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2-Amino-6-Methylbenzoic Acid

    • Product Name 2-Amino-6-Methylbenzoic Acid
    • Alias 2-Amino-m-toluic acid
    • Einecs 226-369-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    855646

    Chemical Name 2-Amino-6-Methylbenzoic Acid
    Molecular Formula C8H9NO2
    Molecular Weight 151.17 g/mol
    Cas Number 1477-50-5
    Appearance White to light yellow crystalline powder
    Melting Point 159-162°C
    Boiling Point Unknown
    Solubility In Water Slightly soluble
    Density 1.26 g/cm3
    Pka 2.18 (carboxyl), 4.78 (amino)
    Pubchem Cid 37917
    Synonyms 2-Amino-o-toluic acid, 6-Methylanthranilic acid
    Inchi Key SSDBHXCRJXKXLF-UHFFFAOYSA-N
    Smiles CC1=C(C=CC=C1N)C(=O)O
    Storage Conditions Store at room temperature, keep container tightly closed

    As an accredited 2-Amino-6-Methylbenzoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 100g amber glass bottle with a tightly sealed cap, labeled "2-Amino-6-Methylbenzoic Acid," includes hazard and handling information.
    Shipping 2-Amino-6-Methylbenzoic Acid is shipped in tightly sealed containers to prevent moisture and contamination. The chemical is handled according to standard laboratory chemical shipping regulations, with clear labeling for safe transport. It should be kept away from incompatible substances and extreme temperatures during shipment. All packages include safety data sheets (SDS) for reference.
    Storage 2-Amino-6-methylbenzoic acid should be stored in a tightly sealed container, in a cool, dry, well-ventilated area, away from incompatible substances such as strong oxidizers. Protect it from moisture, heat, and direct sunlight. Use secondary containment to prevent spills and properly label the container. Store at room temperature and ensure the storage area has appropriate fire protection and spill containment measures.
    Application of 2-Amino-6-Methylbenzoic Acid

    Applications of 2-Amino-6-Methylbenzoic Acid in Industrial Manufacturing

    As a direct manufacturer of 2-Amino-6-Methylbenzoic Acid, we supply this specialty intermediate to leading enterprises that demand consistent quality and traceability. The following sections outline the primary industrial applications where this material is utilized downstream, with a focus on specifications, compatible formulations, and integration points within each sector.

    1. Pharmaceutical Intermediate for Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

    2-Amino-6-Methylbenzoic Acid serves as a core structural intermediate in multi-step syntheses of select aryl acetic acid-based NSAIDs. Downstream pharmaceutical companies incorporate this raw material during the key amide coupling or cyclization step. Our strict process controls, documentation, and analytics support clients’ needs for regulatory submission, especially during investigational drug manufacturing and scale-up to commercial APIs.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EudraLex Volume 4, Part II GMPs
    • USP-NF monographs (relevant for specific APIs synthesized)
    • FDA 21 CFR Part 210/211 (if end-use production occurs in the US)

    Typical usage ratio

    • 0.9–1.2 molar equivalents relative to target NSAID core, with slight excess used to ensure full conversion during amide bond formation; adjusted based on desired purity and yield profile

    Downstream process integration

    • Feeds into the amidation or acylation step after halogenation or activation of the core aromatic ring, requiring high purity for optimal downstream reaction selectivity

    Final product types

    • Bulk NSAID active pharmaceutical ingredients (e.g., mefenamic acid derivatives)
    • Finished dosage forms: tablets, capsules, injectable formulations

    2. Dye and Pigment Intermediate for Disperse Yellow/Orange Dyes

    Commercial dye manufacturers incorporate 2-Amino-6-Methylbenzoic Acid for the build-out of azo and anthraquinone structures, especially for high-fastness disperse dyes. This material forms the diazonium salt precursor for subsequent coupling with chromophoric components. Stringent color index and toxicological requirements necessitate traceable sourcing and tight control over metal impurities.

