Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
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2-Chloro-4-Phenylphenol

    • Product Name 2-Chloro-4-Phenylphenol
    • Alias 4-Phenyl-2-chlorophenol
    • Einecs 210-956-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    977789

    Chemical Name 2-Chloro-4-Phenylphenol
    Cas Number 2828-21-1
    Molecular Formula C12H9ClO
    Molecular Weight 204.65 g/mol
    Appearance White to off-white solid
    Melting Point 100-103°C
    Solubility In Water Slightly soluble
    Density 1.24 g/cm³
    Purity Typically >98%
    Synonyms 2-Chloro-4-phenyl-1-hydroxybenzene
    Smiles C1=CC=C(C=C1)C2=CC(=C(C=C2)Cl)O
    Inchi Key VQQWLJNKQUJILB-UHFFFAOYSA-N

    As an accredited 2-Chloro-4-Phenylphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A sealed 100g amber glass bottle labeled "2-Chloro-4-Phenylphenol," featuring hazard warnings, product code, batch number, and manufacturer details.
    Shipping 2-Chloro-4-Phenylphenol is shipped in tightly sealed containers, protected from moisture and light. It is classified as a hazardous chemical; transport complies with international regulations (such as IATA and IMDG). Proper labeling, documentation, and personal protective equipment are required to ensure safe handling during transit. Store in a cool, dry place upon arrival.
    Storage 2-Chloro-4-phenylphenol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from incompatible substances like strong oxidizers. Protect from moisture, heat, and direct sunlight. Store in a chemical storage cabinet suitable for organics or hazardous chemicals, clearly labeled, and out of reach of unauthorized personnel. Follow all applicable regulations and safety protocols.
    Application of 2-Chloro-4-Phenylphenol

    Applications of 2-Chloro-4-Phenylphenol in Industrial Manufacturing

    2-Chloro-4-Phenylphenol is a specialty chemical serving as a key intermediate and functional additive across multiple regulated manufacturing sectors. Our facility maintains dedicated quality control protocols to support downstream partners in producing compliant, high-performance products in targeted application fields.

    1. Pharmaceutical Intermediate Synthesis

    Pharmaceutical manufacturers frequently use 2-Chloro-4-Phenylphenol as an essential synthetic building block in the preparation of active pharmaceutical ingredients (APIs), particularly for aromatic phenol derivatives. Its role includes serving as a coupling component and as a precursor for certain bactericidal API molecules. The material’s purity and traceability support process validation, batch release, and regulatory filings for final drug products. Typical end uses concentrate on non-sterile oral and topical formulations where regulated phenolic compounds are permitted.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • USP-NF Monograph guidance for raw material qualification
    • EDQM CEP submission documentation for synthetic intermediates
    • Pharmacopoeial compliance for input chemicals per country (e.g., USP, EP, JP)

    Typical usage ratio

    • 2%–15% relative to the total input for designated synthetic reaction stages; adjusted by route-specific stoichiometry and desired yield.

    Downstream process integration

    • Introduced during multi-step aromatic coupling, particularly after halogen exchange or Friedel–Crafts acylation steps.
    • Reacted under controlled temperature and inert atmosphere to form the targeted API precursor.

    Final product types

    • Bacteriostatic agents in oral tablets and topical creams
    • Intermediates for antifungal active ingredients
    • API molecules with phenylphenol backbone structure

    2. Industrial Biocide Manufacturing

    2-Chloro-4-Phenylphenol functions as a primary or co-active component in the production of industrial biocidal formulations. It imparts antimicrobial properties to disinfectant concentrates, wood preservatives, and metalworking fluid additives. Major customers operate with stringent documentation and batch certification to fulfill regulatory notification or registration processes for finished biocidal products in Europe and North America.

    Industry compliance standards

    • EU Biocidal Products Regulation (BPR, Regulation (EU) No 528/2012)
    • US EPA Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) compliance
    • OECD Good Laboratory Practice for product registration
    • REACH registration dossier support for supplied substances

    Typical usage ratio

    • Active content between 0.5%–5% in end-use formulations; adjusted depending on target microbe spectrum and synergy with co-biocides.

