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2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone

    • Product Name 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone
    • Einecs EINECS 401-090-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    846992

    Productname 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone
    Molecularformula C6H6BrNOS
    Molecularweight 220.09 g/mol
    Casnumber 6977-98-8
    Appearance Light yellow to brown solid
    Meltingpoint 95-98°C
    Purity >98%
    Solubility Soluble in DMSO, DMF; slightly soluble in water
    Smiles CC(=O)C(Br)c1nccs1
    Storageconditions Store at 2-8°C, protected from light and moisture

    As an accredited 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

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    Application of 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone

    Applications of 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone in Industrial Manufacturing

    2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone is an advanced building block utilized by the fine chemical industry for downstream synthesis of pharmaceuticals, crop protection products, and specialty materials. Our production integrates stringent in-process controls to meet diverse industry requirements across regulatory environments, enabling manufacturers to access a reliable intermediate for precision transformation. Below we detail key industrial applications based on real-world demand and documented end uses.

    1. Pharmaceutical Intermediate Synthesis for Thiazole-Containing APIs

    In the pharmaceutical sector, this molecule enters multi-step active pharmaceutical ingredient (API) syntheses, enabling the construction of thiazole-based pharmacophores present in anti-infective, anti-inflammatory, and oncology medications. Process chemists employ our material as a versatile alkylating agent or coupling intermediate in both batch and continuous production of pipeline small molecules. Regulatory expectations require strict impurity profiling and traceability, and our plant documentation supports DMF referencing and medicinal chemistry documentation audits.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Parts 210/211
    • EU Guidelines for GMP for Medicinal Products for Human and Veterinary Use (EudraLex Volume 4)
    • Pharmacopoeia specifications (USP, EP, JP as per customer API dossier)

    Typical usage ratio

    • Utilized in a reaction molar ratio ranging 0.8–1.2 equivalents relative to the target intermediate; actual charge determined by stoichiometry, impurity control, and process yield targets.

    Downstream process integration

    • Added as a discrete batch charge under inert atmosphere following initial thiazole ring assembly or late-stage modification; typically enters at the nucleophilic alkylation or acylation step prior to final purification and crystallization of the crude API.

    Final product types

    • Anti-infective APIs with thiazole scaffolds
    • Non-steroidal anti-inflammatory drugs
    • Kinase inhibitors for anticancer pharmaceuticals
    • Reference compounds and API impurities for analytical standards

    2. Crop Protection Chemical Synthesis (Fungicide and Insecticide Intermediates)

    Many thiazole-based crop protection products integrate bromo-ketone intermediates in their side-chain development, often for construction of systemically active fungicides and targeted insecticidal agents. Our product delivers consistent batch-to-batch purity, minimizing risk of agronomically relevant off-target residues post-synthesis. Compliance with agrochemical traceability enables downstream formulators to streamline product registrations internationally.

    Industry compliance standards

    • FAO/WHO Pesticide Specifications
    • ISO 9001:2015 Quality management systems
    • European Regulation (EC) No 1107/2009 (Plant Protection Products)
    • US EPA FIFRA (Federal Insecticide, Fungicide, and Rodenticide Act) process control documentation

    Typical usage ratio

    • Employed at 0.5–1.0 equivalent, adjusted for target molecule scale and downstream coupling efficiency; higher loads used for impurity-limited routes.

    Downstream process integration

    • Inserted at key enolate alkylation or side-chain elongation steps post-thiazole core synthesis; often followed by extraction, solvent swap, and in situ conversion to final crop-protection scaffold.

    Final product types

    • Systemic fungicide actives (thiazole-based analogues)
    • Broad-spectrum insecticide intermediates
    • End product technical concentrates for formulation into EC, SC, or WG pesticides
    • Analytical standards for GLP residue analysis

    3. Specialty Polymer Crosslinker Precursor for Advanced Materials

    Specialty polymer manufacturers employ this raw material in the synthesis of functional crosslinkers or chain-extenders where thiazole and bromo functionalities provide tailored reactivity and thermal stability. The differentiated reactivity profile of this intermediate supports controlled radical or ionic polymerizations, resulting in polymeric architectures for adhesives, coatings, and semiconductor encapsulation.

