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2-Chloroethyl Carbamate

    • Product Name 2-Chloroethyl Carbamate
    • Alias Urethane
    • Einecs 207-344-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    340983

    Chemical Name 2-Chloroethyl Carbamate
    Molecular Formula C3H6ClNO2
    Molecular Weight 123.54 g/mol
    Cas Number 598-09-4
    Appearance Colorless to pale yellow liquid
    Boiling Point 204-206°C
    Melting Point -20°C
    Density 1.283 g/cm3 at 25°C
    Solubility In Water Soluble
    Flash Point 98°C (closed cup)
    Structure ClCH2CH2OC(=O)NH2
    Refractive Index 1.461
    Synonyms Chloroethyl carbamate; 2-chloroethylurethane
    Stability Stable under normal conditions
    Storage Conditions Store in a cool, dry place, tightly closed

    As an accredited 2-Chloroethyl Carbamate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2-Chloroethyl Carbamate is supplied in a 500g amber glass bottle with a tamper-evident cap and clear hazard labeling.
    Shipping 2-Chloroethyl Carbamate should be shipped in tightly sealed containers, protected from moisture, heat, and direct sunlight. It must comply with hazardous material regulations, including correct labeling and documentation. Transport must be conducted by trained personnel to prevent spills, leaks, or exposure. Ensure compliance with local, national, and international shipping standards for chemicals.
    Storage 2-Chloroethyl Carbamate should be stored in a cool, dry, and well-ventilated area away from heat sources, open flames, and direct sunlight. Keep the container tightly sealed and clearly labeled. Store away from incompatible materials such as strong acids, bases, and oxidizers. Use appropriate chemical-resistant containers and ensure access to spill containment measures. Follow all relevant safety regulations for hazardous chemicals.
    Application of 2-Chloroethyl Carbamate

    Applications of 2-Chloroethyl Carbamate in Industrial Manufacturing

    As an established producer of 2-Chloroethyl Carbamate, we supply bulk volumes to specialized sectors requiring controlled reactivity and efficient integration in their formulas. The material’s molecular structure and reactivity profile support advanced synthesis routes in targeted industrial domains. Below we detail key downstream application fields, including regulatory context, recommended ratios, process position, and typical finished products.

    1. Synthesis of Pharmaceutical Intermediates

    Pharmaceutical manufacturers incorporate 2-Chloroethyl Carbamate as a reactive intermediate during API development, frequently in the protection and derivatization steps of bioactive compound synthesis. Our material serves as a carbamoylating reagent, especially for heterocyclic and peptide substrates, where selectivity and purity drive batch acceptance. Compliance with documentation traceability and impurity controls is enforced at every production lot, as mandates from authorities tighten annually.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • 21 CFR Part 211 US FDA cGMP for Finished Pharmaceuticals
    • Ph. Eur. monograph 2034 for related substances
    • ISO 9001:2015 certified quality process

    Typical usage ratio

    • 0.9–1.2 molar equivalents relative to nucleophilic substrate; ratios optimized per target purity and byproduct minimization.

    Downstream process integration

    • Direct dosing into alkylation, carbamoylation, or N-protection step within multi-stage batch reactors, often at 25–60°C under inert gas.

    Final product types

    • API intermediates (e.g., substituted ureas and carbamates)
    • Pesticide precursors authorized for medicinal uses
    • Synthons used in anti-hypertensive and anti-cancer compound pathways
    • Small molecule research intermediates

    2. Crop Protection Chemical Synthesis

    Manufacturers of selective herbicides and growth regulators employ 2-Chloroethyl Carbamate as a building block for carbamate-based pesticides. The compound reacts under controlled condensation and substitution conditions, offering a controllable reactivity window for efficient large-scale batch or continuous processes. Adoption in this sector is governed by environmental and operator safety compliance with strict impurity profiling mandates.

    Industry compliance standards

    • EU Regulation (EC) No 1107/2009 on Plant Protection Products
    • US EPA Guidelines for Pesticide Registration (40 CFR Parts 156 and 158)
    • ISO 17025-accredited analytical monitoring
    • FAO/WHO specifications for technical material

    Typical usage ratio

    • 5–18% (w/w) in reaction blend, adjusted for desired target molecule and reaction kinetics.

    Downstream process integration

    • Fed-batch addition during the formation or derivatization of active pesticides, typically after initial aryl halide formation and prior to purification steps.

