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2-Bromo-2-Butene

    • Product Name 2-Bromo-2-Butene
    • Alias 1-Bromo-2-butene
    • Einecs 211-234-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    272753

    Chemicalname 2-Bromo-2-butene
    Molecularformula C4H7Br
    Molarmass 135.00 g/mol
    Casnumber 7646-97-7
    Appearance Colorless to light yellow liquid
    Density 1.34 g/cm³
    Boilingpoint 91-93 °C
    Meltingpoint -77 °C
    Refractiveindex 1.462-1.464
    Flashpoint 25 °C
    Solubilityinwater Insoluble
    Vaporpressure 29 mmHg (20 °C)

    As an accredited 2-Bromo-2-Butene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, securely sealed, labeled “2-Bromo-2-Butene, 100 mL,” with hazard warnings, chemical formula, and handling instructions.
    Shipping 2-Bromo-2-butene is shipped in secure, tightly sealed containers, typically glass or compatible plastics, to prevent leaks and contamination. It should be transported at ambient temperature, away from heat, ignition sources, and incompatible materials. Shipping labels must indicate it is a flammable, hazardous chemical, and all local regulations and safety protocols must be followed.
    Storage 2-Bromo-2-butene should be stored in a cool, dry, well-ventilated area away from sources of ignition, heat, and direct sunlight. Keep the container tightly closed and properly labeled. Store separately from incompatibles such as strong oxidizers and bases. Use corrosion-resistant shelves and ensure appropriate spill containment. Follow all relevant safety guidelines and wear suitable protective equipment when handling.
    Application of 2-Bromo-2-Butene

    Applications of 2-Bromo-2-Butene in Industrial Manufacturing

    2-Bromo-2-butene is an important alkyl halide intermediate widely incorporated in fine chemical syntheses across several specialized industrial downstream routes. As the direct manufacturer, we support customers with technical compliance and formulation guidance for key applications described below.

    1. Pharmaceutical Intermediate Production

    Used as an alkylating agent, 2-bromo-2-butene participates in the synthesis of active pharmaceutical ingredient (API) side-chains, including intermediates for anti-infective agents and CNS modulators. Our customers deploy it mainly in N-alkylation and C-alkylation reactions for building complex molecules, where tight process controls on purity and reaction byproducts are essential to meet regulatory requirements.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 211 US FDA cGMP for Finished Pharmaceuticals
    • EU EudraLex Volume 4 GMP
    • Pharmacopoeias: USP, EP (if product intended for regulated markets as an intermediate)

    Typical usage ratio

    • 0.9–1.2 mole equivalents per targeted alkylation group, adjusted according to reactivity of the nucleophile and process yield optimization.

    Downstream process integration

    • Dosed at the intermediate building block stage, typically after protection group deprotection, and followed by purification steps to remove inorganic bromide residues and possible side products.

    Final product types

    • API intermediates for antibacterials (e.g. beta-lactam derivatives)
    • Selected CNS active compound intermediates
    • Other fine chemicals for contract manufacturing organizations

    2. Agrochemical Active Ingredient Synthesis

    Manufacturers use 2-bromo-2-butene in the alkylation of functional cores for agrochemical active ingredient production, ensuring precise installation of alkyl groups on aromatic or heterocyclic frameworks. This yields crop protection actives with optimized field stability and absorption characteristics, with attention to minimizing halogenated byproducts in compliance with agricultural residue regulations.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for Chemical Production
    • FAO/WHO Specifications for Plant Protection Products
    • REACH (EC) No 1907/2006 for manufacturing and downstream use in the European Union
    • US EPA Pesticide Registration Requirements

    Typical usage ratio

    • 1.05–1.15 equivalents relative to nucleophilic substrate, adjusted for selectivity and minimizing unreacted alkyl halide.

    Downstream process integration

    • Applied post-core synthesis in final alkylation, with downstream work-up involving phase separation and multi-step solvent washes to ensure agricultural-grade purity. Spent material is removed in compliance with controlled emissions and waste management protocols.

