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2-Aminobenzyl Alcohol

    • Product Name 2-Aminobenzyl Alcohol
    • Alias 2-(Aminomethyl)phenol
    • Einecs 218-700-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    579699

    Chemical Name 2-Aminobenzyl Alcohol
    Cas Number 2680-47-5
    Molecular Formula C7H9NO
    Molecular Weight 123.15 g/mol
    Appearance White to off-white crystalline solid
    Melting Point 61-64 °C
    Boiling Point 262 °C
    Density 1.19 g/cm3
    Solubility In Water Slightly soluble
    Pubchem Cid 164366
    Inchi Key KQDQHZBLCLUPMT-UHFFFAOYSA-N
    Smiles C1=CC=CC(=C1CN)O
    Synonyms 2-(Aminomethyl)phenol, o-Aminobenzyl alcohol
    Storage Conditions Store in a cool, dry, well-ventilated place

    As an accredited 2-Aminobenzyl Alcohol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2-Aminobenzyl Alcohol is supplied in a 100g amber glass bottle with a tightly sealed cap and clear hazard labeling.
    Shipping 2-Aminobenzyl Alcohol is shipped in tightly sealed containers to prevent contamination and moisture absorption. It should be packed according to chemical safety regulations, with proper labeling and documentation. During transit, the chemical must be protected from heat, direct sunlight, and incompatible substances to ensure safe handling and storage.
    Storage 2-Aminobenzyl alcohol should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers. Protect it from moisture and direct sunlight. Ensure proper labeling and keep it away from heat and ignition sources. Use appropriate personal protective equipment when handling this compound to prevent exposure.
    Application of 2-Aminobenzyl Alcohol

    Applications of 2-Aminobenzyl Alcohol in Industrial Manufacturing

    2-Aminobenzyl alcohol serves as an essential intermediate for various industrial segments, supporting high-value synthesis and specialty production. Through precise control of purity, composition, and process integration, our manufacturing expertise ensures consistent material performance in demanding downstream markets. Below are the main application scenarios based on real-world industry usage.

    1. Active Pharmaceutical Ingredient (API) Synthesis

    Pharmaceutical companies use 2-aminobenzyl alcohol as a key building block in the manufacture of active pharmaceutical ingredients, particularly for antihypertensive and antipsychotic medications. The compound participates in nucleophilic aromatic substitution and reductive amination reactions during multi-step synthesis. Our production process achieves pharmaceutical-grade purity, reducing reaction impurities and facilitating downstream regulatory filings. The use of this intermediate enables manufacturers to maintain strict batch-to-batch consistency for high-value APIs.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • USP-NF (United States Pharmacopeia-National Formulary) monographs for related intermediates
    • European Pharmacopoeia reference standards
    • FDA 21 CFR Part 211 for finished pharmaceuticals

    Typical usage ratio

    • 0.2–1.5 equivalents per target API step, adjusted according to specific synthetic route and yield optimization requirements

    Downstream process integration

    • Introduced during early or mid-stage heterocyclic ring assembly
    • Purified by recrystallization and subjected to in-line HPLC and GC quality checks before next synthesis step
    • Used in both batch and flow chemistry processes for multi-kilogram API manufacturing

    Final product types

    • Pharmaceutical active ingredients targeting central nervous system disorders
    • Antihypertensive medication intermediates
    • Key intermediates for oncology compounds

    2. Agrochemical Intermediate Manufacturing

    Agrochemical producers rely on 2-aminobenzyl alcohol in the synthesis of fungicides, herbicides, and plant growth regulators. The compound enters heterocyclic compound formation for active ingredient precursors, such as substituted benzimidazoles. Controlled reactivity and compatibility with chlorination, alkylation, or acylation operations make it suitable for agrochemical mass production, supporting consistency in biological actives.

