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2-Butene-1,4-Diol

    • Product Name 2-Butene-1,4-Diol
    • Alias Crotyl alcohol
    • Einecs 203-729-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    266751

    Cas Number 110-64-5
    Iupac Name But-2-ene-1,4-diol
    Molecular Formula C4H8O2
    Molar Mass 88.11 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 230 °C
    Melting Point 5 °C
    Density 1.118 g/cm3 at 20 °C
    Solubility In Water Miscible
    Refractive Index 1.474 at 20 °C
    Flash Point 127 °C
    Odor Mild, sweet

    As an accredited 2-Butene-1,4-Diol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 1-liter amber glass bottle sealed with a secure cap, labeled “2-Butene-1,4-Diol” with hazard symbols and handling instructions.
    Shipping 2-Butene-1,4-diol is typically shipped in tightly sealed containers or drums under cool, dry conditions. It should be protected from heat, sources of ignition, and incompatible materials. During transport, use appropriate hazard labeling and comply with shipping regulations for flammable liquids. Always refer to the Safety Data Sheet for specific handling guidelines.
    Storage 2-Butene-1,4-diol should be stored in a cool, dry, well-ventilated area away from incompatible materials such as strong oxidizers and acids. Keep the container tightly closed and away from heat and sources of ignition. Store in a corrosion-resistant container with a resistant inner liner. Protect from moisture and direct sunlight. Use secondary containment to prevent spills or leaks.
    Application of 2-Butene-1,4-Diol

    Applications of 2-Butene-1,4-Diol in Industrial Manufacturing

    2-Butene-1,4-diol serves as a specialty intermediate for several high-value industrial chemical manufacturing routes. It enables precise chemical transformations for advanced materials and fine chemicals production. Our facility ensures consistently high purity and tight quality specifications to support demanding downstream applications.

    1. Polyurethane Elastomer Production

    Major polyurethane producers utilize 2-Butene-1,4-diol as a chain extender and cross-linking agent for specialty elastomer systems, optimizing mechanical flexibility and hydrolysis resistance in final polymers. It reacts with diisocyanates in precise formulations, providing greater microphase separation and targeted physical property profiles for high-performance industrial elastomers compared to 1,4-butanediol or other diols.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for raw material traceability
    • REACH Regulation (EC) No 1907/2006 for registration and handling in the EU
    • OSHA 29 CFR 1910 for safe plant workplace procedures
    • Specific customer QC specifications (ASTM D3576 where applicable)

    Typical usage ratio

    • 5–25% of total polyol content, adjusted based on NCO/OH index and mechanical property targets
    • Ratio varies according to the reactivity of co-used polyether or polyester segments

    Downstream process integration

    • Dosed into the prepolymer stage with diisocyanates
    • Introduced prior to the mixing reactor for precise molecular weight control
    • Quality control through FTIR to monitor hydroxyl group conversion post-reaction

    Final product types

    • Custom polyurethane foams for automotive NVH components
    • Industrial elastomer rollers and gaskets
    • Hydrolysis-resistant spandex fibers
    • High-durability footwear sole compounds

    2. Synthesis of Pharmaceutical Intermediates

    Pharmaceutical manufacturers choose 2-Butene-1,4-diol as a core synthon in the synthesis of active pharmaceutical ingredient (API) intermediates, particularly for heterocyclic and unsaturated hydrocarbon building blocks. Its functionality enables selective hydrogenation, cyclization, and protection strategies under GMP guidelines for APIs where tetrahydrofuran fragments are required in the molecular backbone.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) standards for intermediate purity profiles
    • 21 CFR Part 211 for manufacturing quality systems
    • EMA Guidelines on the formalized risk assessment for drug substance starting materials

    Typical usage ratio

    • Mol-equivalent basis as dictated by the synthetic step; typically, a slight molar excess (1–1.2 equiv)
    • Ratio refined via in-process HPLC and NMR monitoring for optimal conversion

    Downstream process integration

    • Charged into a multi-step flow reactor at the intermediate synthesis stage
    • Pre-treated with catalyst systems for hydrogenation or cyclization to transform into pyrrolidine or tetrahydrofuran segments
    • Purification via preparative chromatography as per GMP impurity thresholds

