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HS Code |
681011 |
| Product Name | 2-Amino-6-Chloro-3-Formylchromone |
| Cas Number | 126066-08-4 |
| Molecular Formula | C10H6ClNO3 |
| Molecular Weight | 223.61 |
| Appearance | Yellow to orange solid |
| Purity | Typically ≥98% |
| Melting Point | 237-241°C |
| Solubility | Slightly soluble in DMSO, methanol |
| Storage Temperature | Store at 2-8°C |
| Synonyms | 6-Chloro-2-amino-4-oxo-4H-chromene-3-carbaldehyde |
| Smiles | C1=CC(=O)C2=C(C=C1Cl)C(=C(C(=O)O2)N)C=O |
| Hs Code | 2932999090 |
| Exact Mass | 223.0091 |
As an accredited 2-Amino-6-Chloro-3-Formylchromone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Packaged in a 10-gram amber glass bottle with a secure screw cap and tamper-evident seal, labeled with chemical details. |
| Shipping | The chemical 2-Amino-6-Chloro-3-Formylchromone is shipped in tightly sealed containers, protected from light and moisture. It is packaged according to international regulations for hazardous chemicals, with clear labeling and accompanying safety documentation (SDS). Transportation complies with relevant chemical safety standards to ensure secure and compliant delivery. |
| Storage | 2-Amino-6-Chloro-3-Formylchromone should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and moisture. Keep the container tightly closed and clearly labeled. Store it away from incompatible substances such as strong oxidizing agents. Use appropriate personal protective equipment when handling the chemical to ensure safety and avoid contamination. |
Applications of 2-Amino-6-Chloro-3-Formylchromone in Industrial Manufacturing2-Amino-6-Chloro-3-Formylchromone serves as a specialized intermediate for high-value synthesis in selected industrial sectors. As a direct manufacturer, we supply this compound for advanced applications where purity, reactivity, and traceability are critical. Its chromone backbone with specific amino, chloro, and formyl functionalities supports downstream transformations under controlled conditions. 1. Active Pharmaceutical Ingredient (API) Synthesis for Antitumor CompoundsPharmaceutical developers use 2-Amino-6-Chloro-3-Formylchromone to build novel heterocycles with potential antitumor or cytostatic activities. Process chemists incorporate this intermediate for the construction of fused ring systems through condensation or cyclization with amines, hydrazines, or other nucleophiles. The material’s electronic profile and substitution pattern enable regioselective reactions, critical for API lead development, under pharmaceutical GMP protocols. Industry compliance standards
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2. Synthesis of Agrochemical Actives and IntermediatesThe compound finds targeted use in advanced agrochemical R&D for the formation of nitrogen- and halogen-substituted heterocycles. Formulators use its high reactivity in constructing complex scaffolds for proto-herbicides or experimental crop-protection candidates. Suitability depends on purity, controlled water content, and trace metal levels to avoid interference with biotesting and regulatory dossiers. Industry compliance standards
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3. Development of Analytical Reference StandardsCertifying laboratories and diagnostic manufacturers utilize this compound in preparing reference materials required for calibration and quality control in pharmaceutical residue analysis. Batch lot consistency, exact impurity profile documentation, and precise assay are essential for regulatory acceptance and audit trails. Industry compliance standards
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4. Advanced Dye and Pigment Intermediate SynthesisSpecialty pigment producers select this raw material for the synthesis of nitrogen- and chlorine-functionalized chromone dyes. Its molecular structure enables azomethine and condensation dye formation for textiles and specialty coatings. Formulation requires tight pH and reaction time management to achieve target hue and lightfastness profiles. Industry compliance standards
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Every batch of our 2-Amino-6-Chloro-3-Formylchromone speaks to the precision and tenacity that go into fine chemical manufacturing. We know what chemists and researchers deal with because we're part of the daily grind: sourcing pure ingredients, troubleshooting reactions, delivering consistent results over long syntheses. These truths matter far more than the sterile claims found in too many technical sheets. Over years of large- and mid-scale synthesis, we've seen which details separate a routine production run from one that threatens to derail an entire project. Those lessons led us to refine how we produce this compound, giving researchers and formulators a solid foothold in their downstream chemistry.
This molecule finds its strength in the balance between stability and reactivity. The formyl and amino groups open several pathways for further derivatization, and that versatility unlocks routes in heterocyclic synthesis. We don't lose sight of the small details — the yellow tinge, the faint but persistent odor detectable in a freshly cracked ampule, the way crystals form under careful cooling. Such physical characteristics tell a story to anyone working at the bench. Water content, melting range, and microimpurities can make or break an advanced project, especially in pharmaceutical development. Before scaling up, we pay close attention to crystallinity and keep strict tabs on residual solvents that can interfere with performance in more sensitive reactions.
