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2-Chlorophenyl Cyclopentyl Ketone

    • Product Name 2-Chlorophenyl Cyclopentyl Ketone
    • Alias 2-Chlorobenzoylcyclopentane
    • Einecs 246-848-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    139368

    Product Name 2-Chlorophenyl Cyclopentyl Ketone
    Cas Number 36039-97-7
    Molecular Formula C11H11ClO
    Molecular Weight 194.66 g/mol
    Iupac Name 1-(2-chlorophenyl)cyclopentan-1-one
    Appearance White to off-white solid
    Melting Point 43-45°C (approximate)
    Density 1.17 g/cm³ (estimated)
    Solubility Insoluble in water; soluble in common organic solvents
    Smiles C1CCC(C1)C(=O)C2=CC=CC=C2Cl
    Purity Typically ≥98% (commercial sources)
    Storage Conditions Store in a cool, dry, and well-ventilated place
    Hazard Statements May cause skin and eye irritation

    As an accredited 2-Chlorophenyl Cyclopentyl Ketone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 100-gram amber glass bottle with a tamper-evident cap, labeled "2-Chlorophenyl Cyclopentyl Ketone," including hazard and handling information.
    Shipping 2-Chlorophenyl Cyclopentyl Ketone is shipped in tightly sealed, chemical-resistant containers under cool, dry conditions. Packaging complies with safety regulations for hazardous materials. Each container is labeled with proper hazard warnings and accompanied by a Material Safety Data Sheet (MSDS). Transportation occurs via authorized carriers specializing in chemical logistics.
    Storage 2-Chlorophenyl Cyclopentyl Ketone should be stored in a tightly closed container in a cool, dry, and well-ventilated area away from direct sunlight, heat sources, and incompatible substances such as strong oxidizers. Ensure proper labeling and keep away from moisture to prevent decomposition. Use secondary containment to prevent leaks or spills, and avoid storage near food or drink.
    Application of 2-Chlorophenyl Cyclopentyl Ketone

    Applications of 2-Chlorophenyl Cyclopentyl Ketone in Industrial Manufacturing

    As a specialized manufacturer of 2-Chlorophenyl Cyclopentyl Ketone, we supply this advanced intermediate to globally recognized producers in fine chemicals sectors that require precise raw material inputs for process-critical syntheses. Industrial clients leverage this compound for its targeted reactivity and high yield profile, specifically in synthesis routes where selectivity and purity underpin downstream application performance.

    1. Pharmaceutical Intermediate Synthesis

    2-Chlorophenyl Cyclopentyl Ketone serves as a crucial intermediate in the synthesis of anti-infective and CNS-active pharmaceutical agents, directly integrated into established multi-step synthetic routes for proprietary active ingredients. Major pharmaceutical facilities employ this compound during the construction of pharmacophores containing chlorinated aromatic moieties, where stringent control of positional isomer ratios and impurity profiles is required to meet active pharmaceutical ingredient (API) release specifications. Material enters at the stage of advanced intermediate coupling, where halogen-substituted cyclopentyl ketones facilitate key carbon–carbon bond formations preceding API core assembly.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 211: US FDA GMP for Finished Pharmaceuticals
    • European Pharmacopoeia Monographs—relevant residual solvent and impurity guidelines
    • ISO 9001:2015 Quality Management for Chemical Manufacturing

    Typical usage ratio

    • Applied at 0.6–1.2 molar equivalents in step-growth synthesis, with precise quantities determined by the stoichiometry of the halo-ketone chemistry and target product yield

    Downstream process integration

    • Loaded directly into intermediate synthesis reactors following chlorination or Grignard additions; handled in closed system reactors with reagent-grade solvents under inert gas; downstream purification by crystallization or preparative chromatography prior to pharmacopeial analysis

    Final product types

    • API intermediates for anti-infective tablets and injectables
    • Core structures in CNS therapeutics
    • Building blocks for new chemical entities (NCEs) under clinical evaluation
    • Advanced intermediates for out-licensing and CMO production contracts

    2. Agrochemical Active Ingredient Production

    Leading agrochemical manufacturers employ 2-Chlorophenyl Cyclopentyl Ketone as a foundation in synthesizing selective herbicides and fungicides where the cyclopentyl-ketone motif is critical for biological activity. Chlorinated aromatic systems contribute to molecular stability and facilitate downstream functionalization, such as etherification or amination, in crop protection formulations. Through tightly controlled reaction steps, our clients achieve high conversion yields necessary for regulatory submissions and scale-up, with the ketone introduced during primary batch charging ahead of nucleophilic substitution and subsequent formulation blending.