    Industry compliance standards

    • EN 71-3 (safety specification for migration of certain elements, toys and textiles where applicable)
    • Oeko-Tex Standard 100 class II (textile safety, colorfastness)
    • REACH Annex XVII (restriction of azo dyes)
    • Technical Association of the Pulp and Paper Industry (TAPPI) standards for paper dyes

    Typical usage ratio

    • Up to 1.0 equivalent relative to diazotizable amine; varying ratio from 0.7 to 1.1 depending on color depth and bath exhaustion profiles

    Downstream process integration

    • Enters the diazotization reactor where controlled temperature and pH yield the diazonium salt, which then directly couples with the secondary dye component to form insoluble pigments or disperse dyes

    Final product types

    • Disperse orange and yellow dyes for polyester textiles
    • Water-insoluble pigments for plastics compounding
    • Paper coloration agents for specialty coatings

    3. UV-Absorber Manufacturing – Benzotriazole-Type Additives

    UV-stabilizer manufacturers utilize 2-Amino-6-Methylbenzoic Acid to construct benzotriazole frameworks, widely supplied to plastics and coatings sectors for UV protection. The compound integrates into condensation and cyclization chemistry, where consistent particle size and absence of halogenated by-products are critical in downstream extrusion and polymer blending.

    Industry compliance standards

    • ASTM D5208 (UV resistance of plastics)
    • European Pharmacopoeia 10.0 Appendix IV (migration limits for packaging)
    • ISO 4892 (artificial weathering requirements)
    • RoHS Directive (heavy metal and halogen content in electronic coatings)

    Typical usage ratio

    • 0.9–1.05 equivalents relative to coupling partner; ratio fine-tuned by downstream processor to balance UV absorption spectrum width with polymer transparency demands

    Downstream process integration

    • Feeds into cyclization step to build benzotriazole core, followed by purification and blending with carrier resins; particle size reduction performed post-synthesis for direct masterbatch incorporation

    Final product types

    • Masterbatches for automotive and outdoor plastics
    • Clear coatings for UV-exposed substrates
    • Packaging films for food and beverage protection

    4. Agrochemical Synthesis for Systemic Herbicide Precursors

    Leading agrochemical processors source 2-Amino-6-Methylbenzoic Acid to synthesize key intermediates in the construction of specific phenoxyacetic acid and benzoic herbicide analogues. The acid group and aromatic amine moiety enable efficient esterification and condensation under mild conditions, supporting high-purity downstream synthesis routes that minimize environmental effluents.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001:2015 certified QC protocols for raw material traceability
    • European Regulation (EC) No 1107/2009 (plant protection product authorizations)
    • GLP (Good Laboratory Practice) for active substance trials and residues

    Typical usage ratio

    • 0.95–1.0 equivalents in condensation reactions with various acyl chlorides; ratio adjusted to optimize conversion yield versus unreacted starting material under batch or continuous process modes

    Downstream process integration

    • Reactants charged directly to condensation reactors, followed by selective extraction, crystallization, and isolation steps to purify the target herbicidal acid or ester

    Final product types

    • Technical-grade herbicidal active ingredients
    • Formulated wettable powders and water-dispersible granules
    • Emulsifiable concentrate herbicide products

    5. Specialty Polymer Monomer for High-Performance Engineering Plastics

    Producers of high-temperature polyamides and related specialty polymers use 2-Amino-6-Methylbenzoic Acid as a nucleophilic monomer to introduce tailored side-chain functionality. Such structural modifications within polymer backbones impact melt strength, glass transition behavior, and processing compatibility with reinforcing fillers. Detailed batch records, contaminant profiling, and controlled granulation are required for end-use consistency.