    Downstream process integration

    • Incorporated prior to batch blending alongside surfactants and stabilizers.
    • Dosed under closed-system mixing to ensure controlled exposure and minimize vapor release.

    Final product types

    • Surface and industrial disinfectant liquids
    • Dry-film preservatives for coatings
    • Metalworking fluid microbicide concentrates
    • Wood anti-rot and anti-mold treatments

    3. Specialty Polymers and Resin Additive Formulation

    Manufacturers of engineered polymers and resins employ 2-Chloro-4-Phenylphenol to provide antimicrobial protection and enhanced chemical stability in finished materials. The additive supports the production of specialty plastics and composite resins destined for technical applications where resistance to microbial growth and oxidation is critical, such as in building materials, automotive interiors, and sealants.

    Industry compliance standards

    • ISO 10993-18 for chemical characterization in plastics for medical and automotive sectors
    • ISO 846: Test of plastics – Evaluation of the action of microorganisms
    • ASTM D2566 (Fungal Resistance of Panel Products)

    Typical usage ratio

    • 0.1%–1.2% by polymer mass, tailored by processing temperature and expected service life of the end product.

    Downstream process integration

    • Added during bulk blending before extrusion or molding process steps.
    • Homogenized with polymers and other functional additives to achieve consistent distribution.

    Final product types

    • Antimicrobial floor and wall panels
    • Plastisol-impregnated textiles
    • Sealant and caulk formulations
    • Functionalized automotive trim components

    4. Dye and Pigment Intermediate Chemistry

    The compound serves a targeted role as a specialty intermediate in the synthesis of select azo and anthraquinone dyes. It provides stable phenolic functionality and supports controlled coupling reactions that produce pigments and colorants for industrial coatings, printing inks, and plastics coloring. Downstream manufacturers benefit from precise chromophore tuning enabled by the defined aromatic substitution pattern of the raw material.

    Industry compliance standards

    • EU REACH requirements for supplied dye intermediates
    • ETAD (Ecological and Toxicological Association of Dyes and Organic Pigments Manufacturers) guidelines
    • ISO 9001:2015 for pigment plant quality management

    Typical usage ratio

    • 1%–20% depending on the target shade strength and batch size; lower rates for light color shades, higher for deep tone pigments.

    Downstream process integration

    • Added during the diazotization or coupling stage of colorant synthesis.
    • Undergoes pH-controlled reactions to produce target dye molecules.

    Final product types

    • Synthetic pigments for industrial coatings
    • High-stability printing inks
    • Color masterbatches for plastics processing

    5. Fine Chemical and Agrochemical Synthesis

    Producers of certain agrochemical actives and specialty fine chemicals incorporate 2-Chloro-4-Phenylphenol in multi-step syntheses, often as an aromatic halide source for modular coupling strategies. The molecule’s substituent pattern facilitates formation of structure-specific herbicide and fungicide precursors, with strong attention to lot purity and contaminant control throughout the finished product lifecycle.

    Industry compliance standards

    • FAO/WHO Specification for pesticide technical materials and formulations
    • ISO 17025-accredited laboratory analysis for purity and trace contaminants
    • OECD guidelines for the testing of chemicals and pesticide registration dossiers

    Typical usage ratio

    • 0.5%–8% in the controlled steps; exact charge number defined by the target reaction yield and molecular design parameters.

    Downstream process integration

    • Enter synthesis at nucleophilic substitution or aromatic functionalization stages.
    • Processed under controlled temperature and continuous agitation for reaction consistency.

    Final product types

    • Fungicide key intermediates
    • Precursor compounds for selective herbicides
    • Fine chemical intermediates for specialty industrial use
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    Certification & Compliance
    More Introduction

    Understanding 2-Chloro-4-Phenylphenol: Practical Insights from the Manufacturer’s Floor

    Real-World Introduction to 2-Chloro-4-Phenylphenol

    Every day, we oversee large batches of products that begin as simple chemical concepts and end up as practical compounds powering numerous industries. Among these, 2-Chloro-4-Phenylphenol stands out in our catalog for specific advantages rooted in both its molecular structure and proven, consistent behavior as an intermediate and preservative. Over the years, after thousands of quality control checks and real-world application feedback, we’ve learned to trust this compound for what it offers—stability, reliable purity, and solid performance in demanding situations.

