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2-Amino-4-Sulfobenzoic Acid

    • Product Name 2-Amino-4-Sulfobenzoic Acid
    • Alias Anthranilic acid-4-sulfonic acid
    • Einecs 209-361-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    953884

    Name 2-Amino-4-Sulfobenzoic Acid
    Synonyms Anthranilic acid-4-sulfonic acid
    Molecular Formula C7H7NO5S
    Molecular Weight 217.20 g/mol
    Cas Number 88-23-3
    Appearance White to off-white crystalline powder
    Melting Point 300 °C (decomposes)
    Solubility In Water Soluble
    Pka 2.1 (carboxylic acid), 3.5 (sulfonic acid), 4.5 (amino group)
    Density 1.74 g/cm³
    Ec Number 201-807-0

    As an accredited 2-Amino-4-Sulfobenzoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 100g amber glass bottle with a secure screw cap, labeled "2-Amino-4-Sulfobenzoic Acid," chemical details, and hazard symbols.
    Shipping 2-Amino-4-Sulfobenzoic Acid is shipped in tightly sealed containers to protect from moisture and contamination. It is labeled according to chemical safety regulations. Transport occurs under standard ambient conditions unless specified otherwise, with appropriate documentation provided. Handle with care to prevent spills and exposure during transit. Not considered hazardous for most shipping methods.
    Storage 2-Amino-4-sulfobenzoic acid should be stored in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers and bases. Keep the container tightly closed and protected from moisture. Store in a corrosion-resistant container, clearly labeled, and avoid direct sunlight and heat sources. Ensure appropriate spill containment measures are in place and follow all safety guidelines.
    Application of 2-Amino-4-Sulfobenzoic Acid

    Applications of 2-Amino-4-Sulfobenzoic Acid in Industrial Manufacturing

    2-Amino-4-sulfobenzoic acid is a specialty intermediate with stable sulfonic and amino functional groups, supporting precision synthesis and performance enhancement in several mature industrial segments. As a manufacturer, we deliver this raw material into downstream workflows with exacting purity, consistent particle morphology, and customizable specifications to integrate into demanding process environments while maintaining traceable compliance and robust supply confidence.

    1. Azo Dye Intermediates for Textile and Leather Dye Production

    Textile and leather dye manufacturers specify 2-amino-4-sulfobenzoic acid as a diazo component in the production of reactive, acid, and direct dyes. The sulfonic group increases water solubility and dye-fiber bonding, enabling high color fastness and wash resistance on cellulose fibers and leather. Formulators adjust the ingredient concentration to optimize shade depth, brightness, and dye exhaustion based on substrate and dye class. The integration point typically occurs during the multi-stage coupling process, with careful control over reagent stoichiometry and pH to drive selectivity and yield of target dye molecules.

    Industry compliance standards

    • OEKO-TEX® Standard 100 for textiles
    • REACH Annex XVII (EC) No 1907/2006 for azo colorant safety
    • ZDHC MRSL—Zero Discharge of Hazardous Chemicals for dyes
    • BfR Recommendations for leather safety in consumer goods

    Typical usage ratio

    • 5–18% (w/w) of total dye intermediate blend, adjusted by targeted color index and solubility required for end-use substrate

    Downstream process integration

    • Feeds into the diazotization step where it reacts with nitrosyls and further couples with aromatic amines or phenols to form mono- or bis-azo dyes

    Final product types

    • Reactive dyes for cotton and viscose fabrics
    • Acid dyes for wool, silk, and nylon
    • Direct dyes for cellulosic fibers
    • Colorant formulations for aniline-free leather dyes

    2. Pharmaceutical Intermediates—Sulfonamide Drug Synthesis

    The pharmaceutical sector uses this intermediate mainly for the synthesis of targeted sulfonamide antimicrobial drugs and related APIs. The regulated production environment requires full traceability and material certification, as 2-amino-4-sulfobenzoic acid forms a building block in coupling reactions or functional-group protection steps. Reactivity and purity directly impact final API assay, impurity profile, and pharmaceutical stability, driving preference for narrow particle sizing and absence of heavy metals or related aromatic impurities.

