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2-Cyclohexylethyl Bromide

    • Product Name 2-Cyclohexylethyl Bromide
    • Alias 1-Bromo-2-cyclohexylethane
    • Einecs 211-256-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    930381

    Product Name 2-Cyclohexylethyl Bromide
    Cas Number 1990-77-6
    Molecular Formula C8H15Br
    Molecular Weight 191.11 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 222-224°C
    Density 1.186 g/mL at 25°C
    Refractive Index n20/D 1.502
    Melting Point -22°C
    Purity Typically ≥98%
    Flash Point 93°C
    Solubility Insoluble in water, soluble in organic solvents
    Storage Conditions Store in a cool, dry, well-ventilated area
    Smiles C1CCC(CC1)CCBr
    Synonyms 2-bromoethylcyclohexane

    As an accredited 2-Cyclohexylethyl Bromide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 mL of 2-Cyclohexylethyl Bromide, securely sealed with a screw cap and hazard labeling.
    Shipping 2-Cyclohexylethyl Bromide is shipped in tightly sealed containers, protected from light and moisture. It should be handled as a hazardous material, following appropriate chemical safety regulations, including proper labeling and documentation. Transport is typically conducted via ground or air freight in accordance with local, national, and international regulations for flammable and toxic substances.
    Storage 2-Cyclohexylethyl Bromide should be stored in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, and incompatible substances such as strong oxidizers. Keep the container tightly closed and properly labeled. Store in a corrosion-resistant container made of compatible material. Avoid exposure to moisture and handle under a fume hood if possible to prevent inhalation of vapors.
    Application of 2-Cyclohexylethyl Bromide

    Applications of 2-Cyclohexylethyl Bromide in Industrial Manufacturing

    2-Cyclohexylethyl Bromide acts as a valuable intermediate in specialized organic synthesis, supporting a range of industrial sectors where a controlled cyclohexyl moiety and bromine functionality are required. Our direct manufacturing focus ensures stable supply, consistent purity, and technical insight for high-end downstream applications. The following scenarios highlight its established incorporation in advanced chemical processes.

    1. Pharmaceutical Intermediate Synthesis

    In pharmaceutical ingredient manufacturing, 2-Cyclohexylethyl Bromide serves as a pivotal alkylating reagent to introduce cyclohexylethyl groups into complex drug precursor structures. It is used in multistep syntheses for active pharmaceutical ingredients (APIs), especially in antihypertensive and neuroactive drug platforms that require a cyclohexyl motif to achieve desired pharmacodynamics. Manufacturers rely on this material to enable late-stage modifications under controlled reaction conditions while minimizing side reactions and halogen exchange issues. The material’s reactivity profile and tight grading support its use in both pilot and commercial production environments.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • Current Good Manufacturing Practice (cGMP, 21 CFR Parts 210/211)
    • USP-NF and EP monograph controls on residual bromide impurities
    • REACH registration for intermediates used in pharmaceutical synthesis (Europe)

    Typical usage ratio

    • 2–7 mol% relative to target API precursor, adjusted based on reagent excess strategy and desired alkylation efficiency; precise dosage determined by substrate reactivity and batch kinetics.

    Downstream process integration

    • Material added during intermediate alkylation or cyclization stages after core scaffold assembly, typically under controlled base catalysis or transition metal-catalyzed conditions.

    Final product types

    • Small molecule APIs with cyclohexyl groups (e.g., CNS agents, antihypertensives, certain antivirals)
    • GMP-grade advanced intermediates for contract manufacturing organizations (CMOs)

    2. Agrochemical Active Ingredient Manufacturing

    Leading agrochemical producers apply 2-Cyclohexylethyl Bromide as a chain-extension or alkylation agent in the development of new herbicide and insecticide scaffolds that require a cyclohexyl backbone to impart target-specific activity. This compound’s selectivity and chemical handle allow process chemists to design molecules with improved soil mobility and pest interaction profiles, integrating it into heterocyclic or aromatic systems. Consistent bromide grade helps avoid yield loss or off-flavors during formulation scale-up and regulatory batch validation.

    Industry compliance standards

    • FAO/WHO specifications for pesticide technical materials
    • ISO 9001:2015 Quality Management certification for input traceability
    • EU Regulation (EC) No 1107/2009—Plant Protection Products
    • EPA registration requirements for inert and active ingredient declaration (USA)

    Typical usage ratio

    • 5–15 wt% of the total synthetic step input, optimized according to reaction conversion and downstream isolation efficiency; adjustment depends on the complexity of target molecular structure.

