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2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane

    • Product Name 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane
    • Alias 1,4-dibromo-2-chloro-1,1,2-trifluorobutane
    • Einecs 'EINECS 609-524-2'
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    710178

    Chemical Name 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane
    Molecular Formula C4H4Br2ClF3
    Molecular Weight 318.33 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point Estimated 140-160°C
    Density Approximately 2.1 g/cm3
    Solubility In Water Insoluble
    Refractive Index Estimated 1.43-1.48
    Smiles C(C(C(CBr)F)(F)Cl)Br
    Purity Varies, typically >95%
    Storage Conditions Store in cool, dry place, tightly closed
    Stability Stable under recommended conditions

    As an accredited 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 100 mL, with tamper-evident cap and hazard labels for corrosive and toxic; foam-padded, protective outer box.
    Shipping 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane is shipped in tightly sealed containers under cool, dry conditions. Transport must comply with hazardous materials regulations, including appropriate labeling and documentation. Protective packaging is necessary to prevent leaks and chemical exposure. Shipping is limited to authorized carriers trained in handling hazardous chemicals.
    Storage Store 2-Chloro-1,4-dibromo-1,1,2-trifluorobutane in a cool, dry, well-ventilated area away from heat, sparks, and sources of ignition. Keep the container tightly closed and clearly labeled. Avoid exposure to direct sunlight and incompatible substances such as strong oxidizers. Use secondary containment if possible, and ensure appropriate spill control materials are available. Store under recommended temperature conditions stated on the SDS.
    Application of 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane

    Applications of 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane in Industrial Manufacturing

    2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane is a specialty fluorinated intermediate widely recognized by manufacturers for its effectiveness as a building block in various high-performance industrial sectors. Below, we detail genuine application scenarios where this material makes a measurable impact throughout downstream chemical production, listing regulatory considerations, technical integration points, formulation ranges and illustrative examples of end-use products.

    1. Advanced Refrigerant Synthesis

    This compound is routinely supplied for use as a key intermediate in the multi-step synthesis of new-generation hydrofluorocarbon and hydrofluoroolefin refrigerants designed for high stability and lower global warming potential. Direct halogen exchange and controlled fluorination processes exploit its unique halogen arrangement, giving producers precision over target molecule yields required for stringent equipment and environmental use.

    Industry compliance standards

    • ASHRAE Standard 34 for Refrigerant Safety Classification
    • EU F-Gas Regulation (EU) No 517/2014
    • China’s GB/T 18826 Hydrofluorocarbon Clean Production Standard
    • US EPA SNAP Program Listing Requirements

    Typical usage ratio

    • 10–22% of initial charge by mass in multi-step batch fluorination with adjustments based on desired refrigerant profile and downstream halogen exchange efficiency

    Downstream process integration

    • Charged in the primary halogen-exchange reactor after substrate activation; followed by fractional distillation and purification to isolate refrigerant-grade fluorinated molecules

    Final product types

    • Low-GWP refrigerant blends (e.g., R-1234yf, R-1233zd)
    • Specialty propellants for heat transfer fluids
    • Intermediate feedstock for medical-grade propellant gases

    2. Pharmaceutical Intermediate—Synthesis of Fluorinated API Precursors

    This raw material enters closely regulated pharmaceutical synthesis lines, where its selectivity supports the creation of chiral building blocks for complex active pharmaceutical ingredient (API) precursors. Commercial customers leverage its purity during nucleophilic substitution and halogen-metal exchange stages, supporting downstream formulation of fluorinated heterocyclic and alkyl side chains in clinical candidates.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP General Chapter <823> and Ph. Eur. 5.2.8 for APIs containing halogen substituents
    • Chinese Pharmacopoeia (ChP) guidelines for fluorinated chemical substances
    • ISO 9001:2015 Quality Management Systems

    Typical usage ratio

    • 0.5–5 mol% based on target molecule complexity and scale, with optimization depending on step yield and undesired byproduct formation in multistep syntheses

    Downstream process integration

    • Dosed at controlled temperature and pressure within the fluorination or halogen-substitution module, preceding crystallization or extraction of the fluorinated precursor

    Final product types

    • Fluorine-containing API intermediates for oncology and CNS drugs
    • Chiral fluorinated building blocks for specialty drug candidates
    • Contract-manufactured small molecule research APIs

    3. Electronics-Grade Dielectric Material Synthesis

    Original device manufacturers utilize this intermediate as a controlled halogen source in the polymer precursor manufacturing flows for high dielectric fluoropolymer and copolymer components. Its defined molecular structure and stability allow precise chain termination and incorporation, resulting in finished materials with superior electrical insulation and chemical resistance profiles, tailored for use in semiconductor, cable and electronic encapsulation applications.