    Industry compliance standards

    • ISO 9001:2015 (quality control throughout the polymer manufacturing chain)
    • UL 94 Flammability standards (for engineering plastics)
    • ASTM D4066 (classification of nylon and related polyamides)
    • FDA 21 CFR 177.1500 (regulation for polyamides in food-contact applications, where applicable)

    Typical usage ratio

    • 5–15 mol% incorporated as a co-monomer; ratio selected for targeted molecular weight distribution, glass transition temperatures, and impact resistance profiles

    Downstream process integration

    • Charged with other diamine or diacid components to high-temperature polymerization reactors; polymer chains built via condensation polymerization, followed by granulation and pelletizing before compounding

    Final product types

    • High-performance polyamides for automotive engine covers
    • Metal-replacement engineering plastic parts
    • Fiber-reinforced technical films and molded assemblies
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    Certification & Compliance
    More Introduction

    2-Amino-6-Methylbenzoic Acid: A Closer Look from the Manufacturer’s Bench

    Chemical manufacturing shapes a world few people see up close, where precision and real hands-on experience guide every kilogram of product and every step of process. Among the aromatic building blocks that have earned their place on our production lines, 2-Amino-6-Methylbenzoic Acid offers a standout combination of stability and usefulness. In our operation, we’ve worked with this particular compound for years, learning its quirks and strengths through batch after batch. This is not just product on a shelf: it’s a piece of chemistry that helps unlock new molecules, drive reactions, and bring reliability to industries that can’t afford to gamble on quality.

    Understanding What Makes 2-Amino-6-Methylbenzoic Acid Different

    Our 2-Amino-6-Methylbenzoic Acid carries the chemical formula C8H9NO2, with a molecular weight of 151.16. The methyl group at the sixth position introduces a subtle but important shift in reactivity compared to other aminobenzoic acids. That difference matters, especially in organic synthesis and pharmaceutical intermediates, where it can lead to changes in product output, reaction rates, and even purification steps downstream. Over dozens of scale-ups, we’ve seen that the placement of both the amine and the methyl group really does change the way this molecule interacts with chlorinating agents, acyl donors, or coupling reagents. Anyone who has tried to use the more common ortho- or para-substituted aminobenzoic acids in place of this particular meta isomer can point to lower product yields, new side-products, or purification headaches. These subtle differences wind up affecting a whole production schedule, sometimes months down the drain, so a manufacturer grows deeply attentive to these details.

    Consistency Backed by Years of In-House Quality Control

    We run strict quality checks on every lot. Each batch passes through advanced analytical instruments — high-performance liquid chromatography, melting point analysis, and spectroscopic confirmation. Time after time, we’ve found that tight control of raw materials and reaction times are crucial. Small impurities, if allowed to remain, can cascade through downstream synthetic steps, so we always keep impurity profiles low. For our 2-Amino-6-Methylbenzoic Acid, typical purity reaches above 99%, with trace impurities regularly below 0.5% by HPLC. Experience shows that striving for this kind of purity pays off most during scale-up: reactions perform more predictably, yields increase, and regulatory paperwork becomes less of a headache. Labs that cut corners on purity often return months or years later, seeking a stable supply when project timelines start to slip. This is where manufacturing discipline built on evidence shines. And through it all, our in-house teams work to improve reproducibility with every run, never satisfied with “good enough.”

    From Bench to Bulk: Why Experienced Handling Matters

    The difference between laboratory-scale and industrial-scale production comes down to control, safety, and repeatability. Anyone can create a few grams of an aromatic acid in a flask; producing it by the hundreds of kilos without any surprises demands experience. We’ve invested years to fine-tune our processes, from carefully chosen solvents down to the way we monitor temperature ramps and agitation speeds. 2-Amino-6-Methylbenzoic Acid presents practical challenges: it can form persistent emulsions in work-ups, cake in filters, or crystallize unpredictably when not handled just right. We’ve developed filtration and drying techniques to avoid clumping and ensure a free-flowing powder—small process tweaks that don’t make the textbooks but save enormous time in the plant. It’s these hands-on lessons that translate into real value for those who depend on our chemistries for their own manufacturing or research.

    An Ingredient in Progress: Where 2-Amino-6-Methylbenzoic Acid Finds Its Uses

    This compound’s versatility gives it a respected seat at the table in several industries. Its amine and carboxylic acid functionalities allow chemists to build complex molecules for advanced pharmaceutical research, polymer additives, specialty dyes, and even agricultural formulations. Its role as an intermediate often means it disappears by name before the final product takes shape — but the chemical fingerprints it leaves behind are clear in IR spectra, NMR signals, or chromatograms. Over the years, we’ve collaborated with researchers working on new drug candidates, pigment formulations, and corrosion inhibitors. They come back because they trust the consistency of each drum, not because of empty claims or marketing gloss. Real-world feedback from those customers helps us refine our process, adapt specifications where needed, and address key application challenges before they spiral into costly production stops.

