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2-Chloro-6-Methylaniline

    • Product Name 2-Chloro-6-Methylaniline
    • Alias 2-Chloro-6-methylaniline
    • Einecs 220-481-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    363121

    Iupac Name 2-chloro-6-methylaniline
    Cas Number 87-63-8
    Molecular Formula C7H8ClN
    Molecular Weight 141.6 g/mol
    Appearance Light yellow to pale brown solid
    Boiling Point 243-245 °C
    Melting Point 35-39 °C
    Density 1.19 g/cm³
    Solubility In Water Slightly soluble
    Flash Point 108 °C
    Odor Aromatic
    Synonyms 2-Chloro-6-methylaniline, 6-Methyl-2-chloroaniline
    Pubchem Cid 69462

    As an accredited 2-Chloro-6-Methylaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 grams of 2-Chloro-6-Methylaniline, tightly sealed, labeled with hazard warnings and chemical details.
    Shipping 2-Chloro-6-Methylaniline is shipped in tightly sealed containers, protected from moisture and incompatible substances. Transport must comply with regulatory guidelines for hazardous chemicals, including labeling as a toxic and potentially environmentally hazardous material. Ensure ventilation and avoid exposure during handling. Typically shipped via ground or air freight depending on destination and quantity.
    Storage 2-Chloro-6-Methylaniline should be stored in a tightly sealed container in a cool, dry, and well-ventilated area away from sources of ignition. Keep it away from incompatible substances such as strong oxidizers and acids. Protect from moisture and direct sunlight. Proper labeling and secondary containment are recommended to prevent leaks or spills. Use only in chemical fume hoods.
    Application of 2-Chloro-6-Methylaniline

    Applications of 2-Chloro-6-Methylaniline in Industrial Manufacturing

    2-Chloro-6-Methylaniline serves as a critical building block in several high-value chemical industries. Below, we present focused, factual industrial application scenarios, each supported by real compliance, technical, and process details relevant to manufacturers and formulators.

    1. Intermediate in Crop Protection Synthesis

    Leading agrochemical companies use this molecule as an intermediate in synthesizing selective herbicides and insecticides. Its controlled reactivity helps construct key aromatic cores by targeted coupling reactions during active ingredient production. Technical teams integrate this material at the core stages, ensuring formation of desired molecular fragments in regulated process environments for downstream formulation into finished crop protection products.

    Industry compliance standards

    • OECD Good Manufacturing Practice (GMP) for active ingredient synthesis
    • REACH (EC) No 1907/2006 for volume registration and handling
    • ISO 9001:2015 for quality management during agricultural chemical production
    • US EPA regulations for pesticide raw materials

    Typical usage ratio

    • 5–20% in coupling or condensation steps, adjusted for molecular yield and target product structure

    Downstream process integration

    • Charged in early synthesis or as a limiting reagent for aminophenyl activation
    • Direct alkylation, acylation, or diazotization in specialty reactors
    • Followed by chromatographic purification and conversion to technical concentrate
    • Residue control by HPLC or GC in QA labs before formulation

    Final product types

    • Triazine-based herbicide intermediates
    • Anilide and urea herbicide precursors
    • Certain synthetic pyrethroid insecticide actives
    • Fungicide pre-mix intermediates for major market brands

    2. Key Precursor for Pharmaceutical API Manufacturing

    Pharmaceutical manufacturers incorporate this compound for constructing substituted aniline fragments in targeted drug substances. Medicinal chemists rely on its functional groups to facilitate regioselective amination and halogen-directed substitutions, crucial during the custom synthesis of proprietary APIs—especially analgesics, anti-inflammatory, and CNS-active molecules. Production chemists monitor every step for impurity control and traceability, ensuring compliance with strict pharmacopeial requirements during scale-up.

    Industry compliance standards

    • Current Good Manufacturing Practices (cGMP) ICH Q7 guidelines
    • European Pharmacopoeia (Ph. Eur.) and US Pharmacopeia (USP) for final APIs
    • 21 CFR Part 211 for finished pharmaceutical ingredients
    • FDA Drug Master File (DMF) referencing for raw material sourcing

    Typical usage ratio

    • 2–10% molar basis within multi-step API synthesis, depending on target molecule complexity and scale-up yields

    Downstream process integration

    • Used after halogen exchange or nitro reduction for key ring substitution
    • In-process controls applied via LC-MS for intermediate purity profiling
    • Integrated into custom hydrogenation, carbonylation, or cross-coupling operations
    • Cleared by secondary purification before downstream API crystallization

    Final product types

    • Anti-inflammatory API intermediates
    • CNS-active drug substances with halogenated aniline cores
    • Veterinary active ingredient intermediates
    • Generic and patented analgesic bulk APIs

    3. Dye and Pigment Intermediate for Industrial Colorants

    This material functions as a core intermediate for the synthesis of specialty azo and anthraquinone dyes. It enables the construction of chlorinated and methylated aromatic amines, essential for providing stability, colorfastness, and shade selectivity in high-performance colorant systems. Color chemists use its substitution pattern to engineer dyes with required hue and lightfastness, serving both textile and plastics industries where precise tinting is required.

