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2-Benzylaminopyridine

    • Product Name 2-Benzylaminopyridine
    • Alias 2-(Phenylmethylamino)pyridine
    • Einecs 247-432-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    151644

    Cas Number 10204-02-5
    Molecular Formula C12H12N2
    Molecular Weight 184.24
    Iupac Name 2-(benzylamino)pyridine
    Appearance White to off-white solid
    Melting Point 58-61°C
    Boiling Point 372.7°C at 760 mmHg
    Density 1.13 g/cm3
    Solubility In Water Slightly soluble
    Smiles c1ccc(cc1)CNc2ccccn2

    As an accredited 2-Benzylaminopyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 2-Benzylaminopyridine, sealed with a screw cap, labeled with hazard and identification details.
    Shipping 2-Benzylaminopyridine is shipped in tightly sealed containers, protected from light and moisture, and clearly labeled with hazard information. Transportation complies with chemical safety regulations, utilizing appropriate packaging to prevent leaks or contamination. Shipped by certified carriers, this product requires careful handling and documentation to ensure safety and regulatory compliance throughout transit.
    Storage 2-Benzylaminopyridine should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizing agents and acids. Protect from moisture, heat, and direct sunlight. Store at room temperature and ensure proper labeling. Avoid sources of ignition. Follow all relevant safety and handling guidelines to minimize risk.
    Application of 2-Benzylaminopyridine

    Applications of 2-Benzylaminopyridine in Industrial Manufacturing

    2-Benzylaminopyridine supports a select range of industrial sectors through its chemical functionality, purity profile, and interaction performance within specific advanced formulations. Our manufacturing expertise enables us to serve downstream users with technical consistency and process integration support for established applications outlined below.

    1. Pharmaceutical Intermediates for Active Pharmaceutical Ingredient (API) Synthesis

    This material plays a pivotal role as a coupling intermediate in multi-step pharmaceutical synthesis, particularly in the development of antihypertensive and anticancer APIs containing pyridine motifs. Its benzylamino functionality enables selective modification at key synthesis stages, minimizing side reactions and maintaining batch consistency in medicinal compound scale-up. Process chemists select it not only for condensation and alkylation steps, but also for downstream functional group protection strategies, supporting reproducible yields during GMP production campaigns.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) reference standards for starting materials
    • European Pharmacopoeia (Ph. Eur.) quality requirements for API intermediates
    • FDA process validation guidance for pharmaceutical synthesis

    Typical usage ratio

    • Applied at 0.1–1.2 molar equivalents relative to substrate, adjusted according to route and impurity profile in process validation batches

    Downstream process integration

    • Enters reaction train at reductive amination or nucleophilic substitution stage following upstream pyridine activation or halogenation
    • Acts as nitrogen donor in selective amine introduction during intermediate formation before final API assembling

    Final product types

    • Bulk APIs for antihypertensive and oncology pharmaceuticals
    • Regulated intermediates for clinical candidate synthesis
    • Contract-manufactured custom intermediates for late-phase drug development

    2. Fine Chemical Synthesis in Agrochemical Manufacturing

    Producers in the agrochemical sector employ this building block for introducing tailored pyridine-based structures required in modern crop protection agents. Its utility arises in the synthesis of herbicide and fungicide molecular scaffolds, allowing for structural diversification through downstream functionalization. It supports multi-gram to multi-ton batch manufacturing by delivering high conversion rates and low levels of unwanted byproducts—key for regulatory acceptance and field performance. Downstream operators optimize its dosage based on desired ring substitution and protection yield efficiency.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • OECD Guidelines for the Testing of Chemicals (relevant to purity and residuals)
    • REACH Regulation (EC) No 1907/2006 for raw material registration and risk management
    • ISO 9001:2015 Quality Management System for chemical production

    Typical usage ratio

    • Ranges between 0.25–0.9 molar equivalents per stage, adaptable for cost-performance targeting based on downstream protection or deprotection needs

    Downstream process integration

    • Added to initial condensation or cyclization reactors as a scaffold precursor for pyridinyl agrochemical actives
    • Introduced prior to functional group diversification by selective halogenation or nitration, ensuring positional integrity during subsequent steps

    Final product types

    • Technical concentrates of crop protection active ingredients
    • Herbicide and fungicide precursor intermediates supplied for formulation plants
    • Custom synthesis batches for agricultural R&D programs

    3. High-Performance Material Additive in Specialty Coatings

    Synthesizers of high-end industrial coatings incorporate this raw material to generate advanced resin precursors with enhanced adhesion and customized chemical resistance. Its role is particularly relevant in the functionalization of poly(pyridine)-based resins where the benzylamine group enables durable crosslinking and surface compatibility enhancements. Coating formulators utilize it as a critical additive during resin backbone modification to improve downstream processability and finished product integrity under chemical stress conditions.