    Final product types

    • Carbamate herbicides (e.g., EPTC, butylate, triallate families)
    • Insecticidal preparations for agricultural applications
    • Seed coating actives
    • Fine chemical intermediates for agrochemical formulations

    3. Polyurethane Systems for Industrial Foams

    Producers of rigid and semi-rigid polyurethane foams integrate 2-Chloroethyl Carbamate as a functional monomer or curing agent. The material’s alkylating ability tailors polymer crosslinking, controlling final density and cell structure. Quality departments monitor trace impurity carryover and batch reproducibility, referencing cross-jurisdictional specifications for polymeric consumer and industrial goods.

    Industry compliance standards

    • REACH (EC) No 1907/2006 Annex XVII – Restricted Substances List
    • ISO 9001 Quality Management Systems for polymer processing
    • ASTM D3574 for flexible cellular materials
    • RoHS 3 (2015/863/EU) for consumer-facing applications

    Typical usage ratio

    • 0.5–2.5% (w/w) as a modifying agent in isocyanate-polyol prepolymer mixes, adjusted for target hardness and elasticity.

    Downstream process integration

    • Dispersion in polyol blend prior to isocyanate dosing step, enabling carbamate linkages during exothermic curing and expansion.

    Final product types

    • Thermal insulation panels
    • Automotive foam components
    • Packaging foam blocks
    • Industrial cushioning and acoustic dampening materials

    4. Synthesis of Specialty Textile Finishes

    Advanced textile chemistry units use 2-Chloroethyl Carbamate to prepare durable press and wrinkle-resistant finishing agents. Its carbamoyl function reacts under base catalysis to modify cellulose fibers at the polymeric level, imparting permanent press characteristics and resistance to chemical and heat stress. Process integration balances reaction completeness with preservation of substrate colorfastness and hand-feel, closely monitored by finished goods testing and compliance with textile chemical safety lists.

    Industry compliance standards

    • OEKO-TEX Standard 100 – Certified Product Safety for textiles
    • ZDHC MRSL – Zero Discharge of Hazardous Chemicals program
    • ISO 14184-1:2011 for formaldehyde testing in textiles
    • REACH Annex XVII for apparel use chemicals

    Typical usage ratio

    • 0.8–1.5% (w/w) based on weight of dry fabric; formulation varies by desired finish and textile substrate type.

    Downstream process integration

    • Batched in aqueous pad-batch or pad-dry-cure systems, with reagent addition prior to thermal curing between 130–160°C for fiber crosslinking.

    Final product types

    • Permanently pressed shirts and uniforms
    • Wrinkle-resistant workwear and protective textiles
    • Easy-care home textiles (sheets, pillowcases)
    • Chemical-resistant nonwoven fabrics for industrial filters

    5. Organic Synthesis of Functionalized Monomers

    Chemical manufacturing plants utilize this compound as a specialty reagent in the synthesis of reactive monomers for advanced coatings and adhesives. Its deployment improves the introduction of carbamate or protected amino groups, enhancing thermal stability and process flexibility for UV-curable or two-part systems. These routes follow detailed documentation, batch tracking, and emission control procedures as required by chemical manufacturing standards for specialty polymer additives.

    Industry compliance standards

    • ISO 14001:2015 Environmental Management Systems
    • Responsible Care Global Charter engagement
    • MAK and BAT workplace exposure monitoring (Germany)
    • TSCA (Toxic Substances Control Act) US EPA listing and notification

    Typical usage ratio

    • 3–10% (w/w) relative to total monomer mass, tuned depending on required reactivity and functional group density in the final system.

    Downstream process integration

    • Sequential or one-pot batch addition during prepolymer or oligomer synthesis, followed by purification and end-capping operations.

    Final product types

    • Acrylic and methacrylic monomers for coating resins
    • UV-curable adhesives
    • High-adhesion surface primers for plastics and metals
    • Reactive diluents for specialty paints
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    Certification & Compliance
    More Introduction

    Getting to Know 2-Chloroethyl Carbamate: Practical Insights from the Chemical Production Floor

    Our Experience With the Chemistry

    Long days in chemical manufacturing teach lessons numbers and tables cannot touch. In producing 2-Chloroethyl Carbamate, we handle every batch with a level of commitment that comes from real responsibility — both to our team and to those relying on dependable material. We don’t just bottle a compound, slap on a label, and ship it out. Hands-on control at every step lets us address the quirks of a substance that doesn’t always behave predictably. Our direct involvement means we can respond to feedback from technical managers and process engineers, changing equipment settings, raw material sources, or handling practices to consistently hit the right targets on quality and yield.