    Downstream process integration

    • Enters amidation or nucleophilic substitution reactions during late intermediate or penultimate step synthesis, followed by hydrolysis and formulation blending.

    Final product types

    • Post-emergent selective herbicides containing cyclohexylethyl units
    • Ring-substituted insecticidal raw materials for further technical conversion

    3. Specialty Fragrance and Flavor Compound Synthesis

    Fine fragrance and aroma manufacturers employ 2-Cyclohexylethyl Bromide to generate cyclohexyl-containing aroma chemicals with woody and fresh odor notes. The compound features in Grignard and Friedel-Crafts-type reactions to create custom ketones or ethers for use in designer perfume bases and food-grade flavoring agents. Purity specification and absence of odor-impacting trace bromides are routinely controlled to comply with organoleptic targets and downstream formulation standards.

    Industry compliance standards

    • IFRA Code of Practice (International Fragrance Association)
    • Food Chemicals Codex (FCC; for flavor applications)
    • REACH and TSCA registration for safe use in F&F
    • ISO 9001:2015 for batch consistency in specialty chemical synthesis

    Typical usage ratio

    • 3–10 mol% relative to aroma backbone; customization based on solubilization and final note intensity desired by fragrance/flavor house formulators.

    Downstream process integration

    • Used in nucleophilic or electrophilic substitution steps after ring construction or prior to final distillation and purification of volatile aroma components.

    Final product types

    • Concentrated fragrance intermediates with cycloalkyl structures
    • Bulk perfumery bases and top-note chemicals for fine fragrances
    • Food-safe flavor compound intermediates (subject to local flavor regulations)

    4. Polymer and Surface Modifier Additive Synthesis

    Specialty polymer manufacturers utilize 2-Cyclohexylethyl Bromide to introduce hydrophobic cyclohexyl side chains onto main-chain modifiers, resulting in enhanced surface properties such as abrasion resistance, anti-blocking, or solvent compatibility. The compound typically undergoes substitution polymer grafting or acts as an initiator in controlled radical polymerization systems. Material identification and consistent functionality enable traceable integration into performance additive manufacturing.

    Industry compliance standards

    • ISO 9001:2015 for specialty additive production
    • REACH compliance for new polymeric substances in Europe
    • ASTM D6287 for polymer additive characterization
    • TSCA Inventory Reporting (USA)

    Typical usage ratio

    • 0.5–4 wt% of total monomer charge; precise ratio tailored according to base resin identity and end-use property targets.

    Downstream process integration

    • Material incorporated during co-polymerization or oligomerization feed, preceding functional group conversion and downstream compounding or extrusion.

    Final product types

    • Thermoplastic masterbatch additives with cyclohexyl-modified side chains
    • Surface treatment and primer agents for films and engineered surfaces
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    Certification & Compliance
    More Introduction

    2-Cyclohexylethyl Bromide: Precision Chemistry Straight From the Plant

    The Essence of 2-Cyclohexylethyl Bromide

    At our facility, we turn chemistry into consistent reality. 2-Cyclohexylethyl Bromide (model BCHB-94) serves as a core intermediate across labs and production lines wherever selectivity and effective hydrophobic tagging are sought. Looking back on previous campaigns with our clients, we continually hear about their need for a reliable alkylating agent that offers both manageable reactivity and solid yields. Over the years, our experienced teams have dialed in processes that emphasize reproducibility, purity, and safety, all tested batch by batch, never just by paper data but by in-house synthetic validation that mirrors real downstream conditions.

    Direct from Manufacturer, Not a Shelf-Stock Compound

    We manufacture the compound to meet actual process and synthesis demands, not as a leftover or standardized catalog commodity. This difference shows in the way we handle raw material sourcing, timeline management, and post-process quality checks. There’s no mystery about where your material originates or how it reaches you. Each stage, from the ring system preparation to bromination and final purification, takes place under the watchful eyes of our veteran operators, who have solved more than their share of night-shift bottlenecks and specification hiccups.

    How BCHB-94 Supports Advanced Synthesis

    Many clients have found that our 2-Cyclohexylethyl Bromide opens a cleaner, more manageable route to building cyclohexyl-alkyl architectures. The straight, two-carbon ethyl bridge escaping the ring system means you get strong coupling reliability—not just theoretical, but confirmed by our own downstream pilot runs. Compare this to cumbersome, branched bromide alternatives, where side-products and oligomerization complicate your workflow. The product handles conditions typical to both laboratory and plant: nonpolar solvents, moderate temperature protocols, and controlled-atmosphere reactions. Chemical engineers have pointed out in feedback meetings that they appreciate being able to use BCHB-94 in consecutive alkylation and substitution targets without extensive purification traps.

