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2-Amino-5,6-Dichlorobenzothiazole

    • Product Name 2-Amino-5,6-Dichlorobenzothiazole
    • Alias 5,6-Dichloro-2-aminobenzothiazole
    • Einecs 242-607-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    886141

    Product Name 2-Amino-5,6-Dichlorobenzothiazole
    Cas Number 21265-50-9
    Molecular Formula C7H4Cl2N2S
    Molecular Weight 219.09 g/mol
    Appearance Light yellow to off-white crystalline powder
    Melting Point 220-223°C
    Purity Typically ≥98%
    Solubility Slightly soluble in water; soluble in organic solvents such as DMSO and ethanol
    Storage Conditions Store in a cool, dry place away from light
    Synonyms 5,6-Dichloro-2-aminobenzothiazole
    Smiles Nc1nc2ccc(Cl)c(Cl)cc2s1
    Inchi InChI=1S/C7H4Cl2N2S/c8-3-1-2-4(9)6-5(3)12-7(10)11-6/h1-2H,(H2,10,11)

    As an accredited 2-Amino-5,6-Dichlorobenzothiazole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The chemical 2-Amino-5,6-Dichlorobenzothiazole is packaged in a 25g amber glass bottle with a secure, tamper-evident cap.
    Shipping 2-Amino-5,6-Dichlorobenzothiazole is shipped in tightly sealed containers under ambient conditions. Packaging complies with relevant chemical regulations to prevent leaks and contamination. Ensure labeling includes hazard information. During transport, avoid excessive heat, moisture, and direct sunlight. Follow all local and international guidelines for shipping hazardous laboratory chemicals safely.
    Storage **2-Amino-5,6-Dichlorobenzothiazole** should be stored in a tightly closed container, kept in a cool, dry, and well-ventilated area. Protect it from moisture, heat, and direct sunlight. Store away from incompatible substances such as strong oxidizers and acids. Ensure the storage area is secure and clearly labeled, and access is restricted to trained personnel.
    Application of 2-Amino-5,6-Dichlorobenzothiazole

    Applications of 2-Amino-5,6-Dichlorobenzothiazole in Industrial Manufacturing

    As a specialized manufacturer of 2-Amino-5,6-Dichlorobenzothiazole, we focus on its proven industrial utilization across several downstream production sectors. Below we detail major application scenarios, illustrating precise usage parameters, process involvement, and real compliance systems required in each field.

    1. Synthesis of Pharmaceutical Intermediates for Antimicrobial Agents

    This compound serves as a core heterocyclic intermediate for the synthesis of certain antimicrobial pharmaceutical ingredients, particularly in the production of benzothiazole-based active molecules. During formulation, regulatory research teams control its proportion strictly to ensure pharmacopoeial compliance for downstream active ingredient registration. Manufacturers introduce it during the condensation or cyclization step, integrating it with side chain reagents or modification agents to yield pre-final APIs destined for further purification, granulation, and tableting.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guidelines for Active Pharmaceutical Ingredients
    • EU EudraLex Volume 4 (GMP for Pharmaceuticals)
    • U.S. FDA 21 CFR Part 211 (cGMP for Finished Pharmaceuticals)
    • Chinese Pharmacopoeia monograph references for intermediates

    Typical usage ratio

    • 5%–18% by molecular proportion relative to final API batch size; ratio adjustment reflects the targeted benzothiazole core structure and downstream biological activity requirements.

    Downstream process integration

    • Added during the intermediate stage of multistep organic synthesis, typically at controlled temperature for cyclocondensation or as a coupling agent in functionalization steps.

    Final product types

    • Antibacterial and antifungal pharmaceutical intermediates
    • Precursor materials for veterinary drugs
    • Research-grade benzothiazole derivatives for analytical standards

    2. Raw Material for Rubber Vulcanization Accelerators

    In the specialty rubber processing sector, the compound functions as a precursor for synthesizing custom vulcanization accelerators essential for performance elastomers. Vulcanizer manufacturers insert it into high-pressure, high-temperature reactions forming dichlorobenzothiazole derivatives for tailored crosslinking characteristics. Stability and reactivity are tested batchwise under ISO and ASTM protocols to ensure reliable curing speed and product consistency for tire, gasket, and industrial hose manufacturing.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for Rubber Chemicals
    • ASTM D4671-18 (Rubber Compounding Materials–Accelerator Chemicals)
    • REACH Regulation (EC) No 1907/2006 for chemical safety
    • OEKO-TEX Standard 100 (for select consumer rubber goods)

    Typical usage ratio

    • 1.0%–4.5% by weight of total accelerator formulation blend, dependent on the base polymer type and target vulcanization kinetics.

    Downstream process integration

    • Introduced during dispersing and pre-mixing of rubber chemicals; then subjected to thermal synthesis with sulphur and co-accelerators before masterbatch incorporation.

