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2-Aminonicotinic Acid

    • Product Name 2-Aminonicotinic Acid
    • Alias 2-Aminopyridine-3-carboxylic acid
    • Einecs 210-626-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    236657

    Cas Number 534-03-2
    Molecular Formula C6H6N2O2
    Molecular Weight 138.12 g/mol
    Iupac Name 2-aminopyridine-3-carboxylic acid
    Appearance White to off-white crystalline powder
    Melting Point 291-293 °C (decomposes)
    Solubility In Water Slightly soluble
    Density 1.51 g/cm³
    Pka 2.6 (carboxylic acid), 4.5 (amino group)
    Smiles C1=CC(=NC(=C1)C(=O)O)N
    Inchi InChI=1S/C6H6N2O2/c7-5-3-1-2-4(8-5)6(9)10/h1-3H,7H2,(H,9,10)

    As an accredited 2-Aminonicotinic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2-Aminonicotinic Acid, 100g, is packaged in a sealed, amber glass bottle with a secure screw cap and safety labeling.
    Shipping 2-Aminonicotinic Acid is shipped in tightly sealed containers to prevent moisture absorption and contamination. It should be stored and transported in a cool, dry location, away from incompatible substances. Proper labeling and handling in accordance with applicable regulations ensure safety during shipping. Suitable for ground, air, or sea transport as per regulatory guidelines.
    Storage 2-Aminonicotinic acid should be stored in a tightly sealed container, away from moisture and incompatible substances such as strong oxidizing agents. Keep it in a cool, dry, and well-ventilated area, protected from light and sources of ignition. Properly label the storage container and restrict access to trained personnel to ensure safe handling and minimize contamination or degradation risks.
    Application of 2-Aminonicotinic Acid

    Applications of 2-Aminonicotinic Acid in Industrial Manufacturing

    2-Aminonicotinic Acid functions as a core intermediate in several specialized chemical and life sciences industries. Its unique molecular structure supports the synthesis of higher-value downstream products in pharmaceuticals, agrochemicals, dyes, and electronics, each requiring strict quality control and specific process integration. Below, we outline key industrial application tracks with precise technical relevance.

    1. Pharmaceutical Active Ingredient Synthesis

    Pharmaceutical manufacturing commonly utilizes 2-Aminonicotinic Acid for building advanced pyridine or nicotinamide-based drug molecules. R&D and commercial synthesis often require high purity for use in both API and intermediate stages, such as in the preparation of antitubercular agents or antihypertensive compounds. The raw material introduces the amino-pyridine motif into multi-step synthetic routes through acylation, cyclization, or oxidative coupling, and all operations occur under strict cGMP conditions.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US Pharmacopeia (USP) compliance for related substances
    • EU EudraLex Volume 4 Part II GMP for APIs
    • FDA 21 CFR Part 210/211

    Typical usage ratio

    • Typically 0.5–2 molar equivalents relative to final product intermediate; adjusted depending on route scale and reaction stoichiometry

    Downstream process integration

    • Charged during the first or second synthetic step; reacts under temperature-controlled, anhydrous conditions, often in inert gas or solvent systems (DMF, DMSO)
    • Purified by recrystallization or chromatography prior to further modification

    Final product types

    • API intermediates for anti-infective drugs (e.g., antituberculosis compounds)
    • Antihypertensive drug intermediates
    • Pyridine ring analogues for new chemical entities (NCEs)

    2. Agrochemical Intermediate Manufacturing

    Agrochemical synthesis demands high consistency in intermediates for final pesticide or herbicide formulations. 2-Aminonicotinic Acid introduces a nitrogen-substituted aromatic ring, which is essential for selective crop protection agents. Processing utilizes the material in condensation or amidation stages to tailor activity and persistence of actives. End-use compliance focuses on environmental safety and minimal impurity transfer.

