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2-Benzyl-2-Thiopseudourea Hydrochloride

    • Product Name 2-Benzyl-2-Thiopseudourea Hydrochloride
    • Alias Benzylisothiourea hydrochloride
    • Einecs 241-331-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    629496

    Product Name 2-Benzyl-2-Thiopseudourea Hydrochloride
    Cas Number 555-55-3
    Molecular Formula C9H12ClN3S
    Molecular Weight 229.73 g/mol
    Appearance White to off-white crystalline powder
    Solubility Soluble in water
    Melting Point 174-178°C
    Purity Typically ≥98%
    Storage Conditions Store at room temperature, tightly closed, dry place

    As an accredited 2-Benzyl-2-Thiopseudourea Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 25g quantity of 2-Benzyl-2-Thiopseudourea Hydrochloride is provided in a sealed amber glass bottle with a secure screw-cap.
    Shipping 2-Benzyl-2-Thiopseudourea Hydrochloride is shipped in tightly sealed containers to prevent moisture absorption and contamination. It is transported as a hazardous chemical under controlled temperature conditions, clearly labeled according to regulatory guidelines. Proper documentation and safety handling instructions accompany the shipment to ensure compliance and safe delivery.
    Storage 2-Benzyl-2-Thiopseudourea Hydrochloride should be stored in a tightly sealed container, away from moisture and light, at a cool temperature (preferably 2–8°C, refrigerated). Keep it in a well-ventilated, dry area, separated from incompatible substances such as strong oxidizing agents. Always ensure the storage area is clearly labeled and follows standard chemical safety protocols to prevent contamination and degradation.
    Application of 2-Benzyl-2-Thiopseudourea Hydrochloride

    Applications of 2-Benzyl-2-Thiopseudourea Hydrochloride in Industrial Manufacturing

    As a dedicated producer of 2-Benzyl-2-Thiopseudourea Hydrochloride, we supply validated material supporting multiple specialty applications in organic synthesis, pharmaceutical APIs, agrochemical intermediates, and metal surface treatment processes. Below is a detailed overview of core downstream usage scenarios, highlighting sector-specific compliance, formulation guidance, and the role this key intermediate plays at each production stage.

    1. Pharmaceutical Intermediate for Antithyroid Drug Synthesis

    Leading pharmaceutical manufacturers employ this compound in the synthesis of thioamide-based antithyroid agents, such as methimazole and carbimazole. Critical for constructing the thiourea functional core within active pharmaceutical ingredients, it is integrated during late-stage amidation steps to ensure precise sulfur incorporation and high API purity profiles. Compliance with cGMP and international pharmacopeias is mandatory throughout the process.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US Pharmacopeia (USP)
    • European Pharmacopoeia (Ph. Eur.)
    • China GMP (latest edition)

    Typical usage ratio

    • 0.85 – 1.10 molar equivalents relative to precursor ketones or aldehydes, adjusted based on reaction scale and targeted API yield

    Downstream process integration

    • Reaction stage for thiourea core formation; direct addition to acyl or aryl precursors under controlled temperature
    • Followed by crystallization, aqueous work-up, and purification routines

    Final product types

    • Methimazole bulk API
    • Carbimazole bulk API
    • Finished antithyroid tablets and capsules

    2. Chemical Synthesis of Heterocyclic Compounds

    This intermediate serves as a key building block in constructing sulfur- and nitrogen-containing heterocycles for specialty chemicals and pharmaceutical lead optimization projects. Its unique reactivity enables targeted cyclization reactions, supporting the research-scale and commercial-scale manufacturing of thiazole, imidazole, and benzothiazole derivatives.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems for Fine Chemical Production
    • Responsible Care® Chemical Industry Management Standards
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals, as required in the EU)

    Typical usage ratio

    • 0.95 – 1.20 equivalents per haloketone or aldehyde moiety, adjustable for target ring closure efficiency

    Downstream process integration

    • Core cyclization step in batch or continuous-flow organic synthesis
    • Post-reaction work-up involves pH-controlled filtration and solvent exchange

    Final product types

    • Thiazole derivatives for agrochemical screening
    • Pharmaceutical heterocycle scaffolds for medicinal chemistry
    • Benzothiazole intermediates used in advanced polymer and dye synthesis