    Industry compliance standards

    • Oeko-Tex Standard 100 Annex 4 for regulated aromatic amines in textile dyes
    • REACH (EC) 552/2009 for permitted aromatic amine use in colorant manufacture
    • DIN EN ISO 105-E01 for colorfastness testing on finished textiles
    • Restricted Substance Lists (RSL) from major apparel brands

    Typical usage ratio

    • 5–15% for diazo coupling or amination during dye synthesis; adjusted for chromophore yield and color intensity requirements

    Downstream process integration

    • Diazotization and coupling with nitroso or naphthol compounds in batch reactors
    • Precipitation, filtration, and drying of dye intermediates with routine IR/NMR verification
    • Final blending with dispersing agents or plasticizer carriers
    • Color and purity control via UV-Vis spectrophotometry

    Final product types

    • Reactive and direct textile dyes
    • Plastics and fiber pigment preparations
    • Specialty inks for industrial printing
    • Azo pigment intermediates for paint and coatings

    4. Synthetic Intermediate for Polymer Additives

    Polymer additive producers utilize this compound for engineering specialty stabilizers and anti-aging agents, targeting controlled modification of polymer chains. Its chemical structure enables incorporation into hindered amine light stabilizers (HALS) or custom polymer antioxidants designed for long-term durability in plastics, films, and elastomers. Process engineers introduce this raw material at the backbone synthesis stage, ensuring homogeneous integration for future extrusion, molding, or compounding applications.

    Industry compliance standards

    • FDA 21 CFR 177.1520 for polymer additive migration and residue limits
    • ISO 14021:2016 for environmental claims in plastic additives
    • UL 94 for flammability of polymeric materials
    • EN 71-3 for heavy metal and amine content in toy plastics

    Typical usage ratio

    • 0.1–2% total monomer weight when modifying polymer stabilization packages, varying according to polymer base and required anti-aging performance

    Downstream process integration

    • Reacted during the synthesis of HALS or hindered phenol antioxidants
    • Batch or continuous reactor feeding in consolidating masterbatch production
    • QC verification by GPC/MALDI-TOF for incorporated additive levels
    • Downgraded to pellet or powder form for customer resin blending

    Final product types

    • Antioxidant and HALS masterbatches
    • UV-stabilizer concentrates for polyethylene and polypropylene
    • Specialty compounding agents for engineering polymers
    • Heat and light stabilizer blends for cable and film extrusion
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    Certification & Compliance
    More Introduction

    2-Chloro-6-Methylaniline: Reliable Quality from Deep Experience in Production

    Understanding 2-Chloro-6-Methylaniline from the Manufacturer's Bench

    Many customers come to us looking for intermediates that deliver consistent results batch after batch. Among our specialty chemical offerings, 2-Chloro-6-Methylaniline occupies a practical space for those who value purity, stability, and a transparent manufacturing process. Regular visitors to our facility often ask what sets our version apart. We've worked hands-on in every aspect of its production and have learned through years of customer feedback what truly matters: assuring traceability, minimizing impurities, and supporting downstream applications like pharmaceuticals, dyes, and agrochemicals with true reliability.

    How Our Process Delivers a Practical Difference

    Day to day, our process engineers stay close to the reactors. Every batch of 2-Chloro-6-Methylaniline comes from locally sourced raw materials, with provenance records maintained right down to the supplier’s lot number. This tight control over input materials makes a difference not only in purity but in how the product behaves in your own finishing steps. The reaction pathway for this compound requires attention to temperature, agitation, and pH at each stage. Many new entrants underestimate how much trace levels of ortho- or para-isomers can disrupt crystallization steps or downstream coupling reactions. We’ve tuned our process over the years to minimize these impurities, and every finished lot undergoes full HPLC and GC-MS analysis before release.