    Final product types

    • Pre-emergent and selective herbicide intermediates
    • Insecticide API precursors
    • Fungicide intermediate compounds

    3. Specialty Polymer Modifier Manufacturing

    Polymer chemists incorporate 2-bromo-2-butene as a functional vinyl halide to introduce reactive pendant groups or backbone modifications in specialty acrylics and engineering polymers. The bromine functionality allows for controlled grafting reactions, enabling tailored polymer architecture for customer-specific physical and chemical resistance.

    Industry compliance standards

    • ISO 14001 Environmental Management Standards for Chemical Manufacturing
    • ISO 10993 Biocompatibility for medical-grade polymers, where relevant
    • RoHS Directive 2011/65/EU if used in electronic or electrical applications
    • China GB/T 4946 for synthetic resin and plastic material production

    Typical usage ratio

    • 0.5%–5% by weight as a comonomer or modifier, with final ratio determined by polyolefin or acrylate copolymerization targets and property testing

    Downstream process integration

    • Fed into bulk or solution polymerization unit after initiator addition, allowing controlled grafting or crosslinking with monitoring of monomer conversion and bromine content through QC batch sampling.

    Final product types

    • Impact modified acrylic sheets
    • Specialty elastomers
    • Adhesive and coating resins with tailored polarity and durability

    4. Organic Synthesis Reagent for Fine Chemical Contract Manufacturing

    Contract manufacturing organizations apply 2-bromo-2-butene as a versatile alkylating agent in the production of a wide range of fine chemicals, where structure-specific synthesis routes demand consistent lot-to-lot quality and secure handling of reactive alkyl halides in scale-up. Compliance with chemical handling regulations and batch traceability forms a critical part of product stewardship and customer audits.

    Industry compliance standards

    • ISO 9001:2015 for Quality Management in custom chemical synthesis
    • Responsible Care® Global Charter for chemical manufacturers
    • Specialty chemical industry standards (e.g., SOCMA ChemStewards)
    • GHS (Globally Harmonized System) for chemical labeling, transport, and storage

    Typical usage ratio

    • Stoichiometry varies widely, typical range 1.0–1.2 mole equivalents depending on the substrate type and pilot scale process kinetics; adjusted for yield and waste minimization per contract specifications.

    Downstream process integration

    • Charged during batch-wise alkylation stages, either in glass-lined reactors or stainless steel vessels, followed by phase separation and successive washes to ensure full conversion and residual halide content control, prior to isolation of target fine chemical.

    Final product types

    • Pharmaceutical research intermediates
    • Flavors and fragrance intermediates
    • Specialty colorant building blocks
    • Laboratory-use reference materials
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    Certification & Compliance
    More Introduction

    Introducing 2-Bromo-2-Butene: Practical Insights from the Workshop Floor

    The Backbone of Small-Chain Bromoalkene Manufacturing

    Manufacturing 2-Bromo-2-Butene over the last decade has given us a firsthand look at how specialty intermediates connect fields as different as pharmaceuticals, crop protection, and material science. This compound consistently shows up when researchers and process engineers want precise reactivity with manageable volatility and clear handling properties. Straight from our reactors, 2-Bromo-2-Butene arrives as a clear, mobile liquid that workers recognize for its sharp, characteristic odor. With experience, technicians quickly learn the difference in both performance and safety compared to similar molecules like 1-Bromo-2-Butene—a distinction that influences everything from charging strategy to waste stream management.

    Understanding the Molecular Difference

    Few products teach new chemists the impact of structural isomerism quite like 2-Bromo-2-Butene. The bromo group at the 2-position on the butene chain gives this compound its special balance of reactivity and selectivity. Colleagues familiar with 1-Bromo-2-Butene or 3-Bromo-1-Butene notice immediately how placement changes boiling point, rate of polymerization, and compatibility with certain catalysts. For example, our batches of 2-Bromo-2-Butene typically boil between 91-93°C—easy to distill but less volatile than some lighter analogs, which in practice lowers fugitive emissions in the plant. That detail means less loss at the transfer points and an easier time controlling the environment in the area, especially in summer.

