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2-Chlorophenyl Isocyanate

    • Product Name 2-Chlorophenyl Isocyanate
    • Alias Isocyanic acid, 2-chlorophenyl ester
    • Einecs 213-319-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    979539

    Cas Number 2909-36-9
    Molecular Formula C7H4ClNO
    Molecular Weight 153.57 g/mol
    Appearance Colorless to pale yellow liquid
    Melting Point 14-16°C
    Boiling Point 220-222°C
    Density 1.32 g/cm3 at 25°C
    Solubility Reacts with water, soluble in organic solvents
    Flash Point 98°C
    Chemical Classification Aromatic isocyanate
    Odor Sharp, pungent odor
    Refractive Index 1.574
    Un Number 2206

    As an accredited 2-Chlorophenyl Isocyanate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500 mL amber glass bottle with secure screw cap, labeled "2-Chlorophenyl Isocyanate," hazard symbols, and handling instructions.
    Shipping 2-Chlorophenyl Isocyanate should be shipped in tightly sealed containers, protected from moisture and incompatible substances. Transport must comply with hazardous materials regulations (UN 2206, Toxic, Class 6.1). Ensure proper labeling, ventilation, and prevent exposure to heat or direct sunlight. Emergency response and safety documentation must accompany the shipment.
    Storage 2-Chlorophenyl isocyanate should be stored in a tightly sealed container in a cool, dry, well-ventilated area away from heat, moisture, and incompatible substances such as water, alcohols, bases, and amines. Store under inert atmosphere if possible. Keep away from sources of ignition and direct sunlight. Use appropriate chemical-resistant containers and secondary containment to prevent leaks or spills.
    Application of 2-Chlorophenyl Isocyanate

    Applications of 2-Chlorophenyl Isocyanate in Industrial Manufacturing

    2-Chlorophenyl Isocyanate is used as a core intermediate in several specialized chemical processes across industrial manufacturing sectors. As a dedicated manufacturer, we ensure consistent supply for downstream integrators who demand traceable sourcing, high-purity input, and technical support for advanced synthesis. Below are the main industrial segments that rely on our material for critical synthesis pathways.

    1. Synthesis of Agrochemical Active Ingredients

    Agrochemical formulators use 2-chlorophenyl isocyanate as a key intermediate to construct urea, carbamate, and triazine derivatives with precise pesticidal and herbicidal activity. The reactive isocyanate group enables coupling with various nucleophiles under controlled conditions, forming bonds essential for modulating biological efficacy and stability. This building block is critical for the commercial-scale production of selective weed killers and systemic fungicides, with strict compliance to manufacturing practices that safeguard downstream food chain safety and environmental stewardship.

    Industry compliance standards

    • FAO/WHO Specifications for Pesticide Actives (FAO/WHO)
    • REACH Registration (EC 1907/2006, Europe)
    • ISO 9001:2015 (Quality Management for Chemical Synthesis)
    • China National Standard GB 4839 for Agrochemical Intermediates

    Typical usage ratio

    • Intermediate used 0.85 – 1.15 molar equivalents in condensation reactions, adjusted depending on substrate reactivity and desired product purity.

    Downstream process integration

    • Introduced during the nucleophilic addition stage to amine or hydroxyl functionalized precursors.
    • Reacted in jacketed vessels under inert atmosphere, controlled at 40–80°C to minimize byproduct formation.
    • Isocyanate function ensures targeted ring closure or linkage formation.

    Final product types

    • Phenylurea-based herbicides (e.g., Chlorotoluron derivatives)
    • Triazine-system fungicides
    • Precursor blocks for insect growth regulators

    2. Custom Pharmaceutical Intermediate Synthesis

    Process development chemists utilize 2-chlorophenyl isocyanate in the construction of advanced pharmaceutical intermediates, including aromatic ureas and carbamates with confirmed activity in CNS and antihypertensive agent classes. The isocyanate provides high yield linkage to aromatic or aliphatic amines, facilitating late-stage functionalization in small molecule APIs. Handling under GMP-compatible conditions is mandatory, as trace levels and byproducts are strictly regulated in medicinal chemistry supply chains.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, ICH Q7)
    • US Pharmacopeia (USP) and European Pharmacopoeia (Ph. Eur.) Methodologies for Pharmaceutical Intermediates
    • FDA 21 CFR Part 210/211 (US)
    • Hazardous Substance Regulations (Globally Harmonized System, GHS)

    Typical usage ratio

    • Employed in 1.00 – 1.20 molar equivalents for coupling to primary or secondary amines, with minor excess to ensure conversion in cGMP conditions.

