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2-Chloro-6-Fluorobenzyl Chloride

    • Product Name 2-Chloro-6-Fluorobenzyl Chloride
    • Alias 2-Chloro-6-fluorobenzyl chloride
    • Einecs 'EINECS 252-885-0'
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    466012

    Productname 2-Chloro-6-Fluorobenzyl Chloride
    Casnumber 57381-32-5
    Molecularformula C7H5Cl2F
    Molecularweight 179.02
    Appearance Colorless to pale yellow liquid
    Boilingpoint 223-225 °C
    Density 1.39 g/cm³
    Meltingpoint -
    Purity Typically ≥ 97%
    Refractiveindex n20/D 1.567
    Smiles ClCc1c(Cl)cccc1F
    Solubility Insoluble in water, soluble in organic solvents

    As an accredited 2-Chloro-6-Fluorobenzyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 100g, sealed with a screw cap. Clearly labeled with chemical name, hazard symbols, batch number, and supplier details.
    Shipping 2-Chloro-6-Fluorobenzyl Chloride is shipped as a hazardous material in accordance with international regulations. It is packaged in tightly sealed, chemically resistant containers to prevent leaks. During transport, it is labeled appropriately and stored away from heat, moisture, and incompatible substances, ensuring safe handling and compliance with safety standards.
    Storage Store 2-Chloro-6-Fluorobenzyl Chloride in a tightly sealed container under a dry, inert atmosphere, such as nitrogen. Keep it in a cool, well-ventilated area, away from heat, moisture, and incompatible substances like strong oxidizers and bases. Clearly label the storage area and prevent exposure to acids. Handle with appropriate personal protective equipment and follow standard chemical hygiene protocols.
    Application of 2-Chloro-6-Fluorobenzyl Chloride

    Applications of 2-Chloro-6-Fluorobenzyl Chloride in Industrial Manufacturing

    2-Chloro-6-Fluorobenzyl Chloride serves as a key intermediate for specialized synthesis steps across several advanced chemical manufacturing sectors. Below, we detail primary downstream industrial applications, based on verified industry usage, with a focus on applicable compliance, actual formulation ratios, unique process positions, and real final products.

    1. Agrochemical Active Ingredient Synthesis

    Major crop protection formulators utilize this material in the production of selected herbicides and fungicides. Introduction often occurs during multi-step synthesis, targeting fluorinated and chlorinated aromatic derivatives for enhanced biological persistence. Process requirements call for purity management, controlled reactivity, and dedicated containment due to the compound’s halogen content.

    Industry compliance standards

    • FAO/WHO Specifications for agricultural pesticides
    • OECD Guidelines for the Testing of Chemicals (toxicity, environmental risk)
    • ISO 9001:2015 for quality assurance in production
    • EU Regulation (EC) No 1107/2009 (plant protection products approval)

    Typical usage ratio

    • 10–25% of reaction feedstock, adjusted per synthesis scale and targeted active ingredient molecular yield

    Downstream process integration

    • Feeds into Grignard or nucleophilic aromatic substitution stages, forming halogenated benzyl derivatives, before further functional group activation

    Final product types

    • Fluorinated benzyl-based herbicides
    • Selective fungicidal intermediates for cereals and vegetables
    • Pest control agents relying on substituted aromatic cores

    2. Pharmaceutical Intermediate for API Manufacture

    Pharmaceutical groups employ this compound as a structural intermediate for the construction of specific active pharmaceutical ingredients, particularly those featuring fluorinated aromatic frameworks. The material enters at controlled reaction steps for both branded and generic molecule synthesis, demanding validated purity batches and strict traceability.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • USP/NF and EP monograph alignment (where applicable)
    • 21 CFR Part 211 (US FDA current Good Manufacturing Practice)
    • EMA Guideline on starting materials and intermediates (ICH Q11)

    Typical usage ratio

    • 5–18% by molar equivalents in halogenated aromatic assembly stages, with ratio based on stoichiometry for target API scaffolds

    Downstream process integration

    • Acts as a benzylating reagent or side-chain precursor during preparation of final API scaffolds
    • Integration often follows hydrogenation or dehalogenation after initial coupling

    Final product types

    • Antipsychotic drug intermediates (e.g., substituted benzylpiperazines)
    • Fluoroaromatic-based antihistamines
    • Intermediates for niche CNS-active compounds

    3. Fine Chemical Synthesis for Specialty Polymers

    Manufacturers in the polymer additives space utilize this compound for functionalizing high-performance polymers. Its halogenated structure introduces unique thermal and chemical resistance features. The material is incorporated during specific copolymerization or post-polymer functionalization, optimizing for targeted end-use properties.

