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2-Amino-6-Chlorobenzonitrile

    • Product Name 2-Amino-6-Chlorobenzonitrile
    • Alias 2-Amino-6-chloro-o-cyanobenzene
    • Einecs 219-054-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    457506

    Chemical Name 2-Amino-6-Chlorobenzonitrile
    Cas Number 29341-18-8
    Molecular Formula C7H5ClN2
    Molecular Weight 152.58
    Appearance White to light yellow crystalline powder
    Melting Point 75-79°C
    Boiling Point 328°C
    Solubility Slightly soluble in water, soluble in organic solvents
    Density 1.27 g/cm3
    Purity Typically ≥98%
    Storage Conditions Store in cool, dry place, tightly closed container
    Synonyms 6-Chloro-2-aminobenzonitrile
    Smiles C1=CC(=C(C(=C1)Cl)N)C#N
    Inchi InChI=1S/C7H5ClN2/c8-6-2-1-5(4-9)7(10)3-6/h1-3H,10H2

    As an accredited 2-Amino-6-Chlorobenzonitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2-Amino-6-Chlorobenzonitrile, 100g, is supplied in a sealed amber glass bottle with a tamper-evident cap and safety labeling.
    Shipping 2-Amino-6-Chlorobenzonitrile is shipped in sealed, chemical-resistant containers, protected from moisture and light. Packages are clearly labeled with hazard warnings according to international transport regulations. Shipments comply with all applicable safety guidelines, ensuring secure handling and accident prevention during transit. Proper documentation is included for regulatory and customs clearance.
    Storage 2-Amino-6-Chlorobenzonitrile should be stored in a tightly closed container, in a cool, dry, well-ventilated area away from incompatible substances such as strong oxidizing agents and acids. Protect from moisture, heat, and direct sunlight. Ensure proper labeling and secure storage to prevent unauthorized access. Follow all relevant safety and handling guidelines for hazardous chemicals.
    Application of 2-Amino-6-Chlorobenzonitrile

    Applications of 2-Amino-6-Chlorobenzonitrile in Industrial Manufacturing

    2-Amino-6-Chlorobenzonitrile acts as a critical intermediate in multiple industrial production chains. As an original chemical raw material manufacturer, we serve leading formulators and process integrators worldwide. We support precision applications in advanced APIs, specialty dyes, and agrochemical synthesis, adapting to each sector’s technical and compliance prerequisites.

    1. Pharmaceutical Intermediates for Active Ingredient Synthesis

    This compound primarily enters pharmaceutical manufacturing as an essential building block for certain active pharmaceutical ingredients (APIs), including anti-hypertensive and anti-cancer molecules. R&D and production processes rely on its stable reactivity for introducing aromatic amino and chloro groups, facilitating targeted functionalizations in multi-step organic syntheses. We supply large-scale reactors in validated GMP environments where this material ensures batch-to-batch reproducibility and meets strict impurity profiles.

    Industry compliance standards

    • ICH Q7 GMP Guidelines for Active Pharmaceutical Ingredients
    • USP and EP monograph references for API and intermediates
    • FDA 21 CFR 210/211 for finished drug substances
    • ISO 9001:2015 for quality management systems

    Typical usage ratio

    • 5–12% by molecular stoichiometry within key condensation or substitution reactions, adjusted per route efficiency and impurity control strategy

    Downstream process integration

    • Charged in early to middle steps for ring functionalization
    • Participates in amide or heterocycle formation, then removed in purification
    • Intermediates subjected to column chromatography or recrystallization before API isolation

    Final product types

    • Antineoplastic agents such as kinase inhibitors
    • Anti-hypertensive actives in tablet or injectable dosage
    • Veterinary pharmaceuticals

    2. Agrochemical Synthesis (Insecticide and Herbicide Intermediates)

    Leading agrochemical manufacturers adopt this aromatic nitrile as a core intermediate in the synthesis of selective insecticidal and herbicidal agents. Its molecular structure allows controlled reactions for creating substituted benzamides and further functionalization into target active compounds. Good batch handling and analytical traceability underpin its use in regulated agrochemical production lines where field consistency and shelf stability are mandatory.