    Downstream process integration

    • Added in anhydrous solvents at defined process steps, typically after amine substrate verification via in-process QC.
    • Batch synthesis with in-process sampling for LC-MS or HPLC purity monitoring.
    • Reaction temperature controlled 20–35°C to prevent side product formation.

    Final product types

    • Benzylurea and arylurea pharmaceutical intermediates
    • Antihypertensive agent precursors (e.g., custom sartan analogues)
    • CNS drug building blocks for further derivatization

    3. Specialty Polymer Modifier for Polyurethane Elastomers

    Manufacturers of high-performance polyurethane elastomers introduce 2-chlorophenyl isocyanate into prepolymer formulations to achieve tailored hard segment architectures and fine-tune mechanical properties. The presence of the chloroaromatic group imparts resistance to hydrolysis and enhances flame retardancy in the finished polymer. All synthesis and compounding require adherence to safety and emissions regulations due to the hazardous nature of isocyanates and the need to eliminate residual monomer in the final resin system.

    Industry compliance standards

    • ASTM D3574 (Polyurethane Testing Protocols)
    • ISO 9001 (Polymer Manufacturing Quality Systems)
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)
    • NIOSH Pocket Guide to Chemical Hazards

    Typical usage ratio

    • Used at 0.3% – 2.0% by weight in prepolymer matrix, ratio determined by final Shore hardness target and regulatory limits on free isocyanate.

    Downstream process integration

    • Blended into isocyanate prepolymer stream before chain extension step.
    • Reacted with excess polyol components under vacuum to minimize side reactions.
    • Process temperature typically maintained 30–60°C for controlled polymerization rate.

    Final product types

    • Specialty elastomer rollers for industrial machinery
    • High-durability belt coatings
    • Flame-retardant insulation foams

    4. Chemical Synthesis of Reactive Dyes

    Producers of reactive and disperse dyes rely on 2-chlorophenyl isocyanate to introduce isocyanate moieties that enable covalent bonding to textile fibers during fabric treatment. The chloro substituent allows additional control of dye hydrophobicity and wash fastness. Reactivity to hydroxyl- or amine-containing dye intermediates is typically exploited in multi-step batch processes with stringent effluent and residue management to meet industry dye purity norms and environmental protection requirements.

    Industry compliance standards

    • OEKO-TEX Standard 100 (Harmful Substance Limitation in Textiles)
    • REACH Regulation (EC 1907/2006, Annex XVII for dyes)
    • ZDHC Manufacturing Restricted Substances List (MRSL) for Dyehouses
    • ISO 14001 (Environmental Management for Dye Synthesis)

    Typical usage ratio

    • Applied at 0.5 – 1.5 molar equivalents in coupling reactions with dye chromophores, ratio depends on chromophore reactivity and final fastness requirements.

    Downstream process integration

    • Administered during late-stage dye synthesis after chromophore construction.
    • Performed in jacketed glass reactors, temperature held at 25–45°C.
    • Monitored by thin layer chromatography to confirm complete coupling and limit free isocyanate residue.

    Final product types

    • Reactive dyes for cotton fabric finishing
    • Disperse dyes for polyester and blends
    • Specialty pigment intermediates
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    Certification & Compliance
    More Introduction

    Introducing 2-Chlorophenyl Isocyanate: Practical Insights from the Manufacturer’s Plant Floor

    The Everyday Value of 2-Chlorophenyl Isocyanate in Industrial Production

    Every day in our facility, 2-chlorophenyl isocyanate takes its place at the center of specialty chemical manufacturing. The product’s chemical strength comes from its structure: a chlorinated phenyl ring attached to the reactive isocyanate group. Over years of direct involvement, it’s clear that this compound isn’t just another commodity isocyanate. Its nuanced performance profile shapes production lines, synthesis decisions, and the outcome of diverse finished goods in ways other isocyanates can’t match.

