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HS Code |
886141 |
| Product Name | 2-Amino-5,6-Dichlorobenzothiazole |
| Cas Number | 21265-50-9 |
| Molecular Formula | C7H4Cl2N2S |
| Molecular Weight | 219.09 g/mol |
| Appearance | Light yellow to off-white crystalline powder |
| Melting Point | 220-223°C |
| Purity | Typically ≥98% |
| Solubility | Slightly soluble in water; soluble in organic solvents such as DMSO and ethanol |
| Storage Conditions | Store in a cool, dry place away from light |
| Synonyms | 5,6-Dichloro-2-aminobenzothiazole |
| Smiles | Nc1nc2ccc(Cl)c(Cl)cc2s1 |
| Inchi | InChI=1S/C7H4Cl2N2S/c8-3-1-2-4(9)6-5(3)12-7(10)11-6/h1-2H,(H2,10,11) |
As an accredited 2-Amino-5,6-Dichlorobenzothiazole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The chemical 2-Amino-5,6-Dichlorobenzothiazole is packaged in a 25g amber glass bottle with a secure, tamper-evident cap. |
| Shipping | 2-Amino-5,6-Dichlorobenzothiazole is shipped in tightly sealed containers under ambient conditions. Packaging complies with relevant chemical regulations to prevent leaks and contamination. Ensure labeling includes hazard information. During transport, avoid excessive heat, moisture, and direct sunlight. Follow all local and international guidelines for shipping hazardous laboratory chemicals safely. |
| Storage | **2-Amino-5,6-Dichlorobenzothiazole** should be stored in a tightly closed container, kept in a cool, dry, and well-ventilated area. Protect it from moisture, heat, and direct sunlight. Store away from incompatible substances such as strong oxidizers and acids. Ensure the storage area is secure and clearly labeled, and access is restricted to trained personnel. |
Applications of 2-Amino-5,6-Dichlorobenzothiazole in Industrial ManufacturingAs a specialized manufacturer of 2-Amino-5,6-Dichlorobenzothiazole, we focus on its proven industrial utilization across several downstream production sectors. Below we detail major application scenarios, illustrating precise usage parameters, process involvement, and real compliance systems required in each field. 1. Synthesis of Pharmaceutical Intermediates for Antimicrobial AgentsThis compound serves as a core heterocyclic intermediate for the synthesis of certain antimicrobial pharmaceutical ingredients, particularly in the production of benzothiazole-based active molecules. During formulation, regulatory research teams control its proportion strictly to ensure pharmacopoeial compliance for downstream active ingredient registration. Manufacturers introduce it during the condensation or cyclization step, integrating it with side chain reagents or modification agents to yield pre-final APIs destined for further purification, granulation, and tableting. Industry compliance standards
Typical usage ratio
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2. Raw Material for Rubber Vulcanization AcceleratorsIn the specialty rubber processing sector, the compound functions as a precursor for synthesizing custom vulcanization accelerators essential for performance elastomers. Vulcanizer manufacturers insert it into high-pressure, high-temperature reactions forming dichlorobenzothiazole derivatives for tailored crosslinking characteristics. Stability and reactivity are tested batchwise under ISO and ASTM protocols to ensure reliable curing speed and product consistency for tire, gasket, and industrial hose manufacturing. Industry compliance standards
Typical usage ratio
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3. Intermediate in Agrochemical Active Ingredient ManufacturingThis raw material is a building block for synthesis of certain agrochemical actives, particularly specialty fungicides and seed treatment agents containing a benzothiazole core. It is fed into controlled chlorination and amination reactions designed according to regulatory residue and toxicology standards. Producers precisely calibrate its share in multi-component reactions based on target bioactivity profiles and application concentration limits in final field formulations. Industry compliance standards
Typical usage ratio
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4. Precursor for Dyes and Pigment Intermediate SynthesisManufacturers use 2-Amino-5,6-Dichlorobenzothiazole to develop high-performance benzothiazole-based dye intermediates and pigment components for applications where lightfastness and chemical resistance are critical. The material is charged into diazotization steps or further functionalized with sulfonic or amino groups, followed by molecular tailoring for specific shade properties. Compliance checks focus on azo content, heavy metal thresholds, and product safety for downstream textile, plastic, or ink applications. Industry compliance standards
Typical usage ratio
Downstream process integration
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Our team has spent many years perfecting the art and science behind 2-Amino-5,6-Dichlorobenzothiazole. Turning out every batch in our own workshop grounds every promise we make. This compound sits among the more precise specialty chemicals, demanded by pharmaceutical and agrochemical researchers who need a true baseline standard for advanced syntheses. Getting this molecule right—free of residual contaminants, consistent in melting point and purity—has taken us ongoing refinement to our routes. Each success, and each glitch, has deepened our operational roots.
We do not just hand off raw output. Each lot that leaves the reactor comes under a trained eye, guided by years behind the glass and stainless steel. Serving partners, we see what matters most is knowing the source behind a product, not just the certificate. Because this chemical is built up in a sequence of sensitive steps, it must be closely watched for the kind of subtle color, solubility, or particle size changes that signal something gone off-track. That is the fast lesson that separates makers from brokers—a phone call can chase up a paper trail, but reliable producers deal in lived responsibility.
