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(2-Bromoethyl)Benzene

    • Product Name (2-Bromoethyl)Benzene
    • Alias Phenethyl bromide
    • Einecs 202-322-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    983031

    Iupac Name 1-Bromo-2-phenylethane
    Cas Number 103-63-9
    Molecular Formula C8H9Br
    Molecular Weight 185.06 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 220-221 °C
    Melting Point -56 °C
    Density 1.35 g/cm³ at 20 °C
    Refractive Index 1.551
    Solubility In Water Insoluble
    Flash Point 90 °C (closed cup)
    Purity Typically ≥98%
    Smiles Brc1ccccc1CC
    Synonyms 2-Phenylethyl bromide; Benzene, (2-bromoethyl)-
    Storage Conditions Store at room temperature, tightly closed, away from light

    As an accredited (2-Bromoethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 grams of (2-Bromoethyl)benzene, tightly sealed, labeled with hazard warnings, product details, and safety instructions.
    Shipping (2-Bromoethyl)benzene is shipped as a hazardous chemical, typically in tightly sealed glass or HDPE containers to prevent leaks and exposure. It should be labeled with appropriate hazard warnings and packed according to applicable regulations (such as DOT, IATA, or IMDG). Store and transport in a cool, well-ventilated area, away from incompatible substances.
    Storage (2-Bromoethyl)benzene should be stored in a cool, dry, and well-ventilated area, away from sources of heat, ignition, and direct sunlight. Store it in a tightly sealed container made of compatible materials. Keep it separate from strong oxidizers and bases to prevent unwanted reactions. Ensure proper labeling and secure it within a designated chemical storage cabinet designed for corrosive or halogenated compounds.
    Application of (2-Bromoethyl)Benzene

    Applications of (2-Bromoethyl)Benzene in Industrial Manufacturing

    (2-Bromoethyl)Benzene serves as a valuable building block in advanced organic synthesis for several industries requiring reliable functional group introduction. Our direct production ensures stringent quality control, traceability, and consistent supply for specialized downstream processes demanding pure haloalkyl intermediates. The following application scenarios illustrate implemented use across fine chemical synthesis, agrochemical production, and pharmaceutical development.

    1. Pharmaceutical Intermediate for Active Pharmaceutical Ingredient Synthesis

    Pharmaceutical manufacturers utilize (2-Bromoethyl)Benzene to introduce a phenethyl moiety onto active molecular scaffolds, especially for the synthesis of antihypertensive and antipsychotic drug substances. Its benzylic bromoethyl group provides a controlled reactivity for nucleophilic substitution needed in the preparation of critical intermediates for final API synthesis, where traceability and GMP-grade sourcing are mandatory. Facilities integrate the material in batch or semi-continuous production as part of their registered routes, with strict adherence to validated process controls and impurity profiles documented for regulatory submissions.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU Guidelines for GMP Part II (APIs)
    • US FDA 21 CFR Parts 210–211 (Drug Product and API manufacturing)
    • Relevant pharmacopeia monographs upon final API testing (e.g., USP, EP)

    Typical usage ratio

    • Stoichiometric use, typically 1.0–1.3 molar equivalents relative to nucleophile; exact excess determined by downstream conversion yield targets and side-product minimization studies

    Downstream process integration

    • Introduced during alkylation or substitution steps post-initial scaffold assembly, often under phase-transfer or solvent-mediated conditions using controlled base or catalyst addition
    • Followed by downstream hydrolysis, amination, or coupling reactions depending on the specific API synthesis pathway

    Final product types

    • Antipsychotic APIs such as benperidol-type intermediates
    • Beta-blocker intermediates
    • Hypertension drug precursors containing phenethyl motifs
    • Niche CNS-active pharmaceutical ingredient segments

    2. Agrochemical Intermediate for Herbicide and Plant Growth Regulator Production

    Agrochemical manufacturers incorporate (2-Bromoethyl)Benzene during synthesis of selective herbicide actives and plant regulators requiring a benzylic bromoalkyl structure. The material acts as a key alkylating agent, introducing hydrophobic side chains for target selectivity and field stability. Downstream process design mandates robust environmental controls and hazard evaluation to comply with evolving agricultural chemical production standards. Quality assurance protocols address residual bromide specifications in the resulting technical-grade actives.