    Experience at Scale: Blending Science with Practical Realities

    Running this chemistry at industrial scale teaches real respect for the subtleties of alkene substitution patterns. Our production lines manage every step, from controlled bromination of carefully selected butene precursors to product stabilization and drum packaging. During the initial synthesis, small changes in temperature or reagent ratio quickly affect isomer distribution. Operators accustomed to routine reactions have to stay sharp here. Even within the 2-bromobutene family, small structural differences won't behave the same in downstream alkylation, Grignard formation, or cross-coupling.

    Storage tanks and transfer lines often remind us that 2-Bromo-2-Butene is less prone to spontaneous polymerization than terminal bromoalkenes, yet it never pays to get complacent. In our tanks, we use passivation and nitrogen blanketing. Not everyone mentions that uncontrolled venting of bromoalkenes leads to persistent odors. Technicians learn over time where fittings show corrosion first or which valve packing needs more frequent checks. Small details add up; an operator’s judgment makes the difference between a smooth campaign and a batch lost to contamination.

    Practical Advantages over Similar Intermediates

    On the production floor, chemical differences often translate into practical headaches or smooth workflows. 2-Bromo-2-Butene, compared with the terminal isomer or with 1,4-dibromo analogs, stands out for its relative stability and well-marked reaction endpoints in bench-scale and full-scale use. Users working with us focus on its application in C–C bond construction by alkylation or in forming Grignard reagents where side reaction minimization pays off. That methyl group next to the bromine means less wandering in the reaction flask, fewer by-products, and purer yields—especially when large volumes churn through a reactor.

    Pharmaceutical researchers in our meetings often point to how 2-brominated butenes act as better alkylators with certain nitrogen heterocycles. Process development chemists from agrochemical firms constantly express appreciation for reduction in side-chain functionalization steps. It all comes down to the manageable leaving group behavior of the 2-bromo compound: not so sluggish as tertiary bromides, not so wild as primary, and just reactive enough to make isolation straightforward.

    Specifications That Matter on the Shop Floor

    Our 2-Bromo-2-Butene leaves the factory after rigorous GC analysis. Old hands here know that any brominated alkene run collects trace dimers and higher polyenes unless conditions remain tight. For downstream users—especially those running pharmaceutical or specialty chemical synthesis—trace purity matters. We target assay above 98 percent, usually consisting mostly of the (E)-isomer, with controlled moisture and acidity. Even the trace color differences (often a light straw hue) hint at changes in purity; new team members learn to spot these as a rough check before instrumental analysis.

    Spec differences become important for automated dosing systems. Consistency in density means pumps can be set reliably. Changes in viscosity, even slight, affect mixing and reaction time profiles. Having made thousands of tons over the years, our lab team points out tiny but persistent differences—sometimes related to the butene feedstock, sometimes a function of subtle catalysis effects from upstream bromine sources. By direct and ongoing feedback between line operators and R&D chemists, we keep specs within the tightest ranges our hardware and chemistry allow.

    Lessons from Years in the Industry: Safety, Environment, and Process Optimization

    From our early years, anyone working with brominated alkenes heard stories about safety: how old lines used to weep, how tiny leaks turned into persistent odors, or how vent systems failed on a hot day. Modern protocols, instituted mostly after small but memorable incidents, stress not just PPE but also good system monitoring and routine equipment checks. The environmental questions surrounding volatile organics and halogen compounds add a layer of complexity. Our plant introduced advanced vapor scrubbers and dual-seal transfer systems. As a result, measurements at the fence line stay beneath limits even during heavy filling shifts.

    On the waste side, careful segregation of organic and bromide by-products streamlines in-plant reprocessing and off-site disposal. Down the chain, our customers report fewer regulator queries because the raw material streams we deliver stay inside agreed compositional limits. Technical teams constantly review internal plant data against external audits, ensuring continuous improvement. No level of experience allows you to lose sight of the implications for worker health and public trust. The chemistry demands steady attention.