    Industry compliance standards

    • IEC 60216 Thermal Endurance of Electrical Insulating Materials
    • IPC-4101/IPC-4201 EMC Performance for Laminate and Prepreg Materials
    • RoHS Directive 2011/65/EU for hazardous substances control
    • JIS C 2110 Polymeric Materials Standard (Japan)

    Typical usage ratio

    • 2–8 wt% incorporated into monomer blend, adjusted based on target dielectric constant and process viscosity needs during copolymerization or co-extrusion

    Downstream process integration

    • Dosed during the monomer charging phase of emulsion or solution polymerization prior to catalyst addition and subsequent extrusion or molding steps

    Final product types

    • Fluoropolymer films for printed circuit boards
    • Wire and cable insulation compounds
    • Dielectric coatings for semiconductors and advanced microelectronics

    4. Precision Agrochemical Intermediate

    Major crop protection and land management chemical producers employ this halogenated compound to construct tailored intermediate molecules for selective herbicide and fungicide active substances. Its application in the early stages of methylation or alkylation reactions provides defined halogenation, critical for tuning bioactivity and residual profile, and complies with global environmental and safety requirements.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • EPA FIFRA Registration (USA)
    • REACH Regulation (EC) No 1907/2006—Annex II
    • China’s Pesticide Registration Administrative Measures (2022)

    Typical usage ratio

    • 5–15 mol% in the initial synthesis step, modulated by target molecule and desired halogen loading for downstream biological screening

    Downstream process integration

    • Introduced in the alkylation or substitution reactor during intermediate synthesis, followed by stepwise purification and formulation into pre-final actives

    Final product types

    • Custom agrochemical intermediates for post-patent herbicide synthesis
    • Halogenated building blocks for systemic fungicides
    • Bioactive seed-treatment precursor compounds

    5. Specialty Chemical Polymer Modifier

    Leading global chemical groups integrate this halogenated trifluorobutane compound during the synthesis of specialty performance polymers for industrial coatings and engineered resins. The structure enables precise modification of backbone chemistry to achieve desired hydrophobicity, weather resistance or unique fluorine content in advanced polymer systems for automotive finishes and architectural applications.

    Industry compliance standards

    • ISO 14021 Environmental Self-Declaration for Coating Chemicals
    • ASTM D5200/D5546 for Industrial Polymeric Coating Materials
    • EU REACH premanufacture notification (where applicable)
    • China National Standard GB/T 22235 for Advanced Fluoropolymer Materials

    Typical usage ratio

    • 1–6 wt% introduced during the copolymerization stage, with adjustments depending on end-use requirements such as flexibility, surface energy and crosslink density

    Downstream process integration

    • Dosed at the copolymer feed stage, followed by solvent removal, drying, and milling prior to final letdown or crosslinking processes for industrial polymer production

    Final product types

    • Hydrophobic fluoropolymer coatings for automotive OEM plants
    • Fluorochemical-modified architectural paints
    • Weather-resistant engineered plastic compounds
    Free Quote

    Competitive 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane: A Direct Perspective from the Plant Floor

    Getting to Know 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane

    Days inside our manufacturing plant teach plenty about subtle differences between one fluorinated compound and another. Among the range of halogenated butanes, 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane stands out for its balance of unique halogen coordination and practical reactivity. Those who regularly handle tricky multi-halogen syntheses or specialty intermediates spot quickly how the structure affects not just application but also day-to-day handling and downstream options.

    This molecule carries three fluorines clustered at the first and second carbons, with bromines on the first and fourth positions and a chlorine at the second. The pattern means neither end of the chain acts identically in reactions, and neighboring effects roll through nearly every process decision. In the lab and at the plant, subtle shifts in reactivity pop up. Reactivity toward nucleophiles, impacts on volatility, and selectivity during further substitution all change once bromine and chlorine sit in strategic positions. Fluorine’s electronegativity compresses certain reaction windows, and professional chemists recognize faster than most textbooks how even minor layout adjustments change outcomes.

    Specifications That Matter in Real-World Processes

    Our product—produced under rigorous quality controls—maintains a purity that meets demanding synthesis requirements for advanced organic chemistry work. On a practical level, stringently managing trace contaminants and close-watching the water content, acid numbers, and residual solvents directly influence downstream reliability. We consistently batch-report these measures, understanding that an undetected side impurity derails product consistency and performance in catalysis, pharmaceutical intermediates, or advanced polymers.

    Batches come as a colorless to pale yellow liquid at room temperature with a characteristic dense, slightly sweet halogened odor, familiar to those who work around similar mixed halides. By experience, viscosity and pour points stay stable during drum storage, simplifying logistics and in-plant transfers. Customers who need reliable material transfer from plant to process see fewer headaches, and those handling product at scale notice the absence of sludging, erratic phase changes, or unexpected volatility spikes.

