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2-Chloro-3-(Trifluoromethyl)Benzaldehyde

    • Product Name 2-Chloro-3-(Trifluoromethyl)Benzaldehyde
    • Alias 2-Chloro-3-(trifluoromethyl)benzaldehyde; 3-(Trifluoromethyl)-2-chlorobenzaldehyde; 2-Chloro-3-trifluoromethylbenzaldehyde
    • Einecs 626-087-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    899718

    Product Name 2-Chloro-3-(Trifluoromethyl)Benzaldehyde
    Cas Number 147118-36-3
    Molecular Formula C8H4ClF3O
    Molecular Weight 208.57 g/mol
    Appearance Pale yellow to light brown liquid
    Boiling Point 85-87 °C at 15 mmHg
    Density 1.43 g/cm³
    Purity Typically ≥98%
    Smiles C1=CC(=C(C(=C1)Cl)C=O)C(F)(F)F
    Inchikey WMHDOYQGYFROGR-UHFFFAOYSA-N
    Solubility Slightly soluble in water, soluble in organic solvents
    Storage Conditions Store in a cool, dry place and keep container tightly closed
    Refractive Index 1.527 (approximate)
    Hazard Class Irritant

    As an accredited 2-Chloro-3-(Trifluoromethyl)Benzaldehyde factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Brown glass bottle, 25g, screw cap, white label with chemical name, CAS number, hazard symbols, supplier, and handling instructions.
    Shipping 2-Chloro-3-(trifluoromethyl)benzaldehyde is shipped in sealed, chemical-resistant containers compliant with hazardous material regulations. It is carefully packaged to prevent leaks or contamination, labeled according to GHS and DOT guidelines, and typically transported under ambient temperature with appropriate documentation. Ensure proper handling and storage upon receipt to maintain product integrity and safety.
    Storage 2-Chloro-3-(trifluoromethyl)benzaldehyde should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition. Avoid exposure to direct sunlight and moisture. Store separately from incompatible materials, such as strong oxidizers and acids. Ensure proper labeling, and keep the container in a dedicated chemicals storage cabinet, preferably equipped for flammables.
    Application of 2-Chloro-3-(Trifluoromethyl)Benzaldehyde

    Applications of 2-Chloro-3-(Trifluoromethyl)Benzaldehyde in Industrial Manufacturing

    2-Chloro-3-(Trifluoromethyl)Benzaldehyde serves as a critical intermediate for multiple chemical synthesis pathways, especially across the pharmaceutical, agrochemical, and fine chemical manufacturing sectors. Our production process ensures high purity and consistency, supporting key industrial applications that demand strict compliance and reliable performance.

    1. Pharmaceutical Intermediate for Active Pharmaceutical Ingredients (APIs)

    In pharma manufacturing, many API synthesis routes rely on aromatic aldehydes as building blocks. This compound supports selective fluorine and chlorine incorporation, essential in the assembly of target molecules such as anti-inflammatory agents, CNS drugs, and oncology compounds. Its reactivity allows precision in reductive amination, Grignard, and Suzuki coupling reactions. Endpoint purification typically involves HPLC or recrystallization to meet stringent pharmacopeial requirements.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • European Pharmacopoeia monographs (where applicable for API route)
    • US FDA cGMP 21 CFR Part 210 & 211
    • ISO 9001:2015 Quality Management System

    Typical usage ratio

    • 0.8 to 1.2 mol equivalents per API molecular backbone, adjusted based on target yield and downstream step specificity

    Downstream process integration

    • Reactant in key condensation and cross-coupling steps during API backbone assembly
    • Input at intermediate stage pre-final coupling or cyclization
    • Purification via column chromatography or preparative HPLC before final downstream transformation

    Final product types

    • Non-steroidal anti-inflammatory drug intermediates
    • CNS-active substance cores
    • Selective kinase inhibitor scaffolds
    • Active pharmaceutical ingredients (custom routes)

    2. Agrochemical Synthesis (Herbicide and Fungicide Intermediates)

    This aromatic aldehyde provides high electron-withdrawing substitution, making it ideal for producing key herbicide and fungicide scaffolds. Formulators use it in aldol condensations and nucleophilic aromatic substitutions, enabling the creation of effective active compounds with strong persistence and selectivity. Quality control focuses on trace metal, chloride, and residual solvent limits due to regulatory restrictions on agrochemicals.

