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2-Chloroethylamine Hydrochloride

    • Product Name 2-Chloroethylamine Hydrochloride
    • Alias 2-Chloroethanamine hydrochloride
    • Einecs 217-060-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    763356

    Product Name 2-Chloroethylamine Hydrochloride
    Cas Number 870-24-6
    Molecular Formula C2H7Cl2N
    Molecular Weight 116.00 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 198-203 °C (dec.)
    Boiling Point Decomposes before boiling
    Solubility In Water Freely soluble
    Synonyms 2-Chloroethanamine hydrochloride; Ethanolamine, 2-chloro-, hydrochloride
    Purity Typically ≥98%
    Storage Conditions Store at 2-8 °C, tightly closed, in a dry place

    As an accredited 2-Chloroethylamine Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 100g package features an amber glass bottle, tightly sealed, labeled with hazard symbols, product name, "2-Chloroethylamine Hydrochloride."
    Shipping 2-Chloroethylamine Hydrochloride is shipped in tightly sealed containers, compliant with hazardous materials regulations. Packaging is designed to prevent leaks and exposure, with clear hazard labeling. During transport, the chemical is protected from moisture, heat, and physical damage. Shipping documentation includes safety data and emergency instructions for safe handling and storage.
    Storage 2-Chloroethylamine Hydrochloride should be stored in a tightly sealed container, away from moisture and incompatible substances such as strong oxidizers and bases. Keep the storage area cool, dry, and well-ventilated, ideally in a dedicated corrosive storage cabinet. Protect from light and ensure proper labeling to prevent accidental misuse. Handle with care due to potential toxicity and corrosive nature.
    Application of 2-Chloroethylamine Hydrochloride

    Applications of 2-Chloroethylamine Hydrochloride in Industrial Manufacturing

    2-Chloroethylamine Hydrochloride serves as a specialized intermediate within multiple advanced chemical production fields. We supply this raw material directly from our manufacturing plant to downstream partners who require tight control over formulation standards, consistent quality, and regulatory compliance. Below we present key application areas where this compound plays a targeted and critical role, with application details driven by real usage conditions and quality standards in each sector.

    1. Active Pharmaceutical Ingredient (API) Intermediate Synthesis

    This material acts as a crucial alkylating agent in the synthesis of several pharmaceutical actives, especially for preparations involving chloroethyl functional groups such as certain antineoplastic and central nervous system drugs. Process engineers use it for controlled N-alkylation or amination steps, integrating it early in multi-stage reaction schemes that require high conversion and precise residual control. Reaction parameters factor in regulatory thresholds for related substances, and the compound’s consistent quality reduces risk of downstream impurities.

    Industry compliance standards

    • ICH Q7 GMP for APIs
    • EU EudraLex Volume 4 GMP
    • Ph. Eur. and USP Monographs (relevant to the API pathway)
    • REACH (Annex XVII, where applicable in synthesis process)

    Typical usage ratio

    • 0.7–1.3 molar equivalents relative to target substrate, optimized by impurity profile and reaction efficiency; specific dosage determined by validated laboratory scale-up data

    Downstream process integration

    • Batch or continuous condensation/alkylation stages, typically at early-to-intermediate synthesis phase before ring formation or side chain elaboration; requires controlled inert atmosphere and pH monitoring

    Final product types

    • Chemotherapy drug intermediates
    • Antidepressant precursors
    • Antihistamine building blocks

    2. Agrochemical Active Compound Synthesis

    Procurement managers in the crop protection sector rely on this chemical as a structural precursor for herbicide and pesticide active ingredients. It enables selective monoalkylation reactions necessary for synthesizing certain chloroethyl-containing heterocyclics and bridgehead compounds, ensuring performance consistency in the field. Production teams appreciate its reliable reactivity profile and the ability to track residuals down to ppm levels to meet export and domestic residue standards on final agrochemical products.