2-Amino-5,6-Dichlorobenzothiazole is a fused heterocyclic compound with defined chlorination on the aromatic ring. Much of the value in this molecule comes from those two chlorine atoms at the 5 and 6 positions, which alter the electron profile and selectivity when the compound forms the skeleton of more complex targets. Its rigid profile and dual electron-withdrawing groups give research chemists a predictable starting point for introducing further groups or for building analogues of pharmaceutical or crop-protection compounds.
Our batches typically approach purity levels demanded by medicinal chemistry labs. While not flashy to describe, this is hard-won from dozens of cycles adjusting reaction temperature, washing techniques, and purification columns. Where trace impurities sneak in—often barely registering on standard HPLC runs—they still can trip up subtle later reactions. That is why the focus must remain tight. Specifications aren’t created in isolation: feedback from end-users across different markets keeps us tuned to shifting expectations, so we don’t stand back while others push the frontiers forward.
Small molecule synthesis isn’t just about chemical equations. For 2-Amino-5,6-Dichlorobenzothiazole, unexpected byproducts or leftover chlorinated fragments can gum up downstream syntheses, bearing real consequences in clinical or regulatory work. Inside our shop, we run analysis not because a guideline says so, but because we’ve seen the disruption a poorly-refined material can trigger. We trace back every step—batch numbers, temperature logs, solvent lots—not as an administrative hoop, but as a line of accountability to our partners. If a question arises, that embedded traceability allows us to diagnose and course-correct without theorizing or blaming anonymous upstream providers.
There is a misconception that purity only matters at the drug formulation stage. We see from daily production that even a minor impurity at the input level can show up magnified by tenfold in the final molecule. In this business, attention to upstream details saves months and money further down the line. Our technicians and chemists all live by that rhythm; our best batches often come from someone asking that one extra question, insisting on a second pass in a tricky batch.
Every chemist wants the purest available starting materials, but few see the struggle behind the scenes. Most downstream users of 2-Amino-5,6-Dichlorobenzothiazole pursue a very specific reactivity pattern—either looking for a certain nucleophilic displacement or aiming to tweak the heterocycle toward new drug scaffolds. We communicate closely, learning when solubility tweaks or alternative crystallization can shape yield or ease of handling. Experience has shown us that dropping a percentage point off a solvent impurity or changing the drying time makes a surprising difference in both research labs and scaling plants.
Unlike simple commodity chemicals, this product resists one-size-fits-all approaches. Each customer’s process tells a different story. The repeated feedback teaches us: some want slightly larger particle size for ease of filtration; some worry about carry-over minor halogenated contaminants. There is no substitute for hearing directly from the synthesis teams, especially during early project phases or when downstream routes evolve. Our approach has always depended on phone calls and email dialogues, not just paperwork. Improvements show up more from real questions and shared experience than from theoretical best practices alone.
Out in the field, labels can look nearly identical, but actual batches show day-and-night differences. Some traders pull material from variable sources, blending lots of uneven color and melting points, hoping numbers will average out. Several customers have brought us samples from these routes—sometimes dull gray-tan, sometimes carrying unfamiliar odors. Our in-house batches, by contrast, keep a consistent pale yellow tone, a narrow melting range, and a mild odor profile honest to the base heterocycle.
Some may ask, why not buy a seemingly cheaper batch from another supplier? Years in industry have taught us that upfront savings quickly disappear with wasted time chasing inconsistencies. Researchers aiming for reproducible results rely on knowing their starting material is not shifting underneath them from month to month. Our experience shows that problems rarely stay small; a minor variation at the start quickly grows into cost overruns, rework, or batch rejections. Reliable manufacturing, not aggressive discounting, shapes success for both producer and partner in the specialty chemical segment.
The most common uses for 2-Amino-5,6-Dichlorobenzothiazole stem from its role as a building block. The presence of both amino and chlorines opens specific lines of derivatization, often serving as a precursor in the synthesis of therapeutic compounds, advanced dyes, or certain types of industrial catalysts. Its backbone structure, rigid and well-understood, gives medicinal chemists the room to build targeted analogues with less uncertainty.
We see orders from a diverse group: some teams in pharma try alternate routes to kinase inhibitors, others in crop science use it as a stepping-stone toward new systemic agents. Each field wants something a bit nuanced—a sharper melting point, fewer halogenated side-products, or the confidence that a specification drawn up months ago will still be met after repeated deliveries. That is not something solved by buying generic lots, but by working with producers tuned into the shifting regulatory and technical targets of modern synthetic chemistry.
Packaged chemicals don’t always cross borders or climates smoothly. We have adapted packing for 2-Amino-5,6-Dichlorobenzothiazole based on lessons from partners in tropical or cold climates. In one year, we learned that certain packaging led to clumping when humidity spiked; another season, a box exposed to subzero transit suffered from condensation and damaged crystals. Taking these lessons forward, we moved to slightly thicker liners or added moisture scavengers, and orders since then have arrived trouble-free. Such adaptations come from owning the process and talking things through, not reading marketing promises.