    Applications: Real-World Uses, Beyond Textbook Chemistry

    2-Bromo-2-Butene rarely gets the headlines, but across research and industry, it drives innovation and efficiency. Our work intersects most with synthetic organic groups, scale-up houses, and those needing complex raw materials. Whether for manufacturing active pharmaceutical ingredients or tailored agrochemical intermediates, the compound’s balance of reactivity and stability makes it a favored choice.

    In cross-coupling and alkylation chemistries, C4 bromoalkenes like ours let chemists introduce compact carbon chains and tune reactivity by shifting the double bond. Research chemists visit us or call in regularly to discuss batch-to-batch consistency after pilot runs. Seeing first-hand how large batch synthesis uncovers pitfalls missed at smaller scale reinforces the link between analytical support and practical plant work. A few grams for a university lab may not expose formulation headaches that show up at the hundred-kilo mark. It’s not uncommon to field technical queries where direct plant experience—down to the seal selection—matters more than theoretical yields.

    Manufacturers working with high-value catalyst systems respond well to the consistent halogen content and minimized metal contaminants we maintain here. Not every vendor can say the same. Over the years, resin specialists and advanced materials startups asked about using our product as a linking block for new monomer systems. The even distribution of the bromo group gives them more predictable outcomes in chain reactions or modifying base polymers. We stay in conversation with end users, sometimes rerunning analytics or offering technical details on possible downstream uses. As new electronic chemicals emerge, the need for high-purity, predictable bromoalkenes becomes more apparent.

    Comparisons that Count: 2-Bromo-2-Butene versus Similar Products

    Having handled both 2- and 1-bromo butenes, it’s no exaggeration to say the isomeric switch means less confusion at the worktable. 2-Bromo-2-Butene’s internal double bond brings less hydrobromination by-product during processing. Those running continuous-flow syntheses often report fewer line fouling incidents, and shift operators appreciate reduced vent line cleanouts thanks to the product’s more predictable volatility. For process chemists, that adds up to savings in both solvent and time.

    Compare this to working with 1,4-dibromobutene, where dual halide reactivity amplifies both opportunity and risk. Products like 1-Bromo-2-butene may look similar on paper, but anyone with plant-side experience distinguishes their odor, boiling point, and reactivity on contact. Operators often prefer 2-Bromo-2-Butene for its easier distillation and handling—meaning fewer alarms and less disruption to standard work routines.

    Process safety teams note that 2-Bromo-2-Butene generates less persistent residue inside linework and storage vessels. While terminal alkenes sometimes polymerize unpredictably on stainless or elastomer surfaces, this internal compound reduces worries over gelling or clogging reactors. Site managers budgeting for annual shutdowns count this as a material benefit. It is easy to overlook such hands-on points in theory, but time in the field drives home the importance.

    Industry Shifts and New Regulatory Pressures

    Anyone in specialty chemicals these days tracks both market and regulatory pressure. Regions with stricter airborne halide controls pushed our plant to rework both how we ventilate and how we analyze bulk shipments. Over the years, automation raised both consistency and safety, but high skill levels among senior operators remain irreplaceable. For us, ongoing dialogue with both end-users and regulatory advisory teams pushed innovation around process stability and emissions.

    Technicians and engineers gather in regular cross-plant meetings to share lessons on what works and what cases deserve close watch. Controls installed to stay ahead of changing requirements also let us feed customers exact analytic data on residual organics, heavy metals, and trace free bromide. A philosophy of risk reduction runs throughout the operation. Reliable data and demonstrated repeatability are as important as a product’s chemical specs. Plants that make this commitment pass audits, win repeat business, and keep their teams safer.

    Supply Chain Reliability from Factory to Field

    Direct manufacturing experience leaves a mark. We know what matters to customers because we field support calls from research staff, plant engineers, and procurement managers day to day. Early in our company’s history, supply interruptions and minor spec variations caused more than a few headaches, especially with larger pharmaceutical and fine chemical customers. One missed shot at regulatory compliance or a late delivery during a scale-up campaign leads to real-world costs—missed product launches, idle capacity, and stressed teams.