    What Sets This Molecule Apart? Insights Only a Manufacturer Grasps

    Manufacturing experience across a wide swath of halogenated butanes puts the differences into sharper relief. The triple-fluorine structure here does more than influence reactivity; it shifts the material’s entire safety and handling profile. Triple halide compounds sometimes spook new users, leading to excessive caution that slows production. In truth, direct plant experience shows that, with good controls, the compound remains manageable. The density sits above typical non-halogenated butanes, so standard PVC and steel valve seals hold up well, and the flashpoint—while low—positions the material within known safety confines for halogenated solvents. In the rare event of a spill, volatility does announce itself with that sweet-snap halogen smell, giving an early warning, and everyday PPE mitigates exposure. That’s not to say shortcuts have a place—plant safety depends on respecting these molecular quirks.

    Compared to sister products like 1,4-dibromo-2,3,3-trifluorobutane or a straightforward 1-chloro-3,4-dibromobutane, this blend of halides tilts the reactivity in a few notable directions:

    Long-term handlers of these compounds soon realize how a manufacturing background influences every step, from raw material selection to minimizing hazardous by-products. For instance, our technical team, with decades of hands-on synthesis, leverages reaction routes proven at industrial scale and not just in the literature, avoiding bottlenecks caused by impractical lab procedures. Day in and day out, that means less downtime and higher assurance that a process tweak here won’t cascade into days lost on the end-user’s line.

    Applications from Real-World Feedback

    End markets for 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane do not always match the textbook profiles often cited. Across pharmaceuticals, agrochemical intermediates, fluoropolymer monomer feeds, and custom specialty chemicals, the consistent request remains: reproducibility and predictability. Customers relying on the C4 backbone with this specific halogenation sequence are often working at the edge of new materials, whether in advanced pest management compounds or as embedded blocks for fluorinated surfactant technologies.

    More than once, our team has worked alongside researchers aiming to bridge pilot-scale and commercial volumes. They routinely call out the difference in outcomes between off-the-shelf blends and highly controlled, in-house manufactured product. For them, mismatches in halogen content—even at the tenth of a percent level—can destroy a downstream coupling yield or polymer property. Our process, guided by years of hands-on feedback, maintains narrow compositional drift, giving development chemists a stable foundation.

    Sometimes, the discussion shifts to sustainability, and from a manufacturer’s view, the compound’s inherent stability and low loss rates during synthesis improve the process mass efficiency over many non-fluorinated analogs. Carefully tuned batch controls mean reduced waste generation, making a real-world contribution to greener chemistry initiatives. As a team that wrestles with halogen by-products daily, reducing even minor foulants improves air handling, worker safety, and, crucially, environmental compliance.

    Manufacturing Challenges and Solutions, Drawn from Shop Floor Reality

    Producing multi-halogenated butanes at commercial scale brings technical hurdles only fully appreciated by those clocking in day after day. Fluorination chemistry, in particular, demands specialized vessel materials and leak monitoring, while managing excess halogen gases and vent streams requires more than cookbook solutions. We regularly inspect our handling systems, double-checking joints and welds, since halogen embrittlement remains a constant risk lurking behind high uptime numbers.

    Quality management starts with feedstock selection, proven by numerous incidents where a supposedly equivalent chloride or bromide source, purchased for convenience, later caused a cascade of off-spec batches. Even seasoned procurement professionals learn these lessons after a handful of missteps. Within the plant, real-time trace monitoring and fast turnaround batch QA have become ingrained habits—not just regulatory box-ticking, but critical steps to avoid ruining entire production runs with a bad feed or an unexpected by-product.

    On the logistical side, drum and bulk container selection influences both safety and ease of product use. Early on, we saw issues from using general-purpose containers, leading to halide seepage and minor contamination, prompting us to shift to fluoropolymer-lined drums for this product family. That move trimmed customer complaints, kept batch records cleaner, and—most importantly—cut exposure incidents on loading docks and end-user facilities.

    How the Chemistry Drives Product Value: Lessons Built on Decades

    The value of 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane comes from its chemistry, and only regular handling and scaling experience reveals the big picture. Laboratory chemists might focus on yield for an experiment, but on the production floor, another set of realities surface. Batch-to-batch repeatability, lot traceability stretching back years, and careful documentation shape confidence in each drum.

    Out in the real world, differences from other halogenated butanes show up in places not always predicted by design: rates in batch reactors, color hold in storage, even compatibility with certain catalyst beds. Working side-by-side with technical customers, we’ve seen how a shift from a di-fluoro to a tri-fluoro backbone alters solubility ranges in mixed solvents. Exploratory customers in advanced polymerization often report changes in chain extension kinetics and end-group stability tied directly to the inclusion of this particular mixed halide.