    Safety and Responsible Manufacturing

    Responsibility in chemical manufacturing goes well beyond compliance. Frequent audits, waste minimization, and real-time environmental monitoring are normal in our facilities. 2-Amino-6-Methylbenzoic Acid calls for careful ventilation and reliable protective equipment. We have found over the years that solvents, even trace ones, can pose challenges if not fully removed, so we’ve evolved our drying and degassing steps. Training for new employees stresses respect for the hazards and the importance of incremental improvement. It’s not just about protecting workers but also about safeguarding our communities and the ecosystems around our operations. Regulations serve as a floor, but our teams aim higher. This constant awareness means we avoid costly incidents and have built a work environment where the team stands behind each product as a matter of pride as well as ethics.

    Comparisons to Similar Aromatic Acids

    The chemistry world does not lack for benzoic acid derivatives. Each isomer and side-chain variant brings its set of properties, from solubility changes to electronic effects that shift reactivity. The difference between 2-, 3-, or 4-Aminobenzoic acids can seem academic. In a manufacturing context, these shifts result in real-world effects: substrate compatibility, crystallization behavior, and even shelf-life. The methyl group at the 6-position confers increased hydrophobicity, altering solubility in both polar and nonpolar solvents. That can mean easier or more difficult dissolving in process steps, affecting reactor design and cleanout schedules. We’ve run trials replacing the 6-methyl group with others—sometimes seeking cost savings or trying to streamline a supply chain—but found that product stability and yield often suffer in unexpected ways. These lessons, earned through actual plant campaigns rather than reading a spec sheet, inform our ongoing commitment to this isomer.

    Tracking Down the Reliable Batch

    Customers rarely call to say that a batch is “fine.” They call when yields drop, a solid doesn’t crystallize as it used to, or chromatography shows extra peaks. As a manufacturer, we know every drum has a story. If we receive a query about 2-Amino-6-Methylbenzoic Acid, we track its path from the raw feedstocks, through every blend tank and filter press, all the way to shipping. This transparency isn’t just a marketing tool. Our tech team keeps detailed process logs, and each lot number ties to a robust paperwork trail. For instance, switching a minor solvent one year led to a small but measurable change in final product particle size and flow. After a few client complaints about dissolution time in their reactors, we traced the issue and reverted to our original process. These experiences reinforce the value of meticulous control and responsive support. Over time, this earns trust, transforming what started as a transactional relationship into a long-term technical partnership with those who depend on consistent raw materials.

    Upstream Challenges and the Value of Supplier Relationships

    Sourcing raw materials remains a central challenge for production plants making 2-Amino-6-Methylbenzoic Acid. Quality fluctuations in starting methylbenzoic acids or ammonia sources pass right through to the final lot, impacting reactivity and color. Over the years, we’ve formed close relationships with primary chemical producers. Routine on-site visits to suppliers, joint process troubleshooting, and mutual problem-solving have become the norm. In some instances, a shipping delay, unexpected impurity, or unforeseen price spike required rapid recalibration of our inventory and scheduling. Every upstream hiccup becomes a test of our reputation, and resilience only comes from decades on the ground, knowing both people and processes up and down the supply chain. At the end of the day, clients do not want stories about production issues; they want a reliable batch, on time, that performs exactly as expected. That goal drives everything we do, day after day.

    Market Shifts and Adaptation in a Volatile World

    Global markets shift quickly. Pharmaceutical synthesis demands spike with new drug prospects or drop with regulatory changes. Downstream sectors sometimes substitute related compounds in search of efficiency or cost savings, putting pressure on traditional suppliers to either adapt or disappear. Our teams have weathered raw material price volatility, supply chain disruptions, and changing regulatory standards more times than we care to count. Diversifying our own supply base and refining synthetic routes have allowed us to hold firm on both quality and delivery. While more nimble competitors have come and gone, experience teaches that stable production, clear communication, and proven technical understanding form the foundation customers return to—especially when the unexpected happens.