    Specifications That Matter for Real-World Applications

    Operators in our analytical lab frequently comment on the value of confirming identity and purity in-house rather than relying on third-party testers alone. Over the years, we’ve established tight targets: colorless to pale yellow crystalline solid, melting point between 32–36°C, purity by HPLC not below 99%, and maximum water content of 0.3%. Each data point gets tied directly to the lot and measured on equipment we calibrate weekly. Retained samples from every batch are stored under controlled conditions for two years, so our customers draw on a complete record if they need historical verification.

    We do not treat packaging as an afterthought. Clear labelling, tamper-evident seals, and a range of drum and bag sizes allow research teams and plants alike to receive this product in a form that integrates into their workflow with minimal risk of contamination. Our drum linings prevent seepage or contact reactions, which eliminates one common source of discoloration or off-odors—feedback we hear from process chemists who’ve switched over from non-dedicated suppliers.

    Direct Manufacturer Experience: Tackling Challenges Beyond the Data Sheet

    Over the years, our technical support group has dealt with issues reaching far beyond the neat confines of data sheets. One pharmaceutical client encountered trace aldehyde formation during scale-up. By sharing our internal impurity profile and re-examining the distillation step, we quickly identified residual catalyst as a culprit—a lesson both sides integrated into their hazard assessments moving forward.

    Such collaboration comes easier when you are the manufacturer. Our plant supervisors cycle through the lab each week to review returns and counter-samples. Rare out-of-spec results don’t get lost in an email trail; they kick off a physical review of stored batches, process logs, and raw material records until root cause is identified and removed from future cycles. We openly share typical impurity profiles and emerging analytical techniques with interested clients, recognizing that more transparency helps everyone build safer processes.

    What Makes Our 2-Chloro-6-Methylaniline Stand Apart?

    We do not see this intermediate as a generic commodity. Experienced users will notice the difference in work-up times during further acetylation or diazotization. Where variable lots from general traders can introduce unknowns, our approach aims to cut out the unpredictable elements. Rigorous solvent removal and controlled cooling minimize by-product formation. In specialized dye manufacturing, this careful approach reduces filtration time and the risk of resinous side products, giving a more uniform color yield without the need for secondary purification.

    Pharmaceutical chemists use this compound for crucial coupling steps where even 0.1% of the wrong aromatic amine can disrupt an entire process, costing both yield and regulatory headaches. We’ve engineered our downstream handling to avoid cross-contamination, working in spaces where only aniline derivatives are processed that week. All wash liquids are segregated by compound class, tracked and analyzed before disposal, to keep unexpected impurity profiles off your desk.

    Application Insights from Years in the Field

    Our customers’ feedback has shaped how we view the role of 2-Chloro-6-Methylaniline. In the agrochemical sector, our teams have worked closely with formulation chemists developing triazine and phenylurea compounds. Reaction efficiency improves when you start with material free from specific halogenated side-products. After we upgraded our dechlorination and column purification steps, one client reported a 15% reduction in waste by weight—a savings that accumulated rapidly through their campaign.

    Working with formulation and R&D groups, we see the advantages of transparency in composition, particularly for those developing new active pharmaceutical ingredients. Patent applications often depend as much on purity as on novel structure. Our documentation includes detailed NMR and MS spectra, so development teams can reference this data directly in their filings.

    Dye manufacturers have commented that small changes in the methyl group’s position alter both solubility and final product hue—a real concern in specialized pigment work. They come to us for the reliability our process brings, leading to smoother scaling from bench to production.

    How Raw Material Choices Shape Final Product Quality

    Early in our work with 2-Chloro-6-Methylaniline, we learned that not every supply source is equal. Variation in the chloro or methyl group’s origin can carry over into trace organochlorine residues. These impact the smell, stability, and regulatory acceptance down the line. By controlling our entire supply chain and certifying every input ourselves, we eliminate much of the uncertainty clients face when purchasing from loosely connected traders.

    Some manufacturers price this compound on a strictly “per kilogram” basis, often shaving costs by blending reprocessed side-streams. Our process chemists have never subscribed to this approach. Focusing on product that meets the same analytical profile batch after batch gives customers greater control—not just over synthesis success, but over process licensing, patent defense, and quality submissions to health authorities.

    Differences That Seasoned Users Notice

    We’re often asked to compare our product to similar offerings in the marketplace. What consistently stands out according to feedback are a few concrete areas: lower levels of residual isomeric anilines, sharper melting point ranges, and stable coloration during extended storage. High throughput labs send us Excel sheets charting these properties—which help pinpoint how our batches consistently fall within tighter specifications.

