Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

2-Aminobenzothiazole-6-Carboxylic Acid

    • Product Name 2-Aminobenzothiazole-6-Carboxylic Acid
    • Alias 2-Amino-6-carboxybenzothiazole
    • Einecs 245-873-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    258671

    Productname 2-Aminobenzothiazole-6-Carboxylic Acid
    Casnumber 39229-51-7
    Molecularformula C8H6N2O2S
    Molecularweight 194.21 g/mol
    Appearance Off-white to light yellow powder
    Meltingpoint 280-284°C
    Solubility Slightly soluble in water, soluble in DMSO
    Purity Typically ≥98%
    Storagetemperature 2-8°C
    Synonyms 6-Carboxy-2-aminobenzothiazole
    Smiles C1=CC2=C(C=C1C(=O)O)N=C(S2)N
    Inchi InChI=1S/C8H6N2O2S/c9-8-10-6-3-1-2-5(7(6)13-8)4(11)12/h1-3H,(H2,9,10)(H,11,12)

    As an accredited 2-Aminobenzothiazole-6-Carboxylic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g of 2-Aminobenzothiazole-6-Carboxylic Acid is supplied in a sealed, amber glass bottle with tamper-evident cap.
    Shipping 2-Aminobenzothiazole-6-Carboxylic Acid is shipped in tightly sealed containers to prevent moisture and contamination. The chemical is handled according to safety regulations, packaged in compliance with transport guidelines, and clearly labeled. Shipping usually occurs at ambient temperature unless otherwise specified, with required documentation for safe handling and regulatory compliance.
    Storage 2-Aminobenzothiazole-6-Carboxylic Acid should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of heat or ignition. Protect the chemical from moisture, direct sunlight, and incompatible substances such as strong oxidizers. Proper labeling and secondary containment are recommended to prevent accidental spills and ensure safe handling.
    Application of 2-Aminobenzothiazole-6-Carboxylic Acid

    Applications of 2-Aminobenzothiazole-6-Carboxylic Acid in Industrial Manufacturing

    Our factory supplies high-purity 2-Aminobenzothiazole-6-Carboxylic Acid for targeted applications across key industrial chemical manufacturing sectors. Below is a focused review of real downstream uses in pharmaceutical synthesis, dyes & pigments, agrochemical intermediates, specialty polymer additives, and analytical reagent production. Each segment reflects actual customer processes and integration practices in global markets.

    1. Pharmaceutical Intermediates for Anti-inflammatory Drug Synthesis

    Chemical manufacturers utilize this raw material during multi-step synthesis of heterocyclic-based APIs, especially in the assembly of benzothiazole structured drugs indicated for anti-inflammatory activity. The carboxylic acid group provides a reactive handle for amide coupling or esterification, enabling rapid access to downstream active molecules. This intermediate integrates after initial aromatic substitution reactions, supporting strict analytical quality controls for residual solvents and unwanted isomers. Production environments carefully monitor batch records and cross-contamination to meet drug manufacturing expectations.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP <795/> on compounding non-sterile preparations
    • EMA guidelines on genotoxic impurities
    • 21 CFR Part 211 – US cGMP for finished pharmaceuticals

    Typical usage ratio

    • Batchwise addition at 0.12–0.25 molar equivalents versus principal amine/ester reactant, adjusted upward if subsequent functionalization is required

    Downstream process integration

    • Charged post-coupling as the substrate for ring-forming condensation, or as a carboxylate for salt-form precursor steps

    Final product types

    • Non-steroidal anti-inflammatory drugs (NSAIDs) with benzothiazole motifs
    • Bulk API intermediates for contract manufacturing
    • Pre-formulated granules for oral dosage form production