    Industry compliance standards

    • FAO/WHO Guidelines for the Quality Control of Pesticides
    • ISO 9001:2015 quality management for agrochemicals
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), EU No. 1907/2006
    • OECD Guidelines for the Testing of Chemicals

    Typical usage ratio

    • 0.5–2.0 equivalents per target molecule, depending on target structure and yield considerations in large-scale synthesis

    Downstream process integration

    • Reacted during the condensation or cyclization stages in benzimidazole or phenylurea derivatization
    • Subjected to controlled temperature profiles to minimize by-product formation
    • Monitored by GC-MS and in-process titration for purity assurance

    Final product types

    • Systemic and contact fungicide active ingredients
    • Herbicidal intermediates for broadleaf management
    • Chlorinated growth regulator precursors

    3. Fluorescent Dye and Pigment Synthesis

    Specialty chemical companies use 2-aminobenzyl alcohol in the development of fluorescent dyes for analytical and diagnostic applications. The primary amine and alcohol functionalities make it a preferred nucleophile for condensation with aromatic aldehydes during imine or Schiff base dye synthesis. Our rigorous impurity control ensures chromophore consistency and enhanced photostability of the final fluorescent compounds applied in biomedical imaging and tracer technologies.

    Industry compliance standards

    • ISO 9001:2015 and ISO 14001:2015 for specialty and fine chemical production
    • RoHS Directive 2011/65/EU for restricted substances
    • Quality requirements specified in customer technical agreements
    • Purity conformance to ASTM and internal QC specifications for analytical reagents

    Typical usage ratio

    • 1.0 equivalent as nucleophile per target dye molecule, adjusted by stoichiometric requirements in condensation or cyclization reactions

    Downstream process integration

    • Participates in the key Schiff base formation stage or as a reducing agent in pigment modification
    • Enter downstream chromophore coupling via controlled pH and solvent system
    • Monitored by HPLC for final dye purity and spectral properties

    Final product types

    • Fluorescent dyes for biological staining kits
    • Photostable pigments for optical markers
    • Luminescent compounds for industrial tracers

    4. Polymer Additive and Crosslinker Applications

    Producers of specialty polymers and resins incorporate 2-aminobenzyl alcohol as a chain modifier or curing agent. The alcohol and amine moieties provide dual reactivity for crosslinking with epoxy, isocyanate, or anhydride-containing polymers, enhancing final product durability and specific performance attributes. Used in controlled ratios, it enables tuning of polymer flexibility, chemical resistance, and thermal stability, with direct integration into bulk or solvent-based polymerization lines.

    Industry compliance standards

    • ISO 9001:2015 for polymer manufacturing
    • REACH registration for raw material use in polymer chemical synthesis
    • Technical datasheet compliance for specialty additives (per application)
    • Customer-specific regulatory requirements for end-use sectors (e.g., electronics, coatings)

    Typical usage ratio

    • 0.5–3.0 wt% relative to total resin content, adjusted for targeted crosslinking density and mechanical properties

    Downstream process integration

    • Added in situ during pre-polymerization or as a post-polymerization crosslinking agent
    • Reacted under thermal or UV curing conditions in batch or continuous processes
    • Monitored by FTIR and DSC for crosslinking index

    Final product types

    • Thermosetting resins for circuit board encapsulation
    • Specialty polyurethane adhesives
    • Chemically resistant polymer composites

    5. Fine Chemical and Specialty Organic Synthesis

    Fine chemical manufacturers utilize 2-aminobenzyl alcohol as a versatile intermediate for producing specialty aromatics and custom molecules. Applications include synthesis of ligands, advanced intermediates for chemical sensors, or precursors to photoactive compounds. The material’s combination of nucleophilicity and reductive properties allows its use across multi-step organic programs such as amidation, reductive amination, and selective alkylation, with batch processes benefiting from strict impurity monitoring and traceability.

