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2-Chlorobenzyl Mercaptan

    • Product Name 2-Chlorobenzyl Mercaptan
    • Alias o-Chlorobenzylthiol
    • Einecs 221-627-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    345766

    Chemicalname 2-Chlorobenzyl Mercaptan
    Casnumber 2114-39-8
    Molecularformula C7H7ClS
    Molecularweight 158.65
    Appearance Colorless to pale yellow liquid
    Boilingpoint 92-94°C at 10 mmHg
    Density 1.24 g/cm3 at 25°C
    Solubility Insoluble in water
    Flashpoint 102°C (closed cup)
    Purity Typically ≥ 98%
    Refractiveindex 1.610-1.614 at 20°C
    Synonyms 2-Chlorobenzylthiol

    As an accredited 2-Chlorobenzyl Mercaptan factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 100g 2-Chlorobenzyl Mercaptan is supplied in a sealed amber glass bottle with a chemical-resistant screw cap and hazard labeling.
    Shipping 2-Chlorobenzyl Mercaptan should be shipped in tightly sealed containers, away from light, heat, and incompatible substances. It must be labeled as a hazardous chemical and handled by trained personnel. Transport should comply with relevant regulations, such as DOT, IATA, or IMDG, ensuring safe handling and mitigation of potential leaks or spills.
    Storage 2-Chlorobenzyl mercaptan should be stored in a tightly sealed container, away from light, heat, and incompatible substances such as oxidizing agents. Store in a cool, dry, and well-ventilated area, ideally in a designated chemical storage cabinet designed for toxic and sulfur-containing compounds. Ensure proper labeling, and avoid exposure to air and moisture to prevent decomposition and unpleasant odors.
    Application of 2-Chlorobenzyl Mercaptan

    Applications of 2-Chlorobenzyl Mercaptan in Industrial Manufacturing

    As an established manufacturer, we supply 2-Chlorobenzyl Mercaptan to leading chemical synthesis operations globally. The following key industrial sectors utilize this intermediate for its unique thiol and benzyl chloride reactivity, supporting batch-standard and continuous downstream processes across several specialized applications.

    1. Pharmaceutical Intermediate Synthesis

    Major active pharmaceutical ingredient (API) manufacturers incorporate 2-Chlorobenzyl Mercaptan in targeted heterocycle and thioether formation, especially for anti-infective and antineoplastic compounds. Process engineers typically introduce it during alkylthiolation steps, taking advantage of its nucleophilicity under controlled base or acid catalysis. It often participates in reactions where strict GMP and impurity control are enforced throughout the route. The downstream sequence includes multistep isolation, purification, and quality release according to batch record protocols.

    Industry compliance standards

    • ICH Q7A Good Manufacturing Practice (GMP) for active pharmaceutical ingredients
    • 21 CFR Parts 210 & 211 (US FDA)
    • European Pharmacopeia (Ph. Eur.), relevant monograph specifications
    • Chinese Pharmacopoeia (ChP) where applicable

    Typical usage ratio

    • Applied in reaction charge at 0.8–1.2 molar equivalents relative to target aromatic substrates. Operators may adjust to 1.5 equivalents in high-yielding thioether couplings based on impurity profile, with on-line analytics monitoring excess reagent removal.

    Downstream process integration

    • Dosed into mid-stage reactor streams for thiolation or S-alkylation.
    • Followed by washes, extractions, and purification (crystallization or chromatography).
    • Quality testing for residual mercaptan levels using specific GC-FID methods prior to final API isolation.

    Final product types

    • Sulfur-containing APIs (e.g., antimicrobial thioethers)
    • Advanced pharmaceutical intermediates with aryl-thio linkages
    • Specialty drug substances requiring benzyl-protected sulfur moieties

    2. Agrochemical Thioether Synthesis

    Leading agrochemical producers use 2-Chlorobenzyl Mercaptan in synthesis of key thioether herbicides and fungicides. The compound enters sulfidation or thioalkylation stages following aromatic halide activation, allowing precise modulation of soil-persistence and bioactivity. Batch and flow reactors introduce it under alkaline catalysis with controlled exotherm, using automated feed and real-time thiol tracking. All handling follows environmental and occupational safety mandates to limit exposure and byproduct management.