    Final product types

    • Custom rubber vulcanizing accelerator compounds
    • Radial tire and automotive hose formulations
    • Elastomer blends for high-wear industrial seals

    3. Intermediate in Agrochemical Active Ingredient Manufacturing

    This raw material is a building block for synthesis of certain agrochemical actives, particularly specialty fungicides and seed treatment agents containing a benzothiazole core. It is fed into controlled chlorination and amination reactions designed according to regulatory residue and toxicology standards. Producers precisely calibrate its share in multi-component reactions based on target bioactivity profiles and application concentration limits in final field formulations.

    Industry compliance standards

    • FAO/WHO Pesticide Specifications
    • China GB 2763 Maximum Residue Limits for Pesticides in Food
    • EU Regulation (EC) No. 1107/2009 for Plant Protection Products
    • ISO 17025 Laboratory Quality Assurance (for QC analysis)

    Typical usage ratio

    • 3%–12% by mass in condensation or cyclization reaction formulation, varying with the target molecule's molecular weight and chlorination degree.

    Downstream process integration

    • Added in the initial or secondary synthesis step forming the fungicidal nucleus; undergoes purification and solvent exchange prior to downstream formulation and stabilization.

    Final product types

    • Benzothiazole-based fungicide technical concentrates
    • Seed coating actives for crop protection
    • Agrochemical intermediates for export or captive use

    4. Precursor for Dyes and Pigment Intermediate Synthesis

    Manufacturers use 2-Amino-5,6-Dichlorobenzothiazole to develop high-performance benzothiazole-based dye intermediates and pigment components for applications where lightfastness and chemical resistance are critical. The material is charged into diazotization steps or further functionalized with sulfonic or amino groups, followed by molecular tailoring for specific shade properties. Compliance checks focus on azo content, heavy metal thresholds, and product safety for downstream textile, plastic, or ink applications.

    Industry compliance standards

    • OEKO-TEX Eco Passport certification (for textile chemicals)
    • EN 71-3:2019 (Safety of Toys–Migration of Certain Elements)
    • REACH Candidate List (Substances of Very High Concern restrictions)
    • ISO 105-B02 Color Fastness to Light

    Typical usage ratio

    • 2%–10% by weight during chromophore synthesis batch, proportion determined by target pigment purity and performance requirements.

    Downstream process integration

    • Introduced during diazotization or coupling reaction stage, typically under controlled pH to ensure desired chromophore yield and avoid side product formation.

    Final product types

    • Textile and fiber-reactive dye intermediates
    • Specialty pigments for plastics and coatings
    • Printing ink colorant precursors
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    Certification & Compliance
    More Introduction

    Introducing 2-Amino-5,6-Dichlorobenzothiazole: Reliable Chemical Inputs from Our Manufacturing Experience

    Direct Production Expertise Shaping Quality

    Our team has spent many years perfecting the art and science behind 2-Amino-5,6-Dichlorobenzothiazole. Turning out every batch in our own workshop grounds every promise we make. This compound sits among the more precise specialty chemicals, demanded by pharmaceutical and agrochemical researchers who need a true baseline standard for advanced syntheses. Getting this molecule right—free of residual contaminants, consistent in melting point and purity—has taken us ongoing refinement to our routes. Each success, and each glitch, has deepened our operational roots.

    We do not just hand off raw output. Each lot that leaves the reactor comes under a trained eye, guided by years behind the glass and stainless steel. Serving partners, we see what matters most is knowing the source behind a product, not just the certificate. Because this chemical is built up in a sequence of sensitive steps, it must be closely watched for the kind of subtle color, solubility, or particle size changes that signal something gone off-track. That is the fast lesson that separates makers from brokers—a phone call can chase up a paper trail, but reliable producers deal in lived responsibility.

    What 2-Amino-5,6-Dichlorobenzothiazole Actually Offers

    2-Amino-5,6-Dichlorobenzothiazole is a fused heterocyclic compound with defined chlorination on the aromatic ring. Much of the value in this molecule comes from those two chlorine atoms at the 5 and 6 positions, which alter the electron profile and selectivity when the compound forms the skeleton of more complex targets. Its rigid profile and dual electron-withdrawing groups give research chemists a predictable starting point for introducing further groups or for building analogues of pharmaceutical or crop-protection compounds.

    Our batches typically approach purity levels demanded by medicinal chemistry labs. While not flashy to describe, this is hard-won from dozens of cycles adjusting reaction temperature, washing techniques, and purification columns. Where trace impurities sneak in—often barely registering on standard HPLC runs—they still can trip up subtle later reactions. That is why the focus must remain tight. Specifications aren’t created in isolation: feedback from end-users across different markets keeps us tuned to shifting expectations, so we don’t stand back while others push the frontiers forward.