    Industry compliance standards

    • ASTM D16 Standard Terminology for Paint, Related Coatings, Materials, and Applications
    • ISO 12944 for corrosion protection of steel structures by protective paint systems
    • EU Regulation (EC) No 1907/2006 (REACH) for chemical admixture safety
    • National and regional HSE rules for industrial resin synthesis

    Typical usage ratio

    • Incorporated at 0.5–2.5% by weight in resin modifier premix, adjusted during pilot trials based on targeted mechanical and adhesion parameters

    Downstream process integration

    • Introduced during prepolymerization stage of resin manufacture for backbone modification
    • Participates in crosslinker or adhesion promoter synthesis before dispersion into water- or solvent-borne coating systems

    Final product types

    • Anti-corrosive industrial coatings for heavy equipment or container protection
    • Functionalized primers for automotive or marine substrates
    • Advanced adhesive films for electronics and specialty packaging applications

    4. Organic Synthesis Reagent in Research and Development Laboratories

    R&D and process development laboratories in the chemical and pharmaceutical fields employ this reagent for constructing custom heterocyclic frameworks, facilitating the study and optimization of novel bioactive compounds. Its reliable amination and condensation properties allow synthetic chemists to investigate structure-activity relationships in new molecular entities. Custom compound libraries utilize it for scaffold diversification, and analytical teams value its consistent reactivity for reproducibility in experimental protocols.

    Industry compliance standards

    • GLP (Good Laboratory Practice) Principles for nonclinical laboratory studies (OECD/US FDA)
    • Institutional Material Use and Handling SOPs
    • Hazardous Chemical Management per OSHA 29 CFR 1910.1200
    • REACH registration for laboratory chemical substances

    Typical usage ratio

    • Applied at 0.05–0.7 molar equivalents per step, based on functionalization efficiency and analytical yield requirements during synthetic trials

    Downstream process integration

    • Used in amination, ring closure, or directed ortho-metalation steps for test compounds
    • Integrated into high-throughput screening activities for lead compound identification

    Final product types

    • Screened compound libraries for drug discovery and agrochemical testing
    • Research-scale custom intermediates for preclinical pharmacology
    • Synthesized analytical reference standards for structural elucidation
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    Certification & Compliance
    More Introduction

    2-Benzylaminopyridine: Direct from the Production Plant

    Reliable Quality Rooted in Real Manufacturing

    Working in the fine chemicals sector, precision sets the real manufacturers apart from hopeful entrants. In our case, 2-Benzylaminopyridine represents a product line we control from raw material selection through to final QA sign-off. Other firms often source intermediates for blending, but in our facility, the benzylamine and pyridine derivatives originate onsite. This brings an extra level of consistency batch by batch. Clients who run repeat synthesis routes know the headaches caused by even minor swings in amine content or unpredictable side-reactions from trace impurities. Granularity in monitoring and control presses through from our in-house reactors to every final kilogram we bag. Product purity consistently exceeds 98.5% on GC/HPLC, something verified year over year in third-party audits from seasoned downstream partners.

    What 2-Benzylaminopyridine Looks Like in Action

    Our end users frequently work in pharmaceutical synthesis, agrochemical intermediates, and even colorant development. One customer uses our 2-Benzylaminopyridine for building specialty ligands in coordination complexes, another for coupling with acyl chlorides. Early on, we noticed how users struggled with product uniformity from bulk packed lots that sat in shipping for months. What works well at the kilo scale does not always translate to metric ton levels. Based on feedback, we switched to moisture-resistant bags and adopted an inert-atmosphere packing step. Since then, shelf life under standard warehouse conditions exceeds 12 months without clumping or yellowing. Direct feedback helped us discard a one-size-fits-all specification sheet, choosing instead to focus on the actual needs of compounders and researchers: a straightforward free-flowing crystalline powder, off-white to pale yellow, that handles easily in glove box or hood, whether pipetting or pouring.

