Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

2-Chloro-5-Methylbenzoic Acid

    • Product Name 2-Chloro-5-Methylbenzoic Acid
    • Alias 2-Chloro-m-toluic acid
    • Einecs 217-959-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    178699

    Chemical Name 2-Chloro-5-Methylbenzoic Acid
    Cas Number 3286-46-2
    Molecular Formula C8H7ClO2
    Molecular Weight 170.60
    Appearance White to off-white crystalline powder
    Melting Point 157-161°C
    Boiling Point 332.1°C at 760 mmHg
    Density 1.32 g/cm3
    Solubility Slightly soluble in water, soluble in organic solvents
    Smiles CC1=CC(=C(C=C1)Cl)C(=O)O

    As an accredited 2-Chloro-5-Methylbenzoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 grams of 2-Chloro-5-Methylbenzoic Acid, labeled with safety warnings and product identification details.
    Shipping 2-Chloro-5-Methylbenzoic Acid should be shipped in tightly sealed containers, clearly labeled, and protected from light and moisture. Comply with relevant regulations for chemical transport. Ship at ambient temperature unless otherwise specified, ensuring that containers are cushioned to prevent breakage and securely packaged to avoid leaks or spills during transit.
    Storage 2-Chloro-5-methylbenzoic acid should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and bases. Protect from moisture and direct sunlight. Proper labeling and secure shelving are essential. Store at room temperature and handle with appropriate personal protective equipment to avoid inhalation, ingestion, or skin contact.
    Application of 2-Chloro-5-Methylbenzoic Acid

    Applications of 2-Chloro-5-Methylbenzoic Acid in Industrial Manufacturing

    2-Chloro-5-Methylbenzoic Acid finds critical applications as a chemical intermediate in several specialized industrial sectors. As an original manufacturer, we serve downstream enterprises in fields requiring customized purity, strict regulatory compliance, and consistent lot traceability. Below we outline primary application scenarios, each with precise industrial context, process specifics, and regulatory benchmarks.

    1. Agrochemical Intermediate for Herbicide Synthesis

    Major agrochemical producers use 2-Chloro-5-Methylbenzoic Acid as a building block in the synthesis of selective herbicide actives, particularly within benzoic acid derivative families. The compound introduces specific chloro and methyl substitution patterns crucial for molecular activity during coupling and condensation steps. Its controlled purity ensures consistent conversion and compliance for markets with strict residue and registration requirements, especially in the EU, US, and Brazil. This material is mainly charged into the first-stage coupling reactor and must comply with both process and product-level standards to ensure downstream safety and regulatory adherence.

    Industry compliance standards

    • REACH Registration (EC 1907/2006)
    • US EPA Pesticide Regulation (40 CFR Parts 150–189)
    • China ICAMA Registration Requirements (NY/T 1977)
    • ISO 9001:2015 Quality Management Systems

    Typical usage ratio

    • 0.6–1.2 molar equivalents, depending on desired herbicidal backbone
    • Adjustment based on precursor alkyl/aryl co-reactant ratios and target impurity thresholds

    Downstream process integration

    • Direct charging to primary condensation reactors following substrate preparation
    • In-situ neutralization and acidification for subsequent chlorination steps
    • Integration with pilot-scale or commercial multi-step synthesis lines
    • Final stage filtration to capture pure intermediate prior to downstream formulating

    Final product types

    • Selective post-emergence herbicide actives
    • Benzoic acid-based weed control agents
    • Pesticide pre-mix concentrates
    • Technical grade agrochemical actives for global export

    2. Pharmaceutical Intermediate for API Synthesis

    2-Chloro-5-Methylbenzoic Acid is a key starting material in the multi-step production of select active pharmaceutical ingredients, especially non-steroidal anti-inflammatory drugs (NSAIDs) and antifungal agents that require a substituted aromatic precursor for efficacy and patentability. Manufacturers apply strict cGMP protocols during its use, ensuring compliance with international pharmacopoeias. The material typically enters the synthesis as a coupling substrate following purification, and its integration directly affects downstream yield and final product impurity profile.

