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2-Anilinoethanol

    • Product Name 2-Anilinoethanol
    • Alias 2-(Phenylamino)ethanol
    • Einecs 200-641-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    988862

    Chemical Name 2-Anilinoethanol
    Synonyms N-Phenylethanolamine
    Molecular Formula C8H11NO
    Molar Mass 137.18 g/mol
    Cas Number 122-98-5
    Appearance Colorless to pale yellow liquid
    Boiling Point 265 °C
    Melting Point −4 °C
    Density 1.104 g/cm³ at 25 °C
    Solubility In Water Soluble
    Flash Point 137 °C
    Refractive Index 1.592
    Logp 0.04
    Vapour Pressure 0.017 mmHg at 25 °C
    Pka 9.16

    As an accredited 2-Anilinoethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 500 mL amber glass bottle, sealed with a screw cap; labeled with `2-Anilinoethanol`, hazard symbols, and handling instructions.
    Shipping 2-Anilinoethanol should be shipped in tightly sealed containers, labeled according to local regulations. The chemical must be protected from moisture, heat, and incompatible materials. Ship with proper documentation, using appropriate hazard labeling and transport according to relevant guidelines, such as DOT or IATA, to ensure safety during transit.
    Storage 2-Anilinoethanol should be stored in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and acids. Keep the container tightly closed and stored in a chemical-resistant, labeled bottle. Avoid exposure to light and moisture. Ensure that storage areas are equipped with spill containment and are compliant with relevant safety regulations.
    Application of 2-Anilinoethanol

    Applications of 2-Anilinoethanol in Industrial Manufacturing

    As a specialized manufacturer, we supply 2-Anilinoethanol to downstream sectors that require stringent process control and traceable formulation history. Below, we outline the key industrial application areas where this intermediate directly impacts product quality, regulatory compliance, and process efficiency.

    1. Synthesis of Antihistamine Pharmaceutical Intermediates

    Drug manufacturers use 2-Anilinoethanol as a critical building block during the synthesis of various active pharmaceutical ingredient (API) intermediates, particularly in antihistamine drugs where anilino-alkyl side chains are required. The compound enters the synthetic route via nucleophilic substitution or reductive amination, forming precursors that are further processed via acylation and cyclization. Strict GMP conditions apply throughout production, with close monitoring using validated HPLC and NMR methods. The typical process demands high purity and accurate stoichiometric control to minimize process impurities and by-products, ensuring downstream compliance and product traceability.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • USP General Chapter <791> "Pharmaceutical Compounding – Sterile Preparations"
    • EDQM European Pharmacopoeia Monographs
    • CFR Title 21 Part 210-211 (FDA cGMP)

    Typical usage ratio

    • 0.20 – 0.45 molar equivalents relative to target API, adjusted according to specific intermediate formation yield and reaction path in the patented route.

    Downstream process integration

    • Added during the intermediate stage, prior to cyclization, with pH and temperature profiling based on the sensitivity of subsequent steps; batchwise addition to minimize exothermic reaction risks.

    Final product types

    • Antihistamine tablets and oral suspensions
    • Prescription allergy medication APIs
    • Intermediate bulk pharmaceutical chemicals

    2. Production of Corrosion Inhibitors for Metalworking Fluids

    Metalworking fluid formulators select 2-Anilinoethanol for its amine and alcohol functional groups, which offer effective adsorption onto metallic surfaces, protecting against both acidic and basic corrosion under high-shear machining conditions. When co-blended with triazoles and secondary amines, it enhances film formation and boost hydrolytic stability, extending coolant life and reducing downtime. End-users validate product performance via ASTM D4636 testing, with full documentation required for industrial safety and environmental impact compliance.

    Industry compliance standards

    • ASTM D4636 (Corrosion Preventive Properties of Lubricants)
    • REACH Annex XVII for amine-containing chemicals
    • OSHA Hazard Communication Standard (29 CFR 1910.1200)
    • ISO 12922:2023 for industrial lubricant formulation

    Typical usage ratio

    • 0.5 – 2.5% by weight in metalworking fluid concentrates, adjusted based on end-user metal type and coolant system recirculation frequency.