    2. Dye and Pigment Intermediates for Reactive Dye Manufacturing

    Dye producers integrate this carboxylic acid derivative as a key intermediate during synthesis of reactive dyes, particularly those targeting fiber-reactive and metal-complex classes. The aminobenzothiazole moiety introduces chromophoric properties and enables subsequent sulfonation or halogenation. Operators charge the acid at the diazo coupling stage or amidation phase, ensuring controlled pH and agitation rates to maximize yield of colour-stable intermediates. Downstream manufacturers enforce batch colorimetry and lightfastness testing on the synthetic outputs.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for Dyestuff Manufacture
    • ETAD Ecological and Toxicological Association of Dyes and Organic Pigments Manufacturers guidelines
    • Oeko-Tex Standard 100 for restricted substances
    • REACH Annex XVII standards for dye sector

    Typical usage ratio

    • Added at 4–10% (w/w) relative to base coupler, modulated for target shade and chroma intensity

    Downstream process integration

    • Blended directly into the coupling kettle prior to azo condensation, frequently in presence of water-soluble catalysts and defined pH buffers

    Final product types

    • Reactive dyes for cellulosic textile applications
    • Triazine-based dye preconcentrates
    • Water-soluble pigment concentrates for printing inks

    3. Agrochemical Synthesis: Herbicide Intermediate

    Producers of advanced agrochemicals use this material in the synthesis of select benzothiazole-based herbicides. The acid group participates in direct amidation with chlorinated agents or urea derivatives, forming intermediates that inhibit weed growth by disrupting enzymatic pathways. The product's quality and impurity profile directly affect downstream purity and selectivity. Formulation managers balance addition rates and reaction temperatures according to regulatory impurity limits for pyrazole or oxadiazole frameworks.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • GLP (Good Laboratory Practice) as defined by OECD
    • ISO 17025 Analytical Quality Compliance for Pesticides
    • Chinese National Standard GB 4839-2017 for pesticide product safety

    Typical usage ratio

    • Charged at 8–20% (w/w) compared to primary isocyanate or halide precursor, varied according to required herbicide yield and substructure reactivity

    Downstream process integration

    • Added at the condensation or ring-closure step after initial heterocycle assembly, often followed by controlled hydrolysis and purification

    Final product types

    • Benzothiazole herbicides targeting grass and broadleaf weeds
    • Technical concentrates for bulk formulation
    • Water-dispersible granules for end-user application

    4. Specialty Polymer and Resin Modifier

    Polymer compounders deploy this heterocyclic carboxylic acid as a modifier during synthesis of high-performance thermosetting resins and specialty engineering plastics. It serves as a functional chain-terminator or cross-linker, introducing targeted flexibility or solvent resistance in the final material. Process technicians monitor its controlled dosing alongside epoxy or phenol agents, tuning the copolymer architecture for property optimization. Batch integrity relies on in-process FTIR and GPC characterization to confirm successful incorporation.

    Industry compliance standards

    • ISO 14001 Environmental Management for Industrial Processes
    • RoHS Directive 2011/65/EU for restricted substances in plastics
    • UL 94 Flammability Ratings for resin applications
    • FDA 21 CFR 177.2420 for components of adhesives in food packaging (where applicable)

    Typical usage ratio

    • Utilized at 0.5–3 phr (parts per hundred resin) dependent on targeted cross-link density and compatibility with matrix polymer

    Downstream process integration

    • Mixed into the resin batch prior to curing, ensuring uniform dispersion with high-shear melt or solution blending equipment

    Final product types

    • Solvent-resistant epoxy resins for electronic encapsulation
    • Flame-retardant engineering thermoplastics for automotive or electrical shells
    • High-durability adhesives and coatings

    5. Analytical Reagent and Complexing Agent Manufacture

    Laboratory chemical producers select this compound as a precursor for preparing specialty analytical reagents and complexing agents used in trace metal analysis. Its structural features allow for further derivatization into ligands with selectivity towards transition metals, supporting volumetric titration or spectroscopic determination in regulated environments. Quality assurance officers adhere to strict protocols surrounding purity, water content, and trace metal background during batch manufacture, with custom blending on customer request.