    Industry compliance standards

    • REACH (EC) No 1907/2006 registration for polymer intermediates
    • EN ISO 9001:2015 for advanced material supply chain
    • RoHS 2 (Directive 2011/65/EU), for electronics applications
    • UL 94 flammability standards for encapsulants

    Typical usage ratio

    • Added at 1–5 wt% within crosslinker blend, with precise concentration controlled by desired crosslink density and end-use thermal/mechanical requirements.

    Downstream process integration

    • Introduced during the pre-polymer feed step or post-polymerization modification stage, enabling covalent incorporation or end-group functionalization prior to bulk molding, coating, or extrusion.

    Final product types

    • Thiazole-functional epoxy cured adhesives
    • UV-curable coatings for electronics
    • Thermal interface materials in semiconductor packaging
    • Custom crosslinked elastomers for high-performance gaskets

    4. Research-Grade Fine Chemical Intermediate Supply for API Library Expansion

    Contract research organizations and medicinal chemistry labs integrate this intermediate for rapid lead optimization, SAR (Structure-Activity Relationship) study synthesis, and pilot-scale building block exploration. Our supply features enhanced documentation, batch traceability, and customizable impurity limits, supporting compliance with global standards for laboratory-scale evaluation and early-stage process development.

    Industry compliance standards

    • ISO 17034:2016 General requirements for reference material producers
    • OECD Principles of Good Laboratory Practice (GLP)
    • Customer-specific analytical data package (NMR, HPLC, GC, MS)
    • Material transfer agreements and custom documentation for IP-sensitive projects

    Typical usage ratio

    • Scaled for screening from 0.2 g to 5 g per step in combinatorial reactions, or 0.5–2 equivalents for defined small-molecule synthesis routes.

    Downstream process integration

    • Dispensed under controlled laminar conditions after in situ solvent pre-conditioning, entering as a reagent or alkylating agent for parallel library construction or single-compound optimization.

    Final product types

    • SAR libraries for oncology and anti-infective targets
    • Novel thiazole derivatives for bioassay development
    • Reference standards for clinical biomarker research
    • Custom small-molecule probes for academic or CRO validation
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    More Introduction

    2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone: A Fresh Take on Specialty Chemical Innovation

    The specialty chemicals landscape keeps evolving, always on the hunt for compounds that bring more value and reliability to the table. 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone grabs the spotlight in this search, offering a combination of structure, purity, and adaptability that has caught the attention of researchers, product developers, and manufacturers. Time after time, I’ve seen how the right intermediate transforms workflows—reducing bottlenecks, driving cleaner reactions, and helping teams hit their targets with more certainty. As soon as labs and process engineers tried this molecule, user feedback reflected more than just a chemical supply. What emerged was a tool for problem-solving, rooted in real-world results.

    What Makes This Intermediate Worth Talking About?

    Every compound fights for recognition in an industry brimming with choices. With so many intermediates on the market, 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone stands out because of what it offers in the lab and the factory. For those who regularly work on crafting heterocyclic compounds, tweaking pharmaceuticals, or assembling agrochem intermediates, little details matter—reactivity, shelf stability, and the predictability of forming desired products take priority. This ketone’s molecular structure—rooted in a thiazole ring—lets it participate in a breadth of syntheses, making it a bridge to both simple and complex organic targets.

    From a chemistry perspective, the bromoethyl ketone moiety fused to the thiazole ring encourages nuanced reactions not easily matched by alternatives. Similar compounds might look good on paper, but few can deliver the kind of halogenation and condensation versatility evident in real-life lab runs. I’ve watched colleagues test two seemingly comparable intermediates, only to circle back to this one thanks to improved yields or clearer pathways in later steps. The benefit comes not just on reaction day, but over the entire process—cutting down purification headaches and cutting losses at scale.

    Diving Deeper: Specifications and Performance

    One of the points that matters most in my experience is knowing where a chemical’s limits actually lie. 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone often arrives as a fine, stable powder—easy to handle, with a purity that can push well above 98% on modern chromatographs. Labs rely on that purity, because trace contaminants become headaches in both development and regulatory review. The compound’s melting point gives it enough stability for standard storage, without forcing users into extreme conditions just to keep the material sound. In long syntheses, this pays off. No one wants to babysit their reagents or lose value to degradation waste before reactions even get started.