    Industry compliance standards

    • ISO 9001:2015 for quality management in chemical synthesis
    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • REACH (EC) regulation (EC) No 1907/2006
    • China GB 2763: National Food Safety Standard for Pesticide Residues

    Typical usage ratio

    • Employed at 0.95–1.1 equivalents per mole of halogenated precursor for targeted coupling. Larger scale operations fine-tune ratios to 1.0 equivalent to minimize waste streams, relying on pilot trials for optimization.

    Downstream process integration

    • Pumped into thioetherification modules before crude purification.
    • Excess removed by vacuum stripping or aqueous scrubbing post-reaction.
    • Effluent management adheres to local hazardous substance control.

    Final product types

    • Thioether-based fungicides for cereals (e.g., benzylthio-substituted actives)
    • Sulfur-functionalized herbicide active ingredients
    • Pest control agents with arylthio scaffolds

    3. Fine Chemical Building Block for Aromatic Sulfur Compounds

    Manufacturers in the fine chemical and specialty intermediate sector employ 2-Chlorobenzyl Mercaptan to introduce functionalized benzylthio groups onto aromatic systems. It serves as a key agent in S-alkylations for dye intermediates, photographic chemicals, and custom flavor syntheses. Handling protocols mandate dedicated containment due to odor and reactivity. Batch loading or semi-continuous metering occurs based on required substitution pattern, followed by extensive solvent recovery and post-reaction neutralization stages.

    Industry compliance standards

    • ISO 14001:2015 Environmental Management
    • Responsible Care® guidelines (CEFIC member companies)
    • Strict in-house QC protocols with GC-MS or HPLC for intermediates
    • UN Globally Harmonized System (GHS) hazard communication for downstream users

    Typical usage ratio

    • Introduced at 1.0–1.3 equivalents per aromatic substrate. Excess favored in multi-site benzylation, with precise dosing to avoid polysubstitution. Minor adjustment based on purity of incoming halide and solvent loading.

    Downstream process integration

    • Addition during aromatic substitution or S-alkylation phases.
    • Blending tanks equipped with scrubbers for vapor mitigation.
    • Final crude subject to phase separation and solvent stripping before further synthetic stages.

    Final product types

    • Photographic chemicals and imaging dye precursors
    • Organic synthesis intermediates for advanced polymers
    • Flavor and aroma building blocks for specialty use

    4. Polymer Modifier in Sulfur-Functionalized Resins

    Plastic and specialty resin formulators utilize 2-Chlorobenzyl Mercaptan as a reactive modifier to introduce pendant sulfhydryl groups within epoxy and phenolic resin systems. The compounding department adds it during prepolymer mixing, where it functions either as a chain transfer agent or for site-specific crosslinking. The thiol content is tightly regulated to balance elasticity, adhesion, and chemical resistance in the end-use polymer matrix. Precision metering and in-line blending ensure homogeneous distribution prior to downstream curing and molding operations.

    Industry compliance standards

    • RoHS Directive (2011/65/EU) for restricted substances in electronics applications
    • UL 94 for flame retardancy in plastics
    • ASTM D638 for resin tensile properties
    • ISO 9001:2015 for resin batch traceability

    Typical usage ratio

    • Typically added at 0.5–2.5% by weight to total resin system. Fine-tuned depending on the degree of functionalization required for downstream adhesive or coating formulations.

    Downstream process integration

    • Blended into liquid resin prepolymer tanks under inert atmosphere.
    • Cured with selected hardeners or initiators during composite processing.
    • QA checks for residual mercaptan content prior to packaging or further conversion.

    Final product types

    • Sulfur-functionalized epoxy adhesives
    • Chemically-resistant coatings
    • Modified phenolic laminates

    5. Specialty Lubricant and Antioxidant Additive Manufacturing

    Lubricant and specialty oil producers integrate 2-Chlorobenzyl Mercaptan as a precursor for high-performance sulfur-containing antioxidants and metal deactivators. The blending process introduces the mercaptan into controlled reactors, reacting with alkyl halides or other coupling agents under basic conditions. The resulting thioether additives provide enhanced thermal stability and anti-wear properties, with strict downstream monitoring for residual odor and volatilization during subsequent blending and fill operations. Finished additive concentrates undergo stringent performance testing prior to release.

