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2-Chloro-4'-Fluorobenzophenone

    • Product Name 2-Chloro-4'-Fluorobenzophenone
    • Alias 2-Chloro-4'-fluoro-4-benzoylchlorobenzene
    • Einecs 219-489-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    519365

    Chemical Name 2-Chloro-4'-Fluorobenzophenone
    Cas Number 180897-40-1
    Molecular Formula C13H8ClFO
    Molecular Weight 234.65
    Appearance White to off-white solid
    Melting Point 69-72°C
    Purity Typically ≥98%
    Solubility Insoluble in water, soluble in organic solvents
    Smiles O=C(c1ccc(F)cc1)c2ccccc2Cl
    Inchi InChI=1S/C13H8ClFO/c14-11-4-2-1-3-10(11)13(16)9-5-7-12(15)8-6-9
    Synonyms 2-Chloro-4-fluorobenzophenone
    Storage Conditions Store at room temperature, in a dry place

    As an accredited 2-Chloro-4'-Fluorobenzophenone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 2-Chloro-4'-Fluorobenzophenone is supplied in a 25g amber glass bottle with a tightly sealed screw cap and hazard labeling.
    Shipping 2-Chloro-4'-Fluorobenzophenone is shipped in tightly sealed containers, protected from moisture and direct sunlight. It is handled as a chemical reagent, with labeling compliant with hazardous material regulations. Packaging is designed to prevent leaks or spills during transit, ensuring safe delivery to laboratories or industrial facilities.
    Storage 2-Chloro-4'-Fluorobenzophenone should be stored in a tightly sealed container, kept in a cool, dry, and well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizers. Limit exposure to moisture and direct sunlight. Ensure proper labeling and restrict access to trained personnel. Personal protective equipment (PPE) is recommended when handling the chemical.
    Application of 2-Chloro-4'-Fluorobenzophenone

    Applications of 2-Chloro-4'-Fluorobenzophenone in Industrial Manufacturing

    2-Chloro-4'-Fluorobenzophenone plays a crucial role as a key intermediate in several highly specialized manufacturing processes. We supply this product directly to industrial partners who require consistent quality and controlled specifications to meet stringent downstream requirements. Below, we outline the principal application scenarios where our material is integrated into value-added solutions with a proven industrial track record.

    1. Pharmaceutical Intermediate in Antipsychotic APIs

    This compound serves as an essential building block in the synthesis of select atypical antipsychotic active pharmaceutical ingredients, such as fluoroquinolone derivatives. Its chlorofluorinated benzophenone structure directly supports targeted halogen substitutions required by current generation synthesis protocols. Pharmaceutical producers rely on our material's batch consistency to align with stricter impurity thresholds and validation protocols under regulated environments.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP, EP, JP Monograph Purity Guidelines (where applicable in target APIs)
    • US FDA 21 CFR Parts 210/211 (for cGMP small molecule manufacturing)
    • EU Drug Precursor Regulations (if listed in controlled precursor lists)

    Typical usage ratio

    • 10–18% by mole as the primary halogenated benzophenone precursor in the core API coupling step; optimized via molar excess depending on reaction yield targets and route selection

    Downstream process integration

    • Introduced via direct aryl ketone condensation or Grignard reaction at the initial stage of API scaffold construction, followed by halogen exchange, cyclization, or further functional group modifications within cGMP cleanroom suites

    Final product types

    • Bulk active pharmaceutical ingredients—primarily for oral or injectable finished dosage forms treating CNS disorders
    • Custom contract-manufactured drug substances for regulated markets

    2. UV-Absorber Intermediate for High-Performance Polymer Additives

    Our material finds established use in the production of UV-stabilizer additives for engineering plastics. Downstream manufacturers utilize it to produce specialized benzophenone-based UV-absorbers, which are essential for maintaining polymer stability under prolonged sunlight exposure in outdoor applications, automotive components, and construction materials. The combination of chloro and fluoro substituents enhances both absorption range and thermal stability.