    Industry compliance standards

    • Current Good Manufacturing Practice (21 CFR Part 210/211, US FDA)
    • European Pharmacopoeia (Ph. Eur. 11/EP 11)
    • ICH Q7 Guideline for API Production
    • US Pharmacopeia (USP/NF)

    Typical usage ratio

    • 0.8–1.1 mol per API synthesis pathway, optimized by lab-scale validation
    • Scaling adjustment based on step yield and impurity carryover

    Downstream process integration

    • Charged after initial aromatic nitration or halogenation process steps
    • Purified by crystallization prior to condensation or aminolysis reactions
    • Final QC sampling integrated into batch release
    • Used in multi-step reactions for final API formation and purification

    Final product types

    • Generic and branded NSAIDs
    • Aromatic antifungal drug intermediates
    • Final APIs for tablet, capsule, or injectable formulations
    • Contract-manufactured pharmaceutical ingredients

    3. Dye and Pigment Manufacturing

    The compound serves as a selective aromatic precursor for the synthesis of specialty azo and anthraquinone dyes, critical in textile and plastics coloration. Its substituted benzoic acid structure imparts key reactivity and color fastness, supporting formation of high-performance pigment molecules. Dye manufacturers demand precise isomeric control, and downstream reactors require reliable, impurity-controlled supply for batch-to-batch consistency and regulatory conformance in end-use markets.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (Textile Safety)
    • EN 71-3:2019 for toy and plastic safety
    • GOTS (Global Organic Textile Standard) chemical input criteria
    • ISO 9001-backed pigment QC protocols

    Typical usage ratio

    • 0.5–1.0 equivalent versus primary amine or diazonium co-reactant
    • Ratio further optimized by color strength and shade purity targets

    Downstream process integration

    • Added during pre-coupling diazotization reaction vessels
    • Reactor charging timed with pigment precursor feed
    • Intermediate purification via pH-controlled extraction and washing
    • In-line HPLC or GC monitoring for isomer and impurity profiling

    Final product types

    • High-purity reactive and disperse dyes
    • Anthraquinone pigment concentrates
    • Custom dye intermediates for textile and plastics sectors
    • Colorant dispersions for coatings and inks

    4. Polymer Additive Precursor

    Within advanced materials manufacturing, 2-Chloro-5-Methylbenzoic Acid is used as an initiator for specialty polymers, including benzoate-based plasticizers and certain high-performance epoxy or acrylate resins. Its controlled reactivity provides targeted modification of polymer backbone properties. End users such as resin compounders and plastic goods manufacturers need consistent material flow and impurity benchmarking for both process yield and final compliance with consumer product regulations across various jurisdictions.

    Industry compliance standards

    • EU Regulation (EC) No 10/2011 on plastic materials and articles for food contact
    • FDA 21 CFR 177 for indirect food additives
    • ISO 14001 Environmental Management for polymer processing
    • EN 13432 for compostable materials if used in biodegradable formulations

    Typical usage ratio

    • 0.2–0.7 wt% relative to polymer resin batch size
    • Dosage adapted by type of monomer and desired tensile/flexural properties

    Downstream process integration

    • Pre-blended with resin monomers prior to polymerization, either bulk or solution phase
    • Dosed into closed reactors under nitrogen or controlled atmosphere
    • Polymer property monitored via GPC and FTIR post-synthesis
    • Material traceability linked to finished batch certificate

    Final product types

    • High-performance epoxy and acrylate resins
    • Plasticizer-modified engineering plastics
    • Customized benzoate co-polymers for automotive and electronics
    • Food-contact safe polymer goods
    Free Quote

    Competitive 2-Chloro-5-Methylbenzoic Acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    Introducing 2-Chloro-5-Methylbenzoic Acid: Insights from the Manufacturing Floor

    Product Profile and Real-World Relevance

    Chemistry carries countless fine details that shape performance and safety in every batch and shipment. Over time, seeing the reactions in our reactors and the way raw materials behave, we develop a close understanding of every intermediate and final product. 2-Chloro-5-Methylbenzoic Acid, which many call simply CMBA in day-to-day operations, holds particular value in the lineup of benzoic acid derivatives. In our experience, genuine purity and consistent performance grow from thoughtful attention at each production stage—from charge set-up to crystallization, filtration, and final drying.

    Molecular Details and Quality Markers

    On the chemical side, this compound carries the formula C8H7ClO2 and positions its methyl and chlorine groups in a way that gives it unique reactivity. The specific substitution pattern, with chloride at the 2-position and methyl at the 5-position of the aromatic ring, influences both its solubility and how it interacts with other reagents. Most technical buyers notice these effects especially in reactions such as amidation or when the molecule acts as a building block in pharmaceuticals and agrochemicals.