    Industry compliance standards

    • ICH Q7 GMP for APIs
    • Ph. Eur. 12.0 and USP-NF monographs (for related sulfonic acids)
    • 21 CFR Part 211 cGMP (US FDA)
    • EU EudraLex Volume 4 for API intermediates

    Typical usage ratio

    • 0.8–3.5 mol equivalents per API synthesis batch, varied by route (direct sulfonamidation or protection/deprotection steps)

    Downstream process integration

    • Coupling as an aromatic nucleus in initial API backbone assembly or as a sulfonation agent in multi-step synthetic routes for advanced pharmaceutical intermediates

    Final product types

    • Sulfanilamide antibiotic APIs
    • Non-steroidal anti-inflammatory APIs (where sulfo-aromatic scaffolds are utilized)
    • Intermediate isolates for other regulated pharmaceutical actives
    • GMP pharmaceutical building blocks

    3. Water Treatment Chemicals—Dispersant Additive Manufacturing

    Formulators in water treatment chemical manufacturing select this acid for dispersant backbone construction, owing to its high water solubility and stable aromatic sulfonic functionality. The material provides charge density and resistance to hydrolysis under broad pH conditions, supporting the tailoring of water-soluble polymers used in industrial wastewater, scale inhibitors, and boiler water additives. Dosing concentrations are calculated according to the polymerization method and the specific dispersion requirements of the target wastewater system.

    Industry compliance standards

    • ISO 9001 for chemical manufacturing QMS
    • EN 15039: Chemicals for treatment of water for human consumption
    • NSF/ANSI Standard 60 (Drinking Water Treatment Chemicals—Health Effects)
    • Chinese GB 5749 (Standards for Drinking Water Quality, when applicable)

    Typical usage ratio

    • 2–12% (w/w) as monomer unit in water-soluble dispersant co-polymerizations, tuning for molecular weight and dispersivity

    Downstream process integration

    • Polymerizes with acrylamides or maleic anhydride in aqueous or emulsion systems; integrates before chain termination in polymer synthesis reactors

    Final product types

    • Scale inhibitors for industrial boilers and cooling towers
    • Dispersing agents for municipal and industrial wastewater treatment
    • Water-based antiscalants
    • High-solids water treatment formulations

    4. Specialty Polyester and Polyamide Modification

    Producers of specialty polymers use 2-amino-4-sulfobenzoic acid as a chain-modifying comonomer or end-group modifier, especially in the synthesis of sulfonated polyester resins and polyamides. Its incorporation imparts hydrophilic character and ion-exchange properties, supporting the development of water-dispersible polyesters used in coatings, dispersions, and waterborne adhesives. The sensitivity of the process demands precise monitoring of the acid functionality, reaction temperatures, and condensation timings to maintain resin structure and application stability.

    Industry compliance standards

    • ISO 14001 and ISO 9001 for quality and environmental assurance
    • RoHS Directive 2011/65/EU for polymers in electronics and coatings
    • GB/T 5226 for industrial resin manufacturing safety
    • FDA 21 CFR 177.1590 and 175.300 for indirect food contact polymers (where specified)

    Typical usage ratio

    • 0.5–5% m/m relative to terephthalic acid or isophthalic acid, calculated to control glass transition, water uptake, and dispersibility

    Downstream process integration

    • Feeds at initial melt or solution polycondensation stage, reacting with diols and dicarboxylic acids to incorporate sulfonic groups into the main polymer chain

    Final product types

    • Water-dispersible polyester resins for coatings and inks
    • Sulfonated polyamide for specialty textile finishes
    • Ion-conducting membranes for filtration modules
    • Waterborne pressure-sensitive adhesives

    5. Imaging and Photographic Chemical Formulations

    Chemical manufacturers producing color photographic emulsions and digital imaging supplies employ 2-amino-4-sulfobenzoic acid as a synthetic intermediate for dye couplers. Its robust sulfonic group enhances aqueous solubility and compatibility during silver halide emulsion preparation, allowing sharper color reproduction and grain refinement. Production lines require the acid’s consistent reactivity and low trace metal content to avoid fogging or reduced sensitivity in imaging applications.

    Industry compliance standards

    • ISO 18909 for photographic process chemicals
    • ISO 9001 QMS for imaging chemical production
    • ASTM E2210 Standard Guide for Photographic Processing Chemicals
    • RoHS (EU Directive 2011/65/EU) for chemicals in consumer imaging goods

    Typical usage ratio

    • 3–8% by mass in dye coupler synthesis batches, modified by desired absorption profile and final emulsion performance

    Downstream process integration

    • Chemical coupling in the preparation of color coupler dispersions, introduced at the emulsification and nucleation stage alongside silver halide formation

    Final product types

    • Color negative and positive photographic films
    • Digital proofing paper coatings
    • Specialized photographic emulsions
    • Inkjet printable imaging layers
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    Certification & Compliance
    More Introduction

    2-Amino-4-Sulfobenzoic Acid: Purposefully Engineered for Reliable Performance

    What Sets Our 2-Amino-4-Sulfobenzoic Acid Apart

    Producing consistent and high-purity 2-Amino-4-Sulfobenzoic Acid comes down to more than just following a routine process. We have spent decades developing and perfecting our synthesis pathways to make sure the final product always aligns with repeatable performance standards our customers expect. Processes at the plant have evolved: batch after batch, our operators and engineers have learned firsthand the critical points that can affect purity and yield. Instead of simply reacting raw materials and hoping for the best result, we enforce process discipline and carefully monitor every production stage, controlling parameters such as temperature, pH, and reactant feed to prevent unwanted byproducts and impurities.