    Industry compliance standards

    • FAO/WHO Technical Specifications for Pesticides
    • ISO 9001:2015-certified agro-input production systems
    • REACH Annex VII–X registration for industrial intermediates
    • OECD Good Laboratory Practice (GLP) for test batches and analytics

    Typical usage ratio

    • Formulation input typically 5–15% w/w in precursor synthesis, with end-use formulation content calibrated for required field rates and regional regulatory limits on active content

    Downstream process integration

    • Added at initial synthesis step for non-aqueous batch reaction; transformation options include Friedel–Crafts acylation, followed by isolation, solvent exchange, and technical concentrate preparation; undergoes multi-step downstream derivatization for formulated EC, SC, or WG products

    Final product types

    • Herbicide technical concentrates
    • Fungicide active ingredient pre-concentrates
    • Crop chemical formulation bases (suspension/glyphosate alternatives)
    • Bulk intermediates for fine agrochemical synthesis

    3. Specialty Fragrance and Aroma Chemical Synthesis

    Specialty fragrance ingredient producers utilize this ketone for synthesizing complex aromatic compounds found in exclusive perfumery and flavor blends. The chlorinated benzyl motif imparts unique olfactory characteristics and acts as a precursor for advanced cyclopentyl musk and woody notes. During fragrance development, the compound is subjected to key transformations such as hydrogenation, acetalization, or acyl transfer within semi-batch glass-lined vessels, achieving high-purity intermediates that directly influence olfactory thresholds and stability profiles in commercial fragrance compounds.

    Industry compliance standards

    • IFRA Standards (International Fragrance Association)
    • ISO 9001:2015 for fragrance ingredient manufacturing
    • Good Manufacturing Practices for Flavor Ingredients (FEMA/GRAS)
    • REACH Registration—Aroma chemicals

    Typical usage ratio

    • Applied at 1–8% on aroma chemical weight basis depending on the target note concentration, with batch variations reflecting end-customer scent profile specifications

    Downstream process integration

    • Charged at initial synthesis for core structural assembly; proceeds through reduction or condensation prior to dilution and blending for fragrance compounding; subject to multi-stage quality control (GC/MS, sensory panel)

    Final product types

    • Fine fragrance blend intermediates
    • Personal care essence bases (for colognes, deodorants, shower gels)
    • Flavoring agents in specialty foods and beverages
    • Technical aroma chemical concentrates for downstream blending

    4. Advanced Material and Polymer Additive Manufacturing

    Producers of engineered polymers and specialty materials select this compound as a reactive modifier in performance additive packages where cyclopentyl-aromatic structures improve thermal and chemical resistance. The molecule’s reactivity enables targeted cross-linking or chain-terminating reactions in resins and high-performance plastics, imparting controlled molecular architecture in application-specific composites. Customers introduce the material in compounding steps requiring precision, often using advanced dosing systems to ensure batch-to-batch reproducibility and compliance with sector-specific technical requirements.

    Industry compliance standards

    • ASTM D638 and D256 for polymer physical properties
    • ISO 9001:2015 for additive masterbatch production
    • REACH Annex IX/X registration for performance additives
    • RoHS Directive (2011/65/EU) for electronic polymer components

    Typical usage ratio

    • Typical addition at 0.2–2.0% w/w in engineered plastic blends, modulated based on final property targets (impact strength, glass transition, thermal stability)

    Downstream process integration

    • Introduced during extrusion or melt-compounding; pre-blended with base resin and other additives prior to blending in twin-screw extruders; diffusion and cross-linking verified during thermal/post-curing steps at dedicated QC labs

    Final product types

    • High-performance modified engineering plastics (e.g., PEEK, polyamides)
    • Composite material masterbatches for automotive and aerospace
    • Electronic component encapsulation compounds
    • Custom additive concentrates for industrial polymer processors
    Free Quote

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    Certification & Compliance
    More Introduction

    2-Chlorophenyl Cyclopentyl Ketone: Direct from Our Production Lines

    The Hands-On Reality Behind 2-Chlorophenyl Cyclopentyl Ketone Manufacturing

    In the fine chemicals field, 2-Chlorophenyl Cyclopentyl Ketone stands out both as a foundational building block and a reflection of the intricate art of synthesis. Day after day, in our manufacturing facilities, the journey of this molecule starts with establishing clarity about each reaction parameter, from raw material sourcing to final crystallization. We track every batch to ensure that what leaves our floor arrives in your hands with the consistency only scale producers can guarantee.

    The core of our work centers around getting the reaction between cyclopentanone and 2-chlorobenzene derivatives just right, under controlled temperatures and carefully monitored catalytic conditions. Many might overlook the importance of selecting the correct grade of precursor chemicals, but in practice, small impurities in a starting material can spiral into difficult downstream challenges: colored product, off-odors, unstable intermediates, or residues that cause headaches during scaling up. By keeping a close grip on the origin, storage, and purity of everything that enters our reactors, we sidestep a lot of issues that traders and buy-resell operations often miss.