    Purity Isn’t a Paper Promise

    There’s a difference between a spec and what’s actually delivered. In 2019, an agrochemical user pointed out higher levels of unknown peaks in a competitor sample versus what we shipped. It turned out that some batches from that competitor sat exposed to warehouse air on the dockside. While some labs accept a bit of carbonate or colored impurity, our own process chemistry is built on the principle that clean starting material means fewer surprises after coupling and ring closure. We verify moisture levels every shift and routinely run GC-MS for random lots. These details may seem minor on a spreadsheet but out in the field, contaminated or decomposed amine salt causes headaches up and downstream. Many of our long-term partners operate at the pilot or semi-bulk scale, so unexpected variability in the color, melting point, or odor profile easily triggers equipment cleaning downtime or batch rejection costs running five figures or more.

    Accessible Open Channel to the Production Floor

    From early conversations with process engineers at custom synthesis companies, we realized that too many suppliers keep a wall between production, QA, and customer service. Our technical sales team sits a hundred meters from the reactors. Process improvement requests don’t collect dust. One food colorant customer needed a tighter sieve fraction to prevent dust levels in high-shear mixers; we adapted our mill settings based on their feedback and worked the adjustment into our final QC test. We spent weeks dialing in a repeatable method, and then shipped scale-up quantities with freshly executed COA for each lot. That quick response loop—the kind only possible with day-to-day shop-floor visibility—lets us maintain trust and playoff a long-term rapport.

    What Sets 2-Benzylaminopyridine Apart from Lookalikes

    It’s tempting to lump aminopyridines together, but for specialty synthesis, minor differences matter. Comparing 2-Benzylaminopyridine to 3- or 4-substituted isomers, the regioselectivity and nucleophilicity pattern shift, which changes the outcome of key steps like alkylation or cyclization. Customers who shift to a cheaper or unvetted source often see reaction yields drop, with more downstream purification headaches due to higher byproduct levels. Our process locks the ring structure in, avoiding the kinds of ring-opened or over-alkylated contaminants that sometimes sneak in from high-throughput outsourced operations. Over the years, users in dye and pharmaceutical development told us that the difference between a “standard” and “process-fit” aminopyridine might not be obvious on first receipt, but the delta becomes clear during scale-up or when prodding intermediates through sensitive oxidation or condensation steps. The byproduct and impurity profile can impact crystallization or lead to unpredictable color fading in finished products.

    Traceability and Transparent Data

    Every batch gets logged with full raw material origin, which ampoule of pyridine derivative got loaded, and exactly what time the coupling step initiated. On-site digital logs show reactor temperatures, pressures, and chiller setpoints in real time. When one batch last year had a minor color drift, our internal data system tracked the anomaly back to a particular lot of benzylamine stored under atypical humidity. Our intervention process doesn’t need paperwork bottlenecks for hazard signoff—each operator brings the concern straight to our lab lead, who has full line authority to halt, isolate, or rerun any stage. Regular audits verify that the labeling on every drum matches internal batch logs and COA reference samples held for future disputes. This level of batch forensic detail feels tedious, but trace impurities can produce differences in reactivity, color stability, or shelf life, so we commit the effort up front. Downstream users get a partner who speaks their language, not just a price sheet.

    Regulatory, Safety, and Responsibility: Our Commitments

    We’ve handled stricter audits as environmental and worker-safety rules tightened, and we treat these changes as practical investments. Our 2-Benzylaminopyridine synthesis method uses closed-system reactors, nearly eliminating amine vapor exposures and reducing ambient emissions to well below local limits. The process includes high-efficiency scrubbers so plant neighbors don’t grapple with stray odors. Operators train on updated safety protocols—not copied from data sheets, but written after walk-throughs and real use. For waste, we’ve switched to reclaiming mother liquors and streamlining fines-capture filtration, keeping disposal to a minimum. Some clients requested expanded heavy-metal screening after new pharma guidelines in Asia. It took some trial runs, but in a few months, we built screening into our lot release and updated the COA format to include relevant elements. Even in a highly technical sector, product stewardship and open dialogue matter.

    Customer Input as a Core Ingredient

    When pharma or crop protection customers run into trouble—maybe a new intermediate forms an unexpected side compound, or a downstream product suddenly turns yellow in storage—they call us directly. Our process engineers and lab chemists work alongside their teams to run side-by-side tests and troubleshooting trials. That direct partnership wins us more repeat orders than any marketing outreach. We’ve seen situations where a process tweak, such as substituting a slightly different drying protocol or adjusting the pH of a crystallization solvent, entirely changed the way intermediates handled or stored. Being the actual source manufacturer, we have the agility to modify protocols without a third party blocking quick fixes.