    Why Purity and Traceability Define Our Work

    Small molecule synthesis isn’t just about chemical equations. For 2-Amino-5,6-Dichlorobenzothiazole, unexpected byproducts or leftover chlorinated fragments can gum up downstream syntheses, bearing real consequences in clinical or regulatory work. Inside our shop, we run analysis not because a guideline says so, but because we’ve seen the disruption a poorly-refined material can trigger. We trace back every step—batch numbers, temperature logs, solvent lots—not as an administrative hoop, but as a line of accountability to our partners. If a question arises, that embedded traceability allows us to diagnose and course-correct without theorizing or blaming anonymous upstream providers.

    There is a misconception that purity only matters at the drug formulation stage. We see from daily production that even a minor impurity at the input level can show up magnified by tenfold in the final molecule. In this business, attention to upstream details saves months and money further down the line. Our technicians and chemists all live by that rhythm; our best batches often come from someone asking that one extra question, insisting on a second pass in a tricky batch.

    Organic Synthesis and the Role of Customization

    Every chemist wants the purest available starting materials, but few see the struggle behind the scenes. Most downstream users of 2-Amino-5,6-Dichlorobenzothiazole pursue a very specific reactivity pattern—either looking for a certain nucleophilic displacement or aiming to tweak the heterocycle toward new drug scaffolds. We communicate closely, learning when solubility tweaks or alternative crystallization can shape yield or ease of handling. Experience has shown us that dropping a percentage point off a solvent impurity or changing the drying time makes a surprising difference in both research labs and scaling plants.

    Unlike simple commodity chemicals, this product resists one-size-fits-all approaches. Each customer’s process tells a different story. The repeated feedback teaches us: some want slightly larger particle size for ease of filtration; some worry about carry-over minor halogenated contaminants. There is no substitute for hearing directly from the synthesis teams, especially during early project phases or when downstream routes evolve. Our approach has always depended on phone calls and email dialogues, not just paperwork. Improvements show up more from real questions and shared experience than from theoretical best practices alone.

    Differences Between 2-Amino-5,6-Dichlorobenzothiazole and Competing Products

    Out in the field, labels can look nearly identical, but actual batches show day-and-night differences. Some traders pull material from variable sources, blending lots of uneven color and melting points, hoping numbers will average out. Several customers have brought us samples from these routes—sometimes dull gray-tan, sometimes carrying unfamiliar odors. Our in-house batches, by contrast, keep a consistent pale yellow tone, a narrow melting range, and a mild odor profile honest to the base heterocycle.

    Some may ask, why not buy a seemingly cheaper batch from another supplier? Years in industry have taught us that upfront savings quickly disappear with wasted time chasing inconsistencies. Researchers aiming for reproducible results rely on knowing their starting material is not shifting underneath them from month to month. Our experience shows that problems rarely stay small; a minor variation at the start quickly grows into cost overruns, rework, or batch rejections. Reliable manufacturing, not aggressive discounting, shapes success for both producer and partner in the specialty chemical segment.

    Applications and End-Use Impact

    The most common uses for 2-Amino-5,6-Dichlorobenzothiazole stem from its role as a building block. The presence of both amino and chlorines opens specific lines of derivatization, often serving as a precursor in the synthesis of therapeutic compounds, advanced dyes, or certain types of industrial catalysts. Its backbone structure, rigid and well-understood, gives medicinal chemists the room to build targeted analogues with less uncertainty.

    We see orders from a diverse group: some teams in pharma try alternate routes to kinase inhibitors, others in crop science use it as a stepping-stone toward new systemic agents. Each field wants something a bit nuanced—a sharper melting point, fewer halogenated side-products, or the confidence that a specification drawn up months ago will still be met after repeated deliveries. That is not something solved by buying generic lots, but by working with producers tuned into the shifting regulatory and technical targets of modern synthetic chemistry.

    Real-World Challenges in Sourcing and Shipping

    Packaged chemicals don’t always cross borders or climates smoothly. We have adapted packing for 2-Amino-5,6-Dichlorobenzothiazole based on lessons from partners in tropical or cold climates. In one year, we learned that certain packaging led to clumping when humidity spiked; another season, a box exposed to subzero transit suffered from condensation and damaged crystals. Taking these lessons forward, we moved to slightly thicker liners or added moisture scavengers, and orders since then have arrived trouble-free. Such adaptations come from owning the process and talking things through, not reading marketing promises.

    Shipping restrictions and customs scrutiny over halogenated intermediates often slow the work. Rather than passively let forwarders handle the difficulties, we talk directly with customs officials, explaining the context and showing documentation. Establishing a record of reliable, traceable sourcing has eased delays in more than one case. Each shipping challenge creates a feedback loop; our records not only prove regulatory compliance, but sharpen our understanding of how finished lots survive real-world routes.

