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(2-Aminoethyl)Phosphonic Acid

    • Product Name (2-Aminoethyl)Phosphonic Acid
    • Alias AEP
    • Einecs 206-313-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    859159

    Cas Number 1501-83-9
    Molecular Formula C2H8NO3P
    Molecular Weight 125.07 g/mol
    Synonyms Ciliatine, AEP, Aminoethylphosphonic acid
    Appearance White crystalline powder
    Melting Point 237-243 °C (decomposes)
    Solubility In Water Freely soluble
    Ph 1 Solution In Water 2.0-3.0
    Boiling Point Decomposes before boiling
    Density 1.57 g/cm³
    Iupac Name 2-aminoethylphosphonic acid

    As an accredited (2-Aminoethyl)Phosphonic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of (2-Aminoethyl)Phosphonic Acid is supplied in a sealed, white HDPE bottle with a secure screw cap and labelled details.
    Shipping (2-Aminoethyl)Phosphonic Acid is shipped in tightly sealed, clearly labeled containers to prevent contamination and moisture exposure. Packages comply with all chemical safety and transport regulations. Proper documentation and handling instructions are included to ensure safe delivery. Store and transport in a cool, dry place, away from incompatible substances.
    Storage (2-Aminoethyl)phosphonic acid should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible substances such as strong oxidizing agents. Ensure the storage area is equipped to prevent moisture ingress and is labeled appropriately. Avoid exposure to extreme temperatures and keep out of reach of unauthorized personnel.
    Application of (2-Aminoethyl)Phosphonic Acid

    Applications of (2-Aminoethyl)Phosphonic Acid in Industrial Manufacturing

    (2-Aminoethyl)Phosphonic Acid is widely utilized across several industrial sectors as a specialty intermediate, chelating agent, and functional additive. Our direct manufacturing expertise supports precise integration into various critical processes where strict compliance, accurate formulation, and process stability are essential to final product quality.

    1. Water Treatment Formulations for Industrial Cooling Systems

    This raw material works as an effective scale inhibitor and metal ion chelation additive in industrial closed and open-loop cooling water processes. Its strong metal-binding properties allow stable control of calcium, magnesium, and iron ions at different pH levels. Industrial formulators configure its dosage to maximize component lifespan and minimize equipment fouling under variable system loads, ensuring reliability in petrochemical plants, power generation facilities, and municipal waterworks.

    Industry compliance standards

    • ASTM D512 Standard Test Methods (chloride content)
    • NSF/ANSI 60 Drinking Water Treatment Chemicals – Health Effects
    • ISO 14001 Environmental Management Systems (emission control in effluent streams)
    • U.S. EPA Regulation 40 CFR Parts 141 & 143 (potable water additives in cooling towers)

    Typical usage ratio

    • 5–80 mg/L in circulating water, calculated against total make-up water flow and ionic load.
    • Higher dosage up to 120 mg/L for systems with frequent make-up or concentrated scaling risk.
    • Ratio adjusted for water hardness, total dissolved solids, operating temperature, and target cycle of concentration.

    Downstream process integration

    • Batch dosing into pre-mix tanks prior to entering main water circuits.
    • Continuous injection via programmable pump systems during operation.
    • Quality monitoring with inline potentiometric or colorimetric analytics for process verification.

    Final product types

    • Blended liquid industrial water treatment packages
    • Ready-to-use antiscalant solutions
    • Custom chelating agent concentrates for system maintenance contractors
    • Pre-mixed corrosion and deposit control products for heavy industrial clients

    2. Synthesis of Durable Flame Retardants for Engineering Plastics

    (2-Aminoethyl)Phosphonic Acid serves as a core intermediate for producing phosphonate-based flame retardant additives used in engineering polymers. Phosphonic acid derivatives get reacted with polymer backbones or blended as masterbatches, imparting high thermal stability and flame resistance. This application requires strict analytical controls to meet certified burn resistance and toxicity limits in electrical and automotive components.