    Product Model and Specifications Born from Continuous Process Refinement

    We manufacture 2-Chloro-4-Phenylphenol using processes honed by decades on the production line and in the lab. Each batch comes out with physical and chemical characteristics we confirm not just theoretically, but by repeated in-house pilot runs and scale-ups. The product has a white to off-white crystalline appearance, usually shipped in leak-proof, opaque containers to maintain integrity from factory floor to end user. Melting point stability and low trace impurity levels remain central to our standard here, and we monitor these aspects with calibrated analytical tools before each lot leaves our facility.

    Through standardized protocols, we limit moisture, control particle size, and ensure solubility requirements for various user needs. Looking at it through a microscope or running HPLC tests, operators expect nothing less than consistency. If we observe even a minor drift outside our internal targets—on purity, chlorination degree, or homogeneity—it shows up and gets fixed before the bulk ever ships outside our gates. This hands-on approach may sound trivial, but in our business, this constant practical vigilance shapes end-user trust and business partnerships.

    Usage: Where Technical Experience Drives Application Wisdom

    Talk to any experienced technician in our plant, and they’ll confirm: 2-Chloro-4-Phenylphenol pulls its weight as an intermediate for both specialty and bulk applications. Several customers—especially those in the pharmaceutical and agrochemical circles—lean on this compound as a base for synthesizing active components, where minor impurities can cause downstream headaches. In-house, we’ve run it through extended stress testing under various conditions: temperature swings, humidity spikes, and exposure to air and light. We’ve seen that the compound resists degradation, develops none of the fouling or instability that other, less refined substitutes often do.

    We keep records spanning years, detailing how it holds up during formulation and storage. Our technical teams work side by side with R&D groups from buyer companies, sharing findings on interaction with other reactants and the compound’s compatibility with various solvents, surfactants, and stabilizers. Clients using it in disinfectant formulations appreciate reduced risk of off-odor development and batch-to-batch reactivity. For pesticide formulations, our direct monitoring of residue levels and environmental breakdown products makes the compound a consistently attractive choice.

    In paints and coatings, 2-Chloro-4-Phenylphenol answers the call for both microbial resistance and color stability. We’ve worked with industry partners to adjust our drying and storage techniques, ensuring minimal discoloration and optimal dispersibility, because even a minor deviation can lead to costly rework on user lines. This commitment—tuning process parameters based on accumulated batch history rather than relying solely on reference texts—sets our product apart for users concerned with both yield and safety.

    Direct Comparison: 2-Chloro-4-Phenylphenol Versus Other Compounds

    Direct experience over thousands of production hours has shown us where this compound punches above its weight compared to other phenolic and chlorinated phenolic derivatives. For one, its substitution pattern means we see fewer issues with instability or excessive volatility during processing. In contrast with simple monochlorophenols, which can sometimes release problematic odors or degrade on storage, our 2-Chloro-4-Phenylphenol holds up well under repeated heating and cooling cycles. It resists yellowing—a feature valued not just by coating and formulation teams, but also by warehouse logistics crews tired of product loss from spoilage.

    Many first-timers ask us about reaction selectivity. Through our own benchwork and lab-scale model studies, we’ve confirmed that 2-Chloro-4-Phenylphenol delivers good yields in electrophilic substitution and coupling reactions, especially where fine-tuned control is critical. Compounds with fewer ring substitutions sometimes invite side reactions, causing unpredictable impurity profiles—in our experience, this leads to downstream purification headaches and larger solvent use. We structure our synthetic steps and conditions specifically to capitalize on the inherent selectivity and cleanliness this molecule offers, cutting both costs and secondary waste.

