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2-Chlorophenetole

    • Product Name 2-Chlorophenetole
    • Alias 1-chloro-2-ethoxybenzene
    • Einecs 202-266-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    738219

    Chemical Name 2-Chlorophenetole
    Cas Number 612-37-1
    Molecular Formula C8H9ClO
    Molecular Weight 156.61
    Appearance Colorless to pale yellow liquid
    Boiling Point 211-213°C
    Melting Point -12°C
    Density 1.118 g/cm3
    Refractive Index 1.533
    Flash Point 90°C
    Solubility In Water Insoluble
    Synonyms 1-Chloro-2-ethoxybenzene

    As an accredited 2-Chlorophenetole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2-Chlorophenetole is supplied in a 250 mL amber glass bottle with a secure screw cap, labeled with hazard and handling instructions.
    Shipping 2-Chlorophenetole is typically shipped in sealed, chemical-resistant containers to prevent leaks and contamination. It is transported in accordance with international regulations for hazardous materials, requiring appropriate labeling and documentation. Proper ventilation, temperature control, and handling precautions must be observed to ensure safety during transit and storage.
    Storage 2-Chlorophenetole should be stored in a tightly closed container in a cool, dry, and well-ventilated area away from heat, sparks, and open flame. It must be kept away from strong oxidizing agents and sources of ignition. Store at ambient temperature and avoid prolonged exposure to light. Clearly label all containers and ensure proper secondary containment for spill management.
    Application of 2-Chlorophenetole

    Applications of 2-Chlorophenetole in Industrial Manufacturing

    2-Chlorophenetole serves as an essential intermediate in large-scale synthesis across multiple fine chemical production lines. Our focus as an original manufacturer is to deliver this raw material at consistently high purity for tightly specified use in recognized chemical sectors. Below, we outline the major verified application scenarios based on established downstream integration, technical formulation guidance, and prevailing regulatory requirements.

    1. Agrochemical Intermediate for Selective Herbicide Synthesis

    Large agrochemical companies rely on 2-Chlorophenetole as a strategic building block in the development of specific post-emergence phenoxy herbicides. Manufacturers utilize precision-controlled etherification and substitution pathways to generate core herbicidal moieties known for controlling resistant broadleaf weeds in major crop systems. Raw material lots must meet uniformity to allow predictable reactivity and minimal side-product formation across seasonal production campaigns.

    Industry compliance standards

    • OECD Good Laboratory Practice for Chemicals (GLP)
    • FAO/WHO Specifications for Plant Protection Products
    • European Council Regulation (EC) No 1107/2009
    • China GB 2763 Maximum Residue Limits for Pesticides

    Typical usage ratio

    • 5–12% by mole in key step, calculated relative to substituted aniline core; adjusted to yield optimization, downstream impurity tolerance, and local process economics

    Downstream process integration

    • Etherification with phenolic substrates, followed by halogen-specific aromatic substitution; integration at Stage II of multi-step synthesis; high-purity feedstock required for minimized environmental side streams

    Final product types

    • Selective agricultural herbicide technical concentrates
    • Tank-mix formulations for cereal and soybean markets
    • Pre-mix granules with co-active adjuvants

    2. Pharmaceutical Intermediate for Analgesic Synthesis

    In the pharmaceutical sector, process chemists utilize 2-Chlorophenetole as a precursor in multistep synthetic schemes towards select benzophenone and phenacetin derivatives. These precursors ultimately contribute to APIs deployed in pain management and antipyretic finished products. The material must conform to stringent QC for low trace impurities, supporting both pilot-scale validation and full cGMP batch manufacturing in regulated environments.

    Industry compliance standards

    • ICH Q7A Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) General Chapter <825>
    • European Pharmacopoeia Monographs
    • China Pharmacopoeia (ChP) for API intermediates

    Typical usage ratio

    • 8–15% by weight in condensation and direct alkylation steps; ratio refined based on target yield and kinetic monitoring for intermediate APIs

    Downstream process integration

    • Released into synthesis post-nitration, participating in O-alkylation and acylation reactions to build key intermediate scaffolds; maintained under validated solvent and temperature protocols

    Final product types

    • Intermediate APIs for non-opioid analgesics
    • Bulk pharmaceutical intermediates for export-oriented secondary processing

    3. Fine Fragrance Ingredient Manufacturing

    Fragrance and flavor houses integrate 2-Chlorophenetole during the creation of ether-bridged aromatic notes, especially for modern floral and fresh compositions. The chemical’s unique ether linkage provides high stability under personal care and home fragrance formulation conditions, allowing downstream blending with aldehydes and musks. Quality control labs routinely validate absence of phenolic contaminants that would negatively impact olfactory profiles.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards and Amendments
    • EU Cosmetic Regulation (EC) No 1223/2009 for finished products
    • REACH Registration for hazardous classification and restriction
    • ISO 9001:2015 quality management for fragrance additives