    Industry compliance standards

    • FAO/WHO JMPR guideline on pesticide specification
    • EPA 40 CFR Part 174/180 (United States Environmental Protection Agency)
    • REACH (EC) No 1907/2006 compliance for chemical safety
    • ISO 17025 for analytical testing in batch release

    Typical usage ratio

    • 8–18% input by weight as calculated for multi-step benzamide synthesis or chlorinated aromatic intermediates; varies based on the required selectivity of the target active ingredient

    Downstream process integration

    • Introduced post-nitration and pre-coupling steps in batch reactors
    • Subjected to catalytic hydrogenation, halogen exchange, or condensation with specific amines
    • Intermediates filtered and assayed before formulation into technical concentrates

    Final product types

    • Precursor molecules for chlorinated herbicides
    • Synthons for selective insecticidal amide compounds
    • Granular and emulsifiable concentrate agrochemical actives

    3. Specialty Dyes and Pigments Manufacturing

    Producers of colorants utilize this material in specific dye classes where the aromatic amino and chloro groups increase substrate affinity and chromophore stability. The compound participates in key acylation and diazotization reactions during the synthesis of disperse, acid, and reactive dyes. Consistent purity levels and controlled moisture content ensure compatibility with downstream blending and finishing protocols in textile and polymer dyehouses.

    Industry compliance standards

    • OEKO-TEX Standard 100 for harmful substances in textile dyes
    • EU Regulation (EC) No 1907/2006 (REACH) for chemical traceability
    • ISO 9001:2015 in dye manufacturing plants
    • ZDHC MRSL (Manufacturing Restricted Substances List) compliance

    Typical usage ratio

    • 10–15% by mass of precursor formulation depending on desired chromophore yield; process engineers adjust based on target dye shade and reactivity profile

    Downstream process integration

    • Engaged in primary acylation or diazotization stage
    • Subsequently formulated with metal complexing agents or solubilizers
    • Final dye paste standardized for color strength and migration properties

    Final product types

    • Textile disperse dyes
    • High-performance pigments for plastics
    • Inkjet receptive dye compounds

    4. Fine Chemical Synthesis in Electronic Material Precursors

    Specialty electronics manufacturers employ this compound as a precursor in the synthesis of aromatic intermediates for advanced materials, including liquid crystal compounds and semiconductor processing aids. The precise amino and chloro substituent positioning enables further derivatization, crucial for producing high-purity aromatic systems needed in optical and electronic applications. Purity specifications, trace metal control, and low residual solvents are essential throughout the process.

    Industry compliance standards

    • RoHS Directive (2011/65/EU) for electronic material restrictions
    • JEITA RCRP for chemical product reliability in electronics
    • ISO 14001:2015 for environmental management in fine chemical plants
    • Specific customer technical specifications (semiconductor grade)

    Typical usage ratio

    • 6–15% of overall multi-precursor system; selection based on the performance requirements of the target material

    Downstream process integration

    • Introduced at the first or second synthetic stage for constructing key aromatic cores
    • Processed under controlled temperature and solvent-free conditions to limit by-products
    • High-purity fractions isolated for use in downstream thin-film or display manufacturing

    Final product types

    • Liquid crystal intermediate blends
    • Dielectric materials for microelectronic assembly
    • Special polymer additives for optical films

    5. Custom Intermediate for Chemical Research and Small-Molecule Development

    Contract research organizations and specialty fine chemical houses rely on this aromatic nitrile for rapid synthesis of novel small molecules. Its dual functional groups accelerate route scouting for custom ligands, analytical markers, or innovative heterocyclic compounds. Our integrated supply chain supports laboratory-to-pilot translation, ensuring full trace documentation as required for patent filings and regulatory submissions.