    Industry compliance standards

    • REACH Regulation EC 1907/2006 (Europe)
    • FAO/WHO specifications for pesticide quality
    • ISO 17025 Analytical Testing
    • US EPA Pesticide Registration requirements (40 CFR Part 158)

    Typical usage ratio

    • 0.5 to 1.0 mol equivalents in active ingredient syntheses, adjusted for target a.i. purity and batch size

    Downstream process integration

    • Initial coupling or cyclization during pre-final active substance construction
    • Input for key transformation before functionalization of herbicidal or fungicidal moiety
    • Purity assurance through batch HPLC and GC-MS monitoring

    Final product types

    • Triazole-type fungicide intermediates
    • Amide-type herbicide precursors
    • Halogenated phenyl pesticide cores
    • Active agrochemical substances

    3. Advanced Material Monomer Synthesis (Electronic and Functional Polymers)

    Manufacturers of high-performance polymers incorporate this benzaldehyde derivative to introduce fluorine and chlorine functionalities, improving thermal and chemical resistance in final materials. It commonly participates in the formation of custom aldehyde-based monomers for optoelectronic or piezoelectric applications. Batch records maintain traceability and specification conformance for downstream electronics integration.

    Industry compliance standards

    • IEC 61249 for halogen content in printed circuit boards
    • RoHS Directive 2011/65/EU
    • UL 94 Flammability testing
    • ISO 9001:2015 for process and material traceability

    Typical usage ratio

    • 10–30 mol% (relative to total monomer blend) for specialty polymer formulations, with adjustment by desired end-use functionalization

    Downstream process integration

    • Feedstock for polymerization (step-growth or chain growth) with diamines or polyols
    • Introduced at initial monomer mixing prior to catalyst addition
    • Integrated purity monitoring during reaction via NMR and FTIR

    Final product types

    • Photoresist resins for microelectronics
    • High-durability functional polymers
    • Engineered coatings for medical instruments
    • Dielectric films with controlled halogenation

    4. Fine Chemical and Fragrance Intermediates

    Aromatic aldehydes play a key role in the fine chemical and fragrance sector. This compound contributes unique molecular motifs for creating high-value perfumery and specialty odorants. Industrial processes leverage its strong halogen and fluorine effects to introduce persistence and intensity in finished fragrances, often via acylation or condensation pathways. All batches undergo screening for unreacted halides and residual solvents to meet IFRA standards.

    Industry compliance standards

    • IFRA/IOFI Labelling Manual
    • EU Regulation (EC) No 1223/2009 (Cosmetics Regulation)
    • ISO 9001:2015 for fine chemical production
    • California Proposition 65 (where applicable)

    Typical usage ratio

    • 1–3 wt% in targeted odorant intermediates, customized for desired strength and volatility

    Downstream process integration

    • Condensation or acylation with alcohols and aromatics during intermediate construction
    • Input at initial fragrance blend formulation
    • Screening for aldehyde purity and halide content by GC/FID and LC-MS

    Final product types

    • Specialty fragrance bases
    • Perfumery aldehyde blends
    • Fine chemical intermediates for luxury goods
    • Industrial odorant concentrates

    5. Dye and Pigment Intermediate Manufacturing

    This benzaldehyde offers a reliable platform for synthesizing advanced anthraquinone and azo dye intermediates, allowing for the introduction of specific electron-withdrawing substituents, which are essential for modifying absorption properties and fastness in textile dyes and specialty pigments. Colorant producers use it for controlled electrophilic aromatic substitution, often under acidic or basic catalysis, followed by refined crystallization protocols to achieve consistent color properties.