    Industry compliance standards

    • UL 94 Flammability Standard (plastics vertical and horizontal burn tests)
    • REACH Regulation (EC) No 1907/2006 (substance registration for polymer additives)
    • EN 45545-2 Railway Applications – Fire Protection on Railway Vehicles
    • IEC 60695-11-10/20 Fire Hazard Testing (electronic equipment)

    Typical usage ratio

    • Compounders typically use 2–15 wt% based on polymer type and target flame class rating.
    • Higher loading in glass fiber-reinforced nylons and polyesters up to 18 wt%.
    • Ratio fine-tuned with synergists (melamine, ATH) for different resin systems.

    Downstream process integration

    • Direct chemical synthesis with polymer precursors for reactive flame protection.
    • Incorporation during twin-screw compounding to produce flame retardant masterbatches.
    • Automated gravimetric and aqueous dosing for exact additive dispersion.

    Final product types

    • Flame-retardant polyamide and polyester pellets
    • Non-halogenated flame retardant masterbatches for plastics converters
    • Injection-molded electrical housings
    • Automotive interior and under-the-hood components

    3. Intermediate for Organophosphonate Scale Inhibitors in Oilfield Operations

    Oilfield chemical formulators select (2-Aminoethyl)Phosphonic Acid as a precursor for advanced organophosphonate scale inhibitors. These inhibitors maintain brine flow integrity and protect downhole equipment across upstream and midstream oil production environments. The raw material enters direct syntheses where purity and precise functional group availability support complexation with major scaling cations in high-salinity fields, supporting reliable pipeline and wellbore operation.

    Industry compliance standards

    • API RP 45 Testing Substances in Oilfield Water (performance and compatibility)
    • ISO 9001:2015 Quality Management Systems for oilfield chemical processes
    • QHSE Guidelines for Production Chemicals (major operators: Shell, BP, Chevron, etc.)
    • U.S. EPA Regulation 40 CFR – Environmental protocols for oilfield discharges

    Typical usage ratio

    • Formulators blend 10–500 ppm in brine injections, adjusted to scaling potential and pipeline diameter.
    • Subsea injection concentrations up to 800 ppm for extreme scaling environments.
    • Ratio determined after detailed brine and scale-forming ion analysis (e.g., Ba2+, Sr2+).

    Downstream process integration

    • Batch synthesis of organophosphonate inhibitors in jacketed reactors.
    • Incorporation into ready-to-use field service blends (often with co-antiscalants and corrosion inhibitors).
    • Automated dosing skids for continuous wellhead or pipeline chemical injection systems.

    Final product types

    • Oilfield scale inhibitor concentrates
    • Multi-component production chemical blends
    • Downhole scale and corrosion treatment packages
    • Flow assurance chemicals for FPSO and well services

    4. Synthesis of Biocompatible Phosphonate Ligands for Metal Ion Separation

    (2-Aminoethyl)Phosphonic Acid is a critical feedstock in specialized ligand synthesis for medical and analytical metal ion separation. These ligands, integrated into chelation columns or specialty filtration media, provide superior selectivity for divalent and trivalent metal contaminants. Manufacturers require high purity and trace metal control throughout the synthesis to ensure regulatory compliance and efficacy in downstream purification systems used by life sciences, diagnostics, and pharmaceutical sectors.

    Industry compliance standards

    • USP <823> Radiopharmaceuticals – Quality of reagents and chelating agents
    • ISO 13485 Medical Devices – Quality Management for analytical consumables
    • ICH Q7 GMP for Active Pharmaceutical Ingredients used in chelation technology
    • FDA 21 CFR Part 211 for finished pharmaceutical excipient grade material

    Typical usage ratio

    • Reagent suppliers use 1–10 wt% in ligand formulation for resin or sorbent synthesis.
    • Ratio adjusted to optimize column loading capacity and metal affinity profiles.
    • Lower ratios in membrane-embedded products, with precise active group surface density control.

    Downstream process integration

    • Preparation as a key building block in ligand synthesis via direct functionalization.
    • Impregnation onto silica or polymer beads for metal ion affinity columns.
    • Crosslinking or co-polymerization into membranes, followed by QC of metal extraction efficiency.