    Specification Truth, Tested in Practice

    Every batch is verified by a rotating schedule of NMR, GC-MS, and Karl Fischer water analysis, not just for a one-time COA but in every single run. Our product leaves with a purity consistently above 98.5%, with the remaining fraction comprised principally of well-identified, non-reactive trace material. These numbers come not only from instruments but from actual trial syntheses in conditions that reflect what we hear from you—the users who run a tin-catalyzed alkylation or a late-stage C-N coupling, not pristine academic labs.

    Applications That Rely on Consistency

    Pharmaceutical developers frequently use 2-Cyclohexylethyl Bromide to introduce cyclohexyl groups for enhanced metabolic stability. Material scientists appreciate its performance in routines requiring surface modification or lipophilic chain elongation, especially where more rigid or aromatic systems create solubility challenges downstream. We’ve also seen substantial success stories from agricultural chemistry, where substitution on the two-carbon chain delivers actives that avoid unintentional off-target effects.

    Direct testimonies from contract manufacturers that scale up from kilo lab to several hundred kilos have underlined the advantages of our hands-on production model. They benefit from prompt in-process adjustments: feedback on viscosity, bromide retention, and even unexpected reaction color changes gets a direct line to our operators. Shipping complications rarely derail batches because we have capacity ready onsite to re-batch or retest without logistical delays.

    Why BCHB-94 Stands Out from the Crowd

    The defining functional feature of 2-Cyclohexylethyl Bromide lies in the unique combination of a cyclohexyl ring and a linear ethyl spacer attached to a bromine leaving group. Compared to shorter or bulkier analogues, this configuration provides a balance between sterics and reactivity in transition metal catalysis and nucleophilic substitutions. Customers often encounter isolobal alkyl bromides that bring along excess volatility or provoke undesirable side reactions; BCHB-94, on the other hand, behaves reliably at elevated temperatures and under varied solvent systems.

    Our own scale-up tests showed distinct advantages over 1-bromoethyl or isopropyl bromide: the extra methylene gives improved control over product isolation, minimizes side-chain rearrangements, and keeps off unwanted hydride shifts. Unlike tert-alkyl bromides, which call for low-temperature storage and handling, BCHB-94 holds up well in standard chemical stockrooms and comes ready for use from the drum. At the fine chemicals end, process chemists have told us that they see sharper LC traces with our product compared to multi-component distributor blends.

    Beyond the Drum: A Close Look at Handling and Storage

    Experience scraping through the bottom of countless pilot-scale drums taught us that a clean, pure stream of 2-Cyclohexylethyl Bromide can’t be left to fate. Moisture pickup, especially at the interface during dispensing, ruins entire production runs. That’s why we set the material up to leave the plant only after a final moisture screen. We pack it in air-tight, nitrogen-flushed containers with minimal headspace, based on our own experience watching lesser products fail their uptake thresholds in summer humidity.

    We recommend storage at ambient temperature, protected from direct sunlight and isolated from incompatible reagents, most notably strong bases and oxidizers. Operations staff, new to the compound, usually welcome a quick demonstration of safe transfer and use practices at our site, if they find company SOPs need updating. Actual handling benefit comes from limited volatility and a relatively high boiling point, which prevents accidental loss when transferring between vessels—a feature noted by site logistics teams, who always have to keep an eye on waste and exposure.

    Supporting Real Chemistry, Not Just Paper Formulas

    Our technical staff have long experience in multi-step organic synthesis, meaning we ask hard questions about reactivity before posting new batches for release. The team customizes technical support based on your process specifics, sharing both best practices and real problem-solving. If an unexpected impurity peaks in a process run, we take back the sample, check for source-level issues, and share clear chromatograms from repeat analyses.

    This approach benefits customers scaling from development glassware to fixed or semi-batch reactors. We recall a recent case with a large pharma partner who moved up production and encountered a persistent trace impurity. We traced the source to one of the brominating agents and made adjustments mid-campaign, keeping their schedule intact and saving them from resorting to an alternative route. Few experienced chemists want to gamble an entire batch on a variable supply, especially when downstream costs rise exponentially with a single setback. Our continuous engagement with these real-world cases keeps both our QC standards and production process strong.

    Environmental Considerations and Process Sustainability

    Regulation of alkyl bromides demands vigilance. Our plant invested early in closed system loading and vent scrubbing for all bromine-associated materials, especially during final work-up. This means no venting of fumes into shared air, and verified containment during every transfer operation, with both personal and process safety at the forefront. Waste streams pass through on-site neutralization backed by periodic effluent checks—results posted for both our internal records and oversight by visiting inspectors who know what compounds to look for.