    Industry compliance standards

    • FAO/WHO Technical Specifications for Pesticide Intermediates
    • ISO 9001:2015 for process quality management
    • REACH (EC) No 1907/2006 for registration and use in the EU
    • US EPA 40 CFR Part 167

    Typical usage ratio

    • 1:1 to 1:1.2 molar ratio with downstream halogenating or acylating agents; optimized per target molecule yield

    Downstream process integration

    • Added at step two or three for ring closure, etherification, or amide formation, followed by downstream purification and formulation
    • Monitored for residuals to meet regulatory impurity thresholds

    Final product types

    • Nicotinic-based herbicidal pre-mixes
    • Selective insecticide intermediates
    • Fungicide precursor blends

    3. Colorant and Dye Intermediate Production

    The dye and colorant sector exploits the aminonicotinic acid moiety for synthesizing specialty azo or vat dyes, particularly for polyamide and cellulose fibers. Its integration allows manufacturers to establish chromophore linkages and fine-tune shade stability against light and laundering. Regulatory focus ensures banning of hazardous amine by-products, with full traceability required across supply chains.

    Industry compliance standards

    • OEKO-TEX Standard 100 for restricted substances
    • ZDHC MRSL for manufacturing-restricted substance lists
    • EN 71-3:2019 for colorants in toys and textiles
    • ISO 9001 for batch traceability

    Typical usage ratio

    • Usually 0.8–1.2 molar equivalents per chromophore-forming coupling agent; varies with target dye intensity and substrate

    Downstream process integration

    • Enters coupling stage with diazonium salts under controlled pH and temperature
    • Refined through multiple purification cycles to remove color-stable impurities

    Final product types

    • Azo dyes for textile finishing
    • High-performance pigments for inkjet and offset printing
    • Colorant concentrates for engineering plastics

    4. Electronic Materials Synthesis

    2-Aminonicotinic Acid acts as a building block for organic electronic components, including conductive polymers, OLED emitters, and specialty ligands for complexation. Electronic-grade manufacturing emphasizes ultra-low metal content and particulate control, alongside batch-level documentation for traceability to final devices. Integration often occurs at initial polymerization or ligand synthesis stages, where purity strongly impacts electrical and optical properties.

    Industry compliance standards

    • JEITA standards for electronic and electrical materials
    • IPC-1752 for material declaration management
    • RoHS Directive 2011/65/EU for hazardous substance restriction
    • ISO 14644 for cleanroom operations during production

    Typical usage ratio

    • 0.5–1.5 molar equivalents in condensation or polymerization reactions, customized to molecular weight targets

    Downstream process integration

    • Introduced at precursor synthesis for OLEDs or conjugated polymer chains, followed by solvent removal and controlled crystallization
    • Filtered to sub-micron levels pre-application in device fabrication

    Final product types

    • Polymeric hole transport materials for OLEDs
    • Ligand-modified metal complexes for thin-film semiconductors
    • High-purity intermediates for advanced battery electrolytes

    5. Fine Chemical Catalysts and Ligands

    The acid group and aromatic amine in 2-Aminonicotinic Acid facilitate synthesis of chelating ligands and coordination catalysts for homogeneous and heterogeneous catalysis. Commonly used in fine chemical and pharmaceutical process intensification, the compound serves as a precursor in ligand precursor pools or for functionalizing catalyst supports, enabling high selectivity and activity in controlled reactions.

    Industry compliance standards

    • ISO 17025 for analytical testing of catalyst components
    • GLP guidelines (OECD) for research catalyst development
    • EU Chemical Agents Directive 98/24/EC for workplace safety
    • REACH registration for specialty chemicals

    Typical usage ratio

    • 0.1–0.5 molar equivalents relative to metal source or support; adjusted to achieve desired ligand-to-metal coordination

    Downstream process integration

    • Added during initial ligand synthesis or before metal complexation under inert atmosphere
    • Purified via solvent extraction or column techniques before downstream application in batch or continuous reactors

    Final product types

    • Transition-metal chelates for fine chemical synthesis
    • Enantioselective catalysts for pharmaceutical API manufacture
    • Solid-supported catalyst ligands for industrial reactors
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    Certification & Compliance
    More Introduction