With repeated manufacturing runs and feedback from R&D partners, we’ve developed a strong feel for the quirks of 2-Amino-6-Chloro-3-Formylchromone. For those who have tried synthesizing it themselves, persistent byproducts from incomplete cyclization steps or over-chlorinated analogs can crop up, even with the purest starting materials. Close monitoring through HPLC and NMR helps us gauge lot-to-lot reproducibility. Moisture in the environment causes clumping over time, especially once the drum has been opened a few times in a humid lab. To work around this, our team packs the product under dry nitrogen for long-term transit. Heavy-duty jugs and layered foil lining help keep every shipment as fresh as the day it left our packaging line.
Long before this molecule reaches any customer, the main question on our minds is application. 2-Amino-6-Chloro-3-Formylchromone proves itself valuable as a scaffold in constructing diverse heterocyclic units. In medicinal chemistry, these frameworks serve as starting material for antivirals, antitumor leads, and a range of enzyme inhibitors. We’ve supported labs investigating kinase selectivity, solar cell dyes, and new routes to benzo-fused derivatives. Some have pushed it through Suzuki and Heck couplings to extend aromaticity. Others seek to introduce new side chains at the 2-amino site for SAR studies. Just last year, one team used our material to build novel chromone-dipeptide hybrids for agricultural screening trials. It's always impressive to watch new fields open from the same reliable intermediate.
We know how crowded the specialty chemical space has become, and the difference between a winning synthesis and a failed experiment often starts with a subtle impurity or overlooked particulate. What distinguishes our 2-Amino-6-Chloro-3-Formylchromone isn’t fancy marketing — it’s a track record proven by batch analytics and client outcomes. Our process achieves a melt purity well over 98 percent by GC, minimizing chlorinated and formylated side products. Sulfate ash, commonly left behind in shortcut workups, drops below quantifiable limits in our final crystallized powder. Strong absorption in solution at the expected wavelengths reassures customers seeking photochemical consistency.
Synthetic chemists have asked about comparable analogs, particularly those lacking the 6-chloro group or substituting a nitro unit elsewhere on the chromone scaffold. Subtle electronic changes can profoundly affect downstream reactions. Our experience in multi-ton batches taught us that even a single missed substitution pattern in the aromatic ring changes chromatographic behavior, solubility, and reactivity under nucleophilic substitution. Too many times, we've received distress calls from teams who bought inferior grades only to run into bottlenecks with stubborn contaminants or off-grade melting transitions. Our standard never slips, because each barrel or flask that leaves our facility must pass a multi-point control process and is made under the same hands-on supervision.
We track, lot by lot, the attributes most important to professional chemists: melting range (usually tight and above 165 °C), LC trace, visible foreign particulates, color intensity, and overall stability exposed to light and air. We know that not every user operates in climate-controlled environments, so we've tested our material under a full range of practical lab and pilot plant settings. Sensitivity to moisture and oxygen prompted us to run aging studies at controlled humidity levels, and that data informs our packaging advice.
Our primary production scale runs cover quantities from several kilograms up to multi-hundred kilo batches per campaign. To ensure availability for projects both large and small, we maintain reserves in laboratory and pilot-scale lots. Developing this logistics network took years of coordination, but having such a buffer means we back up our claims about speed: Once a customer places an order, we rarely delay shipment because we’re never caught off-guard by raw material shortages or process hiccups.
Trust builds batch by batch, not through well-worded websites, but through decades-old client relationships. Every process tweak, from the choice of solvents to the fine-tuning of acid washing protocols, comes from experience facing and fixing the unexpected. We've solved scale-up headaches and unexpected crystalline habits. One client project in agrochemical research called for a unique polymorph, and we pushed our equipment to deliver it without missing a day’s schedule. By involving our team at every step, from weighing the first precursor to hand-labeling finished containers, we close the circle between manufacturing and application. As a result, we receive honest (sometimes blunt) feedback with each lot, using it to fine-tune every subsequent run.
Our plant has moved far past off-the-shelf batch chemistry. We implemented cleanroom handling at key crystallization steps, reducing outside contamination risks. Each batch undergoes fingerprint checks, using NMR and mass spectrometry, to catch any off-route cyclization products. We log each deviation and investigate root causes before repeating a batch, so each shipment upholds the same profile of performance. Any lot falling outside specification never leaves the plant, no matter how urgent the deadline. For new users, we provide a complete profile of each batch, supporting regulatory filings and research reports requiring full traceability.