    Health and safety play a crucial role on our lines. Based on exhaustive in-house monitoring and safety surveys, 2-Chloro-4-Phenylphenol gives us straightforward containment and ventilation challenges, unlike more volatile or highly substituted phenolic analogues. During spills or process upsets, our teams don’t face runaway vapor hazards common with certain chloro derivatives. This reduces PPE requirements and lets us run longer, steadier production shifts—benefits that translate straight to uninterrupted customer supply.

    Manufacturing Lessons From the Shop Floor

    Our chemical engineers learn to respect both the theoretical and practical sides of handling 2-Chloro-4-Phenylphenol. Not every batch is perfect right from the first synthesis, and our troubleshooting days stick out in company memory. For instance, in the early stages of introducing more automated reactor controls, we observed temperature hotspots that impacted local purity. Rather than waiting for customers to complain, in-house feedback loops identified the cause—and we refined our cooling protocols and crystallizer feed rates accordingly.

    We emphasize upstream raw material checks, with real people logging and sampling each drum. Every operator knows the stakes; an impurity in the monochlorobenzene source, for example, can echo through every subsequent run, altering trace impurity footprints for the entire lot. Part of why our 2-Chloro-4-Phenylphenol stands out is the diligence with which we screen and document each input—work that pays off when downstream application teams thank us for fractional deviations from spec, not multi-point failures or recall headaches.

    Production teams log weather, humidity, and batch trends daily. In years of operation, we’ve found that minor process tweaks in filtration, washing, and drying step prevent the usual caking or loss of clarity seen with less disciplined operators. These small adaptations—borne of repeated crisis management—lower waste and keep the product flow smooth, even when external conditions turn rough.

    Supporting Customer R&D, Not Just Bulk Orders

    Our job doesn’t end with packaging and shipping. Laboratories worldwide have approached us with new application concepts: developing next-generation biocides, tuning UV-stable coatings, improving preservation in sensitive resin stocks. Our experience on the plant floor has taught us to engage these projects early, providing direct samples and supporting documentation rather than sending customers on wild goose chases across spec sheets.

    We believe in transparent, sometimes tough, conversations. If someone suggests a novel use, our technical service teams walk through historical data and process quirks. We’ve helped scale-up partners avoid pitfalls—such as unwanted discoloration or mismatched solubility—that stem from well-meaning but unrealistic assumptions. Our own R&D teams collaborate with external partners, checking both desktop theory and plant-scale reality. Where we spot a potential mismatch—like a planned solvent system that won’t dissolve or stabilize 2-Chloro-4-Phenylphenol at the required level—we provide real batch data and run test blends on our own time and dime.

    In our view, this blend of direct support and joint problem-solving produces not just better technical outcomes, but stronger business relationships. Client R&D wins translate back to us as product optimization goals and new variant requests. We keep track of each inquiry, using lessons learned to adjust not just specs but shipping and storage protocols for the next season of orders.

    Quality Assurance: A Systemic Approach Rooted in Continuous Feedback

    Consistency counts in chemical manufacturing, both for regulatory compliance and basic customer trust. We monitor every stage of 2-Chloro-4-Phenylphenol production, using real feedback loops: process operators, maintenance teams, external auditors, and analytic chemists all chime in. Each fills out incident logs, quality tracking forms, and deviation reports—not because a checklist says so, but because surprises have cost us time and money before.

    Our QA team runs crosschecks using both routine chromatographic analysis and spot pull samples from bulk containers earmarked for shipping. If a lot falls outside our historical records—on purity, residual solvent, or even physical flow characteristics—the investigation starts internally, with someone who handled the batch directly. The same staff who check melting points and infrared spectra stand ready to troubleshoot packing or transport issues. We see fewer cross-batch contaminations and fewer downstream complaints precisely because this feedback loop holds everyone mutually accountable.

    Quality assurance at our facility means correcting small drifts before they turn into big problems—and every improvement we implement started as a practical suggestion from a technician or a QC operator who caught something amiss. This culture of pride and vigilance has carried us through both high and low market cycles.