    Industry compliance standards

    • ISO 9001:2015 for fine chemical manufacturing
    • REACH compliance for European market distribution
    • Internal GMP or GHP (Good Handling Practice) protocols for specialty and custom syntheses
    • Customer-driven quality and analytical documentation

    Typical usage ratio

    • Variable: 0.3–1.0 equivalents, determined by synthesis step and target molecule structure in both pilot and commercial batches

    Downstream process integration

    • Used in derivatization reactions under controlled solvents and temperatures
    • Monitored by in-process LC-MS or NMR to confirm conversion rates
    • Applied at early or late-stage intermediate coupling, depending on custom project requirements

    Final product types

    • Complex specialty aromatics for electronic materials
    • Ligands for homogeneous catalysis
    • Custom photoactive or sensor molecules
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    Certification & Compliance
    More Introduction

    Precision, Reliability, and Usability: An Inside Look at 2-Aminobenzyl Alcohol Production

    Direct Manufacturing and Real-World Application

    Every batch of 2-Aminobenzyl Alcohol that leaves our plant has a story rooted in experience. Over the last decade, consistent attention to process improvements has shaped the reliable product our customers rely on today. We’ve set our synthesis standards based on a continuous feedback loop from pharmaceutical, agrochemical, and dye industries. Our technicians spend many hours scrutinizing every step, from raw material input to final distillation. By living with this process day in and day out, certain truths become evident about what differentiates a product like ours from generic substitutes.

    Chemical Identity and Model Specifics

    In the lab and on the line, the substance we refer to is 2-Aminobenzyl Alcohol, also known by its chemical identifier as o-aminobenzyl alcohol or 2-aminophenylmethanol. The molecular formula shows as C7H9NO with a molar mass falling at 123.15 g/mol. Its structure integrates a benzyl alcohol backbone, with the amino group positioned ortho to the alcohol function. This molecular setup directly affects reactivity and compatibility in multi-step synthesis, something formulators watch for closely when moving from research to scaling up their production.

    On our standard line, we stick to a minimum purity threshold of 99 percent, measured by HPLC and checked again before packing. Neither reaching nor holding this purity comes easy, but any deviation delivers headaches down the pipeline for customers working on complex synthesis. For comparison, lower purity alternatives sourced through brokers or loosely supervised batch runs tend to introduce unpredictable variations. Customers with experience quickly notice turbidity, off-odors, or inconsistent solubility—signals of impurities that slow down production lines.

    Physical Characteristics and Handling Insights

    In practical hands-on terms, the product appears as a pale crystalline solid, sometimes hue-shifting on prolonged exposure to air. Storing the material in sealed drums, away from light and humidity, protects its shelf-life and stops discoloration. Process engineers have shown that improper storage reduces both the ease of handling and the downstream reactivity, with small-scale manufacturers often contacting us when unexpected clumping or yellowing surfaces mid-project.

    While 2-Aminobenzyl Alcohol dissolves readily in ethanol, methanol, and common organic solvents, it remains only sparingly soluble in water at room temperature. This solvent compatibility proves critical during API intermediate production, where solvent selection can dictate both yield and impurity profile. This insight comes from repeated collaborative process development with clients, who share reaction workups and benefit from our accumulated troubleshooting notes.

    Putting Batch-to-Batch Consistency to the Test

    Quality rarely occurs by accident. Our chemists can point to a catalog of control measures embedded within each step. For example, by maintaining strict reaction temperature profiles and carefully monitoring pH adjustment, we avoid the secondary amine side products that mar lower-grade options. These refinements didn’t arrive overnight. Instead, each improvement grew out of lessons learned from troubleshooting internal issues and addressing custom feedback from formulation chemists and process engineers worldwide.

    Our scale-up operations leave little room for error. Small deviations become obvious during recrystallization and during moisture analysis. Here, the difference between a product synthesized and packed “in-house” under our controls and a material mixed off-site by resellers turns tangible. Customers have flagged contaminants such as benzaldehyde, aniline, and ring-substituted derivatives in off-market samples, making reliable sourcing a top concern for regulated industries. In those cases, documentation that precisely traces each lot’s production run and QC analytics stands as the best defense.