    Industry compliance standards

    • ISO 9001 certified QC processes
    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • China National GB 2763—Pesticide Maximum Residue Limits
    • EPA 40 CFR Part 180 (USA)

    Typical usage ratio

    • 10–18% by weight depending on molecular design and side chain length; adjusted for target crop spectrum and toxicity mitigation

    Downstream process integration

    • Enters as a reactant in first or second step of active synthesis, typically under basic or catalyzed aqueous conditions, followed by neutralization and extraction; monitored for residual by HPLC-MS

    Final product types

    • Pre-emergent and post-emergent herbicide actives
    • Broad-spectrum insecticide intermediates

    3. Epoxy Resin Curing Agent Manufacturing

    2-Chloroethylamine Hydrochloride is used by specialty resin manufacturers as a precursor in synthesizing amine-type epoxy curing agents with high crosslink density. By adjusting its introduction at the amination or modification stage, formulators can fine-tune the hardening speed, heat resistance, and chemical durability of final resins. Batch records focus on traceability and batch conformity, with in-process control for chloride content and amine value to satisfy specifications for electronics and coatings customers.

    Industry compliance standards

    • ISO 9001 Quality Management Systems
    • RoHS Directive (2011/65/EU) compliance in electronics applications
    • REACH SVHC limits for input chemicals
    • UL 94 Flammability standards (for end-use resin evaluation)

    Typical usage ratio

    • 3–8% by weight in curing agent pre-reaction mixtures, with adjustments made based on desired molecular weight and functional group density

    Downstream process integration

    • Dosed during polyamide or polyether amine synthesis as an alkylation/aminoalkylation agent; added in jacketed vessels at controlled temperature under nitrogen sweep to prevent byproduct formation

    Final product types

    • Epoxy floor coatings
    • High voltage electrical encapsulants
    • Industrial adhesives for automotive and aerospace

    4. Water-Soluble Ion Exchange Resin Production

    Manufacturers of cationic and chelating resins integrate this compound during amination steps in resin backbone modification. The reactivity of the chloroethyl group secures stable attachment of amine moieties, tailored for applications in water softening, heavy metal removal, and pharmaceutical purification. In-process analytics focus on swelling index, functional group content, and leachable chlorides, all critical for international potable water standards and medical-grade use.

    Industry compliance standards

    • NSF/ANSI 61 Standard (Drinking Water System Components)
    • EN 15039: Chemicals used for treatment of water intended for human consumption
    • 21 CFR 173.25 (ion exchange resins for food industry, USA)
    • ISO 9001 QC system for traceability

    Typical usage ratio

    • 5–15% of total amine monomer input, tuned by targeted exchange capacity and crosslinking intensity

    Downstream process integration

    • Reacted with chloromethylated polymer beads or copolymer matrices, followed by neutralization and extensive washing; integration point is after pre-polymerization, just before functionalization and bead sizing

    Final product types

    • Domestic water softening resins
    • Heavy metal scavenger beads for industrial effluent
    • Chromatography purification resins for bioprocessing

    5. Organic Synthesis Building Block in Fine Chemicals

    Fine chemical producers value this intermediate for its use in targeted functional group transformation, especially for manufacturing specialty amines, aziridines, and heterocyclic compounds not covered by standard catalog intermediates. It supports selective substitution and ring closure reactions demanded by custom synthesis clients in electronics, photographic chemicals, and advanced monomer sectors, where exacting purity and site-specific substitution are critical to final molecular properties.

    Industry compliance standards

    • Internal ISO 9001 and 14001 systems for specialty chemicals
    • Chemical control in line with local Safety Regulations (e.g., Chinese GB Standards, US EPA TSCA)
    • Custom client specification sheets critical for each synthesis
    • Transport and storage in compliance with UN 2733, IMO/ADR packaging rules

    Typical usage ratio

    • Variable: 1–18% depending on molecular pathway and target end-group formation; determined by stoichiometry and risk of side reactions

    Downstream process integration

    • Fed directly into reaction vessels for substitution, followed by workup and isolation of organochloride or amine derivatives; process focus is on scalability and batch homogeneity

    Final product types

    • Aziridine intermediates
    • Aminoalkyl substituted aromatics
    • Monomers for specialty polymers
    • Heterocycle building blocks for electronics industry
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    Certification & Compliance
    More Introduction

    Introducing 2-Chloroethylamine Hydrochloride: Real-World Insights from a Manufacturer

    A Decade at the Reactor: What Sets 2-Chloroethylamine Hydrochloride Apart

    Every batch that leaves our production floor tells a story—as chemists and operators responsible for 2-Chloroethylamine Hydrochloride, we know each nuance of this compound, from its color shifts under varying pH to how subtle differences in raw material lots can impact downstream syntheses. Years spent behind reactors and in process analytics have built more than routine; they impart a cautious respect for the quirks that set this material apart in the chemical landscape.