    Final product types

    • API intermediates for antiretroviral drugs
    • Custom chiral precursors for oncology therapies
    • Tetrahydrofuran-based building blocks for API libraries
    • Intermediates for synthetic vitamins and hormone analogs

    3. High-Performance Polyester Resin Manufacturing

    Resin formulators incorporate 2-Butene-1,4-diol as a chain modifier during polyesterification for advanced unsaturated and specialty polyester resins. Its unsaturated bond introduces controlled reactive sites, enhancing cross-link density and enabling niche functionalization for corrosion-resistant coatings and high chemical stability resin systems.

    Industry compliance standards

    • ISO 14001:2015 for environmental management during polyester resin processes
    • EN 13986 for chemical emission limits in construction resins
    • DIN EN ISO 16757 for material performance testing
    • VOCs limits based on region-specific guidelines (e.g., US EPA 40 CFR Part 59)

    Typical usage ratio

    • Up to 10 mol% with respect to total glycol feedstock for unsaturated polyesters
    • Loading level fine-tuned according to the desired cross-linking degree and end-use environment

    Downstream process integration

    • Added at the esterification stage with phthalic anhydride or maleic anhydride feed
    • Post-addition vacuum stripping to minimize unreacted diol content
    • Final resin properties verified with GPC and DSC

    Final product types

    • Gelcoat and corrosion-resistant marine coatings
    • Molded fiberglass-reinforced polyester composites
    • Specialty can coatings for chemical filling lines
    • Weather-resistant sheet molding compounds (SMC)

    4. Chemical Intermediate for Tetrahydrofuran (THF) Production

    Producers of tetrahydrofuran utilize 2-Butene-1,4-diol as a direct precursor in catalytic hydrogenation processes. The controlled hydrogenation of the C=C bond yields high-purity THF, avoiding side-products often present in alternative routes. This method meets strict specifications for solvent and polymer-grade THF, suitable for demanding downstream transformations.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • Responsible Care® Management System for chemical safety
    • REACH registration for EU industrial users
    • JIS K2117:2012 for solvent-grade THF quality standards

    Typical usage ratio

    • 100% conversion target based on stoichiometric hydrogenation
    • Feedstock purity determined by downstream THF use, typically >99.5% input purity required

    Downstream process integration

    • Continuous feed to packed-bed or slurry-phase hydrogenation reactor with supported nickel or palladium catalysts
    • Careful control of temperature and pressure to maximize yield and reduce unwanted byproducts
    • Inline distillation to recover high-purity THF and recycle unconverted feedstock

    Final product types

    • Polymerization-grade tetrahydrofuran (polyTHF raw material)
    • High-purity solvent for pharmaceuticals
    • Solvent for specialty coating and adhesives
    • Electronic-grade THF for semiconductor processes

    5. Synthesis of Agrochemical Intermediates

    Agrochemical manufacturers incorporate 2-Butene-1,4-diol as a reactive intermediate in the synthesis of innovative pesticide molecule scaffolds, particularly for heterocyclic active ingredients. Its diol and alkene functionalities allow selective attachment of functional groups and enable cyclization reactions, providing access to customized molecular frameworks crucial for high-performance active ingredient development.

    Industry compliance standards

    • FAO/WHO Specification for pesticide technical grade requirements
    • ISO 17025 for laboratory process validation
    • Good Laboratory Practice (GLP, OECD Principles)
    • REACH registration for relevant agrochemical precursors

    Typical usage ratio

    • 5–15% based on the synthetic route and the complexity of target molecule
    • Reaction ratio optimized by yield analysis and impurity profiling with GC-MS

    Downstream process integration

    • Function as the core building block introduced at the condensation stage in multi-step fine chemical synthesis
    • Enables ring-closure or functional-group protection for selectivity during further transformation
    • Purification using column chromatography or crystallization, in-line documentation for batch traceability

    Final product types

    • Pyrrolidine-based insecticide intermediates
    • Synthetic template compounds for herbicide research
    • Custom designed fungicide scaffold molecules
    • Specialist precursors for biocatalyst screened agrochemicals

    6. Specialty Chemical Additive Formulation

    Additive and modifier producers select 2-Butene-1,4-diol as a functional ingredient for specialized antistatic and dispersing agents. The unique combination of vicinal diol and unsaturation allows its inclusion in formulations where cross-linkable or reactive polymer additives provide high-end compatibility and improved dispersion stability in polar media or resin systems. Custom formulations incorporate controlled doses to meet advanced materials’ customer requests for electronic and packaging applications.