    Environmental and Regulatory Stewardship—Beyond Checkboxes

    Production is never just about what comes out of the reactors. We invest just as much in handling emissions, waste, and packaging requirements for 2-Chloro-4-Phenylphenol as we do in the compound itself. Our wastewater and off-gas treatment operations run daily, not only to meet local laws but because field experience proves that tighter operations mean fewer surprise inspections, less equipment corrosion, and more predictable costs.

    Customers often ask about compliance. Over the years, we’ve walked regulatory auditors through each aspect of our operation and shared real production data during approval cycles. Our certificates and registration forms come from actual scale runs, not pre-production promises. Internal audits keep us honest and ready for tough questions—on storage conditions, personnel training, and residual waste management. Through this rigorous work, we continue to build a record that benefits everyone in the supply chain, from the receiving dock to the end user.

    Our team openly discusses improvements—in batch release protocols, spill management, labeling accuracy, and secondary containment—drawing lessons not just from textbooks but from close calls and after-action reports. By setting internal standards above formal requirements, we protect our people, safeguard the environment, and minimize unscheduled plant downtime.

    Customer Impact: Lessons from Working Alongside End Users

    Most of what we know about 2-Chloro-4-Phenylphenol’s value comes from decades listening to people who use our product in the field. Our large-scale industrial buyers value predictability—fewer shipment holds, cleaner end products, and reliable reactivity profiles. Small specialty labs prize flexibility, depending on our team to adjust packaging, purity, or documentation as projects evolve. The feedback goes both ways; sales and technical managers meet regularly with operations staff to swap notes on returned product, new application pain points, or shifting standards in end-user regions.

    Through this ongoing engagement, we have reduced quality complaints, eliminated packaging slipups, and fine-tuned everything from drum closures to hazard labeling. Our drivers and logistics partners listen as well—handling storage advice, last-mile delivery questions, and requests for specialty pallets. These lessons cycle back; the next batch ships out with changed seals, improved labeling, or tighter moisture controls, all because someone spoke up or a seemingly minor issue was investigated seriously.

    Any chemical supplier can tout broad capabilities, but we see the difference in what changes based on the voice of those actually handling, blending, and repackaging our product. For us, making 2-Chloro-4-Phenylphenol means constant evolution, not empty adherence to a technical form.

    Challenges and Shared Solutions: Navigating the Real World

    No day in chemical production goes exactly as planned. The weather, incoming raw material profiles, and supply chain disruptions all change what we face as a manufacturer. There have been times—raw material shortages, transport strikes, international regulation shifts—when we spent long hours reworking production plans, keeping buyers updated in real time, and even sending technical staff out to customer sites to help adapt processes. Each challenge has reinforced the need for transparent dialogue with everyone downstream and a willingness to troubleshoot side by side.

    Several times each year, a batch may encounter an unexpected analytical blip or a packaging shift driven by regulatory updates or customer requests. We turn to our records, real-time feedback, and years of plant-level experience to steer solutions. Sometimes, this looks like recalibrating an analytical method, triple-checking loading procedures, or pulling product from shelves for supplementary testing. The cultural focus on flexibility—rather than rigid process adherence—has made our team adept at solving problems before they grow.

    We keep lines of communication open with both local and international regulatory advisors, staying ahead of import/export requirements and making sure our material doesn’t face avoidable clearance issues for our customers. This approach, driven by joint problem-solving and actual data, helps prevent supply shocks and instills long-term buyer confidence.

    The Manufacturer’s Perspective: Trust Earned Batch by Batch

    Years of direct work with 2-Chloro-4-Phenylphenol have shown us that long-term product value depends not just on molecule or process, but on the thousands of decisions made daily at each step—raw material arrival, in-process adjustment, real-time customer dialogue, and post-shipment follow-up. Our focus remains on stability, practicality, and honest communication, both inside our operation and outward to those relying on the product day in, day out.

    By combining technical rigor with continuous hands-on adaptation, our facility aims to set a clear standard for how specialty chemical manufacturing supports the industries around it. For us, 2-Chloro-4-Phenylphenol is less a nondescript commodity and more a reflection of operational learning, shared challenges, and real partnership with the people who transform it into solutions in the wider world.