    Application Scope and Direct Use

    Most high-volume orders trace back to pharmaceutical intermediates, particularly for the preparation of certain antihistamines, anti-inflammatory compounds, and specialty local anesthetics. The ortho-amino benzyl alcohol skeleton works well as a building block in the construction of heterocycles and substituted aromatic compounds. In-house, scale-up trials for custom orders often explore coupling reactions where nucleophilic substitutions or amide bond formation depends on the reactivity pattern provided by this ortho orientation.

    Outside of pharma, chemical designers in agrochemical development use 2-Aminobenzyl Alcohol to introduce amine or hydroxyl vector points for active compound modifications. In dye chemistry, it supports azo dye synthesis, where the subtle electron-donating influence of the amino group improves color yield and stability. For these customers, the predictability of material quality becomes more than an asset; it directly correlates to product performance and market success.

    Safety Practices Rooted in Daily Experience

    Years of direct handling mean safety and quality habits stick. Our operators wear fitted PPE, and ventilation systems in production and packing areas catch any vapors or dust long before exposure can occur. Even during batch testing, we train lab crews to handle every container as if it holds a fresh, reactive substance. Storage protocols back up these standards. Every container stays tightly closed, and all open-handling events are logged and reviewed by shift supervisors. These routines draw from both lived manufacturing experience and industry-standard risk management—protecting not just our own team but also every downstream user who handles our product.

    Early on, we learned that accidents come less from the inherent hazards of a substance and more from unpredictable handling or shortcuts. Transparent documentation, properly labeled containers, and regular internal audits form our everyday discipline. We openly share these protocols with clients who want to align their own practices, knowing firsthand how misplaced trust in a “no-problem” attitude results in production stoppages or worse.

    Differences and Value Versus Other Specialty Alcohols

    2-Aminobenzyl Alcohol stands apart from other benzyl alcohol derivatives—including unsubstituted benzyl alcohol and para- or meta-amino variants—by how it balances nucleophilicity and steric accessibility. The ortho arrangement of amino and hydroxyl groups unlocks synthetic routes not easily accessible via the more commonly available isomers. We’ve seen medicinal chemists shift from traditional benzyl alcohol building blocks toward the ortho-amino version for custom libraries, precisely because it brings a different balance of reactivity and selectivity.

    Comparative testing among related products reveals physical and chemical distinctions that matter in large-scale use. Para-substituted isomers typically show greater symmetry but lower reactivity toward certain electrophiles—a difference rooted in electron resonance throughout the ring. The ortho isomer’s unique interplay of electron-donating groups supports reactions at milder conditions and often enhances the rate and yield of desired coupling steps. Project managers placing side-by-side trials routinely report tighter control and higher success rates using our ortho configuration for transforming core structures.

    Typical commercial benzyl alcohol often arrives at a lower cost point but lacks the amine functionality, restricting its use to roles as a solvent, flavoring, or preservative. 2-Aminobenzyl Alcohol’s higher price reflects both the complex synthesis and the demanding QC process, aiming not simply for “commodity” status but for critical, high-stakes applications. With this differentiation comes a responsibility to maintain consistent quality, as even slight shifts in the functional group arrangement or contaminant profile can undermine the value it brings to customers’ advanced projects.

    Each year brings inquiries about the feasibility of substituting alternative aminobenzyl alcohols produced in less controlled environments. We invite project chemists to share their project goals and analyze side-by-side GC/MS, NMR, and HPLC results, highlighting the hard data supporting decisions on purity, safety, and process efficiency. Patterns emerge after repeated comparison—off-spec materials undercut reaction success, lower yields, and jeopardize regulatory compliance, proving again why partnership with a manufacturer invested directly in the synthesis process protects against the apparent “savings” offered by low-cost intermediates.

    Sustainability and Responsible Production

    As direct producers, environmental stewardship affects more than just external reporting. Waste minimization strategies arise from measured solvent use, catalyst recovery, and closed-system venting. These changes stem from direct observation—it becomes obvious to plant crew where materials or energy slip away during off-batch cleaning or unnecessary solvent evaporation. Each time a new solvent or reagent enters the process, risk and cost go beyond regulatory paperwork and reach into the daily operation budget, the safety of staff, and the long-term reputation carried by the final product.