    Industry compliance standards

    • ISO 17034:2016 for Reference Material Producers
    • ASTM D3697 for purity analysis of organic chemicals
    • USP Reagent Grade requirements (where relevant for analysis)
    • ISO/IEC 17025:2017 for chemical testing laboratories

    Typical usage ratio

    • Prepared as reagent stock at 0.1–2% (w/v) in compatible solvent or buffer, concentration tailored to analytical method sensitivity and detection requirements

    Downstream process integration

    • Functionalized through direct sulfonation or metal complexation prior to aliquoting or solid formulation as standard solutions or titrant components

    Final product types

    • Trace metal titration reagents for water and soil labs
    • Spectroscopic standards for calibration
    • Custom analytical blends for process control environments
    Free Quote

    Competitive 2-Aminobenzothiazole-6-Carboxylic Acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    2-Aminobenzothiazole-6-Carboxylic Acid: Clarity, Precision, and Reliability from the Manufacturer

    Recognizing the Role in Chemical Synthesis

    As a long-standing manufacturer with decades of synthesis experience under our belts, we see each molecule as a collaborated achievement between practical chemistry and real-world needs. 2-Aminobenzothiazole-6-Carboxylic Acid stands out as more than a catalog item— it's a trusted foundation for various research pipelines, pharmaceutical projects, and specialty chemical applications. In the hands of a producer who actually runs the reactors and plans the workflow, this molecule requires not only precision in its making but also a keen understanding of the practical expectations set by our industry and our clients.

    Understanding Its Structure and Practical Relevance

    As chemists, we respect the value of a compound with both aromatic stability and useful functional groups, such as the amino and carboxylic acid moieties. The position of these groups on the benzothiazole ring makes 2-Aminobenzothiazole-6-Carboxylic Acid a practical intermediate for those developing new pharmaceutical actives or advanced specialty materials. The molecule’s specific orientation guides predictable reactivity in subsequent steps—whether in amide coupling reactions or selective derivatization required for complex synthesis. Many clients bring us detailed reaction schemes showing where a slight impurity or a misplaced functional group would create failure down the line. Manufacturing this compound to a sharp specification is not alchemy; it’s grounded in manageable, monitored processes and years of problem-solving in scale-up and purification.

    From Lab Bench to Kilo Plant: Scaling Without Compromising Quality

    Producing 2-Aminobenzothiazole-6-Carboxylic Acid at any significant scale requires continuous improvements. Our teams have experimented with temperature controls, alternative solvents, and optimized filtering methods to drive higher purity and better recovery rates. These daily shop floor efforts translate to lot-to-lot consistency. Each kilogram delivers reproducibility in downstream chemistry, essential for teams working toward regulatory filing or academic publication. Story after story reaches our technical support desk: a research group wrestling with lot variance from other sources suddenly sees project turnaround after switching to our material—one batch matches the last, and the members finally get clear NMRs and efficient coupling. Lessons learned on our end? Lab-scale routines rarely translate directly; it takes guts to redesign a process line, and a willingness to invest in analytical methods that most resellers never see as necessary.

    Differences from Similar Compounds in the Marketplace

    Our competitors offer benzothiazole derivatives with similar backbone structures but subtle differences in substitution pattern and purity profiles. Some suppliers push out 2-aminobenzothiazole or the simple carboxylic acid isomer, but overlook the rippling consequences that these variations hold for synthesis pathways. Cheaper alternatives often bring unexpected impurities or alternate polymorphs, which cause problems in reactions that aren’t intuitively obvious to non-manufacturers. From a process chemist's standpoint, the position of the amino and carboxylic groups—the “6” spot—profoundly affects electron distribution, reactivity, and solubility in polar solvents. Our customers have found that switching to our properly characterized product smooths out bottlenecks that arise with less precise isomers, saving both time and waste in pilot trials.

