial for downstream liquid crystal or circular dichroism applications. Our customers require narrow batch-to-batch variance to maintain material consistency across device manufacturing campaigns meeting electronics industry qualification standards.

    Industry compliance standards

    • IEC 61249-2-21 standard for materials used in electronics
    • RoHS (Restriction of Hazardous Substances) Directive
    • Quality Management Systems ISO 9001:2015

    Typical usage ratio

    • 2–8% by weight per precursor or matrix resin, tuned according to desired optical rotation and device performance specifications

    Downstream process integration

    • Blended during synthesis of chiral ligands or functional monomers
    • Removed or retained depending on the target end-use in optical device fabrication

    Final product types

    • Chiral dopants for liquid crystal displays (LCD & OLED panels)
    • Modifiers in photonic polymer films for spectroscopy devices

    4. Research-Scale Resolution for Fine Chemicals and Analytical Reference Preparations

    University laboratories, reference standards suppliers, and custom fine chemical manufacturers apply this salt to produce analytical grade enantiomerically pure compounds required for chemical testing, tracers, or method validation. It is commonly incorporated in bench-scale preparative protocols, enabling accurate chiral purity assessment for complex molecules. Its traceable GMP audit trail supports use in validated reference material production and method transfer across contract labs and accredited analytical facilities.

    Industry compliance standards

    • ISO/IEC 17025:2017 Accreditation for Testing and Calibration Laboratories
    • OECD Guidelines for the Testing of Chemicals
    • Analytical laboratory GMP documentation and traceability

    Typical usage ratio

    • 0.1–0.5 equivalents per target substrate or analytical batch, with adjustments based on compound complexity, resolution efficiency, and downstream purification requirements

    Downstream process integration

    • Added to preparative-scale chromatography systems or resolution reactors
    • Removed through standard workup before final product isolation and certification

    Final product types

    • Certified analytical reference materials for chiral HPLC and GC systems
    • Custom enantiomerically pure fine chemicals for assay calibration and method development
    Free Quote

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    Certification & Compliance
    More Introduction

    2-Dimethylaminoethanol (+)-Bitartrate Salt: Crafting Consistency and Quality at Scale

    Setting the Standard With Our 2-Dimethylaminoethanol (+)-Bitartrate Salt

    From raw input to final packaging, each batch of 2-Dimethylaminoethanol (+)-Bitartrate Salt reflects years of dedication to chemical precision and safety. Manufacturing this compound requires continuous monitoring of reactant purity, reaction time, and temperature control. Over the years, improved crystallization techniques have helped us deliver a reliable supply to customers who rely on clear, reproducible results season after season. This salt—sometimes referred to as DMAE Bitartrate—comes out as a white to off-white crystalline powder.

    Our team sources starting materials, including dimethylaminoethanol and naturally derived tartaric acid, directly from suppliers with a long history of meeting tough quality benchmarks. These inputs pass through several in-house purification systems before feeding into the checked reactors. By sticking to a controlled batch process, we watch out for any sign of inconsistency. Our QA technicians invest time in running reference spectra and moisture analysis on every production cycle. That way, nobody at the end of the chain receives unexpected off-notes or an underdosed bag.

    Model and Common Specifications

    Clients typically order our standard 2-Dimethylaminoethanol (+)-Bitartrate Salt as either model DMAE-BT/01 or DMAE-BT/02. Model DMAE-BT/01 suits applications that demand a purity level of at least 99%, often verified by HPLC or titration to meet the requirements of analytical and pharmaceutical processes. Model DMAE-BT/02, with a slightly broader impurity profile yet bounded within pharmacopoeial standards, offers a cost-effective solution for industrial or feed applications where top-end purity does not add return on investment.

    Particle size is tightly managed—both models come with a custom mesh size range. Instead of pushing a generic, fine powder, we work directly with longtime partners who understand how granule size can affect dissolution speed and blending uniformity. For those who blend directly into liquids or require rapid solubilization, we scale mesh size for faster handling and shorter processing times.