Every manufacturer has faced that tense moment when a major run veers off course. Early in our experience with 2-Amino-6-Chloro-3-Formylchromone, yield frustration dogged us during the dehydration phase — a slight slip in reaction temperature or acid strength could cause incomplete conversion or, worse, decomposition. To tackle this, we installed in-line spectrophotometric monitors and ramped up in-process checks, halving our off-grade rates within months. That same mindset now guides our preventive maintenance schedule and training, equipping each shift to spot process drifts before they threaten a batch.
We monitor developments across pharmaceutical, agricultural, and electronics research. As soon as a fresh set of guidelines emerges — for example, the push for even lower residual solvents or new toxicology restrictions — we run batch tests to confirm compliance. Partnering with analytical labs, we audit our own data against independent standards, welcoming challenges to our findings when anomalies emerge. When a customer flags an issue, whether a borderline specification hit or slight batch-to-batch color variance, we open an investigation log. Solutions rarely come from a single adjustment. Instead, our team works through the entire process, from sourcing raw 4-chlororesorcinol to optimizing dehydration and protecting-group strategies for formyl introduction.
We work hard to reduce environmental burden. Our team installs state-of-the-art filtration to recover and recycle spent acids wherever technically feasible. Spent solvents pass through vacuum distillation, allowing reclamation for internal non-critical rinse steps. By sourcing renewable energy for our production floor lighting and ventilation, we shrink our plant’s carbon impact. These choices stem not only from compliance needs but from a persistent drive to hand off a better process and product to the next generation. Efforts to remove excess packing materials and shift to biodegradable liners have paid off — our shipments now generate far less landfill waste than just a few years ago.
We run regular technical briefings with our most committed customers, discussing challenges, proposed new applications, and even process tweaks that could improve yields on their downstream reactions. Our technical staff attend conferences and workshops, gathering critical insights into the future directions for chromone intermediates and emerging standards that we must meet. These face-to-face conversations give us a clear sense of how our 2-Amino-6-Chloro-3-Formylchromone is genuinely used — not just what the label might suggest. This level of open exchange keeps us nimble and ready to adjust both scale and specification, standing behind every lot we ship.
For teams running high-throughput syntheses or pilot plant campaigns, time really does cost money. Delays from inconsistent raw materials slow the research clock and strain budgets. By delivering each order with transparent documentation — from HPLC chromatograms to water content traces and detailed impurity breakdowns — we give our customers the power to troubleshoot or optimize their own workflows. Our support line fields requests ranging from shelf-life extensions to solubility advice in specific mixed solvents, and every query shapes the practical notes we include for future shipments. If a lot needs retesting, we run fresh samples and forward the results in time for project deadlines.
One partnership with an academic group working on fluorescent probes used our material to screen a novel class of intramolecular proton transfer sensors. Their success, published in an open-access journal, hinged on the clean baseline in their spectra — something only possible with high-purity starting material. Knowing our 2-Amino-6-Chloro-3-Formylchromone underpinned a major innovation validates every hour our team spends on the production floor.
Demand continues to rise for point-to-point intermediates with high structural integrity. Advanced applications now go well beyond traditional textile dyes and pharmaceuticals. Teams investigating organic field-effect transistors or next-generation photovoltaic materials frequently reach out to discuss whether modifications to our standard production could drive new properties. We listen closely to such needs, offering pilot quantities and even running small-lot side-chain elaborations to help partners identify feasibility before they scale.
We’re also tracking global harmonization efforts on chemical safety and impurity disclosure. Our documentation outpaces these standards, giving all downstream users — whether in a university lab or an industrial pilot project — the information needed to meet evolving policies. Each improvement arises from hands-on trials, not theoretical guesswork. That’s the perspective that only direct manufacturing experience can deliver.
Years of engineering and technical work go into the clean, consistently crystalline samples we provide. Each drum or flask bearing this name carries our reputation, one batch at a time. From pre-packed ampoules for analytical use to bulk drums shipped globally, we ensure every shipment upholds the highest standards of purity, stability, and traceability. For chemists demanding certainty, only a direct link to the producer — not a third-party distributor — provides meaningful assurance.
We build every step of our process around what chemists in high-stakes environments genuinely care about: reproducibility, verifiable purity, and responsive support. Anyone can cite textbook figures, but real-world manufacturing for the global research and industrial marketplace comes down to a simple promise — reliable 2-Amino-6-Chloro-3-Formylchromone delivered to exacting standards, ready for your next breakthrough.