    Every batch I’ve evaluated for quality brings one broad conclusion: analytical reports back up claims. There is a trend toward meticulous quality control—visible in infrared spectra and NMR profiles that match reference standards. Users going through compliance audits notice plenty of information and traceability on batch documentation, which isn’t just paperwork. It makes a difference when discussing sourcing with external partners or regulators.

    Applications That Drive Its Value

    So often, the market conversation skips straight to technical data, forgetting how the material actually fits into real applications. In medicinal chemistry laboratories, 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone finds use in assembling thiazole-derived drug leads and fine-tuning bioactivity. Some labs value it for optimizing synthetic routes toward kinase inhibitors or scavengers, since the bromo group opens doors for high-yield substitution, alkylation, or cyclization steps. I’ve noticed up-and-coming biotech companies decide to integrate this intermediate just to streamline access to new scaffolds—especially when custom compound collections feed early-stage screening programs.

    In the agrochemical sector, research teams exploring new insecticides and fungicides count on thiazole functionality for activity against resistant strains. Production chemists favor intermediates that don’t introduce excessive byproducts, and this ketone helps keep total process waste within acceptable limits. The upshot: more efficient syntheses mean fewer headaches during continuous process audits, and the environmental footprint gets easier to manage in the long run. I’ve seen veteran formulators swap their tried-and-true reagents for this ketone and share quiet relief that process controls become less burdensome.

    Polymers and advanced materials also form part of this compound’s audience. Precise functional groups like the thiazole core lend themselves to robust backbone structure or targeted cross-linking, benefitting specialty coatings or adhesives. Here, the reproducible purity and predictable functionalization options matter—a lot. If you spend any time in custom materials development, chasing after that perfect linkage or after high-performance heat resistance, you start prioritizing consistency more than novelty. Reports from R&D teams experimenting with next-generation polymers mention fewer batch failures and less troubleshooting down the line.

    Key Differences: More Than Just Another Halogenated Ketone

    Plenty of brominated intermediates claim to cover the same ground. What changes with 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone is how smoothly it fits into a variety of reactions. Some bromo ketones can trigger unwanted side reactions or escalate purification costs. Here, the balance of reactivity—promoted by the electron-rich thiazole and the electron-withdrawing carbonyl structure—nudges selectivity in your favor. In my own experience, the difference shows up in hands-on work: reactions run cleaner and offer better control, so more resources shift from rework to actual discovery or production runs.

    The everyday chemist, whether deep in R&D or managing scale-up, appreciates short-cutting tedious troubleshooting. Compared to older, less optimized reagents, 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone adds value by avoiding dead ends in synthetic design. This is especially helpful when the pressure mounts to get candidates from bench to pilot plant. Competitor materials may falter under minor shifts in pH, temperature, or reaction time—this ketone sticks with your protocol, so scaling up becomes a realistic goal. The flexibility to respond well in both batch and flow chemistries increases its application bandwidth. You stop worrying about reagent-driven inconsistencies, and start pushing your targets further.

    Safety, Compliance, and the Human Factor

    Working with specialty chemicals always brings the big safety question to the front. Based on published hazard data and observations in the field, 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone does require careful handling, with typical controls for halogenated reagents: chemical gloves, goggles, and good ventilation. Unlike some precursors filled with unpleasant volatility or cross-contamination risk, this compound’s manageable vapor pressure and stable form limit nuisance issues and make training new staff a smaller lift.

    Complying with regulatory frameworks—whether for GxP manufacturing or advanced research—depends on clear documentation and transparency from suppliers. In recent years, I’ve sat through enough procurement audits to realize the importance of traceability and third-party analytical reports. Sourcing this ketone from reputable channels usually keeps that documentation at your fingertips: batch records, spectra, and certificates all line up when called for. Over time, this means fewer workflow interruptions and less banter with compliance officers, which matters more than anyone admits—especially with new product launches on the line.

    Addressing Market Challenges

    Even an intermediate with solid lab credentials needs to face broader industry headwinds. The first challenge involves raw material pricing and shipping stability. As the global trade landscape keeps shifting, lead times matter: the most reliable suppliers invest in robust logistics, protecting customers from unexpected gaps in production. My own sourcing efforts highlight the difference a trustworthy partner can make—long-term relationships often cushion labs from surprise shortages or price swings. Another challenge lies in the constant push for greener practices. Waste minimization and energy-conscious syntheses have become standard asks; to stay competitive, manufacturers are updating protocols and investing in cleaner purification.