    Where 2-Dimethylaminoethanol (+)-Bitartrate Salt Makes a Difference

    Many production chemists keep an eye on DMAE salts for their role as intermediates and excipients. While both the free base and its bitartrate salt play an active part in synthesis and formulation, it’s the salt form that steps up when stability, ease of handling, and dosing precision matter most. The crystalline solid simplifies labor and cuts risk in processes vulnerable to volatility or moisture absorption.

    Over the past decade, more researchers have shifted away from using free amines, citing storage volatility, odor, and tough-to-control base strength. DMAE in bitartrate salt form stores safely at room temperature, avoids the unwelcome odor bursts, and ships smoothly in various climates. We learned early on that certain downstream blends, especially those involved in haircare and anti-aging cream formulations, perform better when built around a salt foundation. The salt buffers the final product, reducing drift in pH and protecting sensitive actives from premature degradation.

    In industrial and animal nutrition, steady uptake of DMAE salts continues for choline fortification and as an intermediate for further functionalization. Powdered salt, with its measured melting point and water solubility, helps clients scale up and automate dosing without retooling for liquids. Nutrition-grade production means reliable absence of solvent residues and trace metals, something we scrutinize batch after batch.

    Why DMAE Bitartrate Outshines Alternative Products

    Direct handling of the pure DMAE base raises several operational headaches. Most production lines integrating DMAE as a free base have to install additional containment measures to limit vaporization and leakage. Facility managers talk to us about the cost of corrosion and frequent maintenance downtime stemming from exposure to amines. By contrast, DMAE bitartrate salt sits stable over a broad temperature and humidity range, with a lower vapor pressure that means longer shelf life and smoother logistics from plant to warehouse.

    Customers in cosmetics, laboratory, pharma, and nutrition sectors pick our salt not just for regulatory compliance, but for daily reliability. The bitartrate counterion, sourced from tartaric acid, keeps the DMAE usable in acidic and neutral systems without introducing unexpected residues. It is easy to handle, pours well—important for automated bottling or filling lines—and leaves little to no dust or clumping when stored in sealed containers.

    A common point raised in business meetings and technical audits is the difference between (+)-bitartrate and racemic bitartrate forms. This matters because enantiopurity affects biological interactions, especially in medical and animal health fields. Sourcing pure (+)-bitartrate ensures consistency—no unexpected interference or off-target effects in sensitive blends.

    Quality Control From Raw Material to Finished Product

    Many suppliers cut corners with minimal batch testing or remote contract testing. In contrast, we take every shipment of raw DMAE and tartaric acid, reviewing supplier histories and analyzing for residual solvents, heavy metals, and optical rotation. Moisture is checked by Karl Fischer titration and consistent melting point checks, with acceptance ranges based on our multi-year production statistics.

    Once the salt is crystallized and dried, our operators run each lot through particle size grading and screen for trace contamination or discoloration. Before we ship, technicians test flow properties, check for caking in simulated storage, and seal off samples for retention—so feedback loops back into the next production cycle.

    Working in this field for many years, we’ve seen how even small lapses in lot control or documentation can disrupt entire supply chains. Our facility uses an integrated digital tracking system, logging date, input weights, instrument calibration, and release records in real time. This way, anyone down the chain gets full traceability—something that builds trust when regulatory inspectors ask for evidence.

    Supporting Sustainable Chemistry

    Sustainability isn’t a buzzword around the production plant. We focus on solvent minimization, water recycling, and careful batch scheduling to minimize waste and downtime during product changeovers. Our environmental management team reviews waste streams from DMAE bitartrate runs, seeking new recovery methods for both organics and filter cakes. Tartaric acid residues get diverted to agricultural partners rather than landfill.

    Logistics and packaging play an equal part. Our packing line makes use of multi-layer, recyclable bags and drums, keeping the final salt dry and protected while reducing packaging waste for our buyers. Many customers build DMAE bitartrate into “clean label” formulas or low-residue blends, so avoiding phthalates, plasticizers, and unnecessary stabilizers throughout the process has become second nature.