    2-Aminonicotinic Acid: Precision Chemistry Direct from Our Facility

    Understanding What Sets Our 2-Aminonicotinic Acid Apart

    Producing 2-Aminonicotinic Acid isn’t just about achieving a chemical reaction on paper. As manufacturers with decades of hands-on experience, we know subtle differences in synthesis, purification, and packaging determine the real value customers receive. This molecule—used widely in pharmaceutical and agrochemical research—requires consistent purity and a reliable process for downstream applications to succeed. Our production lines handle 2-Aminonicotinic Acid with the same care that got us trustworthy recognition among long-term clients. We don’t cut corners. Every batch gets processed using well-characterized routes, and every shipment reflects controls that go well beyond minimum requirements.

    Pure Intention in Material Quality

    Chemists rely on clean starting materials. Off odors, slight discolorations, or uncontrolled isomer ratios cause headaches in a hurry. Our 2-Aminonicotinic Acid, modeled and verified with high-performance liquid chromatography (HPLC), keeps impurity levels in check—so researchers and production chemists don’t waste time troubleshooting unnecessary interferences. Typical specs range above 99% purity, which we confirm with robust in-house analytical data. Moisture, metal content, and particulate matter have dedicated controls. If you compare our shipments to typical distributor-sourced lots, you'll spot fewer out-of-spec surprises. The physical form resembles a pale powder that flows easily and dissolves predictably in water and common organic solvents, reflecting the close quality control that goes into every stage.

    From Synthesis to Storage: Experience Fuels Consistency

    Producing 2-Aminonicotinic Acid starts with choosing solid raw materials. Some feedstocks tempt with lower prices, but they vary batch to batch. Our team evaluates and qualifies vendors, and any supplier drift earns fast scrutiny or outright replacement. Every run’s process conditions target a reproducible structure: aminonicotinic acid free of significant byproducts. The synthetic route—optimized over years of in-house R&D—uses carefully designed conditions to cut formation of problem impurities, including isomeric contaminants and polymeric side products. Recrystallization and drying preserve the solid’s stability until you open the package at your own bench.

    We store finished material in humidity-controlled rooms. Before shipment, the team samples and tests for signs of degradation or contamination. If a drum sits too long, we retest and send nothing but current lots. Chemical stability supports storability, so you don’t need to plan for rapid degradation or unexpected breakdown. With a shelf life routinely measured in years under recommended storage, waste stays low and costs remain predictable for both research and scale-up users.

    Why Customers Choose Direct-Manufacture Sourcing

    There’s a lot of 2-Aminonicotinic Acid floating around the market from unknown sources. Packaging might look professional, but mystery origins breed risk. Third parties often lack visibility into process controls, batch traceability, and production records. By owning every step ourselves, we give end users confidence. If someone calls with a technical question—a synthetic scheme that hits a wall, or a regulatory audit—we pull lab notebooks and retained samples, not just a certificate slapped together by a reseller.

    Clients who need trace-level impurity profiles, regulatory support, or even custom specifications get timely answers from our technical team. Documents aren't generic; they reflect the true process and actual batch records. This real connection—the dialogue between scientists, engineers, and buyers—sets direct manufacture apart from anonymous intermediaries. When your process matters, why rely on someone who can’t access process data or provide verifiable purity results?

    Applications That Depend on Material Integrity

    2-Aminonicotinic Acid isn’t a niche specialty chemical for a handful of labs. Its core structure—a pyridine ring with an amino and carboxylic acid group—gives it wide utility. As a key intermediate for synthesizing active pharmaceutical ingredients, advanced agrochemicals, and dyestuffs, it performs only as well as the starting quality allows. In drug discovery, trace impurities spark analytical noise and regulatory headaches. Our chemists understand that customers need repeatable results. Our analytical department routinely validates our product’s identity by multiple orthogonal techniques: nuclear magnetic resonance (NMR), mass spectrometry, and melting point testing, ensuring no surprises hit your chromatography trace.