    Diversification across end-use industries protects the appeal of 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone. Some labs chase pharmaceutical innovation, others focus on agroscience, while a growing number unlock opportunities in electronics or coatings. Even now, as I track market trends and listen to industry partners, the appetite for adaptable, reliable intermediates stays strong. Keeping the material relevant means always adjusting supply strategies, offering flexible packaging, and listening to what users need for their specific syntheses.

    Supporting Real-World Innovation

    All too often, the flashiest products grab attention, but the real value surfaces with what works across many settings. 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone proves itself both on the bench and in the plant, supporting innovation that’s built on substance over sheen. I’ve sat across the table with scientists who view a strong intermediate as not just a commodity, but an enabler that helps meet project goals under pressure. Conversations shift from “What does this do?” to “How can we get more out of it?” As the chemistry community adapts to digitalization, automation, and sustainability pushes, reliable building blocks like this compound anchor workflows and make ambitious projects viable.

    Many seasoned chemists, myself included, value reputation and results over trend-driven hype. Over years spent troubleshooting syntheses and tightening up process controls, I’ve seen too many projects stumble on flaky intermediates. The best compounds deliver consistent profiles, respond well to tough conditions, and leave enough room in the budget for bigger risks elsewhere. With this ketone, recordkeeping becomes straightforward and the path to regulatory approval shortens—two major wins for any company.

    Potential Solutions for Market Shortfalls

    Industry professionals know that no product is free of challenges. Supply chain hiccups, environmental regulations, and evolving synthetic needs all keep manufacturers and developers on their toes. To address availability, stakeholders should prioritize long-term partnerships and multi-source arrangements—a lesson learned after rounds of urgent restocking. Encouraging suppliers to invest in larger, climate-controlled storage or regional distribution centers would further buffer the impacts from transport disruptions.

    When it comes to supporting environmental commitments, ongoing R&D into waste minimization and safer solvent systems signals progress. Formulators and process chemists can collaborate with suppliers to refine purification practices—extensions like solvent recycling or upgraded filtration may reduce both cost and ecological burden. I’ve seen collaborative vendor relationships lead to custom packaging or smaller, more convenient lot sizes that cut down waste in high-precision labs. This kind of engagement empowers both sides and makes broader adoption easier, even in settings with tight compliance needs.

    Handling and transparency issues remain. Everything comes down to proper training and maintaining clear lines of communication between end users and suppliers. Involvement in trade organizations or professional networks can spread best practices. Sharing application notes, troubleshooting logs, or batch-tested case studies arms users new to the compound with confidence. By contributing insights, vendors signal their commitment to the scientific ecosystem, building the trust needed for long-term adoption.

    Driving the Next Chapter in Specialty Chemicals

    2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone embodies the spirit of progress that defines specialty chemicals. Its strengths stem from grounded reliability, proven adaptability, and a quiet boost to workflows that need fewer headaches and more results. Across projects focused on pharmaceuticals, agriculture, coatings, or emerging electronics, I’ve watched this compound slip into use and quietly outperform older alternatives. It’s not the loudest presence in the storeroom, but its record speaks for itself.

    At the intersection of supply chain shifts, sustainability demands, and competitive innovation, the real test is day-to-day performance. Users keep asking: Does this intermediate actually support what my project demands? Will it clear audit hurdles, or slow down scale-up? Can the supply keep up with changing trends in research and development? Based on the trajectory so far, feedback from labs around the world signals a continued vote of confidence. As new challenges and applications continue to emerge, those built on experience and fact-driven decisions will shape the future for this and other specialty chemical offerings.

    By engaging in open communication, refining process solutions, and holding suppliers to high standards, developers ensure that 2-Bromo-1-(1,3-Thiazolyl-2-Yl)Ethyl Ketone brings maximum value—today and into the future. If my experience counts for anything, the best ingredients rarely need the loudest introduction. They earn loyalty in the trenches, delivering performance that stands up to real-use demands and evolving goals.