    Industry compliance standards

    • ISO 10993 for additives in materials used with electronics
    • EPA TSCA listing for applicable additive chemistries in the US
    • QC protocols per customer NDA for transparency and repeatability
    • RoHS Directive 2011/65/EU for restricted substances in electrical/electronic applications

    Typical usage ratio

    • 0.1–5% by weight, tailored according to the base resin and desired additive effect
    • Ratio established via laboratory screening and validated by customer application testing

    Downstream process integration

    • Added during the compounding phase with active dispersants or antistatic agents
    • Dosed via high-shear mixing to secure uniform distribution and reactivity
    • Quality monitored by conductivity, turbidity or optical transparency benchmarks

    Final product types

    • Anti-static masterbatch additives for polymer films
    • Dispersant packages in inkjet or pigment concentrates
    • Performance modifiers for specialty adhesives
    • Electronic-grade resin modifiers
    Free Quote

    Competitive 2-Butene-1,4-Diol prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    2-Butene-1,4-Diol: A Manufacturer’s Perspective

    Understanding 2-Butene-1,4-Diol in the Chemical Landscape

    Daily, as we run the reactors, measure yields, and monitor quality, we get to see the nuances that set each chemical apart. 2-Butene-1,4-diol has earned a place as a core molecule in specialty manufacturing. It stands out due to how it handles under different process conditions and how it lines up with industry needs for high-purity intermediates. As a company that has spent years investing in refining diol synthesis processes, producing this molecule isn’t just a question of batch output—it's about consistency, reliability, and building trust with users across different fields.

    Product Profile & Typical Specifications

    From a technical point of view, 2-Butene-1,4-diol comes in as a clear, colorless liquid. We control the key purities to 99% or higher, with moisture and acidity checked every batch. The density falls in a reliable range, with boiling points and refractive index values regularly checked against standards. These tight controls are not arbitrary—they reflect years of conversations with polymer chemists, pharmaceutical formulators, and industrial engineers. Small impurities or off-spec batches introduce headaches down the line, so our approach revolves around steady raw material sourcing, constant monitoring, and fast troubleshooting once we spot slight variations.

    We offer R and S stereoisomers, giving users flexibility, though most demand the cis form. Isomer content directly affects downstream reactions, something often overlooked outside the plant floor. By running thorough stereochemistry checks, we can promise users a reliable profile batch after batch—no surprises that throw off catalysis or disrupt formulation.

    The Role of 2-Butene-1,4-Diol in Key Applications

    Our partners use this molecule mainly in the production of specialty polyurethanes, resins, and proprietary solvents. In polyurethanes, for example, the linear structure and unsaturation open up unique reactivity windows. The presence of double bonds offers crosslinking possibilities that architects of polymer chains appreciate, especially when traditional glycols limit the flexibility or toughness their clients are chasing for coatings or foams.

    In resin systems, the dual hydroxyl groups permit integration with isocyanates and other monomers. The result: stronger, more chemical-resistant materials. Formulators tune ratios to exacting standards, and our material lands in their process as a trustable input. We’ve worked with users who tweak small variables—temperature, initiators, residence time—to suit their proprietary resins, and the consistent behavior they seek only comes when the backbone diol matches prior performance.

    Comparing With Other Diols and Unsaturated Alcohols

    There’s often confusion over what makes 2-butene-1,4-diol special, especially as other diols can look similar if you’re only reading catalog pages. As a producer, we see firsthand why this molecule fits certain jobs but not others. Compared with 1,4-butanediol, 2-butene-1,4-diol brings an extra level of chemical flexibility thanks to its double bond. The extra reactivity lets formulators take advantage of addition reactions that are unavailable if the backbone is fully saturated like in the butanediol case.