    Industry compliance standards

    • REACH Regulation EC No. 1907/2006 (Annex XVII entries on chemical safety)
    • RoHS 2011/65/EU (Restriction of Hazardous Substances in electrical and electronic equipment)
    • ASTM D5208 (UV stability testing in plastics)
    • ISO 4892 (Plastics: Methods of exposure to laboratory light sources)

    Typical usage ratio

    • 9–15% by mass relative to the target UV-absorber batch composition, with adjustments up to 20% for high-shear or masterbatch production routes

    Downstream process integration

    • Incorporated during synthesis of benzophenone UV-absorber molecules prior to blending with polymer resins (polycarbonate, ABS, PET); post-reaction filtration ensures removal of unreacted intermediates before extrusion or compounding

    Final product types

    • Finished UV-stabilizer additives (powder/granules) for plastics and coatings
    • Masterbatch concentrates for injection molding, blow molding, and film extrusion

    3. Agrochemical Synthesis for Selective Herbicide Formulations

    This material functions as a critical intermediate in the production of advanced halogenated benzoyl urea herbicides. Agrochemical manufacturers integrate it to achieve distinct electronic effects required for active ingredient profiles, impacting both soil persistence and leaf cuticle penetration. Maintaining high chemical purity is essential to avoid adverse effects on phytotoxicity and application consistency in field environments.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • EPA 40 CFR Part 180—Tolerances and exemptions for pesticide chemical residues
    • ISO 9001:2015 (Quality management systems for agrochemical manufacturing)
    • OECD Guidelines for the Testing of Chemicals (Environmental impact studies)

    Typical usage ratio

    • 8–12% by mole in initial benzoylation step of herbicide active synthesis, modified according to the scale and selected final compound

    Downstream process integration

    • Engaged at the early condensation or acylation phase, typically followed by alkylation and coupling to generate the active benzoyl urea structure, before downstream formulation into water-dispersible granules or emulsifiable concentrates

    Final product types

    • Technical grade active ingredient concentrates
    • Ready-to-use herbicide formulations for row crop, orchard, and turf protection

    4. Intermediate for Specialty Organic Pigment Synthesis

    Colorant manufacturers employ this compound in the tailored production of high-performance yellow and orange pigments for plastics, inks, and coatings. Its substitution pattern facilitates site-specific condensations, impacting both chromophore extension and lightfastness. The strict control of trace impurities ensures compatibility with food packaging and toy compliance standards where migration and extractables must remain within narrow limits.

    Industry compliance standards

    • EN 71-3:2019 (Safety of toys: migration of certain elements)
    • FDA 21 CFR 178.3297 (Colorants for polymers in food contact applications)
    • ISO 8124-3 (Safety of toys: migration of certain elements—colorants)
    • GMP Regulation (EU) No 2023/2006 for food-contact pigment production

    Typical usage ratio

    • 5–10% by mole in the primary precursor stage, with further tuning to balance color intensity and dispersibility based on intended resin base

    Downstream process integration

    • Reacted in controlled batch reactors as the core aromatic starting unit, prior to final pigment molecule assembly through azo or condensation chemistry; pigment cakes then processed into dispersible granules or pastes

    Final product types

    • Color masterbatch for polymer compounding
    • Organic pigment dispersions for coatings, inks, compliant packaging, and children’s toys
    Free Quote

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    Certification & Compliance
    More Introduction

    Introducing 2-Chloro-4'-Fluorobenzophenone: Straight from the Production Floor

    Direct Insights from Years of Manufacturing Experience

    Every kilogram of 2-Chloro-4'-Fluorobenzophenone that leaves our plant represents more than a line on a production schedule—it carries the embedded precision, consistency, and real-world scrutiny that only an experienced chemical manufacturer can offer. Our process control doesn’t just aim for ticking boxes; it seeks to make practical downstream work more predictable for those who count on this benzophenone derivative.

    Our Perspective on Model and Specifications

    We produce 2-Chloro-4'-Fluorobenzophenone using a tightly managed batch synthesis. Quality monitoring kicks off with raw material selection and tracks through every step, until we're loading, storing, or preparing shipment. This product comes as a pale yellow solid, with a chemical formula C13H8ClFO and a molecular weight of 234.65 g/mol. We maintain a fixed melting point range, typically around 80–84°C, and set impurity thresholds that reflect the realities of both stringent synthesis goals and what works best in real applications.

    For every batch, we rely on tried-and-tested analytical tools like HPLC and NMR, not to satisfy regulatory paperwork, but to ensure each lot behaves as expected for you during later synthesis or formulation. If you’ve ever struggled with unpredictable reactivity or issues with purification in past projects, you’ll notice the difference real quality control makes.