    Industry compliance standards

    • ISO/IEC 17025 for laboratory quality assurance
    • GLP principles (OECD and FDA) for analytical verification
    • WIPO Guidelines for patent-pending process records
    • ISO 9001:2015 for research chemical manufacturers

    Typical usage ratio

    • 1–10 mmol scale (laboratory) or 0.5–10% of total batch (pilot); exact load based on experimental design and molecule complexity

    Downstream process integration

    • Dissolved in polar aprotic solvent for direct SNAr reactions
    • Provides critical ring motifs in cyclization screens and cross-couplings
    • Final intermediates isolated via preparative HPLC for further derivatization

    Final product types

    • Experimental heterocyclic scaffolds
    • Substituted pyridines and benzamides
    • Analytical reference compounds for drug discovery
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    Certification & Compliance
    More Introduction

    2-Amino-6-Chlorobenzonitrile: A Reliable Building Block for the Chemical Industry

    Introducing Our Product: 2-Amino-6-Chlorobenzonitrile

    Over years of manufacturing specialty chemicals, we have seen certain products prove themselves again and again in demanding environments. One such compound is 2-Amino-6-Chlorobenzonitrile, a fine white to light beige crystalline powder. Our current model, manufactured at our facility under strict adherence to industry safety and purity guidelines, typically offers a purity above 99% by HPLC and a melting point falling in the range preferred by pharmaceutical and agrochemical customers. Packaging and sizing options adjust according to customer requirements, supporting both laboratory-scale and bulk industrial applications.

    The Value in Consistent Quality

    We understand how even small variations in input materials cause headaches on the production line. Purity, particle size, residual solvents—these aren't just minor specifications; they impact downstream synthesis, yields, and batch-to-batch consistency. Our focus lies in monitoring and controlling each step, from raw material sourcing to final product inspection, so every shipment delivers what the customer expects. Over the past decade, incoming feedback has confirmed that stable supply and proven lot repeatability let customers make formulation changes or scale-up with minimal worries.

    Why Manufacturers Trust 2-Amino-6-Chlorobenzonitrile

    This compound carries weight in industries where synthesis reliability matters. For pharmaceutical intermediates, 2-Amino-6-Chlorobenzonitrile’s molecular structure forms a versatile starting point for the creation of more complex molecules. Its combination of a reactive amino group and a nitrile handle, together with a strategically placed chlorine atom, supports a rich variety of transformations—nucleophilic substitutions, ring closures, amide formations, and Suzuki couplings, among others.

    Pharma R&D teams turn to this material when laying out multi-step syntheses for active ingredients or fine chemicals. Reliable access to high-quality 2-Amino-6-Chlorobenzonitrile minimizes planning and re-qualification delays. Since our facility keeps demand-driven inventory, customers also avoid extended lead times or disruptions found with lower-volume or imported stocks.

    Roles Beyond Pharmaceuticals

    2-Amino-6-Chlorobenzonitrile also finds use in agrochemical synthesis. In this sector, robust process chemistry supports the development of new active ingredients for crop protection. Chemical engineers choosing a nitrile with a well-positioned amino and chloro group get a head start on crafting scaffolds for herbicides, insecticides, or fungicides. Fine-tuning molecular features in the benzonitrile core often leads to new compounds with better efficacy or reduced environmental footprint. Customers appreciate knowing the precursor they specified will be readily available for pilot runs through full-scale commercialization.

    Comparison With Related Benzonitriles

    The market today offers a range of substituted benzonitriles. Chemically, subtle differences in substitution pattern or functional groups can have major downstream impact. For example, 2-Amino-4-Chlorobenzonitrile and 2-Amino-6-Methylbenzonitrile each react differently under standard conditions. The chloro group at the 6-position in our product provides a unique reactivity profile—making certain nucleophilic aromatic substitution reactions more accessible while enabling selective derivatization elsewhere. Customers who tried switching to alternate materials report higher byproduct formation, changes in reaction yield, or even changes in regulatory compliance outcomes due to new impurities.

    Our staff frequently consult with chemists choosing between isomers. Those responsible for greenfield process development can avoid costly re-validation steps by sticking to the tried-and-true 2-Amino-6-Chlorobenzonitrile core in their syntheses. Lessons learned from troubleshooting similar aromatic building blocks led us to invest even more in refining this product's analytical profile, ensuring lower residual solvents and cleaner chromatograms. The result: higher customer satisfaction and fewer project setbacks.

    Specifications Built on Manufacturing Know-How

    While specs might appear straightforward on a certificate of analysis, true quality depends on what happens on the shop floor. We adopted a closed-system approach to minimize contamination risks and ensure reproducibility. Batch records detail process controls for temperature, pressure, and mixing—slight tweaks in any of these variables influence purity and downstream safety data. Operators receive continuous training, reinforcing a culture where hands-on knowledge and pride in craftsmanship drive every batch.