    Industry compliance standards

    • OEKO-TEX Standard 100 (restricted substances in dyes)
    • ZDHC MRSL guidelines (Manufacturing Restricted Substance List)
    • EN 71-3 for safety of colorants in toys
    • ISO 105-A02 for textile color fastness

    Typical usage ratio

    • 2–6 mol% for pigment core modification, with process adaptation for target shade and stability

    Downstream process integration

    • Nucleophilic or electrophilic substitution at initial dye synthesis stage
    • Introduced at pigment precursor formation, pre-final coupling
    • Post-reaction purification by liquid-liquid extraction or recrystallization

    Final product types

    • Lightfast azo textile dyes
    • Anthraquinone-based pigments
    • High-stability printing inks
    • Special effect colorants for industrial coatings
    Free Quote

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    Certification & Compliance
    More Introduction

    Introducing 2-Chloro-3-(Trifluoromethyl)Benzaldehyde: Behind the Manufacturing Process

    Bringing Chemistry to Life on the Production Floor

    We see our work as a direct line between chemical innovation and real-world solutions. Among the range of compounds we produce, 2-Chloro-3-(Trifluoromethyl)Benzaldehyde stands out not just because of its unique structure, but because of the way it transforms downstream chemistries for countless clients. Employees on our lines understand every batch carries a level of trust, shaped by years of hands-on experience, material know-how, and lessons earned from every successful or challenging synthesis.

    The Substance in Focus: What Sets 2-Chloro-3-(Trifluoromethyl)Benzaldehyde Apart

    This molecule brings together a trifluoromethyl group and a chloro group on a benzaldehyde scaffold, yielding a building block valued by agrochemical, pharmaceutical, and fine chemical manufacturers. The model produced here—purity greater than 98 percent, consistent melting point—emerges from years spent refining our methods. Surface inspection, chromatographic testing, and spectroscopic analysis aren’t tick-box routines for us: each step reflects a commitment to uninterrupted performance, free from curveballs that trace back to bottlenecks or unexpected side-reactions.

    The trifluoromethyl group changes the game when it comes to electronic properties. Chemists in the field reach for this compound when they want to manipulate reactivity—whether it’s creating more metabolic stability in a future active ingredient or dialing up selectivity for a specific reaction. The addition of the chloro group further tunes the molecule, giving researchers a lever that simpler benzaldehydes lack. Years spent at the reactor, fine-tuning temperature gradients and solvent ratios, have underscored how critical these functional groups are when aiming for high-yield, low-impurity batches.

    Why Consistency Matters—from the Eyes of Those Making It

    Anyone working in downstream synthesis knows pain points start with upstream inconsistencies. From first raw material selection to handling the nitty-gritty of dichlorination and subsequent oxidation routes, hands-on production experience counts for everything. Predictable behavior in scale-up depends on more than published routes or recipes. We’ve rebuilt glassware, swapped valves, tracked contamination back to barrels, and seen how a small tweak—the order a reagent gets introduced, a half-degree shift in temperature—changes not just the yield but subsequent product stability.

    Our production team handles crystallization with a careful combination of old-school know-how and new analytical tools. Drying conditions, choice of anti-solvent, and batch filtration don’t just affect lab specs: these steps ensure downstream users meet their own quality standards, without backpedaling due to unknown impurities or altered physical profiles. We don’t cut corners, because every hour saved on our end may cost weeks for another chemist chasing failed reactions or by-product headaches.

    Inside the Specifications: What We’ve Learned Over the Years

    Making this benzaldehyde to spec means more than running a standard process. Early runs taught us where shortcuts backfire—batch-to-batch variation crept in when temperature control lagged, or when drying cycles were cut unnecessarily short. Over time, we shifted to using automated in-process controls, sampling every segment, and tying each drum to a transparent batch history. GC-MS and NMR checks aren’t luxury items—they’re the checkpoints ensuring every kilo behaves the same way, no matter which client or sector applies it next.

    Unlike standard benzaldehydes or similar halogenated products, this compound demands tight control over trace moisture and oxygen exposure. We take extra steps—dedicated nitrogen blankets, oxygen-scrubbed storage tanks, and ambient control in packaging rooms—to lock in the aldehyde group’s reactivity and prevent the kinds of side reactions that drive up costs or ruin subsequent processes. These details emerged not from a text but from learning what actually shows up, batch after batch, in our own QA labs and in emails from chemists working late hours trying to figure out a why a trusted reaction suddenly went wrong.