    Model and Specifications Direct from Our Line

    We produce 2-chlorophenyl isocyanate with a consistent focus on purity and controlled handling characteristics. Most batches hit a purity level calculated for industrial-scale, multi-step synthesis, above 98%. Moisture content stays low since even a small water incursion can trigger dangerous polymerization or foul up sensitive pharmaceutical reactions further down the process. The color often falls between colorless and pale yellow; any significant shift gives a quick hint of oxidation or contamination, and staff address it before any quality dips ripple outward.

    Physical form—clear to barely yellowish liquid—remains stable in sealed containers under dry nitrogen blanketing. Packing choices come straight from on-the-floor experience: high-density polyethylene or approved steel drums with tested chemical liner coatings eliminate leaching, and keep small-scale labs or bulk chemical plants safe from corrosion mishaps or permeation risks. Fresh batches run through refractive index and infrared spectroscopy checks on site before leaving shipping; otherwise, any small impurity would complicate later customer processing.

    Usage Grounded in Industrial Realities

    Major application areas, starting with pharmaceuticals and agrochemicals, pull demand week after week. Our teams see 2-chlorophenyl isocyanate incorporated in key synthesis routes for active molecules, where its fine-tuned reactivity profile replaces simpler isocyanates that can’t differentiate between similar functional groups. Research partners gravitate toward this compound for building urea, carbamate, and urethane motifs with controlled substitution patterns, the kind essential for next-generation herbicides, insecticides, and modern medicine alike.

    Polymer chemists regularly draw on the chlorophenyl ring’s influence during copolymer formation and curing. Its electron-withdrawing effect on the ring tunes the speed and selectivity of addition reactions, which matters when aiming for non-yellowing, UV-stable coatings or advanced resins that need both longevity and high thermal resistance. Material engineers in adhesives, sealants, and specialty coatings count on this distinction: mechanical and color stability after months of outdoor exposure depends heavily on the correct isocyanate feedstock.

    Some users leverage the site-specific reactivity of our product for protecting functional groups in intermediates or for stepwise functionalization in elaborate synthesis campaigns. Lab reports from our own R&D as well as stories traded at customer visits confirm the isocyanate’s nuanced performance often reduces the number of steps and allows for higher overall yield, specifically compared against less selective or more generalized reagents.

    Hands-On Differences from Other Isocyanates

    Compared with methyl, phenyl, or even tolyl isocyanates, the 2-chlorophenyl variant stands apart in a handful of repeatedly visible ways. The chloro substituent on the aromatic ring exerts a strong electron-withdrawing pull, lowering the isocyanate’s basic reactivity. This shift gives process chemists increased latitude to drive the chemistry where they want and avoid undesired side reactions. Our staff has seen higher consistency in final product color and purity, especially in complex, temperature-sensitive processes.

    On the safety side, the compound’s volatility marks a middle ground: lower vapor pressure than methyl isocyanate, which means fewer respiratory incidents for on-floor operators and easier vapor containment, but enough volatility to allow controlled introduction via gas-phase or high-dilution liquid systems. Handling protocols follow chronic experience instead of models—the team has replaced less stable or more allergenic isocyanate streams with 2-chlorophenyl isocyanate to reduce unplanned interruptions and lower personal protective equipment usage.

    As for cost, our buyers working on long-term projects regularly calculate variable raw material expenses. While 2-chlorophenyl isocyanate doesn’t undercut commodity isocyanates, it often defrays overall production bills by cutting rework and increasing throughput, particularly where other reagents need extra purification cycles or tighter temperature control to avoid batch failures.

    Process Control, Traceability, and Regulatory Confidence

    Every shipment reflects the sum of repeated audits and process adjustments, shaped by new regulatory bulletins and customer-specific compliance requests. Documentation sits at the core, ensuring every drum carries a unique batch identifier traceable back to raw precursors. Internal quality assurance staff draw on both manual records and digital systems, maintaining transparency well beyond standard product sheets. Since many customers need alignment with pharmaceutical or crop-protection standards, analytical results from our production lab travel together with COAs matching their local regulatory frameworks.