    Academic researchers trust our batches when precise stoichiometry, spectral clarity, or high-yield transformations are on the line. Process chemists scaling to pilot plant levels ask for our product by name, recalling past runs that stayed on target from kilo to multi-ton scale. Those developing advanced materials or functionalized ligands need consistent lot-to-lot reproducibility, so unexpected byproducts don’t confound product performance. They’re not just buying a chemical; they’re investing in peace of mind for their next step.

    Real Differences from Off-the-Shelf or Distributor Stocks

    Purchasing from a direct manufacturer means knowing the molecule’s history. We’ve seen too many cases where clients switch after mysterious batch variability causes trouble in downstream synthesis. One of our long-term pharmaceutical clients struggled for months using spot purchases from a reseller; process yields dropped and unknown peaks appeared in their high-performance liquid chromatography chromatograms. Switching to our lot stabilized their workflow on the first batch, slashed troubleshooting man-hours, and gave them a clear regulatory paper trail.

    Unlike generic distributors, we can adjust drying, particle sizing, or even crystallinity to fit specific technical needs. Our facilities support pilot-scale quantities or research-scale bottles with the same process controls. Customers rely on us to batch reserve, guaranteeing matching product until process validation confirms commercial launch readiness. Instead of searching for ad hoc fixes or running “trials” with mismatched lots, clients write their quality assurance protocols around our consistent product.

    Specifications in the Lab and the Real World

    While it’s tempting to browse catalog numbers and compare price per kilogram, those numbers rarely capture the experience of chemical handling or downstream success. Our analytical support gives more than a snapshot: every lot ships with an up-to-date certificate of analysis, true to the actual batch—not a theoretical or averaged figure. Impurity profiles, melting range, water content, and residual solvents appear alongside spectral data. Sometimes customers ask for expanded heavy metal testing, or guidance on storing the acid under specific process conditions. Our team answers those questions clearly, without boilerplate or evasiveness. If purity or salt form matters for your work, or if you need advice on custom packaging or stability during shipping, this direct access makes the difference between a reliable experiment and a wasted effort.

    We don’t treat 2-Aminonicotinic Acid as static inventory. Process adjustments—guided by customer feedback and in-house analysis—fine-tune yield and purity over time. Some competitors buy and repackage, losing touch with process drift or packaging artifacts. Our facilities bring everything in-house: synthetic chemists oversee process adjustments; quality teams review release data; logistics staff maintain packaging integrity from warehouse to customer. End-to-end control isn’t a marketing slogan—it’s practical risk reduction for everyone in the supply chain.

    Addressing Common Issues and Bottlenecks in Sourcing

    Raw material shortages, shipping delays, and regulatory shifts challenge every chemical producer. During the last five years, we’ve seen several cycles in global pyridine derivatives supply. Clients who rely solely on spot markets face unpredictable costs and missed project deadlines. Our approach involves reserve purchasing, in-house inventory for critical components, and real-time response to demand signals from key customers. We hold material ahead of schedule for routine users, maintain robust safety stocks, and prioritize supply contracts for production-critical clients, keeping their work running even as global logistics wobble.

    Another common problem: mystery impurity profiles in off-brand material. Too many resellers supply chemicals with untraceable origins or incomplete documentation. Some clients do their own extra purification, spending time and money correcting what the vendor should have resolved. Working with us cuts the root issue—our quality team stands ready to supply detailed proof, including impurity fate during downstream transformation, and clarifies regulatory documentation with national and international bodies to meet compliance demands.

    Looking to the Future: Process Innovation and Customer Feedback

    Changing environmental regulations and shifting market demands challenge everyone in specialty chemical manufacturing. As governments tighten discharge restrictions and customer standards evolve, we evaluate greener process routes and waste minimization steps every year. Our R&D staff probes alternative solvents, energy-efficient heating, and next-generation purification options. No process is frozen in time. If a new method can cut waste or improve process robustness, we evaluate, test, and implement the upgrade. These investments pay off not just for us, but for every client who wants reliable supply with a reduced environmental footprint.