    Industry compliance standards

    • REACH (EC 1907/2006 – substance registration for polymer additives in EU markets)
    • ISO 14001:2015 Environmental Management for chemical producers
    • ASTM D5630 (residuals in polymers)
    • National regulatory limits on halogenated organics (China, US EPA, EU REACH restricted substances)

    Typical usage ratio

    • 0.5–5% by weight in copolymer mass for post-functionalization, determined by performance parameters or regulatory thresholds for halogen content

    Downstream process integration

    • Feeds into solution or melt-phase polymerization steps, typically as an end-capping agent or side-chain modifier

    Final product types

    • Fire-retardant polyesters
    • Fluorinated engineering plastics for electronics or automotive use
    • Custom performance films and coatings

    4. Intermediate for Performance Dyes and Pigments

    Producers of specialty colorants adopt 2-Chloro-6-Fluorobenzyl Chloride for synthesizing fluorescent or high-stability pigments. Its dual halogen substitution is crucial in tuning both hue and photostability in advanced dye molecules. The compound is introduced during targeted aromatic substitution, enabling tailored chromophores for demanding applications.

    Industry compliance standards

    • EN 71-3:2019 (migration of certain elements in toy colorants)
    • US TSCA Inventory requirements (industrial colorant substances)
    • ISO 9001:2015 for dye and pigment manufacturing
    • GHS (Globally Harmonized System) for classification and labeling

    Typical usage ratio

    • 3–12% of total organic pigment precursor batch, based on target chromophore intensity and shade control

    Downstream process integration

    • Added at nucleophilic substitution or Friedel–Crafts alkylation stage, prior to ring closure or diazotization for mono- and di-azo dye types

    Final product types

    • High-stability violet and blue pigments
    • Fluorinated dyes for UV-resistant industrial inks
    • Coloring agents for high-end plastics and textiles

    5. Building Block in Advanced Liquid Crystal Manufacturing

    Producers of liquid crystals apply this compound to introduce halogen-substituted aromatic linkers critical for fine-tuning dielectric and optical properties. The material becomes part of multi-step syntheses, especially in the preparation of precursors for nematic and smectic phase liquid crystals used in modern display panels.

    Industry compliance standards

    • RoHS Directive (2011/65/EU) for electrical/electronic applications
    • IEC 62321 (determination of halogenated compounds in electronic materials)
    • ISO 9001:2015 for display material manufacturing
    • REACH registration for non-persistent organic chemicals

    Typical usage ratio

    • 2–8% molar basis per liquid crystal batch, tailored according to molecular design for dielectric optimizing

    Downstream process integration

    • Introduced during key etherification and halogen exchange reactions that precede core liquid crystalline assembly

    Final product types

    • Nematic and smectic phase liquid crystal precursors
    • Specialty aromatic esters for display modules
    • Components for TFT-LCD and flexible electronic panels
    Free Quote

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    Certification & Compliance
    More Introduction

    Bringing Practical Value to Chemistry: 2-Chloro-6-Fluorobenzyl Chloride

    Real-World Experience in Chemical Manufacturing

    In our years of chemical manufacturing, not many substances draw requests as frequently as 2-Chloro-6-Fluorobenzyl Chloride. Working with this material, you witness the balancing act between purity, safety, and process reliability. Each batch demands full attention—from raw material selection to final bottling—because no laboratory or industrial outcome tolerates inconsistency where halogenated benzyl intermediates are concerned.

    We consistently choose to source the cleanest possible chlorobenzyl precursors and employ vetted fluorination pathways. Our manufacturing process allows for tightly controlled temperature profiles, maintaining safe and complete conversion at each stage. This focus avoids hazardous byproducts and keeps impurity drift very low, which is critical when our clients apply this compound in advanced synthesis projects or regulated pharmaceutical steps. Over time, teams working in agricultural R&D, specialty polymers, and fine chemical research have counted on us, largely due to our established track record rather than marketing promises.

    The Compound at a Glance

    2-Chloro-6-Fluorobenzyl Chloride, recognized by its CAS number 196709-05-2, stands out for its dual halogen substitution on the aromatic ring and the highly reactive benzyl chloride function. Unlike generic benzyl chlorides from other suppliers, our expertise lies in maintaining high selectivity between the chloro and fluoro positions. Chemists using other positional isomers soon notice downstream side reactions or unexpected synthesis routes, especially in complex, multi-step projects.

    From every tank to each drum, we verify both the position and strength of each substituent by direct NMR and GC-MS—our internal batch logs span years and stay open to inspection. Small impurities at the meta or para positions can push yields off course or trigger regulatory headaches. Synthetic routes that rely on single purification—often the preferred way to keep costs within project budgets—benefit from this consistent selectivity.

    Model, Appearance, and Key Specifications

    The 2-Chloro-6-Fluorobenzyl Chloride we produce carries our internal model code to distinguish it from similar but less rigorously produced materials on the market. Each shipment contains primary and secondary certificates, providing not just a ticked COA but full in-process data. We dispatch this compound as a colorless to pale yellow oily liquid, free from visible particulates or browning that signals polymerization or decomposition.