    Industry compliance standards

    • FAO/WHO Technical Specifications for Plant Protection Products
    • OECD GLP Principles for industrial pilot and full-scale synthesis
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) for European production/import
    • National pesticide registration guidelines (e.g., US EPA 40 CFR Part 158)

    Typical usage ratio

    • Applied at 1.05–1.2 molar equivalents in the main alkylation stage; adjusted up to 1.5 equiv for multi-step syntheses requiring higher conversion assurance

    Downstream process integration

    • Dosed into the primary synthesis reactor after activation of target nucleophile, typically with alkali bases or amide catalysts
    • Followed by in situ work-up steps, phase separation, and distillation prior to formulation of the technical concentrate

    Final product types

    • Precursor compounds for substituted phenethylherbicides
    • Growth regulator active ingredients with benzylic linkers
    • Technical-grade plant protection products for blending
    • Specialty intermediates for proprietary agrochemical molecules

    3. Intermediate in Synthesis of Functional Dyes and Colorants

    Chemical manufacturers in the colorant sector use (2-Bromoethyl)Benzene to introduce functionalized phenethyl branches for azo and triphenylmethane dye bodies. Its reactivity supports specific chromophore modifications, improving dye fastness and substrate affinity in textile or plastic masterbatch applications. Strict analytical controls confirm residual halide absence and verify downstream process conversion, as mandated by legislation on dye purity and environmental impact.

    Industry compliance standards

    • OEKO-TEX Standard 100 for dyes in textiles
    • EU Regulation (EC) No 1907/2006 (REACH Annex XVII restriction of hazardous substances)
    • EN 71-3 (Toy Safety – Migration of certain elements)
    • ISO 9001 Quality Management Systems relevant for pigment and dye manufacture

    Typical usage ratio

    • Used at 1.1–1.4 molar equivalents in dye precursor synthesis; increased ratio for higher-coupling yields or when downstream chromatographic purification is feasible

    Downstream process integration

    • Added to functional group introduction stage prior to azo coupling or oxidation, often under controlled temperature and multi-solvent conditions
    • Subsequent neutralization, filtration, and spray-drying prior to blending into the final dye concentrate

    Final product types

    • Modified azo dyes for polyester and acetate textiles
    • Benzylated triphenylmethane colorants
    • Branched chain dyes for high-performance plastics
    • Coloring agents with improved migration resistance

    4. Synthesis of Liquid Crystal Monomers for Display Materials

    Producers of advanced materials rely on (2-Bromoethyl)Benzene in the formation of liquid crystal monomers, using its structure to provide flexible spacers or induce targeted dipole interactions for nematic and smectic phase control. Downstream operations demand high-purity feedstocks to suppress ionic and particulate contamination, meeting stringent electronic display device standards. The intermediate enters tightly controlled synthesis environments equipped with dry gas operations and sensitive reaction monitoring to meet specification parameters established by electronics industry consortia.

    Industry compliance standards

    • IEC 61249-2-21 (Materials for printed boards and other interconnecting structures — Part 2-21: Reinforced base materials)
    • JEITA Rules for Electronic Display Materials (Japan Electronics and Information Technology Industries Association)
    • ISO 9001 and ISO 14001 for electronics chemical production
    • Customer-specific purity and ionic content guidelines for OLED/LCD materials

    Typical usage ratio

    • Dosed at 1.0–1.25 molar equivalents in step-growth or chain-extension reactions; usage levels determined by functional group reactivity and performance requirements of the final monomer

    Downstream process integration

    • Introduced at spacer installation or side chain functionalization stage, generally under dry, oxygen-free conditions followed by purification through recrystallization or high-vacuum distillation
    • Final monomers undergo blending, thin-film formation, and optical testing prior to shipment

    Final product types

    • Liquid crystal monomers for LCD and OLED displays
    • Intermediate materials in TFT and flexible electronics manufacturing
    • Specialty compounds for optoelectronic device development
    • High-purity chemicals for photonics and sensor markets
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    Certification & Compliance
    More Introduction