    We update our environmental and safety handling suggestions as best practices shift across the industry, particularly as more information comes to light on long-term isocyanate exposure effects. Experience proves that short-term savings on insufficient containment, inadequate labeling, or poor operator training backfire—often with regulatory scrutiny or insurance claims. Teams train on real-world incident examples from both our own operation and industry cases, which prompts us to innovate stepwise upgrades to local exhaust, personal monitoring, and emergency shutdown response.

    Supporting R&D Without Wasted Steps

    Smaller labs and innovation teams regularly call on us for special-batch production. Early-stage pharmaceutical and agricultural synthesis rarely follows off-the-shelf protocols—instead, clients ask for specific physical states, custom solvent percentages, or enhanced purity bands. Our production staff pulls from direct R&D feedback from both frequent and unique projects to open up processes directly for non-standard customer needs, all while preserving traceability back to core drums. Analytical chemists on our team break down individual requests, and order volumes, delivering insight on more subtle chemical fingerprints like trace halides or rare decomposition side-products—details that often separate a success from a false start in scale-up chemistry.

    Supply Chain Security Forged by Habit, Not Hype

    Global trade patterns keep tightening—import tariffs, shipping bottlenecks, and raw input shortages all leave their mark on specialty isocyanates. Instead of focusing on promotional claims, we keep raw material approvals diversified across qualifying suppliers, maintain larger in-plant buffer stocks, and develop contingency packing options to cut lead-time shocks. After living through enough supply chain swings, plant leaders know that resilience doesn’t come from last-ditch measures when containers get stuck at port. It’s a sustained focus: plenty of redundant infrastructure, open communication both with feedstock traders and customer warehouse managers, and an ongoing drive to preempt any run on inventory that might disrupt customer production lines.

    Relationships with logistics partners don’t rest on spreadsheets alone. Partners receive ongoing safety and handling training at our site, until all promising vendors can reliably move chlorinated isocyanates through to their end-destinations without slips, exposure events, or tampering. Import authorities and customs teams recognize and trust our safety and specification records, because they’re built up organically from actual experience and quality follow-up, not just fine print or broad disclaimers.

    Ongoing Challenges and Practical Solutions

    No one in industrial isocyanates can afford to ignore health and environmental hazards, nor can responsible companies substitute wishful thinking for clean compliance. Our long-term solution grows from continuous process review—changing reaction temperatures and pressures through digital monitoring, introducing new loading limits, and adapting on-site scrubbing technology to match evolving emission standards.

    Waste stream management presents a constant technical problem, with new projects testing disposal and recycling options for chlorinated byproducts. Every new emission permit or regional chemical directive brings another round of solvent recapture redesigns and on-the-ground training. Aging facilities require thoughtful capital upgrades instead of part-time fixes: by sharing long-term environmental audit data directly with customers, we keep all supply chain members aware of impending changes and realistic about improvement timelines.

    On the customer end, tight batch-to-batch consistency ranks higher in real-world value than theoretical purity on a specification sheet. Production engineers from leading agricultural or pharmaceutical firms share stories of line slow-downs caused by outside-supplied isocyanates that varied week to week. We draw from these experiences, applying new batch release protocols, scheduled cross-checks with customer labs, and prompt fact-based troubleshooting talks—creating an industry feedback cycle that drives reliability upward without imposing arbitrary requirements.

    Looking Ahead: Your Partner for Advanced Isocyanates

    Markets for 2-chlorophenyl isocyanate stay resilient because the chemistry brings practical strengths rather than superficial product claims. Experience teaches that no shortcut replaces real-time plant floor knowledge, direct analytical checks, or the accumulated lessons from countless campaign runs. Innovation teams and cost engineers return for renewed business not just for technical merit, but because they see fewer surprises in every drum—cycles run smoother, projects reach goals with fewer wasted steps and setbacks.

    With each advancement in polymer design, crop-protection science, or pharmaceutical synthesis, new demands arise for isocyanates tuned to more exacting requirements. Our plant managers and technical staff welcome these challenges as opportunities—matching real customer feedback with updated process controls, transparent data, and a no-nonsense focus on quality and supply security. This approach keeps 2-chlorophenyl isocyanate as a solid staple among specialty chemical building blocks, ready to support the changing needs and aspirations of every industrial partner who shares our commitment to quality and progress.