    We focus on maintaining a real, practical purity standard. Our typical batches reach a GC purity above 99%. This level doesn't come from just analytical checks at the end—it comes from persistent care in raw material selection, process temperature control, slow addition for chlorination, and measured crystallization rates. Slight deviations in these steps turn up as off-color product or more challenging separation later, so our teams check them batch by batch.

    Where It Performs Best—Applications and Rationale

    From direct customer feedback, we've seen that 2-Chloro-5-Methylbenzoic Acid handles the load in applications seeking intermediate molecules for active pharmaceutical ingredients, dyes, and specialized polymers. Its benzoic acid backbone makes it amenable to halogenation, amination, and further substitutions, but the true difference shows up in yield, ease of purification down the line, and environmental impact of byproducts. For example, in one pharmaceutical syntheses route, the clean conversion of CMBA to amides or esters keeps the downstream process clean—customers appreciate this fundamental change, as it helps minimize waste and troubleshooting.

    Our packaging choices come out of years of seeing what actually reaches users intact. Moisture uptake or micro-contamination costs more time and money later, so in our shops we standardize on high-integrity containers with low permeability and seal every lot with a measured nitrogen blanket. These steps aren't visible on a specification sheet, but they prevent off-odors and loss of free-flowing character.

    Comparisons in Context—Why CMBA Differs from Other Benzoic Acids

    Every aromatic acid brings its own suite of reactivity and byproduct profile. Customers often ask us how 2-Chloro-5-Methylbenzoic Acid fares against other isomers or simple benzoic acids. From hands-on experience, the placement of the chlorine in the 2-position vs. alternative positions (such as 3- or 4-chloro-5-methylbenzoic acids) shifts product polarity and rates in nucleophilic aromatic substitution. For makers of dyes or advanced intermediates, this difference translates to either smoother, faster reactions or frustrating bottlenecks. The methyl group, located at the 5-position, further fine-tunes solubility in organics and moderates the acid strength.

    Compounds with the chlorine at different positions show different patterns in coupling steps. For instance, an adjacent chlorine makes certain couplings either more selective or suppresses side products, something that matters in pilot plant runs where margin for error narrows. In real production, these nuances avoid costly adjustments during scale-up.

    How Practical Know-How Informs Our Approach

    Manufacturing isn't just chemistry on paper. Maintenance of stable product lot-to-lot comes from specialized filtration and washing protocols. Two CMBA batches can claim the same nominal purity, but without careful wash stages, trace solvent or inorganic residues hang on and reappear as haze or precipitate during later use. The market sometimes rewards shortcuts with short-term price pressures, but we've learned that residual impurities turn up as headaches for customers, and they become the manufacturer's responsibility in the long run.

    In our shop, we go deeper than just passing HPLC or GC thresholds. We regularly test for trace metals, residual halides, and moisture content—implemented because past customers pinpointed problems in downstream hydrogenation or catalytic steps caused by trace contaminants. This habit of close follow-up shapes more robust processes, and it builds trust. We often work directly with technical teams at client sites, troubleshooting not as vendors but as joint problem-solvers. Over time, these conversations bring out hidden requirements that aren't listed in public literature, such as preferred particle size ranges, avoidance of certain micro-impurities, or batch-specific certificates of analysis.

    Safety, Handling, and Worker Experience

    Our manufacturing teams operate under strict controlled conditions. CMBA emits a characteristic sharp odor, especially during bulk handling and drying, which calls for reliable fume management and PPE. The crystalline solid nature of the material means dust control and avoidance of cross-contamination stays high on our agenda. Keeping product dry and unexposed ensures clean shipments and consistent reactivity; moisture or caking leads to unpredictable behavior in customer labs or plants, undermining the intended reaction profiles. We developed handling protocols that keep both workers and product in good shape: proper dust extraction, real-time particulate monitoring, and scheduled filter change-outs.

    Safety reviews draw from incidents and lessons over years, not just textbook rules. We keep track of minor leaks, cleaning challenges, and transport mishaps, constantly refining our workflow. Strong relationships with long-haul logistics partners lower transit losses—these connections mean more than any isolated technical guarantee.

