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2-Amino-4-Methoxy-Benzoic Acid

    • Product Name 2-Amino-4-Methoxy-Benzoic Acid
    • Alias Anthranilic acid, 4-methoxy-
    • Einecs 219-731-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    216755

    Chemical Name 2-Amino-4-Methoxy-Benzoic Acid
    Molecular Formula C8H9NO3
    Molecular Weight 167.16 g/mol
    Cas Number 2680-03-7
    Appearance Off-white to pale yellow solid
    Melting Point 189-193°C
    Solubility Slightly soluble in water; soluble in ethanol
    Purity Typically ≥98%
    Synonyms Anthranilic acid, 4-methoxy-
    Smiles COC1=CC=C(C=C1N)C(=O)O
    Inchi Key WBEICWNLUVUXKI-UHFFFAOYSA-N

    As an accredited 2-Amino-4-Methoxy-Benzoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 2-Amino-4-Methoxy-Benzoic Acid is sealed in an amber glass bottle with a tamper-evident cap and labeled.
    Shipping 2-Amino-4-Methoxy-Benzoic Acid is shipped in sealed, chemical-resistant containers, protected from moisture and light. Packages are clearly labeled with hazard and handling instructions according to international regulations. Standard shipping methods comply with chemical safety protocols, and temperature control is maintained if required. Shipping documentation includes safety data sheets and regulatory compliance details.
    Storage Store 2-Amino-4-Methoxy-Benzoic Acid in a tightly closed container, in a cool, dry, and well-ventilated area. Keep away from incompatible substances such as strong oxidizers and acids. Avoid exposure to moisture and direct sunlight. Label the container clearly, and ensure it is stored at room temperature, protected from physical damage and sources of ignition. Follow all relevant safety and handling guidelines.
    Application of 2-Amino-4-Methoxy-Benzoic Acid

    Applications of 2-Amino-4-Methoxy-Benzoic Acid in Industrial Manufacturing

    As the direct manufacturer of 2-Amino-4-Methoxy-Benzoic Acid, we supply this intermediate to specialized industries with well-established technical and regulatory pathways. Our focus remains on downstream segments where this compound plays a defined and irreplaceable role in sophisticated synthesis, contributing both to the performance and compliance requirements of our clients’ finished products.

    1. Active Pharmaceutical Ingredient (API) Intermediate for Analgesic Drugs

    Pharmaceutical companies rely on this compound as a key intermediate during the multi-step synthesis of certain non-steroidal anti-inflammatory drugs (NSAIDs), especially those with an aniline-based pharmacophore. Manufacturers introduce it into the core stages of molecular construction where the amino and methoxy substituents drive specific selectivity in the condensation reactions. Dosing is optimized to balance yield and purity specifications dictated by international pharmacopoeias, ensuring a clean reaction profile for downstream processing into APIs. The technology requires precise monitoring of impurity levels throughout each batch as the final API batch undergoes extensive pharmacological and toxicological validation prior to release.

    Industry compliance standards

    • EU GMP (Good Manufacturing Practice)
    • ICH Q7 Guidelines for Active Pharmaceutical Ingredients
    • Pharmacopoeia standards: USP, EP, JP
    • FDA 21 CFR Part 210/211

    Typical usage ratio

    • Varies from 0.15 molar equivalents up to 1.2 molar equivalents per target API batch, depending on the complexity and yield optimization needs of the synthesis route

    Downstream process integration

    • Fed at the amidation or acylation step during core structure assembly
    • Combined with acid chlorides or coupling agents to form advanced intermediates
    • Integration point is typically in a controlled reactor system with in-situ analytical monitoring

    Final product types

    • Non-steroidal anti-inflammatory APIs such as mefenamic acid derivatives
    • Analgesic compound intermediates
    • Other pharmaceutical actives requiring ortho-amino aryl building blocks

    2. Synthesis of Dyes and Pigment Intermediates

    Specialty dye manufacturers use this material as a coupling component in the diazotization and azo coupling reactions for producing high-performance azo and anthraquinone dyes. Chemical engineers control its quantity to achieve tonal specificity and shadefastness, especially important for applications in high-value textile inks. The aromatic substitution pattern enables precise color tuning and improves dispersibility in both water- and solvent-based manufacturing processes. Downstream partners require batch-to-batch analysis ensuring minimal by-product carryover which can affect the purity of the final pigment dispersion.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006
    • OEKO-TEX® Standard 100 for textile applications
    • GOTS (Global Organic Textile Standard) for certified dyes
    • ISO 9001:2015 for colorant and pigment production

    Typical usage ratio

    • Utilized at 0.7–1.0 equivalents per mole of diazotized aromatic partners depending on required tinctorial strength

    Downstream process integration

    • Added during the primary diazo coupling reaction for azo dye synthesis
    • Acts as a nucleophile in condensation processes for pigment intermediates
    • Integrated in high-shear or stirred autoclaves to enable homogeneous reaction

    Final product types

    • Synthetic textile dyes (disperse, acid, direct dyes)
    • Color pigments for inkjet printing formulations
    • Specialty pigments for plastic masterbatches

    3. UV Absorber and Stabilizer Intermediates

    Producers of UV stabilizers use 2-Amino-4-Methoxy-Benzoic Acid during the synthesis of benzotriazole and benzophenone derivatives, key additives for improving lightfastness in polymers, coatings, and adhesives. The ortho-amino and para-methoxy groups facilitate the cyclization or condensation required to build UV-absorbing chromophores. Manufacturers integrate this intermediate where precise control of substitution patterns is needed, as these dictate the final UV spectrum of absorption and compatibility with polyolefins, PVC, and acrylic systems. Strict quality control ensures minimal trace metal contamination, which can catalyze degradation pathways in photostabilizer formulations.