    3. Agrochemical Intermediate for Fungicide Manufacturing

    Manufacturers of protective crop fungicides rely on this compound in the multi-step synthesis of benzimidazole-class agents, particularly where sulfur atoms improve disease resistance profiles in final agricultural formulations. Used under controlled conditions to ensure both safety and environmental compliance, the compound reacts with aromatic aldehydes and amines at defined stages to assemble the intended molecular architecture.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • OECD Guidelines for the Testing of Chemicals
    • ISO 9001:2015 and ISO 14001:2015 Environmental Management Systems

    Typical usage ratio

    • Typically 0.8 – 1.1 equivalents per active moiety, tuned according to raw material quality and target fungicide potency

    Downstream process integration

    • Incorporated during ethylene thiourea ring-closure reactions for benzimidazole formation
    • Controlled neutralization and extraction are performed before isolation of active ingredient

    Final product types

    • Benzimidazole fungicide intermediates
    • Technical concentrate crop protection agents
    • Registered commercial-grade fungicide formulations

    4. Metal Surface Treatment Additive: Silver and Gold Plating

    Electroplating solution formulators utilize this compound as a grain refiner and brightening agent in precious metal bath chemistry. It modifies crystal growth kinetics and enhances deposit smoothness in the surface metallization of electronic components, jewelry, and specialized connectors. Controlled addition is critical, as excessive dosage can alter plating bath conductivity and deposit purity.

    Industry compliance standards

    • ISO 4527 for Electroplated Coatings of Silver on Metallic Substrates
    • UL Standards for Electronics (e.g., UL 796, UL 1703 as applicable)
    • RoHS Directive (2011/65/EU) for Lead-Free and Hazardous Substance Control

    Typical usage ratio

    • 0.2 – 1.5 g/L in working plating bath; dosage optimized based on bath composition, pH, and desired surface finish

    Downstream process integration

    • Metered into plating tank during solution preparation and replenishment
    • Continuous monitoring of additive concentration throughout production run

    Final product types

    • Silver-plated electric contacts
    • Decorative gold-plated jewelry components
    • Precision-plated circuit board connectors

    5. Analytical Reagent Production

    Specialty laboratories and chemical suppliers incorporate this compound as a reagent for the detection and quantification of platinum group metals and related ions. Employed in gravimetric and colorimetric assays, it ensures high sensitivity and specificity in quality control and environmental monitoring contexts, requiring strict analytical-grade purity and traceability.

    Industry compliance standards

    • ISO 17025:2017 for Testing and Calibration Laboratories
    • ACS (American Chemical Society) Reagent Grade Specifications
    • EPA 40 CFR Part 136 Guidelines for Analytical Methods

    Typical usage ratio

    • 0.2 – 2.0 mg per sample, according to target metal concentration and analytical protocol

    Downstream process integration

    • Dosed into test solutions during preparation of standards and unknown samples for metal ion detection
    • Used directly in complexometric or colorimetric assay systems

    Final product types

    • Analytical reagent kits for heavy metal detection
    • Environmental monitoring test solutions
    • Quality control assay packages for mining and metallurgical processing
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    Certification & Compliance
    More Introduction

    Introducing 2-Benzyl-2-Thiopseudourea Hydrochloride: Purpose-Built Quality from the Production Floor

    Forged by Chemical Know-How, Shaped for Biochemical Synthesis

    In the realm of fine chemical production, not every molecule plays the same role, nor does every batch perform to the same standard. 2-Benzyl-2-Thiopseudourea Hydrochloride stands apart—not because of marketing, but thanks to the direct experience and knowledge that goes into its preparation here. Having spent years in both research and full-scale production, my team and I know the difference between “acceptable” and “reliable” when it comes to this compound, often used in peptide coupling, biological labeling, and further development in agricultural and pharmaceutical chemistry.

    Purpose-Built, Not Mass-Packed: The Real Work Behind Each Batch

    It’s easy to speak in abstracts about quality control, but here on the actual line, we rely on repeatable methods and hands-on observations. 2-Benzyl-2-Thiopseudourea Hydrochloride isn’t hauled out from generic reactors; instead, we calibrate our process to minimize side-products through careful temperature control and precise reagent dosing. Consistency in yield and crystal quality directly owes to years of incremental, deliberate adjustments. The carbon, hydrogen, and nitrogen profile cannot be left to luck. Our in-house teams run every batch through spectroscopic analysis, giving our partners real assurance that the product entering their lab or plant meets their assay and impurity margin requirements, not just the broad definition of “industry standard.”