    How the Manufacturing Process Defines the Model

    We produce 2-Chloroethylamine Hydrochloride using well-controlled alkylation technology that ensures consistent molecular integrity and minimizes side products. Many users ask about nearly invisible variables: moisture uptake rates, particle structure, and reproducibility when scaling from lab blends to multi-ton lots. Take for instance, the crystalline structure—ours develops under temperature regimes tailored to curb co-crystallizing byproducts. During the drying and packaging stage, we monitor hygroscopicity to ensure the product does not clump or evolve residual solvents, which, as research teams often report, matters during fine organic syntheses and polymerizations.

    Beyond the Catalog Entry: Why Quality in 2-Chloroethylamine Hydrochloride Matters

    Too many notes on this compound read like a chemical textbook. In the hands of a process chemist, though, purity becomes more than a number on a spec sheet. Our customers in the pharmaceutical sector, for example, know that micro-level contaminants like diethylamine or organic chloride residues can derail an entire project. After several feedback cycles with formulation teams, we enhanced our in-process analytics and assigned experienced technicians to interpret NMR and GC-MS data, catching anomalies other labs tend to miss. The difference isn’t always obvious until a challenging reaction step runs smoothly without unexpected side reactions.

    Specification Precision—Why Numbers Aren’t Enough

    Our standard material meets a >99% purity threshold, with water content capped at very stringent limits. Some buyers want to squeeze costs at the expense of purity, but we have learned through years of customer troubleshooting that subpar product only leads to headaches later: wasted batches, forked analytical results, or unnoticed regulatory deviations. We put every drum and bag through a multistage quality process that not only confirms identity by high-resolution methods, but also checks for micro-trace impurities that common industry tests overlook. If you ever cracked open a drum from other sources only to spot yellowing or find off-odors, you know how real these problems can get.

    End Uses: From Everyday Solvents to Critical Drug Precursors

    2-Chloroethylamine Hydrochloride sees wide use as a building block for pharmaceutical intermediates and organic synthesis. Over twenty years in the business, we’ve watched its application base grow. Several leading research organizations and manufacturing plants rely on this ingredient in the production of alkylating agents, anti-cancer compounds, and advanced polymers. In pigment modification or specialty resins, chemists require high consistency lot-to-lot, as trace organochlorines or abnormal amine levels can introduce color shifts or reduce downstream product stability. The users building radiolabeled materials depend on exacting standards, since minor impurities compromise experimental reproducibility and safety.

    In the past, some clients used lower-grade imports for exploratory work, but even in non-GMP settings, time wasted on troubleshooting far outweighs savings from choosing lesser grades. By maintaining a direct relationship with end users and adjusting product lots based on their feedback, we have aligned each specification tweak to a field-tested concern rather than to an arbitrary industry minimum.

    Process Chemistry Insights—Why “Just” 2-Chloroethylamine Hydrochloride Isn’t Enough

    Customers sometimes ask, “Why not use cheaper amines or buy a generic variant?” There’s a lesson in this question. In alkylation steps, side-chain nucleophilicity and chloride reactivity matter—a batch that looks fine by thin-layer chromatography can fall short under exacting chromatography or in final crystallization. We have spent months with analysts troubleshooting barely visible peaks in mass-spectrometry caused by minuscule byproduct or air-sensitive impurities. By monitoring each reaction’s endpoint, we adjust parameters to deliver a finished product that exceeds standard market grades.