    Industry compliance standards

    • API Base Oil Standards (API 1509)
    • ASTM D4951 for detection of additive elements in lubricants
    • OECD chemical safety testing and reporting
    • EU REACH registration dossier requirements

    Typical usage ratio

    • Introduced at 1.0–3.0% by weight in additive concentrate formulations. Adjustments made based on end-use application (gear oils, hydraulic fluids), oxidative stability requirements, and field performance history.

    Downstream process integration

    • Charged directly into blending reactors under nitrogen blanket.
    • Final thioether antioxidant distilled and blended with carrier base oils.
    • Batch subjected to compositional and performance QC (DSC, RDE, elemental analysis).

    Final product types

    • Sulfur-based lubricant antioxidants
    • Metal passivators for engine and gear oils
    • High-performance synthetic lubricant concentrates
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    Certification & Compliance
    More Introduction

    2-Chlorobenzyl Mercaptan: A Specialist’s Approach from Factory Floor to Application

    The Real Work Behind 2-Chlorobenzyl Mercaptan

    Every batch of 2-Chlorobenzyl Mercaptan that emerges from our reactors tells a story of practical chemistry, attention to raw material purity, and a hard-earned relationship with safety protocols. Years of refining processes mean the final product reflects a trust built on hands-on experience and daily problem-solving. This isn’t a generic commodity passed from warehouse to warehouse. Each kilogram reflects our deliberate choices in sourcing, reaction controls, and quality checks that stem from mistakes resolved and small victories learned over decades.

    Understanding the Product Beyond the Label

    2-Chlorobenzyl Mercaptan, known in its molecular shorthand as C7H7ClS, carries its weight in organosulfur synthesis thanks to a careful balance between reactivity and selectivity. In our own production lines, we watch for minor impurities that can change downstream performance significantly. A clear color, a sharp persistent odor — these are more than academic details. They are signals that influence how the chemical will act in pharmaceuticals, crop protection, or further intermediates.

    For clients unacquainted with this mercaptan, its distinction lies in the positioning of the chloro group. Dozens of aromatic thiols circulate on the market, but shifting chloro attachment from the ortho to the para position on the benzyl ring changes physical and chemical handling: boiling points, odor persistence, and reactivity with basic nucleophiles all shift. Our operators have learned to adjust distillation regimes and inline filtration accordingly, bridging the gap from theoretical chemistry to plant-floor reliability.

    Profiles in Reliability: Learning from Each Batch

    Not all thiols behave equally once you scale up the reaction. In our workshop, we have observed the difference that even a fractional change in distillation rate makes on purity. Unwanted byproducts like disulfide dimers, formed by air oxidation, show up early if controls slip. We train staff to spot haziness in product, catching contamination before it ships. Each lot is tested using gas chromatography with a sulfur-specific detector, a discipline not always upheld by those farther from the production line.

    Analysis data from the last five years shows a steady improvement in purity. For instance, we have cut typical off-spec mercaptan content from 3% to below 0.2%. This isn’t just numbers on a sheet; lower impurity means less hassle for formulators in agrochemicals or active pharmaceutical ingredient (API) manufacturing. Several headaches have been spared for clients who formerly had to run secondary purifications.

    Where 2-Chlorobenzyl Mercaptan Makes a Difference

    Demand from the pharmaceutical sector keeps us focused on consistent, minimal-residue output. Benzyl mercaptans often serve as key intermediates in coupling reactions, forming thioethers or sulfonic acids. The 2-chloro substitution influences everything from reactivity with alkyl electrophiles to final odor of the end product — which, in turn, affects workplace safety and product compliance.

    Crop-protection makers look for fast reactivity and defined downstream integration. Many discover that skipping proper specification results in legacy problems: off-flavors in synthesis or higher tendency toward peroxide formation, especially if storage environments fluctuate in temperature. Our years involved in in-house storage solutions, from nitrogen blanketing to metal container selection, help stave off spoilage and lost value.

    The chemical isn’t the end goal for most buyers; it’s part of a chain leading to fungicides, herbicides, and high-value custom molecules. Our hands-on production feedback — which solvents work with which glassware, containment practices that keep neighborhood odors to a minimum — saves customers damage control and regulatory headaches. We have witnessed cases where competitors’ shipments, handled carelessly, resulted in notorious off-gassing events or customer delays.

    Usage: Real Stories, Real Lessons

    Many times, our plant has fielded phone calls in the dead of night from users encountering unexpected formation of byproducts due to incorrect pH adjustment or open-air handling. Preempting these issues starts with practical advice rooted in our own events. We routinely recommend well-sealed glass containers, low-light storage, and limited headspace. Lessons learned from small leaks — like a misthreaded barrel lid — have led us to advocate for double-seals and customized logistics protocols.