    Developments in Sustainability

    Today’s buyers increasingly ask for details about the environmental impact of each kilogram produced. As manufacturers, we look upstream at supply chain transparency—our chlorination processes draw scrutiny not just for yield or purity but for emissions, effluent load, and ultimately, total carbon footprint. Our plant infrastructure integrates dedicated scrubbers for hydrogen chloride and other volatile byproducts, and we reclaim and neutralize these emissions in compliance with both local and international regulations. These efforts matter well before public attention shifted toward “greener chemistry” topics—we began data logging and reporting out of practical necessity, since local inspectors and community neighbors keep us honest.

    Process optimization plays a big role. Over the years, we found that catalyst selection and solvent recovery can cut both raw material costs and greenhouse gas impact. Solvent streams are recovered and re-used wherever feasible, since solvent purchase, handling, and disposal make up a major part of both cost and environmental footprint. Where customers need especially pure, solvent-free product, we apply additional drying steps, even if it trades off some process economy. Decisions like this aren't always easy, but we weigh them with customer priorities and our own integrity.

    Customer Collaboration and Process Adjustments

    Each CMBA buyer brings different goals: one might focus on minimizing colored impurities for use in pigment manufacture, while another prizes maximum purity for API synthetics. Over years, we've seen that open discussion about end-use allows us to suggest batch tweaks or extra purification—not just for extra margin, but to genuinely support customer need. Some partners need smaller lots with tighter specs, others need industrial-scale bulk deliveries timed to coordinated production campaigns. We accommodate these with flexibility in batch size, packaging, and documentation, creating longstanding relationships built on feedback rather than promises.

    A real lesson comes from repeated customer site visits. Walking through their production floors, we spot distinct needs: requests for low trace sodium, stable particle size for automated feeders, batch homogeneity for in-line quality control. These inform modifications to our filtration setups, dryer temperature profiles, or packaging lines. As the end-user comes forward with new challenges, we treat them not as one-off complaints but as valuable data for our own continuous improvement.

    Product Traceability and Batch Recording

    Traceability gives buyers comfort, but it also safeguards our process against drift. We maintain comprehensive batch records—from incoming raw material identity and grade, through each stage of production, to final analytical metrics. These documents serve more than compliance: if any deviation occurs, we can review parameters and pinpoint root causes. Checking batch logs for patterns (temperature fluctuation, operator shift, or minor process alarms) allows us to preempt performance issues and uphold consistent product output.

    Regular audits, both internal and by third-party assessors requested by major clients, drive us to keep records current and transparent. Shared digital platforms enable quick access to historical data and offer reassurance to both our teams and the customer’s QA sections. Transparency about such processes reassures buyers who stake their own production on our product reliability.

    Future Directions and Innovation in Production

    Market pressures urge all chemical producers to innovate, whether with more efficient syntheses, less hazardous reagents, or tailored specifications. We invest in R&D to revisit catalyst systems or seek alternative, less toxic chlorinating agents. Where possible, we test continuous rather than batch processes, aiming to lower per-ton costs and improve reproducibility. Some experiments do not pan out on commercial scale; we learn as much from failures as successes. Direct dialogue with formulation chemists, process engineers, and QC leads at user sites informs real priorities and helps us prioritize projects that genuinely move the industry forward instead of chasing trends.

    We work closely with regulatory experts to keep ahead of evolving requirements around hazardous substances, labeling, and export or import. This means investing upfront in both documentation systems and targeted plant upgrades, minimizing surprises when laws shift or inspectors appear unannounced.

    Summary of Real-World Value

    2-Chloro-5-Methylbenzoic Acid means more to us than a catalog entry; it embodies years of manufacturing learning and ongoing adaptation. Its distinct chemical structure delivers both selectivity and flexibility for end-users in pharmaceuticals, dyes, and specialty materials. Subtle differences in structure play out in visible ways for customer efficiency, quality, and process simplicity.

    Manufacturing brings familiarity with the product’s strengths and weaknesses, and with the ways it impacts safety, sustainability, and client workflows. Through careful attention at every step—starting with raw materials and extending all the way through packaging and shipping—we support partners worldwide with a product that stands up under scrutiny and repeat use.

    Long-term trust comes not from claims or glossy data but consistency, open communication, and genuine responsiveness. These principles guide our approach to every kilogram of CMBA shipped. Our door stays open for technical consultation, batch customization, and shared troubleshooting—because chemistry, at its best, is a partnership built on practical know-how and shared success.