    What Sets Our Product Apart

    Looking at 2-Chlorophenyl Cyclopentyl Ketone in isolation—a pale, solid compound, generally presenting as faintly crystalline—only tells half the story. We obsess about practical differences that show up not in lab catalogs, but on actual production lines.

    Our batches typically present a high level of single-component purity, as measured by gas chromatography above 99%. The melting point hovers consistently within a tight temperature window, which signals both precision during synthesis and careful handling after crystallization is complete. Seemingly minor tweaks—like the rate at which solvent is removed at the end of a reaction or the way cooling is applied—can have major effects on how easily the final product handles, whether it compacts into one mass or flows smoothly into your process equipment.

    Years of firsthand manufacturing have hammered home the lesson that visual inspection is never enough. We run not just purity and identity checks, but also closely observe for polar impurities and byproducts that can foil later coupling or reduction steps. Batch-to-batch records tell us how shifts in ambient humidity or warehouse conditions might nudge the product’s appearance or cause caking. This traceability is the only way to avoid surprises once material is shipped offsite.

    Applications: Beyond Abstract Uses

    Requests for 2-Chlorophenyl Cyclopentyl Ketone most often come from R&D or full-scale pharmaceutical and agrochemical developers. Its structure provides both reactivity and unique steric blocking, opening the door to several synthetic possibilities such as coupling, Friedel-Crafts acylation, reductive amination, and direct transformation into other functionalized ketones. In practice, customers trace this intermediate into high-value, late-phase molecules, where functional group compatibility and low impurity carryover provide a baseline for clinical and regulatory success.

    Because our team participates in multi-step synthesis projects, we’ve seen firsthand the pitfalls of poor-quality intermediary ketones. Sometimes it’s the presence of isomeric byproducts that proves fatal—a variant that looks barely different on a spectrum can introduce chirality issues or spoil the yield of a downstream reaction. At other times, minor residues from solvents or insufficiently removed acids interfere with hydrogenation, stalling a whole project. In response, our production uses tightly closed equipment, dedicated washing, and controlled atmosphere sections to keep both obvious and subtle contaminants below threshold.

    In the agricultural sector, this ketone acts as a base for crafting designer crop protection agents. Here, trace residues that wouldn’t be visible even with modern analytical techniques may still influence biological trials and regulatory review. The feedback loop from technical registration testing gets relayed back—sometimes years after initial deliveries—helping us fine-tune in areas others miss. We don’t see these challenges as inconveniences so much as guideposts for smarter production tuning and more open customer engagement.

    Model, Handling, and Experience-Driven Practice

    For labeling, most factories lump this intermediate into lot numbers and broad impurity classes. In our workflow, each model represents not just an identification code, but also a distinct pathway—specific reactor geometries, tailored filtration set-ups, and storage regimes. Over time, patterns emerge: one reactor turns out product with fewer particulate byproducts, but demands strict protocol to avoid local overheating; another offers flexibility but at the expense of a slightly wider melting range. These real-world trade-offs become part of what we share with partners, openly discussing which lot best fits which type of synthetic scheme.

    Since 2-Chlorophenyl Cyclopentyl Ketone falls into an intermediate hazard classification, safe storage and careful packaging shape each shipment. We use high-integrity HDPE drums with tamper-evident seals and inert gas blanketing for both local and international dispatches. Our storage area uses temperature and humidity control, not only to maintain chemical stability but to ensure that even in less-than-ideal environmental conditions, caking and degradation remain non-issues. Years of aggregate data have shown that keeping product at moderate temperatures, away from rapid thermal cycling, pays dividends—preventing the subtle shifts that only show up at a customer's reaction bench.

    Anecdotes from the field have reinforced for us the importance of proper handling: a customer’s mechanical feeder jammed repeatedly due to powder packed in a soft-sided bag; another lab encountered elevated water content from a poorly closed drum left too long on a loading dock. These stories influence how we approach day-to-day production logistics, from double-checking container closures to tracking warehouse dwell times on a digital dashboard rather than handwritten ledgers. Experience, rather than formality, keeps standards ground-floor reliable.

    The Perspective of a Direct Manufacturer

    Unlike brokers or after-market traders, everything we share about 2-Chlorophenyl Cyclopentyl Ketone stems from hands-on synthesis and logistical management. We regularly field queries not just on price or shipping locations but on nuanced technical points. Chemists at our site help troubleshoot reaction anomalies related to solvent choice, temperature profiles, or impurity troubleshooting—not because it’s expected, but because we know every material carries a story from raw ingredient to packed drum. The same batch traced through our documentation has usually been handled by a small, experienced team; each handoff logged, photographs snapped, analytical results consolidated into cumulative records.