    The drive for leaner operations goes hand-in-hand with transparent communication with external partners who audit our performance. Real reductions in water and energy usage reflect choices made on the line by experienced crew, not just top-down directives or green branding campaigns. When international partners visit our facility, they see firsthand how process adjustments, equipment upgrades, and staff training reduce emissions and lower the risk of cross-contamination or unexpected incidents.

    Over time, shifts in sourcing toward greener starting materials open up additional opportunities to cut hazardous byproducts, a trend that secondary resellers with less intimate manufacturing knowledge struggle to match. Our in-house team continually evaluates both sustainable feedstock options and cleaner reaction conditions, sampling and monitoring outputs to ensure downstream purity remains uncompromised. Data from these trials informs updates in protocols—incremental gains that build into meaningful change throughout the supply chain.

    Shipping, Packaging, and Traceability

    With bulk commercial volumes and research-grade orders alike, logistics play a decisive role in customer outcomes. Several years back, technical complaints from a recurring client brought focus to subtle handling mistakes that risk product stability—heat fluctuations in transit, poor seals on secondary packaging, or unlabeled drums holding up customs clearance. In response, the warehouse and shipping team introduced tamper-evident seals, double-layer liners, and robust documentation that tracks each shipment from our dock to the end-user’s door.

    Every outgoing drum features a batch number, QR code, and full traceability records, closing the loop on supply chain oversight. On-site storage before shipment prioritizes temperature and humidity control, checked with data loggers that catch deviation early. Lessons learned from missed details or transit damage don’t get forgotten—they shape how the next batch is packed and shipped, so repeated issues don’t undercut the chain of trust that chemistry-driven businesses require.

    Feedback from customers tackling customs or import documentation has spurred us to streamline compliance paperwork and MSDS reporting. Instead of routing questions through distant brokers, the technical team responds directly to user inquiries, clarifies specifications, and supports transparent validation, making it easier for regulatory teams at customer sites to confirm exact product identity, match lot and batch records, and clear their own risk assessments.

    Challenges and Forward-Looking Commitments

    Working as a manufacturer means facing an evolving set of pressures: rising demand for more rigorous documentation, shifting regulatory standards, and the growing impacts of global supply chain stress. Raw material sourcing, energy cost fluctuations, and unpredictable logistics disruptions all play into the decision-making process on the plant floor. Every round of investment in upgraded systems or advanced analytics gets weighed against both near-term output goals and the long-term reliability customers have come to expect from our line.

    Change often comes in response to setbacks or customer troubleshooting. For example, early analytical methods relying on TLC or colorimetric checks didn’t catch certain trace-level contaminants that HPLC and LC-MS now flag. The commitment grows out of repeated experience—technical and quality teams know that moving past minimum regulatory requirements builds the sort of long-standing customer trust that high-value chemical workflows require. Those lessons now embed into every analytical method and QC checkpoint, setting a baseline that less experienced resellers may find hard to match.

    By participating in direct industry working groups and drawing on feedback from technical users, we stay aligned with practical needs on factory floors and research benches. Chemists need transparent technical detail, fast answers to process questions, and predictable supply. The best solutions often come not from sales pitches but from open conversations with users, comparing notes, sharing troubleshooting tips, and using shared experience to push for reliability and safety improvements in every production run.

    Summary: Commitment through Experience

    Hard-learned experience has shaped every aspect of our 2-Aminobenzyl Alcohol production, from hands-on technical quality controls to the design of shipping and storage systems that actually protect the value packed in every drum. The narrow margin for error, especially in regulated and high-stakes application spaces, makes each layer of scrutiny and feedback count. Purity, reactivity, and batch consistency all matter, but so does the commitment to safety, sustainability, and transparent partner relationships. Differences between manufacturing direct and trading only become more concrete with each resolved technical challenge, every client outcome, and every traceability check that guards against costly surprises. Reliable supply, data-driven purity, and honest communication remain the touchstones of our work—today and for every project still to come.