    Final product types

    • Chromatographic metal ion separation columns
    • Medical-grade chelating resins
    • Specialty filtration media for diagnostics
    • Controlled-release pharmaceutical excipients in chelation therapies

    5. Additive in Concrete and Construction Chemical Enhancers

    Concrete admixture producers incorporate the phosphonic acid to modify hydration, control heavy metal mobility, and reduce efflorescence in advanced building materials. Its incorporation supports compliance with urban environmental construction codes and enhances structure longevity, particularly in high-performance concrete for infrastructure. Production requires controlled blending and trace material analytics to guarantee uniform dispersion and persistent performance in demanding settings.

    Industry compliance standards

    • EN 934-2: Admixtures for Concrete – Definitions, Requirements, Conformity
    • ASTM C494/C494M – Chemical Admixtures for Concrete (performance testing)
    • ISO 9001:2015 for construction material production
    • REACH Registration for chemical additives in building materials

    Typical usage ratio

    • Typically 0.02–0.12 wt% based on cement content, adjusted for concrete type and chloride ion content.
    • Higher ratios for aggressive environments or when targeting heavy metal immobilization.
    • Precise dosage determined via slump, setting time, and leaching tests during pilot batches.

    Downstream process integration

    • Pre-dissolved in plasticizer solutions before admixture blending.
    • Added at batching plants using gravimetric or volumetric metering in truck mixers.
    • Subjected to mixer homogeneity and hydration reaction monitoring via laboratory QC panels.

    Final product types

    • High-performance and self-compacting concrete admixtures
    • Efflorescence control products for precast structures
    • Heavy metal immobilizing additives for environmental construction
    • Ready-mix construction chemical enhancer blends
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    Certification & Compliance
    More Introduction

    (2-Aminoethyl)Phosphonic Acid: Our Perspective as a Dedicated Producer

    Understanding (2-Aminoethyl)Phosphonic Acid
    — A Manufacturer’s Insight

    As producers with decades spent in phosphorus chemistry, (2-Aminoethyl)Phosphonic Acid offers more than a chemical formula. The workforce handling every batch knows how the exact reactants assign this compound its place on the production line. As a white crystalline powder, known structurally as C2H8NO3P, this molecule represents the outcome of strict process controls and continual quality checks. What comes out of the reactor is known for consistency— not just by us, but by users who depend on its properties each week.

    The model produced at our plant—most often referenced as AEPA or CAS 4098-23-1—has always required a close eye from the shift supervisor all the way to the end of the filtration step. Each run pushes for high purity and tight specification limits. The team regularly brings the product above 99% purity in our standard grade. If traces of metals or secondary amines come through, even when below the industry’s general limits, the person in charge gets a call. Reputations on both sides rely on missing out-of-spec material, not just explaining it later.

    Our Production Experience Shapes Every Batch

    Production of (2-Aminoethyl)Phosphonic Acid is different from making simple phosphonates or other amine-phosphorus hybrids. The synthesis usually takes the Mannich-type reaction between phosphorous acid, formaldehyde, and ethylenediamine. The real world does not always run like a textbook. Operators watch temperature and pH curves—small shifts in these can swing product yield and color. Years in large-scale batches taught us how easy it is for a bit of moisture or fluctuation in starting material grade to lead to hydrolysis or unreacted residues. The team tracks each lot by spectroscopic methods as part of normal routine.

    Experienced hands understand that the water solubility ties directly to structure—three functional groups bind water, and low iron content preserves the white appearance. Some plants ignore this detail. Where we run columns to remove color bodies, purified grains slide through with a flatter particle-size profile and firmer flow. We chose stainless steel in our production line not just for looks but for truly minimizing the risk of extraneous ions tarnishing the material. Minor changes in upstream solvents and work-up protocols make a huge difference in the flowability and storage stability. We’ve invested in closed-loop recycling, not only to meet compliance but to cut waste and control input costs, passing the advantage to our partners.