    Our site’s in-line process controls were guided by years of partnership with pharmaceutical and fine chemical clients who tested product performance in real-world protocols. For instance, a single spike in trace-metal content might go unnoticed during simple bench reactions, but can lead to failed regulatory submissions or equipment fouling in large-scale facilities. Regular site audits and hands-on collaboration with both engineers and customers provide insights that drive improvements. This isn’t a theoretical advantage—it’s embedded in every kilogram we ship.

    Quality Through Detail: Why Specification Isn’t a Paper Exercise

    No one asks for trouble. Yet time and again, poorly specified or loosely controlled batches of 2-Chloroethylamine Hydrochloride show up at customer docks—leading to delays, extra filtration steps, or even complete syntheses abandoned due to impurity interference. On our line, production staff document every detail, from the point of raw material entry to final drumming and labeling. This documentation allows for root-cause analysis if any off-spec event occurs. We have invested in automatic dosing systems, nitrogen-purged transfer lines, and closed-drum packaging to cut contamination risk.

    Operators know the pressure to deliver not just on time, but to an exacting level of reliability that meets audit checks by regulatory authorities. Every hour spent in this process leaves zero room for shortcuts—because our own labs use what we make, and our name rides with every shipment.

    Case Study: Trouble in Downstream Syntheses and What it Taught Us

    A decade ago, a customer reported persistent yield drops in their alkylation step. Working together, we tracked the issue to residual dimethylamine in a 2-Chloroethylamine Hydrochloride lot. Instead of issuing blanket recalls, we set up closer batch tracking with microanalysis on each run. By tweaking in-process vacuum control and raw material flow, we eliminated cross-amine contamination. Later, the same customer saw their synthesis yields improve, and even found downstream impurities dropped, simplifying their filtration protocols.

    These are not theoretical wins—each improvement stemmed from hands-on troubleshooting. Our team will often spend time on your production floor, not just in our own, learning whether subtle changes in compaction, flowability, or reactivity alter your throughput or create secondary problems. That feedback loop sets us apart, and in our experience, it is the only way to hone product and process.

    How 2-Chloroethylamine Hydrochloride Differs from Other Similar Products

    On the surface, many small amine hydrochlorides or chloroethyl derivatives seem interchangeable. We often field questions about switching between these reagents, especially for non-critical syntheses. Yet several years spent in scale-up work have shown us important distinctions. Alternative amines with differing chain length or side group substitution may introduce unwanted branching, reduce selectivity, or cause hazardous exotherms in step-growth polymerizations. Even closely related compounds with a methyl or ethyl swap on the backbone alter downstream chemical behavior enough to prevent straightforward replacement.

    As for hydrochloride versus free amine forms, our discussions with process engineers have highlighted the advantage of predictable salt stability, reduced odor and volatility—crucial for open handling or high-shear mixing environments. Free amine products present greater risk of nitrogenous off-gassing, especially in humid conditions or under thermal stress. Storing and shipping hydrochloride salts cuts spoilage and reduces safety concerns, which matters for overseas transit and warehousing.

    Handling and Storage: Insights from the Factory Floor

    Too many complaints about poor product performance stem from mishandling. We do not just pack 2-Chloroethylamine Hydrochloride and ship it out the door; we train users on proper storage, closed handling, and environmental controls. This isn’t just about following protocols. Decades of feedback from customers taught us that careless exposure to air leads to moisture gain, caking, and altered reactivity.

    Even the hardest-wearing industrial bags do not protect against repeated opening and poor closure habits. For customers operating satellite facilities, we recommend minimizing drum opening frequency and using dedicated transfer scoops to reduce contamination risk. Our own warehouses hold product in climate-controlled settings, and we regularly track drum seals and packaging performance to identify improvements.

    From the Lab Bench to the Drum Scale: Suitability for Pharmaceutical and Industrial Use

    Pharmaceutical clients—and academic researchers—demand consistent results round after round. Over the years, we worked alongside R&D teams to develop protocols for both small-batch clinical testing and full-scale active pharmaceutical ingredient production. Our 2-Chloroethylamine Hydrochloride has enabled synthesis of several pipeline drugs, and we remain engaged even after the first delivery, supporting method adaptation and troubleshooting where needed.