    Our product typically presents a density that matches reference tables—usually around 1.3 g/cm3—with storage requirements that resist direct light and humidity. Packing into fluorinated HDPE drums prevents attack from the chloride group and guards against leaching, an important consideration in sites relying on extended storage periods in variable climates. Each batch also comes with a unique IR spectrum, showing the signature absorptions for both the chlorobenzyl C–Cl and aromatic C–F bonds. This approach provides concrete assurance, not just a passing grade on a supplier checklist.

    Why Many Industries Request 2-Chloro-6-Fluorobenzyl Chloride

    On any production floor, schedules and margins often run neck-and-neck with technical demands. Our customers in agrochemicals have turned to our 2-Chloro-6-Fluorobenzyl Chloride as a building block for high-value herbicide and fungicide precursors. Year after year, field performance hinges on clean, reproducible chemistry. Weak points, like trace contamination from co-produced isomers, can undermine the stability and bioavailability these molecules must deliver. Some commercial labs push our material through catalytic couplings to introduce new nitrogen or oxygen functionality; some use it as a starting point for highly specialized cross-couplings in liquid crystal intermediates. The benzyl chloride group stays highly reactive, responding quickly to nucleophilic attack for ether or amine formation.

    On the pharmaceutical side, a few clients have told us their previous supply of benzyl chlorides lacked defined halogen placement. Results suffered—one group saw impurities creep up in HPLC final products, keyed to supply chain shortcuts at the chloride introduction phase. By using the right isomer, they avoided regulatory setbacks and material waste, factors any manufacturer dreads.

    Polymer producers appreciate its role as a halogen-modified monomer or chain-terminator, adding targeted chemical resistance or flame retardancy to specialty plastics. Familiarity with its handling means their plants line up efficient processes that skip extra purification cycles, saving energy and minimizing hazardous waste generations per kilogram of product shipped.

    Direct Comparisons: Quality, Performance, and Process Impacts

    Not every 2-Chloro-6-Fluorobenzyl Chloride is equal. Suppliers with less specialization sometimes co-package closely related compounds or offer blends under imprecise labeling. We’ve analyzed off-market samples for R&D teams and found as much as six percent off-position byproducts in so-called ‘high purity’ claims. Our staff have worked through recall events elsewhere, tracing failed assays or stalling project deadlines back to gaps in the upstream benzyl chloride feedstock selection. Cost and reputation both suffer when customers must repeat or abandon entire synthesis programs.

    By experience, the influence of tight chain-of-custody controls cannot be overstated. On several occasions, clients transitioned to our material after experiencing variations in reactivity and environmental profile. Our 2-Chloro-6-Fluorobenzyl Chloride, with its specific ortho-halogens, brings predictable kinetics to substitutions and coupling reactions, helping labs meet project milestones without ramping up solvent or base consumption to chase yields.

    When compared to mono-halogen analogs, the dual halogenation of this compound introduces unique inductive effects, affecting everything from electrophilic substitution to downstream stability. Chemists in advanced material labs often report better selectivity during coupling steps and fewer side products—this means less waste to treat and fewer headaches scaling up from bench to pilot plant.

    Handling and Storage: Field-Tested Insights

    2-Chloro-6-Fluorobenzyl Chloride reacts sharply with strong nucleophiles and humid air. Our SOPs always include detailed instructions for every drum, linking direct experience from our technical staff rather than just regulatory advice. Cooling and inerting practices, regular inspection for discoloration or pressurization, and real-time logging of opening and closing events have grown from years of practical lessons. Any signs of vented hydrochloric acid point to issues with drum liner integrity or warehouse temperature profiles. On our site, we adjust storage areas seasonally and deliver clear guidelines for third-party warehouses handling our materials.

    We hold product back from shipment at the first sign of instability, and our QC checks every outgoing lot for trace water and byproducts. Customers with long supply chains see value in this: less unpredictability, fewer rejected loads, more consistent process times.

    Cost and Sustainability: What Matters Most

    It’s easy to assume that any benzyl halide will fill the same role. That assumption tends to fall apart during continuous flow runs or when production lines push for hundred-kilo batches. Our plant routinely benchmarks resource inputs, energy consumption, and solvent load. Optimizing against waste discharge remains ongoing—not as a distant environmental goal, but as a direct byproduct of customer feedback and regulatory change.

    Moving from lab to pilot, and from pilot to full production, our team tracks not only direct costs but also indirect savings from lower impurity levels and higher reliability. Less off-spec material means less reprocessing, less solvent waste, and markedly lower emissions. Over the last five years, some users reduced waste by as much as 30% per campaign, utilizing our consistently pure feedstock rather than catching up later with complex remediation. Our internal push for solvent recycling and utility streamlining keeps boundaries tight between cost, quality, and compliance.