    You can see the care in analytical data. Experienced lab technicians run HPLC and titrations on every lot. We focus on keeping sulfonic and amino groups intact in high yield and limit heavy metals to well below industry tolerances. If the finished product veers off spec, we track back through our comprehensive batch logs to identify and solve the source of deviation before any shipment goes out the door. Our approach makes a visible difference in the clarity, the solubility, and—most importantly—the downstream reaction reliability that our partners in dyes, pharmaceuticals, and intermediate manufacture report back to us year after year.

    Model and Specifications—the Result of Hard-earned Experience

    We built our 2-Amino-4-Sulfobenzoic Acid model on a transparent understanding of what our customers actually deal with, not just what’s written in a textbook. Take a look at physical appearance: a fine off-white to beige powder with a distinct, slight odor that comes from controlled side products, not contamination or decomposition. Our analysts check for color and moisture content every day. 2-Amino-4-Sulfobenzoic Acid from our line typically lands between 99% and 99.5% HPLC assay. Each lot consistently falls under the 0.01% mark for heavy metal contamination, far outperforming generic-grade material. Particle size can sometimes make or break an application, so our milling and sieving crew targets a median size under 100 microns, making it easier to dissolve or disperse when used in water-soluble systems.

    Salt or hydrated forms sometimes pop up on the market, but we find these can introduce process water or increase variability. Our commitment to the anhydrous free acid means the chemistry in your hands matches what you see on a certificate of analysis. Storage is less complicated too; customers don’t have to fuss around with controlled environments since the product is stable at room temperature away from strong oxidizers.

    Real-World Applications We See Day-to-Day

    Most of the 2-Amino-4-Sulfobenzoic Acid we produce finds life as a dye intermediate—an area our technical service team keeps in close communication with customers about. Over the years, several large-scale users in azo and anthraquinone dye syntheses have shown us just how critical purity is during diazotization and coupling reactions. We have witnessed downstream batches gel or fail entirely from low-cost, high-salt 2-ASBA that introduced unwanted sodium ions or residual acid. That’s why we emphasize our purification and finishing process—clean product means greener technology, smoother filtration, and far less sticky residue on reactor glass.

    Our team frequently works with formulators who use this compound as a raw material in pharmaceutical syntheses. We understand where things can go wrong: trace metals can poison catalysts, and batch-to-batch inconsistency causes compliance headaches with regulators. To keep our partners running smoothly, our QA system tags every lot with traceable records, backed by years of successful audits and customer reports. Keeping the byproduct load low is not just about meeting a spec—it’s about reducing headaches down the line, speeding up purification, and avoiding last-minute rework.

    Another significant slice of our production ends up in specialty performance chemicals: dispersing agents, surfactant blends, and complexing agents. R&D chemists in those areas don’t just buy chemical commodities—they look for predictability and specific impurity profiles so their own customers don’t end up with off-target shades or stability issues. When our product delivers the expected results, it means less troubleshooting and higher satisfaction for them. We’re in the background, supporting people we may never meet, but by controlling what’s coming out of our own reactors, we help keep their factories on schedule.

    How Our Production Choices Matter

    Choices in raw material sourcing set the tone. Sourcing only high-grade aromatic precursors keeps unexpected byproducts and trace contaminants in check. We’ve built a robust process that starts with tried-and-tested sulfonation, followed by a carefully staged amination. The result isn’t just about cost—it ensures the sulfonic acid and amino groups are always where they should be, so our partners in synthetic chemistry avoid issues in their subsequent steps.

    Rather than rely on standard filtration alone, our team uses a combination of solid-liquid separation and multi-stage washing. Doing this a few extra times than some competitors costs us in labor and time, but it saves customers from embarrassing performance surprises. To minimize batch-to-batch differences, we take random samples throughout the production run—not just at the end. Any drift prompts an immediate process check, not a wait-and-see approach.

    Our drying operations run at a carefully chosen temperature range—no scorched material, no excess moisture. This ensures powder that stores well, pours easily, and dissolves reliably. Shipping crews have direct line-of-sight to our packaging workflow, and before orders leave, quality controllers double-check for container integrity to avoid contamination during transit. We treat our end-to-end process as if the next user will be standing just down the hall from the production floor.