    Purity and Analytical Approach from the Factory Floor

    Clean chemistry does not happen by accident. Simple assay numbers or generic purity claims do not capture the complexity that goes into each batch of 2-Aminobenzothiazole-6-Carboxylic Acid. We don’t just lean on HPLC areas or single-point LCMS checks; we maintain robust screening by full NMR, elemental analysis, water content quantitation, and—when required—chiral purity checks. Technical teams painstakingly develop retention time standards, ensuring that the carboxylic acid group stands undisturbed and that no byproduct mimics the structure in downstream methods. Such detail matters when customers ship samples worldwide for third-party validation or build the molecule into a medical candidate requiring strict documentation. Before new batches leave our warehouse, specifications are not just met—they are dissected, each deviation chased to its root, and fixed, not forgotten. This approach stems from years of client-driven troubleshooting: if even a trace sulfoxide impurity pops up, our chemists overhaul the process instead of writing it off.

    Safe Handling and Transportation: A Manufacturer’s Challenge

    Shipping fine chemicals demands more than secure packing. A direct manufacturer like us handles regulatory compliance, cold-chain logistics if needed, and technical guidance tailored to customer protocols, all rooted in a clear understanding of the material’s chemical nature. 2-Aminobenzothiazole-6-Carboxylic Acid’s crystalline powder form can be sensitive to moisture and excessive light. From our experience, overlooked packaging details—such as inadequate desiccant or oxygen ingress—spell disaster down the line in sensitive synthesis contexts. Our logistics and warehouse crews work with sturdy, fit-for-purpose containers and define transit conditions up front, based on insights from actual reported issues and on-site audits. Fielding calls from a lab halfway across the planet with a question about hygroscopicity keeps us grounded in accountability, not marketing gloss.

    Common Uses and Real-World Impact

    Outside textbook summaries, the story of 2-Aminobenzothiazole-6-Carboxylic Acid lives in research stories—projects ranging from kinase inhibitor programs and agricultural protection chemistry, to dye intermediates and fluorescence probes. In pharmaceutical discovery, chemists often rely on this compound’s responsive amino group to cut reaction steps off multi-stage syntheses, which speeds up early-stage projects. Several pharma innovators push our material through amidation and Suzuki couplings, charting paths to new chemical entities. Commercial users value its stability and reactivity profile for scaling up initial laboratory hits to kilo production. As a manufacturer, our input does not end with the shipment; our technical staff takes calls about synthetic conditions, recommends purification tweaks, or offers custom modifications that tune reactivity or solubility further.

    Adaptability to Customer Needs: The Technical Service Side

    Manufacturing for scientists and engineers means working hand-in-hand, not just shipping whatever is in stock. On more than one occasion, end users have hit a wall in downstream processing—maybe solubility in a new solvent or crystallization issues for formulation R&D. Drawing on batch history and analytical archives, we can point them toward effective recrystallization solvents, or suggest modifications in the isolation steps that sidestep degradation routes. For custom bulk supply, we have adjusted particle size distribution, re-dried batches for improved shelf-life, and supplied detailed impurity profiles to regulatory teams. Unlike one-size-fits-all sellers, our practice is rooted in matching our output to real feedback from actual users, and making technical data transparent for review at each stage.

    Environmental and Safety Considerations

    Responsible production means thinking beyond the compound’s final use. The benzothiazole framework in 2-Aminobenzothiazole-6-Carboxylic Acid is not one to take lightly when it comes to environmental fate or the safety impact of byproducts. Our environmental team studies process streams for legacy contaminants, flagging any trace that could raise compliance issues or public concern. Waste minimization programs start at process design, not afterthought—less solvent in, less effluent out. Over years, we have reduced the need for halogenated solvents and improved the ease of handling powders with safer, closed-system transfer, reducing inhalation risk for the workers directly handling this chemistry. A safety-first approach carries through to customer-level hazard communication, giving users honest hazard profiles based on actual manufacturer experience, not just Safety Data Sheet citations.