    Understanding (2-Bromoethyl)Benzene from a Manufacturer’s Lens

    Introduction to (2-Bromoethyl)Benzene: Built from Each Day in Production

    Every chemical has a story, and (2-Bromoethyl)Benzene’s story unfolds daily on the production line. This compound’s reputation isn’t built from mere theory or catalog entries—it’s shaped by the demands of practical industry work and the need for a consistent, reliable building block in synthesis. From each batch, minute adjustments and careful observation go into producing a material users can trust, minimizing downtime and rework. In our factory, (2-Bromoethyl)Benzene’s signature attributes start with carefully sourced raw benzene, modern bromination technology, and on-hand experience to keep the process running safely and cleanly.

    Product Model and Key Specifications: The Stuff Behind the Name

    Model: (2-Bromoethyl)Benzene C8H9Br (CAS: 103-63-9). We manufacture this compound as a clear, faintly aromatic liquid under standard conditions, with a typical purity running above 99%. Each lot passes close GC validation for bromide content, and free phenethyl base assessment. Water content holds low by design, tracing beneath 0.5% due to controlled distillation, and we target a low halide contaminant baseline, reflecting down-to-earth attention to source purity and reactor conditions.

    Industrial customers ask about appearance, odor, and shelf stability before they care about jargon or paperwork. This product comes as a colorless to pale yellow clear liquid; if oxidation sets in, even slight yellow hints act as an early warning. Properly stored in dry, sealed steel or amber glass, it holds up for months without breakdown—a test we routinely confirm with our own retained samples. For bulk buyers: we offer drum quantities or intermediate containers, filled under nitrogen to prevent any risk of hydrolysis.

    Production Details: From Reactor to Drum

    Years at the reactor show the difference between simply making a chemical and making one that keeps end-users coming back. Our (2-Bromoethyl)Benzene relies on a batch bromination method, pairing consistent agitation with sharp temperature control to drive selectivity and minimize byproducts—especially dibromo and unwanted aromatic impurities. Each cook involves halide control, regular sampling, and immediate response to even the smallest color or odor change. Little details, like pre-treatment of raw benzene and fast quenching, pay off in purity and reactivity for downstream users.

    Next comes fractionation, a step sometimes skipped in less-experienced facilities. Proper distillation shapes the final profile—cutting out top and bottom fractions. Those cuts appear small in numbers, but they transform into an actual reduction in non-volatile residue and inconsistent behavior during customer syntheses. Our operators track pressure, condenser temperature, and reflux split vigilantly. QC keeps GC standards and calibrations active for every production cycle, and managers routinely audit both batch sheets and the physical stations.

    Application Insights: Real-World Chemistry Drives Decisions

    Lab and plant users know that (2-Bromoethyl)Benzene opens doors that standard alkyl bromides close. Its most common industrial destinations are as a precursor for pharmaceuticals, specialty solvents, and functionalized polymers. The ethyl-benzene backbone brings together aromatic stability with aliphatic reactivity, so organic chemists treat it as a launching point for Grignard reactions, carbon chain extensions, and for introducing the phenethyl moiety in syntheses. Each ring gets brominated under controlled conditions, so our clients in drug research and intermediate production rely on its consistent behavior—batch to batch, year after year.

    Smaller alkyl bromides like ethyl bromide tend to volatilize, risk runaway, or slip into vapor loss. Less-experienced users learn quickly that failure to control volatility turns into safety headaches or process yield loss. But (2-Bromoethyl)Benzene’s boiling point sits higher, its vapor pressure comes in more manageable, and bench chemists appreciate the extra handling window. In practice, this means fewer losses in open-flask stages, and less risk during work-up and purification.

    Pharmaceutical research positions this chemical as a key intermediate in certain antihistamines, CNS therapeutics, and as a foundation for tailored sidechains. We have seen it move from the pilot plant to kilogram-scale in fine chemical synthesis, supporting medicinal chemistry teams looking to build in controlled aromatic character. Polymer chemists also incorporate it, leveraging its backbone to craft new functionalized materials. Directly from experience, stability and purity often determine whether a synthesis runs smoothly or leads to extra purification steps down the line—a reality many in the business have lived through.