    Real-World Uses — Chemical Industry, Daily Practice

    For technicians, (2-Aminoethyl)Phosphonic Acid earns its reputation through steady service as a complexing agent and phosphonate backbone in specialty applications. Its dual amine and phosphonic acid functions mean it doesn’t fit the mold of simple amino acids or monophosphonates. Our product is poured into drums destined for water treatment systems—the molecule readily chelates calcium and magnesium, keeping pipes clean in industrial cooling water and preventing mineral fouling in boilers. Some users rely on its structural benefits for scale inhibition under severe pH and thermal cycling. We’ve seen consistent repeat orders from nuclear and semicon cooling sectors, not just low-bid tenders, which says the molecule earns a role where stakes are high.

    In the agricultural export sector, buyers trust AEPA’s performance as a micronutrient stabilizer. With heavy metals under close watch, our batches meet strict thresholds for use in liquid fertilizer blends. Its affinity for metal ions plays a role in keeping micronutrients plant-available longer without soil lock-up. Over the years, several crop nutrition developers reported fewer compatibility issues when switching from more traditional chelators, particularly in high-pH soils common in arid regions. Our process leaves the molecule without extra impurities, which farmers and spray contractors often detect within a growing season.

    The biomedical research community sometimes selects this acid as a novel cell growth regulator or as a backbone for further derivatization. We supply research quantities with certificates detailing residual solvents and related compounds. While not an API nor a food-grade ingredient, our highest purity lots have supported several polymer and drug delivery research groups. They return looking for the same trace profile, having verified the absence of amine byproducts that could skew their endpoints.

    How (2-Aminoethyl)Phosphonic Acid Stands Apart

    Molecular differences matter where performance is critical. Unlike aminomethylphosphonic or simple phosphonic acids, the two-carbon spacer in this molecule improves solubility and increases the number of coordination sites for cations. In our plant’s records, analytical comparison shows AEPA remains stable at temperature and oxidative conditions that break down other amino-phosphonates. Bench-scale and full-scale application feedback confirms that chelation persists longer in circulating systems, reducing make-up chemical requirements for users. Several municipal water authorities noted less sludge in filters and reduced treatment cost after migrating away from traditional EDTA or DTPA blends.

    The solid-state form we supply flows readily and dissolves quickly, unlike flakes or viscous intermediates. Competing products, including aminotrimethylene phosphonic acid, show more stubborn clumping or slower dissolution, especially in winter warehouse conditions. Some plants in northern zones need their tank additions to dissolve without down time; our product consistently delivers this advantage, counted by users who have cut back on mixing time and energy bills with our powder.

    Quality Principles—Not Just a Slogan

    From a production supervisor's standpoint, quality means more than meeting a minimum. We use inline IR and periodic HPLC checks—borne of necessity, not only certification demands. Our approach does not leave room for “close enough”; entire lots are rejected if trace amines exceed the purging limit. Mid-shift, operators have the freedom to hold and retest material without bureaucratic delays. Repeatable certificates of analysis serve more than compliance—they support a system where downstream teams adjust process or cleaning cycles if something is off.

    Our engineers have worked to keep batch variation within 0.5% of spec. This translates to predictable results for dosing in customer systems. Stability testing across seasonal storage, including exposure to humid summer months and freezing winter, is part of our release process. Users in plant operations call back with practical feedback, confirming no visible caking or loss of flowability—knowledge we build into next year’s production plans. These lessons shape upgrades and retraining in our team.

    Meeting Environmental Standards

    We face expectations from regulators, but real pressure comes from our own sustainability targets. All phosphonic acid derivatives challenge waste handling. Our plant invested early in washing water recycling and solvent abatement, leaving a smaller environmental impact than some older facilities. Wastewater leaves the plant low in phosphate and organics, and the monitoring schedule runs tighter than basic regulation. This focus reduced our utility load and supported ISO 14001 certification long before it became a typical line on supplier audits.

    Our team tracks international trends on phase-outs and green chemical alternatives. The specific stability and lack of bioaccumulation of AEPA makes it a candidate for safer water treatments. We developed a fluorescent marker method to check downstream losses, helping customers reduce run-off and improve containment. Keeping phosphorus out of the wrong ecosystems matters to us locally, as well as meeting customer requirements abroad.