    We've found 2-Chloroethyl Carbamate, also known as Chloroethyl Urethane, takes particular care during reaction and isolation. Even small shifts in temperature, pressure, or feed purity influence its appearance and behavior. This is not a “set it and forget it” synthesis. Operators stay alert, watching for subtle color changes or unexpected by-products. In our setup, experience counts. An eye trained over years picks up what automation cannot.

    The Stuff That Matters: Specifications from the Ground Up

    Most people see 2-Chloroethyl Carbamate as a technical material, a raw input in the synthesis of various pharmaceuticals and agrochemicals. On our lines, typical product specs include a purity in excess of 99% by HPLC, moisture consistently under 0.1%, and controlled chloride and heavy metal content. The solid form runs as white crystalline powder, though even slight contamination can turn it gray or yellow. We package moisture-tight and flush with nitrogen to keep the product dry and stable. These might seem like bland details, but small lapses in storage and transport multiply over time. Those compounds running down the glassware after a rushed batch aren’t just “losses.” They are signs the work has fallen short.

    From our shop floor, purity isn’t about marketing claims or certificates stuck in an attachment. One lot with higher residual starting material can set off a domino effect—plugged catalyst beds downstream for a pharmaceutical manufacturer, or off-odors that signal trouble in subsequent chlorination. For customers converting this intermediate to more complex molecules, those hidden impurities surface only after many steps, wasting time and money. We back our guarantees with batch-by-batch analytical runs.

    Function in the Real World: How 2-Chloroethyl Carbamate Delivers

    Talk to formulators or research chemists actually using our product and you’ll hear stories of surprise reactions or variables that threw them off. A lot of what gets written about 2-Chloroethyl Carbamate focuses on textbook chemistry. Once the batch sizes grow and tanks are measured in tons rather than liters, practical limits set in. This material enters as a protected amine source in pharmaceutical synthesis, handled with caution because of the reactive chloroethyl group. It also serves as a building block for certain plant protection products, or as a bridge compound introducing both nitrogen and chlorine into a growing molecule.

    We’ve worked closely with customers troubleshooting fouling reactors or inconsistent crystallizations stemming from small shifts in our output. One week, a minor residue spike in a distillate created unexpected orange by-products in a customer’s alkylation step. Another month, water pickup from a mislabeled drum led to unanticipated gas evolution during their synthesis. In both cases, tracking the issue to our own floor let us revisit operating discipline, tweak our dehydration equipment, and run extended quality checks that kept the lines running smoothly on both ends. Every batch taught us something new about keeping chemistry predictable.

    Difference Means More Than Purity Numbers

    People often ask what sets our 2-Chloroethyl Carbamate apart from other intermediates in the same reaction family. Sometimes customers want to compare it to analogues like 2-Bromoethyl Carbamate or unsubstituted ethyl carbamates. Experience shows that swapping halides, or even switching between sources, changes not only the reaction rates but also bolsters or weakens later steps in synthesis. The chloro group in our product brings a balance: reactive enough for efficient downstream alkylations, yet less aggressive than the bromo or iodo analogues, cutting some of the uncontrolled side-reactions those heavier halides provoke.

    Divergence between suppliers does not always trace back to what’s listed on spec sheets. Solubility and melt point, by themselves, matter only if the process downstream can handle minor fluctuations in consistency. Moisture, residual solvents, or slight color changes impact how powders flow through augers or how readily they dissolve in your solvent mix. After standing on the receiving end at a number of customer audits, we built up experience around minimizing off-odors, picking drum liners to cut static cling, and improving crystal size so dust doesn’t halt loading lines. Customers bring in their questions about trace contaminants or differences in physical appearance not listed in a traditional certificate of analysis. Our teams tie those questions back to the manufacturing strain, examining each stage from charging, reflux, stripping, and drying, and making small, constant changes for a cleaner, tougher intermediate.

    Challenges We Face and What Keeps Us Going

    Production isn’t just clicking “start” on a reactor. We buy and purify raw materials from sources many thousands of kilometers apart. Shipping conditions at sea or at border crossings can stretch lead times and shake up quality. Several years ago, a shipment of chloroethanol arrived with trace metallics above our baseline. Running that through the process revealed how even small upstream slipups ripple out. We fixed the situation only by tightening up supplier audits and blending incoming lots, but not before several late nights rerunning purification to get our carbamate back within specs.

    Every production shift gives new lessons in keeping operators safe, too. 2-Chloroethyl Carbamate carries some of the usual hazards seen with reactive chloro compounds — inhalation risk, sensitization, and the sort of slow, hidden leaks you only detect by walking the plant floor and sniffing out odd odors at valves. We invest in PPE, local exhaust, and batch-wise checks. Training matters just as much as automation. Many young engineers arrive not realizing the smell of chloro compounds lingers, quietly marking a small flange that needs tightening or a filter that caught its limit.