    We know transportation regulations for chemical shipments inside and outside national borders keep tightening. That’s why we focus on providing material in forms—powder, microgranule, tablet—that move safely and pass customs with clear hazard classification. Each shipment leaves our dock with the documentation and verified batch identity regulators expect.

    Collaborative Product Development

    Years spent working side-by-side with formulators at multinational and regional firms have shaped our production processes. Early in the product’s rollout cycle, we adjust mesh size and hydration state based on technical trials run with clients. Cosmetic producers want fast-dissolving, low-irritation grades; feed suppliers require dense, free-flowing powder for bulk integration.

    Rather than offering a single format and expecting customers to adapt, our team visits client sites to gather feedback on batch blending, storage, and shelf life. We adapt the water-of-crystallization if local climate or downstream mixing equipment suggests adjustment. Each technical file builds over time—modifying not just one spec sheet, but how we stage washing, conditioning, and packaging for future orders.

    Meeting Tight Regulatory Demands

    2-Dimethylaminoethanol (+)-Bitartrate Salt often lands on lists for detailed regulatory review, especially when destined for nutritional or pharmaceutical use. Our compliance professionals put every batch through dietary supplement, GRAS, and pharmacopeial specification audits. Analysts review the latest toxicology data, update impurity profiles, and verify documentation against destination country standards.

    We invest in periodic, third-party laboratory cross-validation. This ensures our in-house results line up with independent reference data, a critical step for certifications or supply contracts where false negatives or unreported contaminants mean major liability.

    Sample retention and controlled documentation address both customer audits and regulatory requirements. Batches can be traced, with storage samples ready for retesting if any question arises months or years down the line. Our plant has hosted regulatory auditors from multiple regions, sharing process data transparently. These relationships build over time and inform process upgrades well before a surprise inspection.

    Listening to Feedback and Solving Field Challenges

    Modern chemical manufacturing doesn’t end at the loading dock. We keep open lines with buyers, technical leads, and laboratory staff using our DMAE bitartrate in downstream applications. If a bag arrives with unexpected clumping, altered color, or solubility outside established benchmarks, our technical support group traces the lot back, runs retests, and consults on remediation or replacement.

    No batch leaves our warehouse without a feedback loop. Over the years, certain storage and shipping routines have been updated in response to recurring customer input. For example, we now add humidity indicators inside larger drums and adjust packaging density based on buyer requests. These steps came from real-world use, not just marketing committee suggestions.

    Looking Ahead: Continuous Improvement

    We live in a world of changing market needs, regulatory revisions, and rising expectations for product purity. As new sectors explore DMAE derivatives—whether for advanced polymers, improved animal nutrition uptake, or more stable pharmaceutical blends—our production team experiments and refines based on new findings.

    Collaboration with downstream users leads us to pilot new micro-granulation techniques for better dispersal, or tweak crystallization conditions to eliminate trace impurities. The product evolves through practical engagement; whenever an industry trend emerges—like demand for GMO-free or allergen-free confirmations—we invest in new analytics and supply chain transparency to adapt.

    Choosing a Manufacturing Partner for Stability and Support

    For buyers, sourcing a chemical like 2-Dimethylaminoethanol (+)-Bitartrate Salt isn’t just about purity numbers on paper. Reliable sourcing starts with manufacturing partners who back up claims with real-time data, open records, and years of hands-on experience working through technical and logistical problems. It takes more than automated blending and a polished spec sheet—real expertise shows up in responsive support, detailed traceability, and a willingness to problem-solve together.

    Our commitment remains: keep processes transparent, invest in continuous technical improvement, and treat every order as a chance to exceed expectations for safety, consistency, and long-term partnership. DMAE bitartrate gives formulators a reliable tool—what sets it apart is the human expertise, operational care, and practical trust invested in every batch that leaves our production floor.