    Model and Specifications: Driven by Actual Process Feedback

    Product grades aren’t just numbers on a spreadsheet here. Our routine production for 2-Benzyl-2-Thiopseudourea Hydrochloride focuses on purity levels that allow clear, accurate downstream reactions, with assay values above 98%. We produce in both pilot and ton-scale quantities, and feedstock storage involves genuine temperature and moisture control, not just listed shelf procedures. The hydrochloride salt’s distinctive crystal habit comes from extended crystallization and staged drying. We monitor both turbidity and static charge as factors in solid handling—because those nuances define the reproducibility of a final reaction step, not just the convenience of packaging.

    Why Laboratories and Process Developers Return to This Compound

    Many of our long-term partners work in peptide synthesis, especially where the structural integrity of amino acid derivatives or complex heterocycles depends on precise coupling or protection steps. 2-Benzyl-2-Thiopseudourea Hydrochloride finds its primary application here. Whether serving as a guanidinylation agent, selective protecting group, or coupling promoter, the absence of trace thiol or benzyl contaminants keeps their results clean and their yields high. For pilot-scale users, we tune drying protocols so the final product flows freely and doesn’t cake upon storage, avoiding time-wasting downtime in high-throughput solid feeders. In smaller research labs, chemists tell us often that the batch-to-batch consistency saves hours revalidating controls and recalibrating stock solutions. Such feedback comes direct, not filtered through sales teams.

    Distinct from Bulk Commodities—A Chemistry-First Approach

    Much of the market offers a “good enough” grade, where appearance checks and assay alone pass for thorough vetting. Here, we operate by a tighter definition. For 2-Benzyl-2-Thiopseudourea Hydrochloride, our focus lies in minimizing odiferous by-products and transition metal residues—the very impurities that sabotage peptide syntheses and specialty organics. Even those well-versed in small-molecule coupling have reported how unwanted side reactions diminish when using our grade of material. From firsthand troubleshooting, I can confirm that cheap alternatives invariably introduce either off-odors, discoloration after months of storage, or inconsistent solubility. Our filtering steps and wash protocols target not just common, but also stubborn, batch-specific contaminants, so each lot maintains anticipated visual and analytical profiles long after dispatch.

    Supporting Emerging Sectors Beyond Classic Applications

    Traditionally, 2-Benzyl-2-Thiopseudourea Hydrochloride belonged to peptide labs and select fine chemicals makers. We have seen steady expansion into agrochemical lead discovery, and into certain med-chem screens that rely on stable, predictable guanidinium functionality. Researchers tell us this compound brings both reactivity and shelf-stability to early phase exploratory work, often enabling more flexible design of protected intermediates. Having handled numerous joint-development projects, I can say that consistent product handling means everything when scaling an idea from discovery all the way to kilo-scale pilot—no matter the end sector. Storage behavior, dry transfer, and reaction reproducibility carry more practical weight than any catalog guarantee.

    Day-to-Day: The Subtleties That Set a Batch Apart

    Some folks expect crystals to look identical under the microscope. Yet we’ve learned through countless filtration and drying cycles that even clarity, particle size, and trace moisture matter for proper function in automated systems. Our operations crew checks for dusty fines and agglomerates because these directly affect dosing accuracy in automated peptide synthesizers. Where previous suppliers’ material clumped or left sticky residues on stainless transfer lines, detailed re-tuning of our process led us to a more free-flowing batch, with minimal attrition even after weeks in storage. Lab techs from partner companies often single this out as the deciding factor—something that standard “fit for purpose” grades never address.

    Comparing Product Variants: No Substitute for Direct Control

    As a manufacturer, not every lot is destined for the same use case. Kilo-scale process engineers demand bulk deliveries in fiber drums, desiccated and sealed with humidity cards. Discovery labs rely on grams-to-hundred-gram batches in high-barrier pouches that prevent air incursion. Our batches for early-phase med-chem groups run an extra filtration step to eliminate ultrafine particulates. This granularity results only from running both small and large lots under real-world conditions, then listening to chemist feedback on handling and yield. Many alternatives in the market ship in bulk, undifferentiated formats, with minimal QA and no practical concern for end-user workflow. We believe in configuring materials to match the projects they support, and our product options grow directly from those repeated, open feedback cycles with actual users.