    Typical usage ratio

    • 2–6% by mass in concentrate; further diluted in final formulation to below 0.5% total; ratio set according to intended fragrance note intensity and regulatory allergen limits

    Downstream process integration

    • Added to the aromatic core mixture pre-esterification; processed with other stable ethers and fixatives to ensure compatibility with alcohol bases used in high-purity fragrance blending

    Final product types

    • Fine fragrance compositions for eaux de toilette and parfum
    • Room and fabric fresheners blending

    4. Dye and Optical Brightener Production

    Dye manufacturers employ 2-Chlorophenetole for the preparation of complex aromatic ether intermediates essential in the synthesis of stilbene-based optical brighteners and specialty dye stuffs. The material’s reactive aromatic ring and ether function support targeted substitution reactions, enabling control over finished dye chroma and solubility properties required for high-performance textile and paper applications.

    Industry compliance standards

    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals, Manufacturing Restricted Substances List)
    • OEKO-TEX Standard 100 (dye safety in textiles)
    • REACH Dye Registration (EC No 1907/2006)
    • ISO 9001:2015 QMS for dye intermediate supply

    Typical usage ratio

    • 10–18% by mole in downstream dye intermediate synthesis; adjusted depending on targeted optical strength and lightfastness of the end dye material

    Downstream process integration

    • Direct addition to sulfonation-based reactions; enters as coupling partner during synthesis of biphenyl and stilbene frameworks

    Final product types

    • Optical brightener agents for paper and textile whitening
    • Sulfonated azo dyes for synthetic fiber coloration
    • Brightener blends for laundry detergent manufacturers

    5. Custom Engineered Polymer Additive Synthesis

    Specialty polymer manufacturers use 2-Chlorophenetole in the engineering of monomeric additives which impart targeted flexibility and weatherability in advanced plastics. The material’s ether-linked aromatic ring is critical for enabling nucleophilic substitution in the creation of custom phenolic resins and block co-polymers. Reviewing finished polymerization kinetics and final polymer performance guides the strict QC of incoming raw material purity and consistency for each production batch.

    Industry compliance standards

    • UL 94 Flammability testing for polymer applications
    • RoHS 2011/65/EU (Restriction of Hazardous Substances Directive)
    • ISO 14001 Environmental Management for polymer facilities
    • ASTM D638 for polymer mechanical performance

    Typical usage ratio

    • 3–10% by mass incorporated during additive synthesis step; precise percentage determined by required mechanical properties and polymer matrix compatibility

    Downstream process integration

    • Introduced as a reactive monomer or modifier in pre-polymerization stage, enabling post-synthesis grafting or direct copolymerization with acrylates or styrenics

    Final product types

    • Flexible polymer films for packaging
    • Premium phenolic compound-modified plastics
    • Co-polymer modifier blends for automotive and electrical use
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    Certification & Compliance
    More Introduction

    Introducing 2-Chlorophenetole: Reliable Performance Rooted in Experience

    Practical Chemistry, Pure Results

    From the chemical reactors at our facilities, 2-Chlorophenetole emerges as a clear, colorless liquid that carries a distinct aromatic character. This substance, refined through years of hands-on production, has become a reliable contributor to fine chemical and pharmaceutical synthesis. The process starts with high-purity raw materials, and all reactions receive continuous supervision from skilled technicians trained to spot even a whisper of inconsistency.

    2-Chlorophenetole goes by the chemical formula C8H9ClO, with a molecular weight of 156.61 g/mol. Unlike some substitutions on the phenetole backbone, the chlorine atom in the ortho position influences both reactivity and downstream compatibility. Our reactors run batches with targeted specifications, and every lot gets checked using gas chromatography to ensure its assay rises above 99%. By steering clear of unnecessary impurities, such as residual chlorobenzene or unreacted phenetole, we support repeatable processes in any laboratory or manufacturing plant that chooses our product.

    Putting 2-Chlorophenetole to Use: From Fine Chemistry to Scale Production

    There’s no shortcut to consistent performance in chemical synthesis. In our own operations, we see 2-Chlorophenetole put to work as an intermediate in the creation of pharmaceutical building blocks. Its structure allows for selective activation and controlled reactivity, especially when carrying out further substitution or oxidative coupling. Specialty agrochemicals also draw upon its characteristics, where its stability and manageable volatility minimize the risk of side reactions. The boiling point, measured at about 215°C, makes it practical for distillation and solvent removal without losing control of product quality.