    Innovation, Sustainability, and Looking Forward

    In our manufacturing halls, innovation moves at both the incremental and breakthrough scale. We constantly test new solvents, greener purification methods, and waste minimization tactics that can quietly transform routine operations. Sustainability isn’t a banner slogan here—it’s part of every monthly review. 2-Amino-6-Methylbenzoic Acid, though produced on a modest scale globally, faces scrutiny for process effluents, energy consumption, and resource use. Over the years, process engineers have developed closed systems where possible, regenerated process solvents, and maximized electricity savings by optimizing reaction profiles. Each new improvement, no matter how small, compounds into safer and more environmentally responsible operation. As regulators sharpen their focus and industries shift toward lower environmental impact, we’re ready and willing to lead those changes from the ground up. Real progress emerges not just from following rules, but from anticipating where expectations are headed and making sure our operations get there before mandates arrive.

    Knowledge Shared: Collaborative Problem Solving with End Users

    Product success for 2-Amino-6-Methylbenzoic Acid doesn’t begin or end inside our four walls. Our relationships with formulating chemists, production managers, and R&D groups have produced real-world improvements in handling, performance, and application. We’ve been invited into partner labs to observe bottlenecks in formulation, tackle solubility snags, and develop custom packaging solutions that make their jobs easier. A good manufacturer listens as much as they talk—and often, the best project ideas come from the day-to-day challenges of the end user. Early feedback pointed out how certain driers left micro-residual solvents or how increased packaging density changed dispensing rates. Acting on these points, we modified equipment, updated container designs, and trained our logistics teams, resulting in lower waste and less user hassle. These are not grand headlines, but cumulative progress that roots our business in practical outcomes.

    Beyond the Molecule: Earning Trust through Long-Term Stewardship

    Chemical manufacturing relies on technology, chemistry, and equipment, but at the core stand the people—the teams who compound accuracy with shared purpose. Year after year, we see that knowledge grows through persistence: carefully logged discoveries, lessons from setbacks, tweaks that cut an hour from a wash step or prevent an off-spec lot. 2-Amino-6-Methylbenzoic Acid has traveled this path with us. We remember the stalled batches, head-scratching emissions readings, and the long hours required to find a root cause hidden in a minor raw material change. Each experience shapes a better, more robust operation, so clients trust us not just for one shipment, but over a working relationship measured in decades. Whether responding to an emergency order due to an unexpected regulatory change, or collaborating on developing a new use for our chemical, the foundation is always trust, transparency, and proven experience on the ground.

    A Chemical’s Journey from Raw Material to Reliable Resource

    Inside each drum or pail of 2-Amino-6-Methylbenzoic Acid is a history of trials, improvements, and actual hands-on experience. While this molecule itself stands as a tool, its true value emerges through the lessons learned in making, refining, and delivering it safely and consistently. Compounds like this are not commodities on a chart, but carefully balanced results of real effort—a synthesis of chemistry, knowledge, and grit. For those who depend on chemical intermediates to keep their own plants running or to unlock new innovations, a steady and responsive supply remains the foundation. Our own story, told one batch at a time through both the successes and challenges, defines how we treat every order, every customer, and every opportunity to improve.

    Summary: Why the Manufacturer’s Perspective Matters

    No marketing gloss replaces the reassurance that comes from knowing your supplier understands not just the product, but also the real-world challenges of making and delivering it batch after batch. 2-Amino-6-Methylbenzoic Acid, in all its chemical specificity and application breadth, stands as a reminder of the difference experience makes. The little things—sterile equipment, steady process controls, exhaustive documentation—make products trustworthy and help partners overcome their own technical hurdles. Real quality stems from repeated effort, honest feedback, and the humility to know there is always more to learn and more to improve. So while the compound itself stays constant, our resolve to do it better grows every year, keeping pace with a world that demands cleaner, safer, and more reliable chemistry from those who understand manufacturing from the inside out.