    Fitting the Needs of Modern Synthesis

    Every year, feedback from customers encourages further improvement. We keep an open line with those building complex intermediates, new herbicides, or drug lead candidates. Experienced process chemists know how rapidly a bottleneck can arise when even a minor impurity slips through, or when physical consistency doesn’t match expectations. Each batch dispatched from our plant represents hundreds of variables managed in real time—solvent recovery, waste stream management, cooling water checks, staff training in handling sensitive compounds—all woven into the supply chain behind this molecule.

    Out in the field, users of 2-Chloro-3-(Trifluoromethyl)Benzaldehyde don’t have patience for surprises. They rely on this compound for Grignard reactions, formylations, or cross-coupling applications, and each workflow brings its own unyielding requirements. Having delivered multi-metric ton runs, we understand scale makes all the difference. Bigger orders mean more risk, more room for small deviations to amplify into bigger setbacks. Years in the business have taught us to treat every request—from a drum-sized order to multi-ton contracts—with consistent lab verification, rigid documentation, and the same commitment from our operators.

    How Experience Has Shaped Our Process Controls

    Scale brings fresh challenges. Years ago, we leaned heavily on operator intuition, but as batches grew, we invested heavily in in-line monitoring, real-time analytics, and routine supplier audits. Even a single percentile drop in impurity specs can signal a pump valve ready to fail, or condensers due for maintenance. Close relationships with raw material suppliers matter, because trace metals, or even drum lining residues, can tip the balance between a high-performing intermediate and a batch heading to waste.

    Our team runs weekly improvement meetings on the shop floor—front-line perspectives always surface shortcomings faster than any paper trail. If a filter cloth style leads to crystal agglomeration, or if one lot reacts slower due to a new solvent blend, we pivot quickly. This kind of adaptive learning can only come from actually standing at reactors, managing midnight maintenance calls, and troubleshooting side reactions that only show up in real-world flows, not just in literature.

    Practical Differences from Similar Benzaldehyde Products

    Chemists sometimes ask why they wouldn’t use a simpler benzaldehyde, or opt for a related halogenated aromatic. After thousands of batches, we see where 2-Chloro-3-(Trifluoromethyl)Benzaldehyde really performs: the electron-withdrawing trifluoromethyl and chloro groups dial in exactly the right balance for targeted nucleophilic or electrophilic steps. The reactivity profile stands apart from monochloro-benzaldehydes or trifluoromethyl-only analogs. Physical handling brings differences as well—a slightly higher density, greater handling caution due to reactivity with some amines or basic reagents, and a marked odor that demands well-designed fume handling.

    By working with hundreds of chemists on custom syntheses, we know how upstream intermediates shape the cost and cycle of complex molecule construction. Cheaper or less refined starting materials might offer short-term savings on a balance sheet, but in the long run, workup complications, downstream yield loss, and purification headaches eat away those gains. Taking the time to chase down impurity sources—whether from a solvent lot or a gasket material—translates into a more reliable final product for our partners.

    Sustainability and Responsibility: Not Just Marketing

    Any producer can draft a sustainability mission. Putting it into practice, especially with specialty organofluorine and organochlorine compounds, requires daily decisions at every step. Solvent recycling started as a regulatory requirement, but over years, our reclaim units have been fine-tuned to recapture usable material, lowering waste output and cost. Heat exchange systems, wastewater handling, and energy recovery from exothermic steps now form part of every process review.

    Workers on our shop floor see the downstream impacts, not just on immediate safety but longer-term environmental footprint. By keeping close tabs on halide and fluorinated waste streams, actively working to minimize emissions, and monitoring effluent more stringently than outside inspectors would demand, we keep ourselves accountable to partners and neighbors. No one can afford shortcuts where persistent or bioaccumulative chemicals are involved, so improvements in containment, scrubber efficiency, and closed transfer systems get priority in our capital investments.

    On the Line: Training and Skills Transfer

    Operators and chemists at our facility don’t come ready-made with expertise in handling aldehydes, much less multi-functionalized derivatives like 2-Chloro-3-(Trifluoromethyl)Benzaldehyde. Skills transfer happens through years of side-by-side learning—handling leaks, managing spill protocols, checking batch progress not just by printout but nose and eye. Recruitment and retention depend on building up internal knowledge: stories about earlier missteps and recoveries, process changes that shaved off entire cleaning cycles, and updated handling rules when new tanker shipments show up with minor but crucial differences in raw material packaging.