    Differences Compared to Other Market Offerings

    We have come across quite a few competitors who cut corners, especially in finishing steps. Some attempt shortcuts in sulfonation, which results in a mixture of mono- and disulfo isomers. These unwanted byproducts don’t always announce themselves upfront but show up in yield loss and off-specification color in dye manufacture. Our single-step process selects precisely for the intended para-sulfonated isomer—confirmed by both IR and NMR spectra analysts on staff—so downstream users don’t lose precious time backtracking on mystery contaminants.

    Material from traders and resellers often passes through a chain of middlemen unfamiliar with the quirks that cause batch rejections. Every batch from our facility comes with full traceability, starting from raw material lot through the finished pack-out. Our experience says this traceability pays off whenever an end user needs an explanation for a rare off-spec event or a technical inquiry from a regulatory audit.

    Packaging is another place shortcuts creep in. We use thick-wall polyethylene drums and double-layer liners. Some sources ship in re-used bags or drums that introduce fibers, dust, or external chemicals that can interfere with careful syntheses. We stopped putting up with bag failures a long time ago, and while it adds a marginal cost, the feedback from long-haul shipments proves this choice right. Customers have told us that storage and handling are much simpler on their end with our upgraded packaging policy.

    Over the years, we have learned that fine differences in impurity profile have real consequences. Pharmaceutical partners have shown us the extensive post-reaction purification needed if a batch brings along even trace levels of organic impurities—sometimes tripling their purification time. Dyers report shifts in final product color that cost them batches of textile. We listen closely when these users report back, and feed every bit of this experience into our process improvements.

    Supporting High-Quality Outcomes in Customer Operations

    Every successful synthesis starts with materials that behave predictably. This is true whether you’re running a kilo-lab or full-scale production. Our technical team stays involved with end-users who run both batch and continuous processes. They share tips on solvent choices, pH optimization, and even integration with automated dosing systems for scale-up. We’re not just making claims from a sales brochure; we make regular site visits, review pilot batches, and if something goes off track, host joint troubleshooting sessions. Partners keep returning not just for the material, but because they can count on straight talk and practical support when scaling up.

    Sustainability, efficiency, and operator safety are becoming more important each year. Our management team knows that inspectors and customers ask tough questions about waste, emissions, and energy use, so we have prioritized closed-loop wash water recapture and exhaust scrubbing to keep everything above board. Reducing water use and handling waste efficiently are no longer optional—they’re table stakes for responsible chemical manufacture. This approach, while demanding more R&D hours upfront, reduces our own compliance burden and builds long-term trust.

    Looking Ahead: Challenges and Ongoing Improvements

    Markets shift fast. Some years, demand surges from the dye industry. Other years, pharmaceutical regulation tightens unexpectedly. We stay alert by keeping extra process and analytical capacity ready for rapid scale up or spec adjustments. Our internal dialogue with operators, lab analysts, and scale-up chemists keeps raw, on-the-floor feedback cycling back into SOP updates.

    Raw material prices have swung wildly in the past. To protect our customers and maintain quality, we locked in multiple supply sources for core starting materials years ago. This stability lets us maintain batch reproducibility without sudden compromises. We are always searching out next-generation analytical methods for even better impurity fingerprinting, so we can spot upcoming end-user requirements before they become mandatory.

    Waste reduction has become part of our culture. Younger colleagues, fresh out of chemical engineering school, constantly bring up energy efficiency projects—from heat integration on reaction vessels to better solvent recovery. Sometimes these changes are incremental: a valve replaced here, a sensor recalibrated there, but the savings add up. We also pay close attention to operator safety, reinforcing PPE use, updating MSDS sheets, and running regular hazard scenario drills. Not every plant has zero-accident years, and we don’t take for granted that luck can change with a small oversight.

    Decades of Cumulative Learning

    Manufacturing 2-Amino-4-Sulfobenzoic Acid at scale has taught us that process discipline, routine hands-on oversight, and close customer relationships are what distinguish reliable products from the rest. Our systems have been built on generations of hard-won knowledge—incremental improvements from batch notes, customer calls, and plasma emission scans, not just textbook ideas.

    Day in and day out, we remember that our compounds feed directly into products people use and rely on: life-saving medicines, vibrant textiles, and specialty applications we may not even hear about until years later. Behind every drum or packet of 2-Amino-4-Sulfobenzoic Acid leaving our yard lies a trail of care, precision, and genuine pride in responsible chemical manufacturing. No matter the end application, we stand behind the product, the process, and the people who bring them all together.