    Supply Reliability and Contingency Planning

    Delivering fine chemicals has taken on new urgency as global supply chains face bottlenecks from logistics shocks and raw material scarcity. We have weathered more than one supply crunch, thanks to a diversified sourcing approach and deep stockpiled inventories of critical intermediates. In one recent year, border slowdowns delayed imports for months across many sectors; our pre-investment in key precursor stocks allowed us to keep supplying pharmaceutical partners with virtually no interruption. Project managers on the client side appreciate candid delivery timelines, and our policy is to update not just on shipping status but on any emerging factors likely to impact batch release date. Our customers can plan, not guess, because hard data from the manufacturing floor reaches them early and in plain language.

    Continuous Improvement: Rooted in Real-World Testing

    In-house R&D teams depend on daily feedback to refine every manufacturing stage for 2-Aminobenzothiazole-6-Carboxylic Acid. From the start, pilot batches run side-by-side to commercial lots, each subjected to incremental adjustments. Sometimes those tweaks seem small—minor pH adjustments or alternative crystallization cycles—but over hundreds of cycles, these shifts build toward sharper purity and more efficient yields. The process of adopting feedback is not top-down but interactive; chemists from several continents have sent us pointers on hydration state effects and hints for downstream reactivity. We do not hide batch defects from internal review. Instead, learning from failed runs or flagged out-of-spec samples means our formulas evolve in lockstep with both user need and environmental compliance.

    Collaborative Wins: Supporting Innovation Beyond Our Walls

    Our place in the value chain stretches beyond factory gates. Academic partners seeking gram quantities for fundamental mechanistic studies depend on our flexibility. Pharmaceutical and agrochemical developers need kilogram to multi-kilogram sums, delivered with both speed and a complete documentation trail. Multi-year supply agreements are supported by analytical transparency, not vague assurances. Our technical and sales teams act as one: chemists talking to chemists, drawing on lived examples, not boilerplate. Over the years, several startups and established R&D organizations credit much of their timeline acceleration to knowing their critical building blocks would not be the roadblock.

    Relevancy in a Competitive Global Market

    Markets shift, regulation tightens, and raw materials fluctuate. As a direct manufacturer, our edge comes from visibility over the entire lifecycle of 2-Aminobenzothiazole-6-Carboxylic Acid, from weighing the first charge to cleaning out the last reactor. Transparency in pricing and specification shields our customers from sudden surprises or veiled cost inflation. When global demand spikes unpredictably—from sudden discovery trends or regulatory shifts—we quickly realign capacity, communicating production schedules clearly. For those in research and production, knowing the story behind each batch, not just the headline spec, offers security in a competitive space where sloppy supply chain management costs real time and real money.

    Looking Forward: Building Value for End Users

    End users want reliable material and actionable insight from those closest to production. Our feedback loops are as open for a new Ph.D. student as they are to procurement heads negotiating multi-year contracts. Technical documentation goes beyond regulatory compliance, answering specific “how was it made?” and “has this process changed since last batch?” questions. Requests for alternate salt forms or higher-grade purification get serious review, not knee-jerk refusals. We review each proposal for custom synthesis closely, balancing plant safety, capacity, and use-case merit. Our priority remains centered on supplying 2-Aminobenzothiazole-6-Carboxylic Acid at quality and scale, drawing confidence from the thousands of batches already on record. Our practices reflect respect for the molecule, the chemistry, and the broader purpose it serves in the growing network of scientific progress.

    References and Technical Community Integration

    Beyond selling a chemical, we join discussions in technical forums, international consortia, and scientific meetings, contributing knowledge gathered from both failed projects and successful launches involving 2-Aminobenzothiazole-6-Carboxylic Acid. We review published protocols, compare them with our in-house practices, and often offer analysis or troubleshooting in peer-to-peer settings. Our technical bulletins cover supply insights, regulatory updates, and sustainability practices, building a shared information ecosystem that benefits the broader user base. By staying current with literature, safety advisory trends, and raw material position papers, we stay ahead of both risk and opportunity. For clients who care deeply about steady quality, traceable manufacturing, and real technical support, our manufacturing footprint assures them that their material is more than a stock number.