    Experience convinces us that the best operators care about more than yield and throughput. They track subtle changes in crystal appearance, catch faint color shifts, and sense when filter clogging signals deeper issues with process control. Their vigilance, layered with rigorous in-house certification and routine retraining, underpins every batch we produce.

    Building Trust Through Reliability

    We trace each lot back not just through certificates but through real-world episodes—feedback calls, rush shipments, and occasional troubleshooting partnerships with customers. Each time someone flags a concern about color, solubility, or unexpected side products, the response draws on hands-on knowledge built over thousands of successful runs and plenty of rebuilt procedures.

    New users sometimes fixate on purity specs or supplier reputation. The narrative we emphasize to the customers we’ve worked with for years goes deeper: reliability comes from our own plant floor, from operators who remember which process tweaks really made the difference last season, and from plant engineers who design improvements after a close call, not just an audit finding. That willingness to dig in makes a critical difference when multiple customers stake a campaign’s success on a handful of intermediate drums.

    Solving Problems Before They Start: The Role of Active Engagement

    Modern manufacturing of specialty chemicals brings thorny problems no one can solve by spreadsheet. Each week, we keep a close eye on global supply chain disruptions—delays in fluorine or chlorine feedstocks, rising freight costs, and even regulatory backlogs on transport of hazardous goods. Sometimes, pivoting quickly to secure incoming supply avoids production gaps that could drag out for weeks, impacting customer delivery.

    We’ve responded to solvent shortages by qualifying in-house distillation, switching carriers, and holding strategic inventories when raw material volatility threatens continuity. The lesson learned keeps recurring: those who stay on top of shifting logistics, potential regulatory shifts, and upstream supplier practices provide a stability partners across industries appreciate, even when volatility spikes elsewhere. Feedback loops that matter most develop on the floor and in the lab, not purely in the procurement office.

    Perspective from Years in the Industry

    It’s tempting to market a specialty benzaldehyde solely on lab numbers or promise broad applicability. True sustainability in supply and practical utility for chemists depend on rigor at every link of the process: careful raw material vetting, process adaptability when routes require tweaking, and active collaboration when an unexpected process hiccup needs a solution same day. We're always learning—each batch brings a lesson, a point for review, or a new demand from a downstream user.

    This isn’t a compound for those who plan to skim quality assurance or who see it as a commodity. Our experience says superiority comes from close monitoring, repeated process optimizations, and a sense of stewardship over how these chemicals enter and behave in a complex world of interconnected syntheses and regulatory expectations.

    Continued Commitment to Quality and Safety

    Safe production and rigorous analytical controls define our day-to-day work. We hold ourselves—and encourage any partner or end-user—to maintain the highest vigilance with storage, use, and downstream processing. Improper handling, unnoticed moisture ingress, or a slip in process discipline can undermine months of R&D or cause downstream bottlenecks that ripple across entire campaigns. We’re firm believers in regular training, robust process mapping, and solid personal accountability.

    Process safety isn’t an afterthought. It pervades the layout of our lines—from double-sealed storage tanks to routine atmospheric sampling and batch record archiving. The tone is set not just by management but by old hands who pass down lessons from earlier batches—both successes and close calls.

    Looking Ahead: The Future for High-Performance Benzaldehydes

    Demand for advanced intermediates with both halogen and fluorine functionality shows no sign of slowing, especially as synthetic targets grow more complex and regulatory hurdles climb. Knowledge gained from continuous production—managing regulatory updates, supplier relationships, and product traceability—equips us to meet emerging challenges. Every innovation, every iterative workflow, builds on years of applied learning.

    As more partners worldwide face tighter compliance requirements or move toward greener synthesis, the value of reliable, well-documented, and process‑informed intermediates rises. We commit each day to refining our practices, engaging with the realities faced by end users, and never taking shortcuts with a molecule as versatile and challenging as 2-Chloro-3-(Trifluoromethyl)Benzaldehyde.

    Each new project on the schedule, every returning order, stands as a testament not just to the product, but to the network of expertise, care, and dedication that shapes every kilo dispatched from our facilities.