    Industry clients in coatings, plastics, and resins emphasize bulk reliability instead. For them, purity and moisture control link directly to final product strength and durability. Our product supports both ends of this market by adhering to batch control beyond basic statistical sampling. We test every lot for reaction suitability—not just against spec values, but under representative real-world syntheses. If our product leads to a delayed endpoint, unexpected haze, or flaky precipitate in a customer formulation, we investigate and adjust the following production runs to correct these issues.

    Addressing Waste and By-Product Handling

    Behind every kilogram of 2-Chloroethylamine Hydrochloride shipped, a story of waste minimization and byproduct management unfolds. Regulatory frameworks in our country keep getting tighter, demanding more traceability and cleaner discharge. Instead of seeing compliance as a hurdle, our operations team devised solvent recovery and amine scrubbing protocols that cut both emissions and cost. Practical investments in distillation and filtration cut raw material waste, reclaiming value while improving environmental performance.

    Much of this progress comes from daily experience: nobody likes halting production due to solvable bottlenecks in waste treatment. From line workers to management, we charted inefficiency sources and worked with equipment suppliers to reduce downtime and boost yield recovery. These incremental steps support continuous improvement in both our environmental and economic outcomes, translating to a cleaner, more reliable product for end users.

    Navigating Regulatory Demands from a Manufacturer’s Perspective

    Compliance isn’t about filling out paperwork after the fact. Over the years, as international regulatory demands around chemical manufacturing have tightened, we found that robust documentation starting at material receipt and continuing through every process stage brings the most favorable audit outcomes—not just for our protection, but for customer peace of mind. When partners ask for detailed substance origin or trace contaminant reports, we reference data traced from source to finished batch, satisfying both local and overseas requirements.

    Occasionally, a market change or rule revision compels all factories to revisit their protocols. We keep a close ear to regulatory trends by participating in technical workshops, industry consortia, and regular knowledge exchange with compliance officers. This attention to evolving requirements means our 2-Chloroethylamine Hydrochloride keeps pace without reactive scrambling or temporary workarounds.

    True Partnership in Chemical Supply: Supporting Real-World Innovation

    We rarely see our role as just supplying a raw material. Over the years, we’ve engaged in technology transfer, joint troubleshooting with customers, and knowledge sharing initiatives. Chemical manufacturing remains a collaborative industry—our clients’ R&D successes often feed back into process improvements on our side, sharpening analytical controls and tightening process windows. In several cases, academic or industry partners have uncovered new fields of application for 2-Chloroethylamine Hydrochloride, with our technical team working closely to refine the product for those unique needs.

    Ongoing dialogue is key. Many times, a single customer report has alerted our team to a trend or technical pitfall, prompting investigation, root-cause analysis, and product adjustment before it becomes a market-wide issue. In this way, the relationship becomes more than transactional—it represents a strategy for sustainable innovation and reliability across industries reliant on this versatile chemical.

    Looking Ahead: The Responsibility of Reliable Manufacturing

    Producing 2-Chloroethylamine Hydrochloride matches the pace and complexity of the industries we serve. Every tweak in process design or analysis, each improvement in waste handling, and all effort poured into consistent packaging reflects a commitment built over years of direct experience. We stand behind our product not just because of brand or compliance, but because our teams rely on similar attention to detail in their own chemical processes.

    This compound, while humble in its molecular makeup, rides on careful stewardship: control at every process step, practical knowledge gained over many years, and a tight partnership with our user base. It’s not just a product—it represents hundreds of hours of hard decisions, quality checks, and lessons learned over time.

    Your Experience Matters: Our Promise as a Manufacturer

    If you encounter an issue with application or notice a secondary reaction not flagged in mainstream literature, you will have a direct line to our technical and quality team. We do not believe in offloading troubleshooting; we believe all questions deserve direct, experience-based answers. As chemical landscapes shift and new applications for 2-Chloroethylamine Hydrochloride develop, rest assured that our commitment to pragmatic manufacturing, deep process insight, and customer partnership stays rooted in the realities faced at both the laboratory bench and factory floor.