    Some manufacturers emphasize surface uniformity or theoretical yield, but in real-world conditions, product purity keeps reaction routes predictable. By removing trace byproducts that tend to accumulate in lower-grade materials, we cut down on unexpected color changes or scent development, which often signal failing synthetic steps. More than a few experienced operators have phoned us after encountering off-odors or sticky residues in past batches from outside sources; attention to detail pays off over the long term.

    Quality from Start to Finish

    We’ve learned through repetition and setbacks that a solid quality assurance routine beats quick fixes. Our team tracks each ton from initial raw material selection to final packaging. GC and HPLC analyses do more than fill paperwork; they help us pick up on trace contaminants before these slip through to your processes. For example, excess moisture in 2-Chlorophenetole can throw off Grignard reactions or even trigger decomposition in more sensitive routes. We handle raw material storage in temperature-controlled tanks and keep product transfers under nitrogen when moisture sensitivity proves crucial.

    On the production line, distillation columns use fraction collectors to segregate pure cuts from any tails containing heavier byproducts. Waste streams move to dedicated tanks and never mix with high-value intermediates. Each time a customer opens a drum from us, the appearance, clarity, and odor match batch to batch, year to year, since our operators follow strict protocols and intervene promptly if something seems amiss.

    Safety, Handling, and Practical Experience

    Anyone in this industry knows respect for chemical hazards is not optional. 2-Chlorophenetole does not escape this reality. Its handling requires care; standard PPE, eye protection, and proper ventilation should be routine in any plant using the compound. Our staff has firsthand experience with concerns like skin contact or vapor buildup, so every shipment leaves our plant in containers checked for leaks and sealed for storage. We’ve had customers in northern climates ask about drum performance in cooler temperatures, and through field testing, we recommend agitating the contents before drum opening during winter months to ensure consistency.

    We consult MSDS recommendations but pair that with plain experience. If a spill occurs, early containment and disposal using appropriate absorbents keeps operations direct and safe. Our training sessions don’t just repeat codes of practice; they share lessons learned from both uneventful years and from the rare mishap, so everyone who handles 2-Chlorophenetole benefits from a broader base of knowledge.

    Understanding Where 2-Chlorophenetole Excels

    The ortho-chlorinated position matters. Compared with its para- or meta-substituted relatives, this compound tunes the electron density on the aromatic ring in a way that shapes further synthetic routes. In our own lab-scale optimizations, that structure translates into higher selectivity in alkylation and Friedel–Crafts acylation. For a customer making fine agrochemicals, this subtle structural difference translated directly into less catalyst degradation and higher isolated yields. Shifting just one functional group on the aromatic core produces measurable differences in downstream performance.

    Take competitor products, some of which rely on older manufacturing routes. These sometimes leave higher levels of di-chloro impurities or traces of acidic residues, which can trip up steps such as alkoxy group migration or oxidative coupling. With careful process design, starting from cleaner 2-Chlorophenetole, those issues step aside so the synthesis can keep moving.

    Batch Control and Logistics Lessons Learned

    Fresh out of the reactor, 2-Chlorophenetole can seem identical from run to run, but seasoned operators know subtle differences add up in later stages. Early on, we noticed batch-to-batch differences from minor variations in raw chlorobenzene quality. These tiny shifts amplified later, cropping up as cloudiness or discoloration after storage. Moving to tighter supplier oversight and improved feedstock traceability, we tightened purity windows. Now, even after months in storage, a properly sealed drum opens up looking and smelling the same as on the day it was filled.

    Our tanks sit indoors to limit temperature swings and condensation. Automatic drum fillers prevent headspace oxygen ingress. Years back, before we made those investments, we had to confront the occasional off-odor or slightly yellow hue after long-term storage. Trials and stubborn adjustments brought us to our current system, one where customers have stopped reporting off-brands and costly rework steps.

    Application Stories from the Plant Floor

    In the pharmaceutical sector, we see regular orders for 2-Chlorophenetole bound for key intermediates in active ingredients. One customer, running a multi-step synthesis, reported on several chemical input trials. With our product, their purification time dropped by nearly a third. High selectivity and predictable boiling kept side reactions to a minimum.

    Elsewhere, in pesticides and fine chemicals, the need for clean aromatic ethers led formulators to 2-Chlorophenetole. Years ago, a formulation specialist described a trouble spot with color pickups on long-term stability testing. Switching to our material eliminated the problem, as residual color body precursors never crossed the drum’s seal. Over dozens of production cycles, they experienced not one failed batch or shelf-life shortfall tied to input quality.