    Downstream process integration

    • Blended into base oil-emulsifier package at controlled temperature (40-60°C); integrated during initial additivation before homogenization to maximize surface activity.

    Final product types

    • Industrial metalworking coolant fluids
    • Corrosion-inhibiting additives for cutting oils
    • High-performance rolling lubricants

    3. Dye and Pigment Intermediate Synthesis

    Specialty chemical companies leverage 2-Anilinoethanol as a precursor in the synthesis of azo and anthraquinone dye intermediates. Its aromatic amine and terminal alcohol moieties enable selective diazotization and coupling reactions, allowing precise color development and improved solubility characteristics for dyeing synthetic and cellulosic fibers. Production follows detailed quality assurance protocols, including analysis per AATCC and OEKO-TEX restricted substances lists to meet textile industry export requirements.

    Industry compliance standards

    • OEKO-TEX® Standard 100
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • AATCC Test Method 61 (Colorfastness standards)
    • REACH Registration and Authorization

    Typical usage ratio

    • 0.8 – 1.1 equivalents relative to diazo or coupling component, depending on target chromophore and desired solubility of the dye intermediate.

    Downstream process integration

    • Introduced at the amination or coupling stage during dye precursor synthesis; heat and pH optimized to control reaction kinetics for high-yield conversion to active dye bases.

    Final product types

    • Reactive dyes for cotton and synthetics
    • Soluble anthraquinone pigments
    • Special tone textile colorants

    4. Epoxy Resin Curing Agent Component

    Advanced composites and electronics manufacturers incorporate 2-Anilinoethanol as a functionalized curing agent or chain extender within formulated epoxy systems. This raw material provides improved flexibility and adhesion through primary and secondary amine reactivity, with the terminal alcohol group acting as a moderating crosslinker. Its measured addition tailors working time and mechanical properties, with specific attention to its impact on Tg and hydrolytic aging. Production lines maintain ISO 9001 certified QC protocols and apply batch traceability for aerospace or critical electronics supply chains.

    Industry compliance standards

    • IEC 61249-2 industrial epoxy standards
    • ISO 9001 (Composite materials manufacturing)
    • RoHS Directive (2011/65/EU) for electronic components
    • UL 94 Flammability Testing for polymer systems

    Typical usage ratio

    • 1.5 – 4.0 phr (parts per hundred resin) in formulated epoxy/amine blends; finalized based on performance testing for adhesion and crosslink density in final part geometry.

    Downstream process integration

    • Metered into premixed epoxy resin at the compounding station; reacts during room temperature or thermal cure, with NCO/OH balance managed by in-line FTIR monitoring.

    Final product types

    • Printed circuit board laminates and prepregs
    • Structural adhesive films
    • Encapsulation resins for electronics
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    Certification & Compliance
    More Introduction

    Experience and Insights on 2-Anilinoethanol: More Than Just a Chemical

    Understanding 2-Anilinoethanol from a Manufacturer’s Bench

    Every drum of 2-Anilinoethanol leaving our plant reflects years of hard-won process control, engineering problem-solving, and close attention to the needs of chemists who rely on a consistent starting material. This compound, also known by its CAS number 122-98-5, sits at a crossroads in specialty and fine chemical synthesis. In our experience working with customers in pharmaceutical intermediates, dyes, agrochemicals, and personal care, this compound’s flexibility keeps it high in demand. The trust in quality doesn’t grow overnight; we’ve learned firsthand how tight specifications can make or break downstream processes. Each patch of impurity risks costly interruptions or failed batches. We have watched lab teams call out off-odors, color changes, or subpar purity more than once during customer audits. 2-Anilinoethanol, produced under tightly managed conditions, avoids these headaches and has proven its value as a reliable ingredient in countless final products over the years.