    We test each lot for purity, moisture, trace metals, and residual organics to ensure suitability for rigorous synthesis. Consistency means less rework at the customer’s plant and more time spent focusing on product innovation. We've learned over time that stability, both in the chemical sense and in supply chain reliability, matters just as much as any published assay data.

    Supporting Safe and Ethical Manufacturing

    Responsible chemical production extends beyond quality checks. We prioritize environmental stewardship and workforce safety by investing in closed-system engineering, advanced air filtration, and automated waste handling. Our real commitment shows in maintaining full traceability on each raw material lot, working with inspectors to meet ever-tightening global environmental and safety regulations.

    Downstream industries use 2-Amino-6-Chlorobenzonitrile for regulated applications. Our direct customers, whether in pharmaceuticals or crop sciences, want to know the upstream supply chain stands on solid ethical footing. Ongoing investments—in laboratory analytics, monitoring, and documentation—back our promises with proof, not just marketing. Auditors examining our facility have direct access to data confirming adherence to REACH, GHS, and other regulatory frameworks for safe handling and use.

    Product Evolution and Customization

    Innovation in fine chemical manufacturing isn't limited to creating new molecules. Over the years, we've responded to industry requests for tighter purity brackets, customized particle sizing, or lower target levels for regulated impurities. Process adjustments took time. Our team worked through dozens of pilot trials to balance output yield with the added steps necessary for impurity reduction or crystallization control. What customers gained: a predictable product that matches specific synthesis needs, with clear documentation supporting every change.

    Our technical service group maintains dialogs with synthesis chemists, offering insight drawn from large-scale production. Questions about solubility, compatibility with different solvents, or observed side-product formation get answers based on lab results and production experience. Customers taking on new product development projects value access to real, firsthand manufacturing insight. The technical team can supply bench-scale samples for process optimization long before larger orders get placed, reducing the risks associated with downstream scale-up.

    The Upside of Vertical Integration

    Supplying a specialty molecule like 2-Amino-6-Chlorobenzonitrile requires more than simply reacting raw material and packaging the result. Our integrated facilities handle everything in-house, from raw material synthesis to purification and final packing. The advantage: tighter control over all input streams and a proven ability to address supply disruptions swiftly. During the recent raw material shortages faced globally, our facility’s flexibility and advanced inventory systems allowed us keep regular shipments steady without quality compromise or extended delivery times.

    End users tell us this peace of mind gives their operations a significant edge, removing the uncertainty that sometimes comes from fragmented or brokered chemical supply chains. Our direct accountability for each production step means customers can trace each bag or drum back to a single origin, with documented oversight and traceability at every stage.

    Beyond Standard Analysis: Analytical and Application Support

    Our built-in quality assurance program covers more territory than routine wet chemistry or HPLC. Customers with sensitive downstream applications benefit from our investment in advanced impurity profiling using LC-MS, GC-MS, and elemental analysis systems. If a project demands, we review multi-year product consistency documentation and can provide detailed records on the observed impurity trends or batch performance for regulatory filings.

    Some customers carry out demanding downstream scale-ups where even minor impurities interfere with complex transformations. Our analytical team works closely with theirs, exchanging data and feedback to ensure product fits the application and avoids unwanted side reactions. Years of direct lab and plant feedback have given us a proven workflow for fast troubleshooting and process modifications. Responsive support like this minimizes lost time and helps protect multi-million dollar R&D investments.

    Addressing Industry Challenges: Purity, Traceability, and Regulation

    With tighter standards and growing scrutiny on chemical safety, the market for 2-Amino-6-Chlorobenzonitrile places a premium on traceability. Our company commits to not only maintaining compliance with international standards but also proactively seeking ways to improve transparency. From blockchain-supported batch logs for high-value shipments to digital certificates of analysis, customers gain confidence in both the materials themselves and the documentation supporting each delivery.

    Feedback from downstream manufacturers shapes our priorities for process and documentation improvements. In cases where a regulatory authority raised concern over a particular impurity, our team worked backward through the synthesis and supply chain, pinpointing the source and adjusting process control points. This level of responsiveness isn’t possible without hands-on experience in chemical process engineering and a genuine partnership mentality with our customers.