    Global Reach Grounded in Local Know-How

    Chemical buyers in Europe demand full REACH compliance, and partners in North America often request supply chain transparency to counter counterfeit or adulterated imports. Drawing on years of cross-border shipments, we maintain prompt documentation, outwardly clean labeling, and detailed shipment tracking. Each market brings unique registration and customs demands. By running shipments directly from our main plant rather than a third-country warehouse, we expedite customs clearance and enable response to shipping delays, urgent resupply needs, or customs queries immediately. In a market awash with re-bagged or relabeled intermediates, we provide chain-of-custody records without hesitation.

    Listening to R&D: Supporting Innovation with Reliability

    Our best R&D collaborations start when clients open up about pain points: maybe existing benzylaminopyridine does not achieve clean coupling in their process, or standard grades allow through trace side compounds. Several major pharma customers trusted us with novel condensing agents or tricky ring closures, banking on our plant’s ability to tailor drying, purity, or grain size within tight tolerances. Some years ago, a customer developing a new anti-inflammatory API described issues with residual ionic contaminants in their aminopyridine source killing reaction rates. We trialed modified wash and recrystallization steps, reported every trace byproduct, and supplied test lots with full characterization rather than vague “spec-compliant” promises. Following six months of back-and-forth iterations, they achieved a clear improvement at kilo and pilot batch levels.

    Every Step Focuses on End-Use Practicality

    From handling to storage and downstream application, we design 2-Benzylaminopyridine batches for real-world users, not theoretical lab scenarios. After years supplying both pharma plants and academic teams, we saw where process engineers or graduate students run into bottlenecks—spillage during manual transfer, stickiness that gums up autosamplers, or static charge buildup that taints analytical runs. Tiny details, like dust levels after milling or how tightly we seal the drums, can have cascading effects through the supply chain. By maintaining open lines between our production team and end users, we solve hang-ups before they escalate.

    Supply Chain Reliability Takes Real Commitment

    Every producer claims reliability on a website, but actual performance gets measured during raw material shortages or demand spikes. Over the past decade, raw benzylamine supply ran through price swings and logistics blockages. We responded by pre-contracting annual requirements directly with supply partners and building a small but flexible buffer. During the recent pandemic disruptions, we were able to ship contracted orders on time, holding to pre-agreed pricing while others delayed or invoked force majeure. Customers who rely on consistent multi-ton shipments for active ingredient manufacture or scale-up runs learned to trust our ability to deliver, no matter the market stress.

    Differences Matter Beyond the Safety Sheet

    Some technical buyers ask about “differences” between 2-Benzylaminopyridine from various vendors. For us, difference roots itself in trace impurity levels, physical handling, ease in scale-up, and batch-to-batch predictability. If another supplier sources semiprocessed intermediates or outsources blending, their finished product may show wider swings in melting point, color, solubility, or even odor. Chemists making fine intermediates, dyes, APIs, or crop protection actives know that a single off-norm batch causes weeks of cleanup or lost campaign time. Our batch traceability, documented processing, and production rooted in hands-on adjustment make a real difference in the long run. The product isn’t just another pyridine: real value shows up in yield and predictability through to the final application.

    Knowledge Grows Through Every Batch Shipped

    We believe deep knowledge comes from repetition, feedback, and ongoing technical exchange. Employees join our production and QA teams for the long haul, getting to know the character of each process and the quirks of every equipment line. This hard-earned experience shapes the way we manage every order, adapt to new regulations, or react to customer requests. The open channel we maintain with formulation chemists and process engineers doesn’t just solve current problems—it seeds future innovation and improvement. If a user develops a new application or requests extra guidance, we bring direct plant experience to every call or site visit. For us, manufacturing means a real partnership fostered through technical depth and direct conversation.

    Summary: Real Production for Real Solutions

    2-Benzylaminopyridine from our integrated plant means more than dropping a name on a drum. Our product reflects refinements shaped by actual plant maintenance, years of process tuning, hands-on troubleshooting, and direct input from thousands of downstream users across pharma, agrochemicals, and specialty chemical sectors. By keeping every step under our own roof, we offer true transparency, tighter quality controls, and a willingness to adapt with every feedback cycle. Distinct from bulk traders or formula blenders, we place knowledge and customer partnership at the core, delivering reliable quality batch after batch.