    The Making: Consistency Through Hands-on Process Control

    Years of working on the production floor have underscored the difference between routine chemical manufacturing and delivering material that holds up under industrial scrutiny. Our process for manufacturing 2-Anilinoethanol uses carefully sourced aniline and high-purity ethylene oxide, reacting under monitored pressure and temperature conditions. Many operations that aim for shortcut methods end up battling byproducts—a trace nitrosamine or leftover catalyst can have a real impact, especially in pharmaceutical work. We have responded to this by tracing every batch, from raw material to finished liquid, running infrared, GC-MS, and elemental analysis at each checkpoint. A transparent approach with detailed batch records speaks volumes to auditors who need every assurance about what goes into their own manufacturing chain. Efforts go beyond just the synthesis steps; shipping drums must be protected against moisture pickup and photo-oxidative yellowing. Storage at the right temperature and avoidance of air ingress prevent material degradation, something you can see with your eyes in clear glass and confirm with a quick melting point measurement.

    Real Specifications with Real Impact

    Talking with production supervisors about why batches seem to perform differently in methylation or amidation reactions often traces back to specification drift in 2-Anilinoethanol. The best practice keeps water content below 0.1%, because even slight hydrolysis ruins next-step yields. Each bottle leaving our facility carries a specification: minimum 99% assay by GC, less than 0.5% total impurities, and a faint pale-yellow tinge at most. High-color material indicates breakdown or contamination—customers have returned more than one shipment from less scrupulous suppliers when such flaws have slipped through. Packing in lined drums, sampling before and after transit, and providing a full certificate of analysis for every lot illustrates what rigorous specification really means, not just on paper but in the real world of chemical manufacturing.

    Differentiating from Lookalike Amino Alcohols

    Some buyers mistake 2-Anilinoethanol for relatives like N-phenylethanolamine or N-methylethanolamine, thinking one can substitute for another. They quickly find headache if a parallel run stalls, or a tint appears overnight in a dye bath. 2-Anilinoethanol’s secondary amine group, as opposed to a primary amine, reacts differently in condensation and coupling reactions. Synthetic chemists favor our product where selective alkylation or acylation makes or breaks a process. In surfactant manufacture, the solubility profile of 2-Anilinoethanol leads to better emulsification compared to bulkier analogues. We have responded to inquiries about using cheaper aminoethanols but experience and hard data reinforce the risks—narrow margins on raw material savings disappear amid troubleshooting and off-spec product runs.

    Key Uses Shaped by Practical Demands

    On the plant floor and in customers’ R&D labs, the use cases for 2-Anilinoethanol extend further than textbooks suggest. One of the most substantial applications came up during our work on developing intermediates for analgesic pharmaceuticals, where minute impurities passed through in API synthesis. Similar controls apply in crop-protection agents, where regulators scrutinize precursor traceability. In dye houses, batches of 2-Anilinoethanol serve as modifiers giving unique hues or improved fastness, especially in acid dyes. We spent years collaborating with textile engineers to balance reactivity and color stability, adjusting process buffers and reaction temperatures to stretch the capabilities of this material. Paint and polymer formulators rely on 2-Anilinoethanol as a functional additive, providing amine cross-linking and controlled hydrophilicity—attributes tested to their limits in automotive and household coatings. Hair color products and specialized cosmetic treatments benefit from the mild reactivity and manageable toxicity profile, filling a safety requirement unmet by more reactive aliphatic amines.

    Why Purity and Handling Shape Process Success

    Stories from the lab are filled with frustrated R&D teams whose pilot batches failed because of metal residues or inconsistent viscosity—not because formulas were wrong but because starting material lacked modern process purifying steps. 2-Anilinoethanol, clear and free-flowing, signals proper distillation and exclusion of environmental contamination. Sampling frequently and checking water by Karl Fischer titration catches out small leaks or corked containers, both of which can cause substantial losses. Proper personal protective equipment and clear ventilation practices shape daily routines for plant staff, reducing the risk of exposure-related dermatological issues linked with aniline moieties. Having spent hours in the QA lab, we view every rejected carboy as a wake-up call: an impure batch costs time, upsets downstream schedules, and can even jeopardize business relationships. Pinpointing the root cause means learning from your errors, not hiding them.