    We often receive requests for comparison samples or technical consultations involving 2-butene-1,4-diol and glycols such as ethylene glycol, propylene glycol, or longer-chain molecules. In almost every case, the difference comes down to reactivity and downstream processing: if an unsaturated handle is required, 2-butene-1,4-diol wins. If the process seeks pure flexibility with no reactive sites, others take the lead. The fact that our product can serve both as a starting material and an intermediate opens doors in custom synthesis. This versatility isn’t academic; it comes back to how well we’re able to keep purity high and contamination low throughout the reaction setup, distillation, and finishing phases.

    Manufacturing Realities and Quality Control

    Running a plant making 2-butene-1,4-diol at scale involves more than just following a standard recipe. Raw material quality shapes the whole pathway. In periods of supply crunch, small deviations in the feedstock can ripple into the final product. We learned over time that investing in better dehydration and purification technologies pays dividends every year, not just in fewer complaints but in building a reputation as a supplier who doesn’t cut corners. Small things—like batch traceability, headspace analysis for solvent residues, and active discussions with end users—make the difference.

    After launching a third distillation column two years ago, our rejection rates dropped sharply. A single off-specification batch can cost days in downstream customer plants, so it’s not a margin game. Laboratories now run real-time gas chromatography snapshots, and the operations team maintains logs that track tiny shifts in process variables. The better we understand how the molecule behaves across temperature and pressure changes, the more confidently we meet the needs of sophisticated users in coatings, adhesives, and advanced materials.

    Storage, Handling, and Safe Shipping

    Our experience confirms that 2-butene-1,4-diol stays stable under normal warehouse conditions, provided it avoids strong oxidizers and isn’t exposed to extreme heat. The hydroxyl and alkene functional groups give it certain sensitivities you won’t see with a saturated diol. We pack the product in steel drums, totes, or bulk tankers lined with protective coatings to prevent product loss or contamination. Over the years, we’ve optimized storage recommendations, emphasizing clean, moisture-free conditions with vapor barriers where possible.

    Shipping logistics teams flag batches that show elevated acidity or color, stopping any material from leaving until it clears all checks. We regularly retrain freight partners about temperature needs and drum handling procedures. It’s not about worrying for worry’s sake—customers rely on uninterrupted supply. Unexpected degradation, water ingress, or transit heating reduce utility, even if every number checks out on paper.

    Technical Support Beyond the Lab

    Customers often run into issues not found in textbooks. One partner once noticed a slight haze in their polymer batch, traced back to a subtle impurity in a diol shipment. Because our engineering staff runs frequent process and impurity mapping, we traced the contaminant to a minor equipment glitch and resolved it within days. There’s no formula for these troubleshooting events. They depend on a producer’s years of understanding both the chemistry of the product and the quirks of their own facilities.

    We field requests for custom volumes, specialized handling instructions, and technical reviews of application-specific data. We pride ourselves on transparency—if something shows up in quality control that doesn’t match past benchmarks, customers know quickly. Adaptation is the rule. Standard solutions rarely fit real supply chains with their own temperature spikes, batch-to-batch variation, and unique end-user faucet points.

    Environmental Responsibility and Process Optimization

    Environmental stewardship is not a marketing slogan; it's a daily operational metric. In making 2-butene-1,4-diol, waste minimization and byproduct recovery rank as top process goals. Across a typical production run, any unreacted feed or inefficient catalyst use shows up not only as yield loss, but as a long-term challenge for wastewater treatment and air emission management. By incorporating closed-loop chilling, vapor recovery, and continuous process data review, we’ve cut solvent and water usage significantly over the past five years.

    One example: streamlining the hydrogenation stage reduced both processing time and on-site energy costs. Small investments in flow monitors and reaction heat recovery show up as real savings, both for us and downstream customers who depend on stable pricing and supply. These adjustments, born out of operational necessity, matter for the environmental audit chain. We remain accountable for our environmental footprint due to regulatory, social, and customer-driven feedback, not just for compliance reporting.