    Real manufacturing brings a blend of opportunity and accountability. If someone comes back with a question about reactivity or performance, we go back not just to the final batch test, but to process logs, chromatography printouts, even spectrometer archives. We keep closely aligned with customer R&D and production teams, sometimes conducting parallel laboratory confirmations if a target molecule throws a curveball during downstream reactions. Years of this back-and-forth have gradually built up a rich, almost anecdotal store of information, some written, some passed along as operating wisdom. A trader, or even a contract packager, simply doesn’t touch the level of technical engagement that daily plant supervision demands.

    Interpreting Real-World Differences from Other Intermediates

    Some in the field ask about distinctions between 2-Chlorophenyl Cyclopentyl Ketone and similar aryl cyclopentyl ketones or analogs with bromine, fluorine, or different ring systems. From a direct synthetic perspective, the presence of the chlorine atom at the ortho position brings more than just a regulatory or nomenclature change. It leads to subtle electronic effects—modifying the reactivity in subsequent steps, especially where Grignard or cross-coupling reactions figure in downstream plans. In practice, selectivity differences show up in yields, byproduct profiles, and ease of purification in later steps. Other analogs bring their quirks but also introduce logistical headaches, including different hazard codes or shorter shelf-lives under ordinary storage.

    We don’t just list differences as a chart. Every year, we run side-by-side experiments on process optimization, updating our team on whether a seemingly minor substitution can make a crucial difference at scale. Sometimes, the flow properties of a product shift dramatically, affecting dosing and metering in continuous production. Sometimes, only patient solvent screening reveals which variant will work best in a specific coupling or acyl transfer. Our manufacturing strategy relies heavily on what works in repeat runs on real equipment, not just what passes muster in bench-scale reports.

    Continual Quality Focus and Direct Responsiveness

    In a market where modern analytics and automated reactors promise easy answers, the best results usually come from daily, manual attention to process drift and feedback loops from live projects. This applies as much to well-understood intermediates like 2-Chlorophenyl Cyclopentyl Ketone as to high-ticket specialty molecules. We try to keep communication open and transparent. Customers have called with obscure analytical observations or physical quirks—say, a subtle shift in solid-state texture or trace impurities revealed only by advanced NMR. We hand those tickets back to our lab and process engineers, who look beyond specification sheets to the realities of scale, human handling, and real-world packaging logistics.

    The only workable path for us is treating every new batch as both a refinement and a learning opportunity. Feedback—positive or negative—gets folded into the next manufacturing cycle, aiming for closer alignment with those in the field actually using the product. We document tweaks, not just for compliance, but as breadcrumbs for the next team member facing a troubleshooting call or an unusual analytical request.

    We respect the cost and risk that goes into process development projects using 2-Chlorophenyl Cyclopentyl Ketone. Before scaling up, most end-users need more than a paperwork trail. We back up our documentation with access to technical Q&A, batch histories, and—where needed—side-by-side pilot runs using customer-supplied analytical criteria. The direct manufacturing model gives us this flexibility, while third-party resellers typically operate with only as much information as appears on a supplier’s specification.

    Outlook and Steering Through Challenges

    If years of production experience with intermediates like 2-Chlorophenyl Cyclopentyl Ketone have taught us anything, it’s that getting the fundamentals right makes later innovation possible. In a landscape packed with new technologies, regulatory changes, and evolving analytical demands, only those who maintain direct control at every step can respond to shifting customer needs and unforeseen technical demands.

    We keep a watchful eye on the trends shaping the active pharma and crop chemistry worlds. Increasing attention to trace impurity profiles, regulatory filings covering cradle-to-gate lifecycle, and the pressure to limit process byproduct waste all intersect with how an intermediate is made in real time. Our facility investments—beyond just reactors and drums—extend to continuous monitoring, in-process sampling, and a culture of real-time issue reporting rather than post-hoc analysis.

    Environmental awareness influences our production choices, from the solvents we recover and recycle to closed-system transfer at drum filling. Our team tracks not just volume yields but long-cycle resource utilization—managing energy, water, and supply chain input to minimize waste. Any step that shrinks the carbon or waste footprint of 2-Chlorophenyl Cyclopentyl Ketone manufacturing is scrutinized, validated, and shared internally, driving steady improvements for all downstream users.

    Conclusion: Value Rooted in Manufacturing Experience

    Direct experience with 2-Chlorophenyl Cyclopentyl Ketone gives us a clear, practical view of what customers actually face—from big-ticket synthesis to rarely noted handling headaches. Our approach targets consistent quality and close partnership with end-users, drawing on years of hands-on process knowledge and a constant improvement cycle. Every batch, every improvement, every troubleshooting success reflects real decisions made on the production floor, not marketing departments or distant warehouses.

    This commentary comes not from detached product literature, but from the everyday grind and the skills honed by daily work with chemical manufacturing. Every team member—from operator to analyst—keeps pushing toward ever more reliable results, confident that expertise built up one shift at a time delivers value that abstractions, spec sheets, and distant resellers can’t replicate.