    Reducing Environmental Impact in Fine Chemicals Manufacturing

    Operating a chemical plant responsibly requires constant vigilance to manage effluent streams, minimize solvent waste, and deploy energy efficiently. For many years, teams across our facility have adopted new solvent recovery and closed-loop processes to cut the carbon footprint associated with producing 2-Amino-6-Chlorobenzonitrile. Filtration and post-reaction workup generate wastes, and managing these byproducts has shaped our approach to lean manufacturing.

    We frequently share best practices from our own environmental audits with interested customers, who need hard data to back up sustainability claims in their own markets. Stepwise reductions in emissions, combined with ongoing investments in infrastructure modernization, have both improved our local environmental performance and also given our customers new confidence in the ethical footprint of their purchased materials.

    Practical Handling and Storage on the Factory Floor

    Safe storage and handling routines for this compound stem from long operational practice, not just paperwork. Our packaging standards withstand tough transport conditions and maintain the stability required for extended warehouse storage. Customers dealing with regular batch inventory can rely on the stable shelf life under reasonable conditions, reducing the need for extra retesting or recertification repeated every few months.

    During shipping, we use tamper-evident seals and robust containers, supported by real-world shipping route data to minimize temperature excursions, moisture ingress, or accidental exposure. All these steps evolved from incidents and lessons learned by the production team through hard experience on the factory floor. Because we manage logistics in-house, any issues reported by customers are checked against our own delivery logs, speeding up resolution.

    Applications in Product Development and Process Optimization

    R&D groups operating in pharmaceuticals, agrochemicals, or specialty polymers use 2-Amino-6-Chlorobenzonitrile to push the boundaries of molecular design. Its structural features allow rapid modification to test new hypotheses or improve bioactivity, and dependable upstream sourcing lets researchers focus on innovation, not procurement issues. Synthesis teams also run pilot batches to fine-tune yields, impurity profiles, or reaction efficiency before launching at full scale.

    Our team supports development by providing studies and technical documentation that can smooth the path for regulatory acceptance or intellectual property protection. Whether crafting a new drug lead scaffold or building a smarter herbicide backbone, customers find value in a stable supply of this key aromatic amine, paired with guidance from experienced synthetic chemists who helped bring the substance to market.

    Solving Sourcing Bottlenecks and Guaranteeing Supply

    Recent disruptions in global supply chains reinforced the value of domestic, vertically integrated specialty chemical manufacturing. Our proactive inventory management and deep supplier relationships buffer customers from delays seen elsewhere. Short-term supply interruptions not only hinder ongoing production but also risk regulatory compliance if substitutes bring unapproved impurities or variations. This is why we keep critical materials like 2-Amino-6-Chlorobenzonitrile in steady production, working well ahead of demand forecasts and keeping open communication with key customers.

    We actively monitor input costs, freight routes, and market shifts, so that our customers have early warning if economic or regulatory changes threaten supply stability. When shortages hit the market, customers relying on imported intermediates can experience downtime or forced reformulation. With us, chemists reach out and often receive prompt updates directly from our operations team—no third-party red tape or confusion about lead times.

    Looking Forward: Commitment to Customers and Innovation

    The fine chemical sector moves quickly, adapting to new science, regulations, and market needs. Standing still is not an option. Our long-term focus on dependable manufacturing, transparency, and active technical support grows out of the shared challenges faced by those who rely on 2-Amino-6-Chlorobenzonitrile. Industry partnerships, ongoing investment in process efficiency, and tight integration between plant and technical teams set the stage for continued improvement—both in the quality of molecules delivered and the trust built between supplier and customer.

    With a history built on listening to end users and solving real-world challenges, we continue aiming for product excellence, regulatory transparency, and shared success. Sourcing the right intermediates drives progress in everything from pharmaceuticals to agriculture to materials science. The journey of a molecule, from plant to laboratory to final product, deserves careful attention. Through practical experience and hands-on commitment, we ensure that each shipment of 2-Amino-6-Chlorobenzonitrile helps support safer, more efficient, and more innovative chemistry worldwide.