    Some fine chemical customers ask about switching to bulk chlorinated or brominated alternatives, looking for short-term savings. The conversation always circles back to performance and risk. Nearly every time, end results in field trials signal that a dashed-off substitution leads to unreliable intermediates or downstream splits. Our experience tells us which structure works when you need certain halogen placements for specialty reactivity.

    Keeping Consistency, Protecting Stakeholders

    Decades of chemical production don’t just build expertise—they build responsibility. Each order shipped carries safety precedents, customer specs, and a history of continuous improvement efforts. Plant veterans understand how even routine blending and transfer chores present risks unique to these multi-halogenated butane series. Regular refresher courses, internal audits, and a work culture that encourages questioning decisions lower the chance of small oversights causing big problems. Every member on the plant floor, from maintenance to operators, contributes knowledge and action to ensure batches stay within spec and the product arrives safely at its destination.

    This kind of practical vigilance—paired with experience-driven tweaks to process and packaging—keeps the material’s advantages intact for customers. Whether responding to an urgent order shift or troubleshooting a manufacturing hiccup, everyone from production tech to QA draws on shared history with halogen-handling complications and lessons learned from both high and low moments.

    Supporting Evolving Applications and Advanced Development

    Customers approach us with questions on using 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane in emerging sectors, from high-performance coatings to electronics and specialty surfactant precursors. Out in the market, new polymer architectures or cross-coupling protocols often require this precise halogen sequence. We have supported process development teams bridging bench-top methods to commercial runs, confirming that the batch-to-batch purity and isomeric consistency only comes with controlled, plant-direct manufacturing.

    Our technical support often draws from direct handling and troubleshooting. Illustrative feedback from customers running scale-up trials underscores this point: access to fresh, tightly specified material means fewer issues with unwanted side-product formation, especially in fluoropolymer block co-polymer work. Other customers cite improved performance in agricultural chemistry actives, where controlled release or selectivity hinges on well-managed halogen layouts. Our technical and operations teams often work together to provide feedback, insights, and custom solutions drawn from firsthand experience on both manufacturing lines and in customer R&D partnerships.

    Safety, Compliance, and Sustainability—Practical Commitments, Not Slogans

    Safety and regulatory compliance build a foundation in this field, but they’re far from checklists. Everyone on the manufacturing side sees the impact of legislative changes, environmental audit cycles, and evolving industry guidelines. Halogen chemistry—especially with highly fluorinated intermediates—brings frequent review, both internally and from regulatory authorities. Routine process audits, operator retraining, and investment in improved containment and monitoring limit environmental escapes and exposure risks. Chasing emissions tighter with every cycle becomes part of the process, not just headline-friendly news.

    Conversations with EHS teams lead to regular upgrades: containment system improvements, waste minimization projects, and investment in more advanced air scrubbing. Our facility’s location has survived regulatory waves where “good enough” became “unacceptable,” and experience shows that anticipating inspector questions prevents shutdowns and smooths customer certifications.

    Reducing batch losses and product discard rates also supports both product economics and planetary stewardship—sourcing higher quality raw materials, minimizing halide waste, and streamlining purifications help keep us honest in our green chemistry ambitions. Regular data review, transparency with supply chain partners, and proactive engagement with clients support a collaborative, responsible operation—not a theoretical sustainability goal, but a lived practice where everyone benefits from less waste and tighter controls.

    The Power of Direct Manufacturing: Putting Knowledge and Control Front and Center

    Cutting out the noise of middle-men, brokers, and resellers means every question, every spec deviation, every unique use case comes straight back to the factory. That’s how lessons get captured and improvements deliver real impact. Our engineers, operators, and lab chemists see patterns and edge cases not filtered through another layer. Decades of bruised knuckles, celebrated successes, and lessons learned the hard way infuse every barrel of 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane that leaves our floor.

    Whether the compound is headed into a pilot reactor, a pharma intermediate step, or an advanced composites plant, we support every shipment with the confidence that comes only from knowing the chemistry inside, out—and the reality of how production-scale molecules behave. Our attention to the direct realities of synthesis and handling built this reputation: rigid focus on real-world process, technical transparency, and a practical approach to supporting our clients’ innovation. Each project—however novel or routine—gains from direct manufacturer engagement and a commitment to delivering chemical products that perform in today’s toughest applications.

    This is 2-Chloro-1,4-Dibromo-1,1,2-Trifluorobutane, not just from a spec sheet or data list, but from the lived experience of those producing it daily for clients who count on precision, reliability, and practical insight.