    Customers notice these improvements. Several longstanding partners requested greener packaging and better information on process sustainability. We swapped many legacy shipping containers for recyclable materials and now offer customers details on waste stream management. The feedback loop from direct users keeps us improving. It’s rare to get that conversation with a distributor. Here, customer comments spark concrete changes—improved drying technique, tighter packaging, and more granular analytics on request.

    Meeting Tough Regulatory and Analytical Standards

    The pharmaceutical and agrochemical markets continue to raise the bar on analytical scrutiny. Trace contaminants that slipped through detection years ago now trigger costly delays, repeat syntheses, or even regulatory notice. Our laboratory stays ahead, calibrating modern equipment and training technical staff in advanced analytical techniques. Nuclear magnetic resonance, gas chromatography–mass spectrometry, and inductively coupled plasma methods validate each batch. Our customers know that regulatory submissions, tech transfer, and even patent disclosures demand solid, verifiable data. Working with direct manufacturers removes the guesswork—our control over source data means every number, graph, and report is ready for regulatory review, reducing the risk of repeat testing or adverse findings.

    Partnership Beyond the Molecule

    Anyone can sell a molecule. Very few back that sale with an experienced technical team, transparent process, and an open dialogue on problems as they arise. Some customers have worked with us long enough to remember our earliest process iterations—several process chemists use our 2-Aminonicotinic Acid as their internal standard in downstream synthesis, noting its consistency, batch after batch. Long-term users attest to smoother scale-ups and fewer setbacks during pilot manufacture. One major agricultural science client cited years of uninterrupted supply of our acid as a key factor in meeting their own internal goals for product launch and regulatory clearance.

    Why Quality Matters for Process Scalability

    Research success often starts in a small flask, but commercial viability depends on process scalability and repeat consistency. Poor-quality 2-Aminonicotinic Acid causes more problems than a failed experiment; it can shut down entire product lines or push back drug development timelines by months. Our experienced staff—many with a background in process development—understand that any variable at this step multiplies into bigger costs later on. That’s why every production batch is tracked, from gram to ton scale, with process logs available for customer review. Our technical support doesn’t disappear after delivery—clients regularly engage us during scale-up under load, and we step in quickly with documentation, retained samples, or even process design advice.

    Economic and Environmental Considerations for Modern Sourcing

    Rising raw material costs, regulatory fees, and customer demand for sustainability push manufacturers to innovate year over year. We run frequent cost analysis on our process to identify savings, so end users see real value in both bulk orders and specialty lots. Waste stream reductions, energy-efficient production, and solvent recovery distinguish our environmental record from less transparent suppliers. Certifications for safety, sustainability, and quality management reinforce practices customers have come to expect. These aren’t just forms on a wall—internal audits and third-party inspections back up every claim.

    Building Trust From the Ground Up

    Investing in a direct relationship with a manufacturer lets clients de-risk their critical work at a fundamental level. Our 2-Aminonicotinic Acid comes with a traceable, repeatable process, locked in with every shipment and backed by real technical support. If a product recall ever becomes necessary—which remains rare—the direct connection enables us to act swiftly, contact every impacted user, and review root causes transparently. In the rare event of a quality investigation, we open our records proactively and support root-cause analysis with retained samples. Clients who start with us rarely look back: the improved documentation, real-time technical support, and freedom from the mystery of “grey market” material reduces stress for every user along the chain.

    Closing Thoughts: A Relationship Built on Chemistry

    2-Aminonicotinic Acid isn’t just another interchangeable commodity. For chemists, process engineers, and regulatory teams, this compound marks the starting line for compounds with massive impact—from advanced medicine to next-generation crop protection and new functional materials. As direct manufacturers, we bring the best of experience, process rigor, and technical partnership to every container that leaves our dock. We know our process inside out, and our commitment to real, repeatable quality stands clear in every order. Real results follow real diligence—and in the world of specialty chemicals, that difference shapes careers, projects, and lives across the entire supply chain.