    Innovations in Synthesis and Scale-Up

    No two facilities make their 2-butene-1,4-diol the same way. Our production pathway has evolved through years of pilot work and feedback from chemists running real-world syntheses. With batch and continuous-flow options available, our ability to adjust throughput and purity on tight schedules gives a genuine competitive edge. By investing in catalyst technology and integrating better online monitoring, we catch trends before they become problems—a lesson learned through a few hard years of troubleshooting unexpected residue or off-odor complaints.

    Scale-up challenges never stop. Achieving consistently high selectivity with minimal side reactions means we regularly reassess process bottlenecks. This isn’t academic theorizing—our engineers hold direct accountability for resolving the root cause, from pump performance analytics to monitoring the complete reaction fingerprint by high-end spectroscopy.

    Working Closely With Customers for Unique Solutions

    Users often push the limits of what 2-butene-1,4-diol can do. R&D teams develop new elastomers, UV-cured coatings, and performance plastics that call for not only a base diol, but one with certain impurity profiles or altered water content. We learn most about our own process from these requests. For instance, delivering product that meets the fine balance between unsaturation for reactivity and hydroxy balance for crosslinking capacity depends on precise process management. End-use testing, pilot feedback, and iterative analysis have helped us move away from ‘one size fits all’ offerings into partnerships that depend on deep product knowledge.

    By jointly troubleshooting new applications—addressing yellowing, controlling gel times, optimizing for downstream polymerization—we share responsibility for the final outcome. This shared accountability turns into robust product performance, decreased user downtime, and mutually beneficial long-term relationships. It’s in these cycles of improvement and transparency that we see the real value of working as a producer, not just a seller.

    Regulatory Trends and Compliance Challenges

    As expectations for chemical traceability and purity increase, regulatory reporting becomes integral to daily operations. Specialty chemicals face rising scrutiny for trace impurities—phthalates, residual solvents, and unreacted monomer content draw attention from both authorities and sophisticated buyers. We invest in upgrading analytical capabilities and updating all documentation so every shipment stands up to audit-grade review. Lab teams run more extended impurity panels and new tests long before users ask for them, removing the risk of unpleasant surprises.

    Process records must link every output to precise plant conditions, batch logs, and incoming raw materials. The reality is, regulators and large customers want immediate answers to any question about provenance or safety. Through digitization of process files and tighter integration with our supply chain partners, our operation is ready for today's higher level of scrutiny.

    Market Shifts and Forward-Looking Adjustments

    The demand profile for 2-butene-1,4-diol changes as new materials and technologies emerge. Over the past decade, we’ve seen cycles where polyurethane innovations drive volume jumps, followed by increased calls from pharmaceutical firms looking for specialty intermediates. Each shift brings new specs requirements, tighter impurity tolerances, or calls for different isomer balances. We’ve built flexibility into both the plant and the business mindset for exactly these market turns.

    Larger users sometimes need huge bulk consignments with JIT delivery. Boutique clients might need just a drum, but with a level of purity only possible through special routes or post-processing. Scaling up or down isn’t a matter of flipping a switch. Plant teams plan maintenance, adjust feedstocks, or reroute output streams to hit both high-volume orders and special requests, guided by the principle that reliability beats short-term shortcuts.

    Continuous Improvement by Living the Process

    We gain the deepest insights into product performance by interacting closely with the chemistry, equipment, and people every day. Our product isn’t just a data sheet—it reflects countless hours spent testing process changes, reviewing analytical trends, and working with users through formulation or processing challenges. Real improvement doesn’t come from theoretical plans; it grows from direct connections with evolving customer needs, shifts in the regulatory context, and the lessons learned by every team member as they solve practical problems.

    At the core, 2-butene-1,4-diol represents the results of deliberate investments in technology, expertise, and long-term partnerships. Each batch bears the mark of operational experience and the willingness to adapt that drives our reputation in the chemical industry. For users who depend on stable input quality, technical transparency, and ongoing dialogue about product adjustments, the difference is tangible. Every molecule that ships out of our site is part of that tradition of consistency and real-world problem solving, shaped daily by the hands that make it.