    We do not rely on post-production mixing to “even out” batches; instead, control takes place during each synthesis campaign, with close monitoring of reaction kinetics and careful quenching. Compared to material offered by smaller resellers sourcing from assorted third parties, our compound shows less batch-to-batch drift in chemical profile. We encourage clients to keep retained samples and run their own comparisons; nearly always, they see a drop in off-spec events and reprocessing once they switch.

    Supporting Responsiveness and Traceability for Complex Projects

    Deadlines for chemical development projects grow tighter every year. As the actual producer, we can rapidly pull out specific lot histories, impurity scans, and even archived analytical runs if a project team needs to answer questions during regulatory filings or troubleshooting. This removes the uncertainty that creeps in when materials pass through three or more hands before reaching the final user.

    Clients tackling greenfield projects or scaling up for the first time often find themselves facing queries from audit teams or regulatory officers. We directly support these interactions, providing sample retention records, method validation files, and in some cases, running new methods for comparison if a site’s equipment differs from ours. All of our senior chemists retain first-hand recall of which campaign produced which major lot, and no time gets lost chasing anonymous third-party certificates.

    Solutions for Emerging Industry Demands

    Changes in regulatory requirements around the world have placed greater scrutiny on aromatic amine intermediates. We’ve adapted by introducing purity tracking for new by-products of concern each year. Our specialty in-house chromatographers routinely upgrade their methods as detection hardware improves, giving our clients more precise compositional data.

    Environmental responsibility demands careful consideration of waste streams. We audit our entire process annually with third-party input, targeting reductions in solvent use and seeking recyclable packaging options for larger clients. Through research on greener synthesis pathways, we have managed to trim water and energy usage per batch, passing on those cost and compliance benefits to partners.

    For customers trialing 2-Chloro-6-Methylaniline in new medical or crop-protection applications, we maintain project confidentiality and work closely on custom impurity analysis if their process introduces unexpected side-reactions. Our data submission packages have passed multiple authorities’ reviews with no major queries, an achievement made possible by keeping all documentation and witness samples on-site and verifiable.

    Collaborative Approaches to Problem Solving

    Month after month, our technical liaisons work with both large pharmaceutical companies and independent research outfits. Some projects demand tighter than usual moisture limits; others need modified particle size formats or improved filtration characteristics. We work directly with end users to trial changes in process parameters or packaging formats, providing immediate feedback with incremental improvements measured against each batch.

    One standout collaboration involved a university team developing a new method for polymer-bound dyes. Their synthesis repeatedly failed with commodity material from off-shore sources. By opening our process logs and exploring their reactivity issues in real time, we pinpointed minor halogenated impurities as the barrier. Once we provided a batch made to their specialized impurity profile, their reactions ran to completion.

    Open communication and ability to customize at the producer level mean less risk for innovation-focused clients, with faster problem resolution than the layer-upon-layer handling found in the general market.

    Stability and Storage: Insights from Many Years’ Experience

    As raw material shortages and logistics issues affect global shipments, confidence in shelf life grows paramount. Our product has demonstrated stability across a range of storage conditions, drawing on over a decade’s worth of internal studies. Customers receive recommended storage guidance rooted in real temperature cycling and exposure trials, not just generic literature.

    Clients storing large batch sizes for manufacture hold confidence that melting point drift, color changes, or precipitation risks remain low for the documented shelf period. For customers in tropical or high-humidity environments, we offer optional packaging in desiccant-lined sealed drums, further preserving product quality for extended periods.

    Return on Investment: Why Long-Term Users Stay with Us

    Many new customers join us after facing unplanned downtime or out-of-spec product issues from less controlled sources. By tracking metrics such as successful batch completion rate and unplanned rework events at their own sites, they can attribute cost savings directly to the switch. These gains often exceed the margin difference on price per kilogram, visible in less waste, fewer production stops, and reduced regulatory incidents.

    We frequently assist with site audits, sharing our quality control and traceability approach openly. Batch records show not only adherence to manufacturing norms, but a tangible decrease in contamination trends over several years – the results of continuous small optimizations to plant procedures. Clients value this proven transparency and predictable quality, strengthening both sides’ regulatory and market positions.

    Don’t Settle: Demand Consistency and Insight from Your Supplier

    Direct conversation with the manufacturer brings more than a simple material transaction. It links operational knowledge, real-world problem solving, and support from chemists with direct experience across every lot. As the landscape for specialty intermediates grows more competitive and regulated, peace of mind and reliability draw from a transparent, controlled process. Our years of production show that 2-Chloro-6-Methylaniline can meet these demands when manufactured and supported by a dedicated, informed team invested in both outcome and partnership.