    Troubleshooting and Technical Support: Lessons from Real-World Failures

    Few things clarify the importance of product support more than seeing a customer’s process grind to a halt. We’ve walked factory floors with clients to diagnose unexpected discoloration in a resin batch, only to trace it back to trace metal pickup in a drum valve. By sharing our manufacturing and quality control procedures openly, we help technical teams on both sides pin down issues fast, reducing downtime. Some challenges require tweaking reaction pH, others demand fine-tuning storage temperatures or switching to new packaging. Direct interaction between manufacturer and end-user reveals the subtle interplay between equipment limitations, environmental factors, and the chemistry itself. No single specification fits all users, but common ground emerges when sharing firsthand insights from years in the industry.

    Regulatory and Environmental Responsibility: Earning Trust Beyond Labels

    Stakeholders from regulatory bodies demand far more than a line in a safety data sheet. Our compliance teams maintain up-to-date registrations at country and international levels, following detailed guidance on permissible uses, emissions, and worker exposure limits. Being both a manufacturer and a supplier places greater responsibility in ensuring that each drum, pallet, or tank is tracked, properly labeled, and supported with robust documentation. Environmental stewardship means recycling wash solvents, keeping emissions below legal thresholds, and designing batch sizes that minimize waste. Inspections are frequent, and stakeholders don’t hesitate to dig into cradle-to-grave documentation tracing every gram of 2-Anilinoethanol through the supply chain. Years of preparing for spot audits, third-party certifications, and periodic product recalls have shaped our approach. Open disclosure of methods and results doesn’t just build trust; it reflects an understanding that our license to operate extends well beyond the fence line of the plant.

    The Challenge of Competing Claims in the Marketplace

    In the chemical world, buzzwords travel quickly—promises of “high purity,” “lowest price,” “guaranteed performance” hit websites and trade shows globally. Years ago, a run of low-cost 2-Anilinoethanol entered some markets, leading to a spate of complaints about process instability. Labs waste days troubleshooting, only to uncover product adulteration or mishandling between producer and trader. We believe in offering traceability all the way to the raw material invoice, which reinforces accountability. Repeat customers stick around not because of best marketing, but because their own quality metrics show consistent results and predictable performance batch to batch.

    Practical Guidance on Storage, Safety, and Shelf Life

    Experienced production managers—not just in our plant, but among our most successful customers—keep a close eye on how 2-Anilinoethanol is stored. Neglecting simple steps like sealing containers, managing humidity, or sheltering from sunlight can undermine weeks of careful synthesis. Shelf life depends not just on the initial quality, but on how the material is treated in the warehouse. Crystallization at low temperatures or discoloration from metal contact signals improper storage. We mark each drum with best-use-by dates, and provide direct support for those with unique storage setups, including advice on nitrogen blanketing and temperature-controlled transport. Some of the sharpest feedback from our community has revolved around misunderstandings on safe handling; we respond with documentation, training, and visiting technical staff when required. Workers deserve straightforward answers, not jargon or vague reassurances, and every lesson learned from prior incidents shapes future training.

    Innovation Driven by End-User Feedback

    The most effective improvements in our process stem from dialogue with users, whether it’s developing a cleaner catalyst system or adjusting distillation parameters to minimize high-boiling impurities. In one case, a large customer in specialty dyes collaborated with our process chemists to untangle a batch-to-batch reactivity issue. By tweaking the reaction conditions and filtering protocol, both teams saw more robust runs and fewer rejects. We encourage feedback about performance in the field, packaging convenience, and compatibility with automated dispensing, taking each comment as a prompt for better calibration. Manufacturers who close this loop run fewer risks of being blindsided by new regulatory issues or quality shortfalls.