    Beyond the Numbers—Why Sourcing Direct Makes a Difference

    In research and commercial production, even minor deviations in raw material quality can translate to hours of troubleshooting or lost yield. We’ve faced these headaches ourselves—in our lab, on our coating lines, and in conversations with teams that try to pick up the slack for underperforming feedstock. By owning the whole process from start to finish, we keep contaminants, by-products, and residual solvents below levels that repeatedly cause hang-ups in Friedel–Crafts acylations or downstream halogen-based coupling reactions.

    Tracing each drum or bag back to a specific tank is not about record keeping for us. If a customer calls with a question about solubility in a particular organic phase or needs clarification on potential side-reactions during photoinitiator manufacture, we don't reach for generic data. We pull the relevant batch data and share our own processing notes—often right down to the catalyst system we used or observations during crystallization. This approach saves our partners time, and it fosters the kind of relationship where you can get an honest answer to ‘what might go wrong?’—because we’ve been there, and know how to fix it on our end if there’s ever an avoidable hiccup.

    Practical Use Cases in Industrial Synthesis

    2-Chloro-4'-Fluorobenzophenone fits neatly into several critical R&D and production activities. Colleagues in pharmaceutical synthesis often use it as an intermediate in small-molecule discovery programs, especially in the preparation of substituted diarylketones and complex aromatic scaffolds. We see heavy demand from units developing new crop protection actives, where the product’s combined halogen pattern allows targeted, sequential functionalization—ideal for building up selectivity or tuning metabolic stability.

    Teams working on specialty polymers and liquid crystal materials value its dual halogenation: the chlorine and fluorine give the finished machinery, such as light-absorbing layers or alignment films, very specific polarizability and steric characteristics. We've worked directly with engineers trying to tune melting and glass transition points in advanced engineering plastics, and they come back to this product because it lets them slide in new properties where needed. The synthetic route holds up even during scale-up, so research gains aren’t lost once the benchtop is swapped out for pilot reactors.

    How Our 2-Chloro-4'-Fluorobenzophenone Holds Up Against Others

    Anyone who has swapped suppliers for halogenated benzophenones knows that not every lot delivers consistent quality. We’ve analyzed plenty of competitor samples in-house, at the request of process chemists frustrated by batch-to-batch variability. What we routinely find in imported lots, or those bought off small traders, is a grab bag of residual by-products: leftover acid chlorides, hydrolyzed precursors, and sometimes worrying levels of non-volatile tars. These impurities do more than muddy the physical appearance; they can stall key coupling reactions or lead to batch failures, especially in water-sensitive or anhydrous processes.

    With our product, you’ll find less haze in solution and more reliable crystallization profiles. The difference comes down to our real day-to-day investment in purification—distillation and recrystallization stages aren’t skimped because we understand the cost, both financial and operational, of production downtime or spoiled material on your end. We’ve stayed away from shortcuts and invest heavily in analytics, not because it sounds good in a brochure, but because we need traceable, measurable, enduring performance for our own product development, too.

    Another practical difference: we won’t leave you chasing for documentation. All our specification sheets and COAs are the result of daily lab work, not cut-and-pasted from a generic template. If you’ve got unusual handling or solubility requirements, you get thoughtful, real-world recommendations from chemists who actually touch the product. We don’t pass you to a sales desk or offer canned responses.

    Supporting Reliable Scale-Up and Process Transfer

    Bench-scale reactions often look robust until they move to pilot or manufacturing. We’ve walked this path, both within our own projects and side-by-side with partner companies. Two stories come to mind: one, a young startup who used trade-sourced material and struggled with inconsistent yields for a key aromatic substitution; and another, a well-staffed industrial lab whose best-laid plans got upended by solubility problems from unflagged side impurities.

    After swapping over to our material, each saw tighter schedules, more predictable isolation, and, after some honest back and forth, a near-elimination of batch rejections. It wasn’t a matter of minor tweaks—it stemmed directly from receiving a material that actually matched its analytical cert, every single consignment. Trust gets built when documentation, product performance, and technical support line up every time. That’s more than a marketing claim; it’s a promise grounded in daily operations and hard-earned reputation.

    How We Minimize Pitfalls in Consistency and Safety

    Beyond purity and physical parameters, there’s another critical side to specialty chemical manufacturing—proactive risk management. We use closed systems for transfer and solid handling, because we’ve seen how dust control and accidental exposure can get overlooked until there’s a problem. Using the right PPE and containment approaches lets us maintain process hygiene not just for regulatory satisfaction, but to protect both our staff and yours from the unexpected. Dry powder is managed under inert atmosphere where relevant, and detailed batch traceability means faster root cause investigations if a question ever arises.