    Safety, Handling, and Regulatory Experience

    Within active laboratories, safety depends on accurate labeling and honest communication. Our own plant procedures—tested through safety audits and lessons learned—shape our directions for users. 2-Amino-5,6-Dichlorobenzothiazole itself requires good ventilation and responsible personal protection during weighing, not just adherence to a checklist. We stress real communication of hazards because our crew faces them as a daily matter.

    From a regulatory perspective, changes in listed status or permitted residue levels surface quickly within the global chemical trade. We stay alert to new rules, as incidents from nearby factories or transportation networks can tighten oversight unexpectedly. That vigilance isn’t academic: failing to keep pace with restrictions on aromatic chlorinated species has tripped up more than one exporter, leading to expensive recalls or loss of market access. Through decades of cumulative practice, our files contain correspondence and responses for every level of regulatory inquiry, reducing uncertainty for downstream users.

    Environmental Responsibility and Waste Control

    Every chlorinated intermediate carries an environmental footprint, and our history teaches us shortcuts on waste result in trouble. At our site, solvents are recycled where feasible, and any process water meets discharge rules before leaving the property. Our records show how subpar effluent can chase a manufacturer for years, drawing not only fines but lasting stigma within the supply network. Upstream diligence limits headaches for our partners and for our own site’s continued operating licenses.

    Within the operation, team members watch for subtle process improvements that shave off both raw material and energy inputs. Many of these fixes come unprompted, a product of long-term staff invested not just in today’s batch, but in continuity and safety for the next generation. Sharing best practice across manufacturers—while still protecting the unique routes and intellectual know-how—improves industry-wide standing and reduces opposition from outside the field.

    Ongoing Improvements Drawn from Hands-on Work

    Advances in product quality rarely come from grand strategy sessions. In practice, a small group on the shop floor or in the QC lab will suggest a trial change to the wash solvent or hold a reaction at a slightly different agitation rate. Some improvements happen by chance: a delay during a maintenance cycle led us to discover a longer crystallization period sharpened the melting point. Years later, that change stays in our official batch protocol.

    Feedback from end-users plays a crucial role. We encourage direct critiques—sometimes brutally honest—about how the product performs in scale-up or advanced synthesis. Our best process improvements have come from addressing “minor” annoyances relayed from technicians actually handling the powder, not just researchers optimizing a reaction yield. Taken together, these threads forge a more resilient supply chain—one where chemical structure, real production expertise, and technical support travel in step.

    Market Trends and the Pressures of Innovation

    Specialty intermediate markets feel the push and pull of larger regulatory, supply, and research forces. In recent years, increased scrutiny over aromatic halogenated compounds has led to greater demand for verified traceability, steady physical properties, and unambiguous documentation. We have adapted by tightening in-process controls and maintaining a steady dialogue with customs, regulatory, and customer technical teams.

    More pharmaceutical innovation depends on fast access to reliable building blocks. Projects stall not just from lack of ideas, but from lumpy, waitlisted supply caused by fragmented sourcing chains. Our operational model—direct production without rebranding lots—puts us closer to the sticking points teams face inside real synthesis programs. The ability to deliver a consistent supply, answer technical requests, and provide incremental improvements brings tangible gains not just in cost, but in trust and project timeline for every player in the field.

    The Direct Producer’s Difference

    We bear the marks and experience of direct involvement. Years in the business bring a kind of realism: paperwork and polished marketing can mask the grit involved in moving kilograms of high-value intermediates across global markets. Reliability means keeping tight connections to materials suppliers, strict attention to plant maintenance, and honest engagement with the customers who push the chemistry forward.

    Standing as a chemical manufacturer comes with responsibility—not just to bottom lines, but to colleagues, customers, and the communities among which plant sites sit. The best chemical product is one forged through rigor, ongoing learning, and a bit of humility when things don’t go as planned. Every successful run of 2-Amino-5,6-Dichlorobenzothiazole reflects those values, and pushes us to stay tuned-in to what matters for the next run, and the customers depending on it for their next breakthrough.

    Looking Ahead: Building Trust and Supply Resilience

    With the constant churn in pharmaceutical research and agrochemical innovation, dependable intermediates serve as the backbone of progress. By keeping our focus on quality control backed by genuine production knowledge, we not only sell a product, but offer a relationship grounded in transparency and technical collaboration. As standards rise and new applications emerge, our first-hand approach to manufacturing helps keep customers prepared for the next challenge.

    There is no magic bullet for every synthesis; real value comes from a clear-eyed focus on execution, shared learning, and the long patience it takes to refine what works. For partners needing 2-Amino-5,6-Dichlorobenzothiazole, that ethos shapes each delivery—today, tomorrow, and as the chemical world keeps shifting forward.