    Distinct Value Compared to Distributor-Sourced Material

    We’ve seen first hand that material moving from distributor to warehouse picks up risks of tampering, incorrect labeling, or improper conditions—each a hidden cost for the end user. Direct supply from our plant means every drum, tote, or bulk container leaves with a history of traceability, current certifications, and a process owner available for problem-solving. Customers working with complex regulatory regimes count on that difference, rarely gambling with unvetted sources when specifications matter. Our investment in modern analytical instrumentation and trained personnel far outpaces the shortcut approaches of bulk traders. Real-world results, reflected in uninterrupted production lines and fewer customer complaints, offer proof stronger than any sales pitch.

    Adaptation for Regulatory, Market, and Technological Change

    Markets shift as regulatory scrutiny, cost pressures, and technical trades shape new customer requirements. Years ago, the push for greener and safer processing inspired us to retool unit operations and reduce water and energy demands. Ongoing staff training and periodic upgrades to analytical labs underscore our focus on upholding both performance and compliance. As trade restrictions or labeling laws evolve, the ability to maintain continuous product availability and meet shifting documentation requirements sets a manufacturer apart from a distributor or trading agent. Our team views adaptation not as upselling but as a daily reality—staying ahead of the curve requires practical vigilance, and a steady investment in people and systems. Returning customers and fewer process interruptions testify to this mindset far more than generic assurances or certification logos.

    Building a Community of Practice

    The trust earned between chemical manufacturer and customer goes beyond periodic shipments. It extends into technical working groups, standards committees, and informal networks that shape best practices for storage, handling, and process optimization. Our technical representatives frequently contribute to industry forums and training workshops, not just as marketers but as hands-on experts whose reputation rests on the material’s reliable performance in demanding applications. This collaborative approach pays back in both process learnings and mutual respect. Accounts of a smoother scale-up, averted recall, or recovered batch underscore the dividends of such partnership. We find that sharing data, discussing failures honestly, and inviting critique sharpens both our team and our community, raising the bar for quality and responsible chemical practice.

    Sustainability as a Built-in, Not a Buzzword

    Over the years, sustainability has become more than just a line in promotional material. Our investments in safe disposal, engineered controls for emissions, and solvent recycling reflect not only compliance requirements but practical lessons from reducing costs and earning community trust. Buyers seeking reliable 2-Anilinoethanol recognize that sustainability is integrated—every step from sourcing through delivery builds lasting value for workers, neighbors, and customers alike. Efforts to minimize waste, lower energy use, and protect everyone in the production and handling chain come from knowing the real dangers posed by shortcuts. The lessons we bring from countless audit cycles and incident reviews reinforce that sustainability measured in actual workplace safety and environmental compliance lasts beyond a single contract or transaction.

    Real-World Evidence: The Bottom Line of Quality Control

    Every manufacturer markets with slogans; the real credibility emerges in the field, in repeated tests by independent users. Years of working alongside customers through process development, regulatory approvals, and the inevitable troubleshooting build a unique perspective for those who take chemistry seriously. Our position as a direct manufacturer ensures not only access to technical expertise but also the weight of practical proof—a record of batches shipped, audits passed, and applications enabled. The real test of 2-Anilinoethanol’s value arises in consistent dye lots, reliable crop-treatment intermediates, robust API syntheses, and smooth operation of automated dispensing lines. Selective partnership with responsible manufacturers benefits not only production efficiency, but also the confidence required to take on new markets and technical challenges.

    Conclusion: Commitment Rooted in Experience

    For those of us tasked daily with the responsibility of making, testing, and delivering 2-Anilinoethanol, every batch represents both technical mastery and stewardship of customer trust. We base every claim on practical outcomes, not just analytical numbers or price points. Years at the bench and on the production floor have taught us that attention to detail, transparency, and openness to feedback mark the true difference in specialty chemical manufacturing. The journey of each drum, from initial synthesis through shipment to application, is guided by more than standard protocols—it's informed by lessons learned through collaboration, adaptation, and an unwavering focus on quality. This perspective informs every step, and serves as our commitment to those who rely on consistent, traceable, high-specification 2-Anilinoethanol for their next breakthrough process.