    Addressing Potential Hazards—A Grounded Approach

    Chemical manufacturing is not risk-free. Safety teams treat every drum as a potential hazard, not afterthought. Our plant keeps dust levels consistently low using local extraction and negative-pressure transfer stations. This is not just for our own—maintenance teams on the line confirm less residue on equipment and fewer calls for shutdown cleanouts. End users benefit from easier handling even without needing complex PPE. We keep packaging sealed in heavy-duty, water-resistant liners to prevent uptake during transit.

    All workers receive training on spill control and first aid for skin or eye exposure. The acid’s low volatilities and low acute toxicity profile mean it does not carry the same hazard as stronger corrosives, but no one takes this for granted. Labels include clear identification—not just hazard pictograms—so warehouse and receiving crews do not mix up materials. This careful approach extends from production to delivery, keeping the supply chain safe and predictable.

    Reliability in a Volatile Market — Producer’s View

    Markets shift on feedstock dynamics, geopolitical events, or even late monsoon rains affecting basic chemicals. The supply chain for producing (2-Aminoethyl)Phosphonic Acid starts long before the reactor and runs through port closures, shipping container availability, or changes in regulatory requirements. We hold reserves of upstream essentials—phosphorous acid and amines—on site, so customers weather less disruption. During pandemic shutdowns and last year’s logistics crises, our inventory buffers and flexible scheduling kept output meeting demand, while some industry peers had to pause shipments or cut allocations.

    Repeat buyers and long-term partners often receive shipment updates within hours, not days. This stems from closely coordinated logistics teams, early warning on upstream bottlenecks, and an attitude that delay is not acceptable. Orders are built around production, with real plant insight rather than spreadsheet planning. We learned these lessons through missed shipments in years past, holding ourselves to a standard that grew from facing high-pressure deadlines with little warning. This approach fosters transparency, and our customers see quickest recovery after supply chain shocks.

    Continuous Improvement—From a Plant Floor Perspective

    The process never stands still. Our technical crew reviews each campaign for minor adjustments—improving evaporator throughput, checking heat exchanger scaling, or reducing manual touchpoints in packaging. Some changes come from process engineers, others from seasoned operators watching trends over time. These details keep yield up, minimize downtime, and make the line safer and cleaner for the next shift.

    We run frequent root-cause analyses on any process deviation, feeding results into training programs for new workers. Regular feedback comes from customers too—advising on product use under novel conditions or suggesting ways to customize bulk pack sizes. Customer suggestions led to adoption of improved bag liners and tamper-evident drums. Live data logging and upgraded process controls reduce error rates and catch problems faster than relying on lab checks alone.

    Customization and Application Support

    Requests often come for different particle size, solubility, or blend compatibility. We respond by tweaking crystallization conditions or providing product as a slurry rather than a powder, based on feedback. When a specialty polymer customer needed a low-dust, low-static version, we worked alongside their technical team to trial antistatic additives. The process changed facility-wide, benefiting other users as well. Such changes demand plant flexibility—and willingness—for small, controlled experimental runs.

    Large users sometimes ask for adjusted shipping containers, staggered deliveries, or split-lot certificates. Rather than push back, we coordinate with our partners to resolve each issue at a practical level—no excess documentation, just the right record for the receiving site. For customers scaling up new formulations, our technical team draws from past studies and user trials, ensuring smooth integration and quicker time to market for those developing next-generation products.

    Lessons from Decades of Chemical Manufacturing

    Over years in phosphorus chemistry, priorities shifted from maximizing output to guaranteeing the kind of reliability, transparency, and technical competence real users demand. No substitute exists for real production knowledge. Each operator, technician, and plant engineer knows every leak, every shift in crystallizer yield, every hazard of unfiltered effluent. That shared experience translates into higher performance batches, reduced waste, and trustworthy delivery.

    AEPA continues to prove value through repeated use, not just technical data. We still see customers returning after trying competitors—citing smoother dissolution, cleaner delivery, and better support. These qualities speak more than any marketing copy. We take pride in each container, knowing our work fits critical points in industry, supply, and research. The lessons our team learns each campaign make the next batch better. Industry is built on trust and performance, and (2-Aminoethyl)Phosphonic Acid represents both from our factory gate to users worldwide.