    Understanding the Broader Supply Chain: The Manufacturer's View

    Commercial chemical distribution carries plenty of uncertainty, especially when intermediaries re-bottle or relabel materials. As end-producers, we know precisely which feedstocks went into a batch, and every reagent’s lot history. Facing increasing scrutiny around supply chain transparency, our batch records aren’t just vague certificates—they reflect the actual raw material and stepwise progression from starting benzonitrile derivatives to finished hydrochloride salt. Partners investigating GMP or ISO traceability can request production logs that go back to the very solvents and catalysts used. There’s a tangible difference in risk management when the makers themselves vouch for every key input—experience has shown this to be the only way to avoid unexpected disruptions at scale-up or validation.

    Storage Life and Stability—Choices Informed by Real Reactions

    Unlike some academic sources that merely quote a theoretical shelf life, we monitor real-time, room temperature stability across regularly sampled batches. Our tracked retention samples demonstrate no visible caking, yellowing, or odor for over sixteen months, even at fluctuating warehouse conditions. Where others see hydration as a theoretical concern, we routinely check for hygroscopicity and actual pH drift. This vigilance has uncloaked minor formulation issues that, left unchecked, could have derailed large customer campaigns. We fail batches that show these issues, preventing downstream headaches for partners.

    Listening to Users: Lessons from Field Applications

    Every customer runs their process with unique quirks—dosing methods, solvents, vessel materials, reaction scales. We’ve fielded numerous calls about solubility quirks in non-traditional solvent systems, or the tendency of certain batches to foam during dissolution. Over time, we tuned final drying cycles and granulation to minimize these annoyances. Solutions rarely come from broad policy or generic advice. Instead, hands-on troubleshooting—sending process technicians to user sites, or inviting partner scientists to review our plant—has led to tweaks that made the biggest difference. No catalog spec or data sheet can substitute for that real-world collaboration.

    Why the Manufacturer’s Touch Matters Most

    For buyers who treat 2-Benzyl-2-Thiopseudourea Hydrochloride as a mere commodity, missing the production origin means risking unplanned downtime, batch failures, or regulatory headaches. Our company stands behind the product not out of branding, but because each stage from raw material receipt to finished product runs under our plant manager’s scrutiny. Our own R&D specialists have used this chemistry, so we feel the same pain when a reaction underperforms or quality slips. This breeds a seriousness that weaves through every drum shipped. We never source nor cut corners with outsourced intermediates; each step, reaction, and purification stays in-house or under direct allied plant management—no bottlenecks, no blame-shifting if things drift off-spec.

    Meeting Regulatory and Documentation Needs: Built on Experience, Not Paperwork

    Customers often need thorough support when registering a project or qualifying a supplier. We provide MSDS, analytical data, and full traceability, not because someone asked but because we know the headaches missing information can cause. Our participation in multi-national audits and technical questionnaires means every process step already aligns with common regulatory frameworks. Over the years, that same attitude resulted in faster project greenlights and reduced time-to-qualification for many partners—something that makes a crucial difference for tight project schedules. In one case, a partner flagged micro-level benzyl chloride as a risk; our team validated it out through extra GC checks and process refinement, simplifying their subsequent submission. These small details come naturally when hands are on the actual batch, not filtered through relabelers or packagers with limited authority to make changes.

    The Human Element: Skilled Hands and Real Accountability

    All too often, fine chemical production is described only in terms of reactors, vessels, or analytic devices. Here, it’s the operators, chemists, and technical troubleshooters who elevate normal production to something exceptional. Our teams share learnings in real-time, posting outlier results and lessons on a daily shift log. Problems caught by one shift become focus points on the next, so persistent minor issues get ironed out. In a facility producing 2-Benzyl-2-Thiopseudourea Hydrochloride, this means lower batch-to-batch deviation, better handling, and a stronger foundation for partners seeking scale or reliability. Chemists and production workers who touch the same process week after week spot subtle changes—whether in color, odor, or reactivity—and those observations feed directly back into process improvement cycles. This is something a remote distributor or bulk relabeler simply cannot replicate.

    Practical Value, Not Just Chemical Purity

    At the end of the day, 2-Benzyl-2-Thiopseudourea Hydrochloride made here starts from tested raw materials, advances through vetted staff, and reaches users in a state they can trust. We’ve sweat the small points—particle morphology, bulk density, interim odiferous steps—because they shape the real-world value delivered to each partner. When someone in the lab says, “This batch ran clean; no adjustment needed,” we take it as the highest compliment. Over the years, our investment in hands-on QA, practical feedback, and process integration has built more than a good product: it’s enabled chemists worldwide to make better discoveries, meet tougher deadlines, and run smoother operations—and that, to us, beats any catalog description hands down.