    Differences from Similar Products: Practical Lessons Learned

    Not every brominated aromatic can substitute for (2-Bromoethyl)Benzene. Compare it to benzyl bromide, for instance: benzyl bromide brings a simple, reactive CH2Br group, but also much greater lachrymatory and handling issues, making accidents or skin exposure far more likely. Over years, customers tell us that (2-Bromoethyl)Benzene—although needing solid ventilation and care—remains easier on operators and equipment and shows less corrosion risk in most settings.

    From our vantage in manufacturing, traditional mono-bromo aromatics often deliver lower chain reactivity, leading to stubborn conversion yields and inconsistent downstream chemistry. Our product’s two-carbon chain offers a spacing advantage when constructing longer molecules, providing that added flexibility when assembling sidechains or modifying aromatic cores. Commercially, this sets up (2-Bromoethyl)Benzene as a preferred intermediate when simple benzylic materials fall short.

    Dibromides and polybrominated analogs promise reactivity but come with costlier purification and sometimes trigger regulatory snags at export. Focusing on mono-brominated, well-fractionated materials like ours keeps processes streamlined, reduces downstream waste, and lets QA/QC efforts concentrate on the end product, not intermediate clean-up. Working closely with polymer manufacturers, we see this product solve practical issues—giving engineers an option that balances chemical potential with sensible storage, lower hazard classification, and multi-industry compatibility.

    Challenges in Manufacturing and Solutions: Lessons from the Shop Floor

    The underlying challenge in (2-Bromoethyl)Benzene production lies in controlling side reactions. Any careless temperature spike or feed irregularity can introduce dibromides, unwanted isomers, or off-odors. Our solution: strict process auditing and continuous operator training. Even one inattentive moment can have a ripple effect on yield, purification cost, and final usability. Each line worker undergoes regular retraining—not just on paper, but hands-on with actual batches and QA personnel overseeing every deviation report.

    Managing bromine use and neutralization also tests any manufacturer’s capabilities. Off-gassing, environmental control, and safe venting call for robust fume systems and reliable personal protection protocols on the plant floor. Modern air handling, dedicated scrubbing towers, and solid emergency drills create a safer environment not just for our people, but for the local community as well. Whenever regulatory guidelines update, we review them against our existing practices and bring in external safety engineers to check gaps and reinforce learning.

    Logistics and packaging, though lower profile, take real planning. If a shipment leaves our loading dock on a humid summer day, the risk of slow hydrolysis or label degradation rises. Extra care goes into drying, nitrogen blanketing, and scheduling early-morning or late-evening loads to sidestep temperature spikes. The lessons here do not read like textbook solutions—they come from hard-won trial and error, learning about seal choices, vapor barrier effectiveness, and real-world temperature excursions in container yards.

    Purity and Reproducibility: Why They’re Not Marketing Slogans

    Trust in chemical supply means consistent purity, day after day. Some plants chase the highest possible purity without understanding what their real users need, leading to higher costs or wasted effort. We’ve worked with R&D and production teams who appreciate not chasing “numbers for numbers’ sake” but achieving the critical purity threshold that guarantees reaction completeness, minimizes byproduct interference, and reduces odor and color impurities that muddy downstream work.

    As a manufacturer, seeing repeat business tells you when your approach works: when a kilo-scale pharma team places the same order, or a fine chemicals company requests specific lot data because their own process glitches vanished after switching supply. Instead of keeping purity checks in the lab alone, we invite plant supervisors to join review cycles—giving the teams who run reactions a direct say in what counts as good product.

    More than paperwork, we hold back retains from each main batch, test shelf life, and run periodic spot checks against new samples. That’s how we confirm that actual long-term stability matches the numbers promised at delivery. Any deviation triggers a root-cause dig, and findings loop into production training.

    Supporting Client Success: Beyond the Order Sheet

    Our relationship with clients doesn’t pause after the bill of lading. One large pharmaceutical customer approached us about minor residual odor dissatisfaction—the sort many traders might brush off. We invited their chemists for a plant visit, traced the source to a subtle batch byproduct, and rebuilt a section of our fractionation protocol to address their concern. Soon after, the same team returned, reporting cleaner HPLC baselines and more straightforward purification in their pilot trials.