    The Road to Better Practice

    Success in chemical manufacturing rarely comes from theory alone. We’ve dealt with the complaints about mishandled input drums left in the sun, where heat distorts the lid or vapor pressure builds. We learned to store, transfer, and ship by treating each delivery as though it mattered to the final tablet, the last liter of solution, or the end-user waiting for steady results. Every delivery we dispatch takes that lesson to heart.

    Product stewardship sits at the center of each decision our teams make. We work with haulers to minimize transit delays and keep containers dry throughout the journey. Our staff remains available to support partners with handling tips, troubleshooting, and even practical advice for setting up better storage at receiving sites. Chemical production may seem repetitive from afar, but every link in the chain — from production tank to customer reactor — touches on years of experience and countless tests.

    Standing Apart: The Details Matter

    What sets our 2-Chlorophenetole apart isn’t just the molecular fingerprint or the numbers stamped on a certificate of analysis. Our drive for quality comes from repeated feedback — when a product line runs without hiccups or an operator calls out a visible improvement in clarity or ease of separation, that’s when the details shine through.

    We see growing demand for specialty ethers like 2-Chlorophenetole in research labs exploring new routes to substituted aromatics and in plants scaling specialty additives. The adaptability of this molecule opens up progress beyond what some competitors achieve with bulk or off-brand materials. Day-to-day, strict adherence to tried-and-tested procedures preserves reputation and retains the loyalty of customers who know and demand consistent foundational inputs.

    Environmental and Regulatory Considerations

    No industrial process works in isolation from the world outside. Regulations governing aromatic chloro compounds have evolved, and our commitment to compliance tracks right alongside those shifts. Waste capture, responsible emissions reductions, and recycling of spent solvents all feed into our daily decisions. Our quality control labs enforce environmental standards not as a matter of form, but from practical necessity after years of adapting to new guidance and keeping audit-ready process documentation.

    Our records stay up-to-date for each shipment batch, from synthesis through transport. Inspection teams can track the origin, test results, and final destination of every drum. We respond to global chemical regulations directly and have adapted production layouts to minimize both fugitive emissions and process losses. Energy recovery steps waste neither heat nor product. Small changes, like switching to low-permeability packaging for certain markets, add up over an entire year’s production volume.

    Moving Forward: Challenges and Solutions

    Chemical manufacturing has no shortage of challenges — rising raw material prices, stricter emission limits, and pressure to lower the environmental footprint keep us problem-solving and reevaluating routines. In the past decade, we cut unit emissions while raising batch yields, learning to reuse and recondition solvents in-house instead of sending them offsite. Shaving even a fraction off the process waste rate has helped both margins and sustainability goals.

    On the product side, we collaborate with customers to fine-tune input specifications. One research team working on rare disease therapeutics came to us with exacting purity requirements and a tight impurity profile. Over a yearlong partnership, we gradually honed mixture separations, moved to finer GC calibration, and shared monthly data with the client. Outcome: their downstream testing success climbed, and they shared those real-world results with our technical team, feeding new insights right back into our improvement program.

    What Customers Can Expect From Our 2-Chlorophenetole

    Each drum contains more than a well-tested batch of chemical. It’s the product of long-running attention to stability, reactivity, and a record of handling the quirks that come up during real-world manufacturing. From temperature-cycled warehouses to tightly controlled pharmaceutical environments, our shipments arrive ready for use, unaffected by transit or seasonal conditions.

    Order after order, the clarity and physical attributes of our 2-Chlorophenetole stay consistent. Supply partners point to trusted batch documentation, but what they notice most shows up after the reaction is over: no lumpy byproducts, no throwaway tails, and no after-the-fact rework eating up valuable plant time.

    Looking Ahead: Upholding Quality and Value

    As downstream requirements become stricter, the burden for tighter controls in input chemicals only increases. Analytical labs in pharmaceutical development and agrochemical scale-up projects pay careful attention to solvent profiles, side reactions, and reaction troubleshooting. Our role as a manufacturer means owning every outcome, good or bad, that travels downstream with our intermediates. So we track, adjust, and overhaul as needed — a steady loop built on feedback, operational know-how, and shared goals.

    In all, 2-Chlorophenetole only achieves its role as a synthetic intermediate or process aid when behind-the-scenes work turns out transparent, reliable inputs. Hundreds of batches later, with ever-growing records of customer satisfaction and tight quality benchmarks, the details that once seemed minor now stand as everyday priorities for our teams. That’s how we’ve come to trust 2-Chlorophenetole as a foundation for consistent results and trustworthy downstream chemistry.