    Through collaboration with neighboring facilities, we have implemented a shared bromide reclamation system. This drops our environmental footprint well below legacy standards, ensuring both regulatory alignment and lower operating costs. Whenever a customer asks us to support green chemistry designs, we offer technical sheets outlining water and energy load for each batch. Trial partners have applied this data to justify process route selection during their own audits, knowing their inputs help satisfy stricter waste and carbon limits.

    Future Paths: From Niche to Large-Scale Applications

    Growth in the customized fine chemical sector keeps driving our push for better, more sustainable 2-Cyclohexylethyl Bromide. Expansion of capacity allows us to meet needs ranging from a few kilos for R&D to tons supporting multi-site manufacturing. Our raw material contracts ensure a steady input stream, locking in quality and continuity—two elements our recurring clients have learned to value above any price break on trial lots.

    Synthesis teams report that as new reaction methodologies emerge (cross-coupling, late-stage modifications), the cyclohexylethyl group’s moderate size and shape let them build new molecular targets that bulkier or more reactive groups would block. End-users in specialty polymers or next-generation surfactants have begun using BCHB-94 as a backbone modulator, capitalizing on its balance of hydrophobicity and manageable reactivity. The feedback loop between our innovation team and partners means we tweak specifications based on actual outcomes, not just standard test runs.

    User-Driven Adjustments and Problem Solving

    We keep our phone lines and field staff open for users who run into practical problems. In the past, we’ve helped process teams adjust storage logistics, tested compatibility with new solvents, and even retooled some purification steps to help partner operations speed up throughput. Our troubleshooting doesn’t stop at a shipment’s gate—real support means ongoing follow-up after delivery and a willingness to roll up sleeves and tackle ongoing process puzzles.

    Case in point: one agricultural chemist trying to scale up a sulfonamide synthesis met recurring emulsification and separation headaches. Our technical crew visited, sampled the phase layers themselves, and suggested in-line co-solvent optimization. Yield rose 5%, and the purification headaches disappeared at the next trial. Direct field intervention, rather than off-the-shelf advice, keeps projects moving faster and avoids downstream escalation.

    Clear Differences from Distributors: Manufacturing Approach

    We run our reactors, not just order from distant plants. With that comes a commitment to both deep process knowledge and accountability—there’s no blaming an anonymous upstream partner for out-of-spec batches. Our maintenance logs, process deviations, and solution archives belong to the same shop in which your orders get filled. This makes it easy to follow up, iterate, and build relationships based not on paperwork but on performance.

    The feedback from veteran plant operators and chemists has repeatedly highlighted one major point: a compound produced in a plant with direct customer engagement beats generic alternatives in consistency and traceability. Whether it’s matching a new customer’s NMR result to ours or syncing a timed release to a tight project deadline, we build in trust and verification at every level. Changeovers and process updates stay rooted in what end users have learned through actual work—not just checkboxes for regulatory approval, but adaptations that help all partners stay ahead of shifting industry norms.

    Practical Learning and Technical Exchange

    Years on the floor, blending, scaling, and problem-solving with 2-Cyclohexylethyl Bromide, have shown us that synthetic chemistry rewards foresight, steady process control, and a willingness to adapt. We host periodic technical roundtables that bring process chemists, QC leads, and even plant floor operators together to drive new ideas. These sessions led to improvements in both analytical throughput and on-line monitoring, accelerating batch releases and resolving investigation cases without long delays.

    A recent collaboration with a major contract manufacturer sparked a method rewrite for handling trace oxidant impurities. By co-developing the new protocol, we cut out dozens of hours of lost work annually and strengthened crosstalk between labs and operation cells. Through these shared projects, our BCHB-94 output benefits from both internal discipline and customer-driven innovation—a pairing that generic supply chains seldom match.

    Conclusion: Trusted Chemistry, Made With Accountability

    Production of 2-Cyclohexylethyl Bromide at our plant remains a hallmark of how deep process knowledge, direct manufacturing oversight, and long-term industry partnership can create a product that genuinely serves those pushing synthetic boundaries. What separates BCHB-94 from distributor stock or blended alternatives is the layers of real-world testing, user-centered adjustment, and technical engagement found only in a plant with skin in the game. For teams who value both predictability and a direct line to their supplier, our approach supports successful projects from first sample to production-scale quantities—and adapts over time, as technology and regulation march forward.