    Polymer manufacturers working with us have flagged subtle viscosity drift in their formulations tied to trace impurities. In response, we partnered over several monthly lots to map each impurity pathway, using parallel distillation and routine analytical panel reviews. Fixing these invisible roadblocks means collaborative work—not simply sending a COA, but opening up batch notes and inviting feedback from those actually using the product in reactors and extruders.

    Market Demands and Future Trends: Reading the Signs Early

    Shifts in the chemical industry don’t wait for news feeds. Years of supplying (2-Bromoethyl)Benzene show that user expectations keep moving: lower environmental footprint, tighter traceability, and clear innovation in product form. Green chemistry trends ask us to minimize waste, design safer reaction protocols, and make recycling or recovery options easier downstream. We respond first in our own process, targeting less solvent wash generation, improved bromine recovery, and regular updates to staff on eco-friendly production methods.

    Regulatory requirements push us to document every sourcing and handling method. End-users expect detailed, transparent data on impurity profiles, origins of key raw materials, and on-the-ground safety procedures. We work with third-party auditors and customer QA staff to keep records not just complete, but open for inspection. This builds trust, and lets customers know exactly what stands behind each lot they purchase. Instead of shuffling documentation, we treat compliance as a tool for improvement, not just an obligation.

    Continuous Improvement: Stories from the Production Line

    Making (2-Bromoethyl)Benzene is less about “just good enough” and more about a live commitment to get better—batch by batch, year after year. Our team logs process anomalies, tracks near-misses, and finds ways to feed these lessons into safer, cleaner, and more reproducible runs. Even outside the main reactors, warehouse and packaging staff meet regularly to discuss shipment performance, weather-related incidents, and long-term product integrity.

    Periodic plant shutdowns, planned well in advance, give space for overhaul and unexpected discoveries. We replace seals, inspect control wiring, and swap out outdated valves—practices that help prevent unplanned breakdowns and surprise contamination. These investments pay off, as seen by lower reject rates and more stable inbound QA reports from loyal clients.

    Supporting Traceability and Transparency: What Buyers Deserve

    More buyers, especially from pharma and specialized material sectors, come to us with increasing traceability requests. We field them not as burdens, but as part of honest business. Digital batch records, sample tracking, and source transparency all shape confidence that you’re buying consistent, legally sourced material. If a product recall or inquiry does happen, we have every batch traced, mapped, and ready to answer hard questions with real data from the shop floor.

    In years past, some markets might have tolerated “good enough” documents or loose handling details. Today, we see serious end-users send technical teams to our site for firsthand checks—sometimes more than once in a year. We always reinforce that open-door policy, embracing scrutiny as a spur to raise our own standards.

    Choosing (2-Bromoethyl)Benzene from the Source: The Manufacturer’s Difference

    Any buyer deciding where to source (2-Bromoethyl)Benzene faces many product options, but few come straight from the hands that built them. As an actual manufacturer, we see the difference in our daily attention to raw material acceptance testing, reactor operation, close monitoring of each process parameter, and the living knowledge of both managers and operators. Our people have weathered supply disruptions, regulatory shifts, equipment issues, and a steady stream of customer feedback—lessons that shape each liter we deliver.

    For developers designing new routes or scaling up a proven process, the reliability in purity, physical character, and supply responsiveness counts more than any sales pitch. We field questions that traders, brokers, and resellers can’t answer—why a color shift appeared after three months, how bulk storage interacts with humidity, whether an invisible impurity could explain an unexpected lab side outcome. These are the everyday challenges that shape a manufacturer’s confidence and define genuine partnership.

    Final Thoughts: Value Built from Experience

    Our story with (2-Bromoethyl)Benzene unfolds through each challenge solved, each lot perfected, and each customer relationship earned. For every specification on a data sheet, there’s a human story of work, learning, and real improvement. Handling chemistry this way supports not only industrial progress but a safer, more traceable, and collaborative industry for all stakeholders. In our experience, this makes all the difference for those who depend on this key intermediate for their next innovation—now and in the years to come.