    Feedstock Transparency and Sourcing Integrity

    Having direct control over precursor acquisition means nobody is left guessing the origin story of any lot. We’ve signed long-term partnerships with core suppliers and periodically audit their sites. We don’t introduce new intermediates or change key input grades on a whim. If supply chain disruption demands a temporary switch, everyone affected gets a heads-up and a full run-down on what analytical safeguards we’re using to verify equivalence.

    Years ago, we tried outsourcing a specialized intermediate. We lost weeks to troubleshooting and customer complaints, so we brought synthesis entirely in-house. That move might have meant a steeper short-term investment, but what we gained—process visibility, cost containment, and reliability—paid back ten-fold in customer loyalty. That experience still shapes our sourcing strategy today.

    Listening to Chemists—Product Improvements Driven by Feedback

    No one knows better what works and what needs fixing than the people who actually work with 2-Chloro-4'-Fluorobenzophenone every day. We take this to heart by keeping an open door to end-users—university labs chasing new catalytic pathways, process chemists looking for batch optimization tips, and operations managers with thoughts on packaging improvements. We’ve swapped out fiber drums for lined kegs because enough people shared their stories about moisture uptake and caking. We’ve adjusted drying curves to cater to customers with extremely low water tolerance, after seeing how floaters in certain solvent systems could wreck entire charge lots.

    Underneath these changes sits a simple mindset: credibility comes from continual interaction with users, not grand statements about product superiority. Every improvement cycle keeps us close to the shop floor and the formulation bench, where reality dictates what we ship out next.

    Adapting to Regulatory and Market Shifts

    Our customers operate in tightly regulated industries—pharmaceuticals, electronics, crop protection, and more. We watch for upcoming changes in chemical control lists, REACH registrations, or customs declarations, so our compliance documentation doesn’t lag behind. One season, customs added a new HS code for halogenated ketones, which hung up inbound material for weeks. We readjusted paperwork, pre-registered incoming batches, and worked up a process for customers to get temporary import waivers. It’s not glamorous, but being present for these curveballs makes all the difference when market dynamics shift.

    Being close to the ground also alerts us early to trends—such as the growing preference for lower-residual solvents or concern about halogenated waste. We tweak solvent systems, modify wash cycles, and invest in better waste treatment equipment, tracking both regulatory requirements and what customers themselves identify in the field. These shifts are rarely announced months in advance. By running our own plant, we retain the agility to make process changes on the fly, instead of waiting through long lead-times another contractor might introduce.

    Logistics and Downstream Flexibility

    Shipping specialty chemicals comes with surprise hurdles, especially for sensitive or low-volume materials like 2-Chloro-4'-Fluorobenzophenone. We manage our own stock and allocate safety inventory not based on planners in distant offices, but on seasonal demand and regular customer input. If you face sudden upswings—a launch, a scale-up, an urgent program acceleration—chances are we’ve set aside buffer stock or can ramp up an extra batch with minimal lead time.

    Packaging gets tailored in response to real needs, not catalog descriptions. Glass bottles, lined drums, or anti-static bags all have found their way into our packing room because end users provided concrete feedback on what worked best for their settings. Our drivers learn delivery quirks of different plants, and we don’t treat customs brokerage or after-hours support as afterthoughts. A missed deadline is not just an inconvenience—it can translate to idle teams and missed targets. We work hard to anticipate such challenges so the finished product shows up in the right place, at the right time, ready for immediate deployment.

    Commitment to Practical Solutions in Every Batch

    The real test of any chemical, especially a specialized intermediate like 2-Chloro-4'-Fluorobenzophenone, comes in how reliably it helps end-users solve concrete problems. From the first inquiry through final delivery, our focus is on actionable detail, direct communication, and a steady willingness to adapt. Decades of on-the-ground learning have shown us that the human side of manufacturing cannot be separated from technical excellence. If you’ve struggled with inconsistent supply, incomplete data, or slow troubleshooting, consider talking through your technical or operational challenges with our team. We bring both product and process expertise to bear on every request, big or small—because that’s how progress gets made with real chemicals, in real labs and shops, every day.