    Working With Global and Regional Demands

    Different markets bring their own expectations. Our clients in Europe often tie acceptance to detailed impurity profiling and documented traceability back to each drum. Asian buyers might ask for bigger shipments, longer shelf life, or custom drum sizes. We do the documenting and batching ourselves. Nothing we ship leaves the plant without a documented training record for the crew on that production line. It’s not about paperwork for its own sake. Bringing in third-party labs for random cross-checks has sometimes kept us honest, too, showing up the odd spot discrepancy before it reached a partner’s plant.

    Global regulations and standards keep progressing. Product bans and new contaminant limits come up every few years, usually with little warning. We keep up both through direct technical engagement and conversations with colleagues at other producers, not just relying on big public news. A recent shift in allowable N-nitroso impurities pushed us to review not only our own process but the sources upstream, and to invest in some method development at the bench. Keeping records of what has changed batch to batch helps not only with compliance, but also when a familiar customer rings with a concern years down the line.

    Not every producer has the resources to do all of this themselves. We have watched competitors who focused on larger volume over deeper product knowledge, but that route quickly gets exposed when a process upsets or a niche customer needs a precise answer instead of a simple document. Our investment in small-batch, methodical analysis stands us in better stead, especially when facing rare requests for lots with altered particle sizing, or when seeking to minimize carryover solvents that might interfere with pharmaceutical applications.

    Sustainability and Safety: More Than Buzzwords

    Modern chemical production holds a double-edged sword. Volumes demanded by industry stand at odds with waste, emissions, and workplace hazards. Years ago, flaring mildly toxic vapors in the open seemed normal. Now, those who do not tighten emissions with scrubbers, recycle water, and invest in downstream treatment get left behind both in regulation and cost. For 2-Chloroethyl Carbamate, the main challenge after product collection stays in controlling trace emissions from vent points. We collect and treat tail gases, condenser washings, and any mother liquors for chlorine and organic content. Working at this scale, little is left to chance. A neglected valve or overfilled drum brings both safety risk and cost, so the team checks every step from the control room dashboard, but more importantly, with feet on the ground.

    Good environmental practice isn’t just regulatory compliance or checking a box. Fewer leaks, more efficient purification, and smarter packing keep both product and people safer. Our own safety record owes more to senior crew sharing real stories about near-misses and what not to do with stubborn lines or venting hoses than any top-down policy update. Sometimes that means stopping a line for a failed gasket, accepting a day's lost output, because cutting corners for speed brings bigger setbacks in the long run.

    The Human Element: Ties to Innovation and Success

    Ownership in manufacturing draws from the pride crew members take in showing each shift’s results. Every operator who turns a valve or checks a reading wants to know the finished batches run as they should. Small differences in batch temperature ramps or agitation speeds, often learned by hand feel and sight rather than by numbers alone, imprint on every lot shipped. We welcome direct critiques from customers rather than hiding behind impersonal email threads or polished presentations.

    We’ve seen projects shift after a customer proposed a process shortcut, only to realize material performance changed in unexpected ways. For example, at one point, a group using 2-Chloroethyl Carbamate in API synthesis noted solid formation in storage, traced back to a slightly altered milling process. Collaboration on both sides led not only to a batch correction but to the development of a more robust drying protocol.

    This kind of problem solving builds better chemistries and partnerships. Too often, factory teams feel cut off from the science and market pressures felt by users. In our plant, technical visits remain frequent, and the factory gates stay open for trusted partners to walk the lines, run their own samples, and share in the daily problem-solving.

    Looking Forward

    Working directly in chemical manufacturing, no amount of theory can replace the stubbornness and teamwork needed to keep 2-Chloroethyl Carbamate running at high quality. Opportunities for improvement come as frequently as challenges, and staying ahead demands real focus and respect for both the chemistry and the people behind it. By keeping detail at the core—measurements, conversations, and care for each step in the line—we help keep both customer processes and our own teams safe, productive, and ready for whatever needs the future may hold.

    As applications and performance demands grow, every kilogram of 2-Chloroethyl Carbamate tells a story. Our team stands behind each lot: not just as suppliers, but as part of a much larger chain of science, responsibility, and constant learning. The skills built from years of hands-on production help drive solutions for downstream users, ensure rapid response to variability, and support a culture of reliability from batch, to drum, to the finished product at your site.