Shipping restrictions and customs scrutiny over halogenated intermediates often slow the work. Rather than passively let forwarders handle the difficulties, we talk directly with customs officials, explaining the context and showing documentation. Establishing a record of reliable, traceable sourcing has eased delays in more than one case. Each shipping challenge creates a feedback loop; our records not only prove regulatory compliance, but sharpen our understanding of how finished lots survive real-world routes.
Within active laboratories, safety depends on accurate labeling and honest communication. Our own plant procedures—tested through safety audits and lessons learned—shape our directions for users. 2-Amino-5,6-Dichlorobenzothiazole itself requires good ventilation and responsible personal protection during weighing, not just adherence to a checklist. We stress real communication of hazards because our crew faces them as a daily matter.
From a regulatory perspective, changes in listed status or permitted residue levels surface quickly within the global chemical trade. We stay alert to new rules, as incidents from nearby factories or transportation networks can tighten oversight unexpectedly. That vigilance isn’t academic: failing to keep pace with restrictions on aromatic chlorinated species has tripped up more than one exporter, leading to expensive recalls or loss of market access. Through decades of cumulative practice, our files contain correspondence and responses for every level of regulatory inquiry, reducing uncertainty for downstream users.
Every chlorinated intermediate carries an environmental footprint, and our history teaches us shortcuts on waste result in trouble. At our site, solvents are recycled where feasible, and any process water meets discharge rules before leaving the property. Our records show how subpar effluent can chase a manufacturer for years, drawing not only fines but lasting stigma within the supply network. Upstream diligence limits headaches for our partners and for our own site’s continued operating licenses.
Within the operation, team members watch for subtle process improvements that shave off both raw material and energy inputs. Many of these fixes come unprompted, a product of long-term staff invested not just in today’s batch, but in continuity and safety for the next generation. Sharing best practice across manufacturers—while still protecting the unique routes and intellectual know-how—improves industry-wide standing and reduces opposition from outside the field.
Advances in product quality rarely come from grand strategy sessions. In practice, a small group on the shop floor or in the QC lab will suggest a trial change to the wash solvent or hold a reaction at a slightly different agitation rate. Some improvements happen by chance: a delay during a maintenance cycle led us to discover a longer crystallization period sharpened the melting point. Years later, that change stays in our official batch protocol.
Feedback from end-users plays a crucial role. We encourage direct critiques—sometimes brutally honest—about how the product performs in scale-up or advanced synthesis. Our best process improvements have come from addressing “minor” annoyances relayed from technicians actually handling the powder, not just researchers optimizing a reaction yield. Taken together, these threads forge a more resilient supply chain—one where chemical structure, real production expertise, and technical support travel in step.
Specialty intermediate markets feel the push and pull of larger regulatory, supply, and research forces. In recent years, increased scrutiny over aromatic halogenated compounds has led to greater demand for verified traceability, steady physical properties, and unambiguous documentation. We have adapted by tightening in-process controls and maintaining a steady dialogue with customs, regulatory, and customer technical teams.
More pharmaceutical innovation depends on fast access to reliable building blocks. Projects stall not just from lack of ideas, but from lumpy, waitlisted supply caused by fragmented sourcing chains. Our operational model—direct production without rebranding lots—puts us closer to the sticking points teams face inside real synthesis programs. The ability to deliver a consistent supply, answer technical requests, and provide incremental improvements brings tangible gains not just in cost, but in trust and project timeline for every player in the field.
We bear the marks and experience of direct involvement. Years in the business bring a kind of realism: paperwork and polished marketing can mask the grit involved in moving kilograms of high-value intermediates across global markets. Reliability means keeping tight connections to materials suppliers, strict attention to plant maintenance, and honest engagement with the customers who push the chemistry forward.
Standing as a chemical manufacturer comes with responsibility—not just to bottom lines, but to colleagues, customers, and the communities among which plant sites sit. The best chemical product is one forged through rigor, ongoing learning, and a bit of humility when things don’t go as planned. Every successful run of 2-Amino-5,6-Dichlorobenzothiazole reflects those values, and pushes us to stay tuned-in to what matters for the next run, and the customers depending on it for their next breakthrough.
With the constant churn in pharmaceutical research and agrochemical innovation, dependable intermediates serve as the backbone of progress. By keeping our focus on quality control backed by genuine production knowledge, we not only sell a product, but offer a relationship grounded in transparency and technical collaboration. As standards rise and new applications emerge, our first-hand approach to manufacturing helps keep customers prepared for the next challenge.
There is no magic bullet for every synthesis; real value comes from a clear-eyed focus on execution, shared learning, and the long patience it takes to refine what works. For partners needing 2-Amino-5,6-Dichlorobenzothiazole, that ethos shapes each delivery—today, tomorrow, and as the chemical world keeps shifting forward.