    Our continuous investment in both reaction chemistry and logistics—separate, nitrogen-purged storage, a dedicated loading bay, and rotary-joint isolation for filling—did not come about by accident. Over multiple market cycles, unpredictable weather, and raw material volatility, these investments kept customers supplied. It takes more than quoting a COA or putting product in a drum: insight into real-world downstream use comes only with time and attention to detail. Backend system upgrades—the kind that let us track product movement down to the hour or temperature deviation inside loaded tankers—make mistakes rare. Customers trust that the 2-Bromo-2-Butene arriving fits their process flow and plant setup, not just a paper specification.

    Ongoing Innovation from the Manufacturing Floor

    We do not treat 2-Bromo-2-Butene as a commodity, despite years of experience. Regular R&D meetings push production staff to challenge assumptions—about raw material workflows, waste reduction, and process intensification. The gap between the theoretical “best route” and a reliable, safe, scalable reaction only closes through hands-on practice. Our laboratory and engineering staff exchange feedback with the operations team, reviewing yield optimization, energy input, and downstream handling. Pilot plant trials, guided by operators, ensure that every new route actually delivers in a day-to-day manufacturing environment.

    The best process changes often come from the floor. Someone nearby might spot a subtle shift in color or viscosity, or a fill cycle that runs ten minutes faster on a new feedstock. Feedback loops—both informal chats and formal tracking—help us tune both the plant and the product itself. In-house training for production and QC staff balances technical theory with practical troubleshooting learned only by repeated campaigns. This cumulative experience keeps the process adaptive, efficient, and safer for everyone involved.

    Responsibility Through Every Step: From Sourcing to Delivery

    Manufacturing any brominated intermediate means shouldering a host of responsibilities. Raw bromine handling remains a high-risk job. Over the years, we took steps to compartmentalize every material flow, install real-time leak detection, and implement zero-spill loading systems. Cross-functional safety teams meet monthly to review incidents and preventive actions, creating a workplace culture where speaking up quickly becomes normal. Environmental reporting—once a burdensome afterthought—now connects directly to our internal metrics and performance incentives.

    Customers depend on the chain of custody from drum filling to site delivery. Each shipment of 2-Bromo-2-Butene travels with a full analytic record from our in-house lab. We set aside on-spec material for sampling and reference, not just for the rare quality dispute but because this proves commitment to batch traceability. Regional and global audits welcome this type of record-keeping, especially for regulated industries where provenance matters as much as purity.

    Building Relationships Across the Value Chain

    Trust in chemical manufacturing arrives slowly and can vanish quickly. Having worked through market volatility, regulatory change, and unforeseen supply chain glitches, our team learns that transparency and responsiveness count in ways transactional vendors sometimes overlook. Customers phone in with questions ranging from spec confirmation to handling tips; our staff, often operators who have run the actual batches, reply with details based on real process history.

    Collaborative product development—especially in custom projects—shows its value in both troubleshooting and innovation. Customer feedback shapes not only our 2-Bromo-2-Butene, but also system improvements plant-wide. Installing better emission traps or enhancing plant automation stemmed directly from multinational client requests during on-site technical visits. Working through these issues together pays off for both sides, tightening product specs, lowering costs, and reducing risk.

    The Path Forward: Experience, Adaptation, Results

    Each batch of 2-Bromo-2-Butene carries the lessons of years—sometimes hard-won—on the plant floor. From exacting bromination at the reactor to robust, leak-free filling, continuous attention to detail matters. This compound no longer stands as a hard-to-source specialty; dedicated production, steady investment, and active customer engagement keep it flowing across industries. The differences from other C4 bromo analogs show up at every stage, from operator’s bench to the chemist’s flask.

    End users depend on more than a specification sheet. Actual plant experience, open dialogue with technical staff, and a practical approach to both routine work and critical incidents shape the real product. Together, we keep processes safe, efficient, and reliable step by step, batch by batch. For those seeking reliability and insight—not just a commodity drum—the hands-on knowledge and shared history behind our 2-Bromo-2-Butene make a difference every day.