    Troubleshooting: Standing with Our Clients

    Inevitably, process hiccups arise, especially on scale-up. Over the years, field teams have encountered everything from overexposure to trace moisture—affecting yields through hydrolysis—to bulk shipments confronting unexpected inspection delays. Our approach means direct access to the chemists and engineers who run the reactors, not just to the back-office staff. Customers receive troubleshooting rooted in practice, not just in regulations or literature. Sometimes, a single call saves entire production weeks by connecting users to adjustments we devised on our own lines, whether in charging order, process cooling, or quench techniques.

    Once, an agricultural research operation reported a recurring drop in downstream conversion percentage. Our staff traced the problem to a minor but consistent impurity—detectable only by comparison to our in-process monitoring. After adjusting their reactor configuration, conversion improved, cycle times dropped, and the output matched spec on the next analytical review. We keep all such findings in our internal knowledge base, building up a record of what works—often far exceeding anything found in public reference databases.

    Regulatory Experience and Documentation

    Navigating the thicket of local and international regulations goes hand in hand with supplying specialty chemicals like 2-Chloro-6-Fluorobenzyl Chloride. Our documentation leads with precise batch history, controlled substance logs where necessary, and clear hazard panels that mirror our own on-site procedures. Clients in Europe, North America, and East Asia reference our supplied dossiers when preparing their own REACH, TSCA, or PIC compliance paperwork. We’ve learned that shortcuts at this step almost always result in costly or delayed cross-border shipments.

    Where labels differ, we extract the relevant hazard and transport guidelines, flagging issues unique to halogenated aromatics. Discrepancies in drum markings, secondary labeling, or tonnage reporting can halt projects or trigger audits. Over the past decade, we have formalized in-house audits to repeatedly calibrate paperwork and ensure it meets client requirements—tightening traceability and avoiding regulatory friction.

    Continuous Improvement and Industry Connections

    Our record of producing 2-Chloro-6-Fluorobenzyl Chloride rests on steady improvement and open channels with end-users. Plant managers and chemists meet regularly—sharing experience from successful campaigns and tough troubleshooting cases alike. The dialogue has shaped changes in everything from analytical standards to packaging upgrades, influencing the way we run distillation and purification lines.

    Some of our best insights have come straight from users scaling up new formulations or adapting to new safety guidelines. Early on, we adopted several changes in microfiltration and drum liner selection as direct responses to client testing feedback. Each improvement feeds forward into the next production cycle, reducing headaches for all and raising the bar for what users expect from a reliable chemical partner.

    Facing Challenges and Finding Solutions

    No chemical manufacturer avoids industry-wide challenges. With halogenated handling, the key risks involve personal safety, environmental compliance, and equipment corrosion. We run regular site audits for atmospheric leaks or vent stack residues. After expanding our drum recycling program, waste volumes dropped, and shipment rejections on environmental grounds fell dramatically. Regulatory pressure is real, so making updates swiftly translates to staying ahead, not just keeping up.

    Another persistent challenge hits in transportation. Temperature control, security, and clear documentation can make the difference between on-time delivery and a returned shipment. Years ago, delayed clearance on a summer batch prompted us to develop seasonally adjusted distribution pathways—saving costs on both sides and keeping materials ready when new syntheses begin. Our ability to reroute or warehouse on demand has grown from experience, not abstract planning.

    The Firm Difference

    What distinguishes our 2-Chloro-6-Fluorobenzyl Chloride hits close to home for our staff: repeatability, actionable documentation, and a willingness to confront supply chain hurdles as soon as they emerge. Instead of chasing impossible purity levels or hiding behind vague specifications, we focus on what end-users actually experience in the lab, the reactor, and the production warehouse. Our reputation grows out of process controls and the real stories shared between technical teams. With every barrel shipped, that collective experience becomes part of our product, and increasingly, the foundation of research and production in labs worldwide.

    Looking Forward: Commitment to Our Community

    Trust in 2-Chloro-6-Fluorobenzyl Chloride comes from more than a string of COA approvals or milestone projects. It comes from the daily discipline to address actual field and laboratory challenges, documenting mistakes, learning from them, and sharing those lessons with end-users. By staying rooted in what works, iterating improvements, and tackling complications as they happen, we have established a standard of quality and reliability you won’t find by sorting through bulk distributor lists.

    This feedback loop fuels both innovation and a sense of shared accomplishment. When partners introduce the material into pioneering agrochemical syntheses or breakthrough pharmaceutical research, their practical insights loop back to us—fueling the changes that define future manufacturing runs. Far from a static commodity, 2-Chloro-6-Fluorobenzyl Chloride serves as both a tool and a reflection of our commitment to the chemistry community: focused on process, integrity, and long-term partnership.