    Users in the dyestuff and flavor synthesis spaces who tried to swap related mercaptans have run into issues with flash points and incompatibility in alkylation reactions. Our on-site chemists guide them through these practical pitfalls — explaining how the ortho-chloro variation changes reactivity, and why attempts at straightforward substitution often lead to yield losses or altered sensory profiles.

    Product use often triggers local odor complaints in areas with little tolerance for organosulfur emissions. We have developed capture and filtration strategies for customers based on experiments and setbacks from our early days. We share best practices such as closed-loop off-gas capture, blending with scavengers, and staged reaction quenching, because failure on our lines has meant learning through necessity and neighborly negotiation.

    Differences That Matter: 2-Chlorobenzyl Mercaptan Versus Other Thiols

    Most technologists running synthesis plants stumble across the differences between 2-chlorobenzyl mercaptan and other structural isomers only after a process stalls or a batch fouls their equipment. Without a clear understanding, substitutions using 4-chlorobenzyl mercaptan or unsubstituted benzyl mercaptan may appear trivial, but yields, side-product formation, and even plant odor control change considerably.

    Years back, a major user in API manufacturing faced repeated setbacks due to misjudged substitution. Standard process tables failed to predict sulfur impurity breakthrough and increased batch exothermicity in their high-throughput reactors. Our factory’s technical team was called, and we pinpointed that 2-chloro placement slowed down nucleophilic displacement, slightly lowering conversion temperature. This experience — shared openly with the customer — helped them redesign their protocol, improving reliability and cutting cycle times by over 15%.

    Clients focusing on heavy-metal-free catalysis rely on our product’s narrow boiling range and documented absence of transition metal traces, logged from our raw input audits. For them, “close enough” purity leads to catalyst poisoning and runaway costs. The technical assurance they need comes not just from analysis sheets, but from our team’s willingness to run parallel small-scale syntheses and document the outcomes, including yields, sensory differences, and clean-up requirements.

    Chemists working with electron-rich aromatic substrates have run into solubility and compatibility problems using other mercaptans. Direct consulting with such users taught us to offer guidance on solvent selection, agitation rates, and temperature controls based specifically on the properties of 2-chlorobenzyl mercaptan, not just generic aromatic thiols.

    Meeting Modern Standards: Safety, Traceability, and Environmental Awareness

    Increasing regulatory pressure demands full traceability, not just basic specifications. Every 2-chlorobenzyl mercaptan shipment leaving our facility comes backed by records detailing raw input lots, operator signatures, and on-site analysis logs. We have experienced the hard lessons of incomplete records during audits, and our current system stems directly from that. This reduces liability risks for downstream processors and helps pinpoint root causes during troubleshooting.

    Our team takes special interest in environmental controls, given the reputational risk and regulatory fines associated with volatile organosulfur emissions. Real-world accidents — not just theoretical risks — have shaped our emission abatement approaches: peroxide scrubbing, activated carbon traps, and contingency plans for transport mishaps. It’s not always possible to keep production absolutely silent or odor-free, but years spent balancing production scale, vent design, and real-time monitoring means we usually identify problems before the authorities do.

    Listening to the User’s Needs — Not Just Supplying a Product

    Not all manufacturers engage with their customers after the truck leaves the factory gate. From our vantage point, partnership goes far beyond filling up a drum. Many of our ongoing improvements come from direct user feedback: an agrochemical company flagged a need for smaller packaging to reduce waste, which led us to launch safe-pour canisters and cut packaging-related loss considerably.

    A recurring issue reported by buyers in the flavor industry involved trace halogen carryover affecting downstream sensory purity. Instead of passing off the problem, our chemists investigated each link in the input chain, pinpointing and aligning with suppliers able to deliver tighter raw input controls. This cut complaints and reduced batch rejection rates.

    During pandemic-driven logistic bottlenecks, we scrambled to secure stable supplies of critical raw materials; price hikes and delays hit us as hard as any downstream user. By keeping our buyers informed with real forecasts and real data, we built trust that lasted past the crisis. Transparent communication, including warnings about periods of potential volatility, helped customers adapt their own production lines and safeguard deadlines.

    Improving the End Result for Users — A Focused Commitment

    We don’t only see ourselves as chemical suppliers. The drive to improve stems from practical challenges, not only market surveys or textbook diagrams. Maintenance staff report on line fouling and pipe compatibility. QC teams debate detection thresholds for off-odors or fluorescent impurities. These conversations from across our facility feed directly back into process tweaks, handling guidelines, and even new product offshoots.

    Resin manufacturers using our 2-chlorobenzyl mercaptan found that switching from imported alternatives cut down on unpredictable downtime by almost half, due to tighter purge schedules and easier cleaning. Close collaboration with their process engineers, mixing plant walkthroughs, and a willingness to analyze slurries on-site all contributed to practical process improvement.

    Over the years, plant managers have experimented with different containment types: PE drums, lined steel, and break-bulk options. Real-world results shape recommendations: lined drums maintain color and olfactory stability; standard steel or bulk IBCs work well only with dedicated, cleaned return loops. These aren’t points buried in a manual, but rather lived experiences from spill responses and shelf-life trials.

    Quality Isn’t a Slogan — It's Hands-on Discipline

    Stability and specification are sometimes seen as just checkboxes. In our facility, quality assurance blends laboratory monitoring with on-the-ground vigilance. Workers on the floor don’t just log data; they identify shifts, notify supervisors about off-odors, and pull samples when a batch seems off. There’s always a temptation to skim on analytical runs — but we know from hard lessons that a single missed impurity waveover can cost weeks in customer troubleshooting and lost trust.

    Continuous feedback loops link every step, from delivery and storage to use in application. Clients running small pilot plants in fine chemical synthesis have called for different cut-points in distillation curves to best match their flow reactors. We’ve responded by widening our fractional distillation setups, running custom protocols, and then following up over months and years to see if the change paid off at scale. Real returns show up in more repeat orders and word-of-mouth recommendations.

    Beyond the Molecule — Building Enduring Trust

    The small size of the specialty chemical world means word travels fast — both praise and complaint. Our fulfillment record stays strong because we don’t hide flaws or deflect blame; if a shipment fails QA at a customer site, we work back through both our own logs and anything the user can share from their process line. Where mistakes have occurred, as with a past episode of hydrolyzed product caused during humid monsoon storage, we have paid to replace the stock, and revised our internal storage practices accordingly.

    Veteran buyers value these hard-won lessons and reward them in the long term. Our reputation — and by extension, the actual market value of 2-chlorobenzyl mercaptan — has improved not just by hitting specs, but by keeping open channels to users, being quick with technical help, and pushing for rigorous documentation at every hand-off. This approach cements a level of predictability that most resellers or third-parties cannot supply.

    Looking Ahead: Growth and Evolution in Specialty Chemicals

    Markets for 2-chlorobenzyl mercaptan respond fast to regulatory and demand shifts. Our continual process adaptation aligns with new technical standards, including trace VOC thresholds and halogen-free claims increasingly sought by end-users. Each regulatory pressure or industry trend has forced us to scrutinize not just what leaves our gates, but what inputs and processes actually work at scale with today’s expectations.

    Industries using such intermediates often navigate uncertain ground as end-user expectations, speed-to-market, and even global freight reliability shift every season. Our approach centers on resilience — developing broad contingency plans, tertiary suppliers, and local warehousing. We plan for outages, run mock recalls, and train staff down to the last forklift operator on what to watch for in daily operations.

    From Our Floor to Yours: A Shared Mission in Specialty Chemistry

    Innovation in specialty organosulfur chemistry doesn’t simply mean publishing data or patenting a new process. For us, it’s a daily craft informed by years of trial, error, and customer interaction. Products like 2-chlorobenzyl mercaptan exist within a living network of experience, part science and part hands-on trade. Our advantage grows not from price point alone, but from the deeper engagement with every use-case, challenge, and practical need encountered in real-world labs and plants.

    Every successful batch that ships out represents teamwork across departments and a steady cycle of learning. Each time a new user approaches us with a challenge — from odor reduction to downstream process compatibility — we don’t just cite the literature or hand over a spec sheet. We test in our own labs, draw on our plant floor history, and bring honest feedback rooted in what has worked, and what hasn’t.

    That’s the real substance at the heart of our product: not just a chemical, but a living commitment to reliability, transparency, and continued growth, forged from the daily realities of specialty manufacture.