    Industry compliance standards

    • EU Regulation (EU) No 10/2011 on plastic materials and articles
    • ASTM D5208 for UV stability testing
    • ISO 4892-3 test methods for outdoor polymer exposure
    • RoHS Directive 2011/65/EU (when used in electronics plastics)

    Typical usage ratio

    • Commonly employed at 0.5–1.3 mole per mole UV absorber backbone during synthesis; adjusted to fine-tune light absorption range and concentration

    Downstream process integration

    • Introduced in pre-condensation with hydrazines or salicylates
    • Reacts under controlled temperature in closed-reactor systems with nitrogen inerting
    • Purification via crystallization or column filtration to meet photostability criteria

    Final product types

    • UV stabilizers and absorbers for plastics
    • Coating additives for automotive and industrial finishes
    • Adhesive additives for electronics and packaging

    4. Agrochemical Synthesis: Herbicide and Fungicide Intermediates

    Manufacturers of specialty agrochemicals employ this raw material to provide core scaffolding for certain amide and ester-linked herbicidal and fungicidal compounds with selective action. It enters into the condensation phases where its substituted aromatic structure steers both biological selectivity and environmental persistence. Batch engineers set the dosing based on the desired activity profile and environmental fate requirements, as over- or under-use can dramatically affect the spectrum of weed or fungal control. At the plant scale, downstream conversion to final actives involves chlorination, esterification or amination, all monitored under regulatory traceability systems.

    Industry compliance standards

    • FAO/WHO Specification for Pesticides
    • ISO 9001:2015 for agrochemical manufacture
    • EU Regulation (EC) No 1107/2009 for Plant Protection Products
    • EPA FIFRA (40 CFR Part 158) for active ingredient synthesis in the US

    Typical usage ratio

    • Generally in 1.0–1.2 mol equivalents per batch, depending on the target compound and the step efficiency in multi-stage syntheses

    Downstream process integration

    • Charged at initial condensation with acid chlorides or alcohols to form pre-active intermediates
    • Further processed by chlorination or amidation with bioselective substituents
    • Subject to in-process controls for purity and conversion

    Final product types

    • Precursor molecules for selective herbicides
    • Intermediate blocks for triazole or anilide-based fungicides
    • Technical-grade actives for formulated agrochemical concentrates

    5. Synthesis of Fine Chemical Photoinitiators

    Fine chemical producers leverage this intermediate in the elaboration of aromatic photoinitiator frameworks, particularly for UV-curable inks, coatings, and printing plates. The electron-donating methoxy group and nucleophilic amino function play decisive roles during Friedel-Crafts and nucleophilic aromatic substitution reactions, enabling efficient routes to high-purity chromophores. Engineering teams set ratio and feed rates based on the photo-reactivity specifications of the intended end-use, with quality control ensuring residual amino acid levels remain below thresholds to prevent yellowing or degradation in the final formulation. Finished photoinitiators directly influence cure speed and lifetime in industrial and commercial printing operations.

    Industry compliance standards

    • ISO 2834-1:2006 for printed ink applications
    • EN 71-3 for chemical safety in photoinitiators used in toys
    • REACH SVHC screening
    • RoHS if used in electronic display applications

    Typical usage ratio

    • Introduced at 0.9–1.1 equivalents per targeted chromophore core, with adjustments based on process optimization and light absorption targets

    Downstream process integration

    • Fed in controlled addition to aromatic substitution reactors after base catalysis setup
    • Key step in photoinitiator molecular assembly under UV-free conditions
    • Followed by multi-solvent extraction and thin-layer chromatography for purity check

    Final product types

    • Photoinitiators for UV-curable inks and coatings
    • Photoresist raw material for PCB manufacture
    • UV-cure adhesives for optics and electronics
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    Certification & Compliance
    More Introduction

    2-Amino-4-Methoxy-Benzoic Acid: Building on Precision and Experience

    Introducing 2-Amino-4-Methoxy-Benzoic Acid from Direct Factory Production

    Around our site, batches of 2-Amino-4-Methoxy-Benzoic Acid head from reactor to filter within clear timelines and close control. Over years of hands-on work, our team has tuned the process—not only for purity, but with every load we see, we better understand the quirks of this compact, functional molecule. Model: AMBA-2024, batch after batch delivers a powder with tightly held assay and moisture. Real-world production does not run on hope; quality starts with metered feedstocks, human oversight, and the insistence that every bag or drum gets a hard look before it leaves.

    Molecular Qualities That Count

    We manufacture the compound as a white to off-white crystalline powder, crystallizing carefully to minimize mechanical stress and prevent excess fines. At our scale, this means every lot of 2-Amino-4-Methoxy-Benzoic Acid needs to meet strict structural uniformity—checked by up-to-date HPLC, melting range, and visual inspection. The amine and methoxy groups offer unique synthetic sites. Chemical formula C8H9NO3, with a molecular weight near 167.17, this material sets itself apart through its stable aromatic backbone.

    Solubility sometimes determines success in a formulation, so we check actual performance in both organic and aqueous solutions. Each production run gets logged for water content and residue, with any variance flagged by our QC managers. From our floor, I have seen that even minor moisture variations mean big headaches in downstream reactions, so we meticulously seal finished product and use double vacuum-pack for export.

    What Sets Our 2-Amino-4-Methoxy-Benzoic Acid Apart

    As raw chemical manufacturers, our whole aim sits in reliability and transparency. Unlike broad-distribution or trade channel offerings, our process delivers fixed origin, steady documentation, and detailed lot records. We do not mix from multiple suppliers or allow carry-over between batches. Traceability remains clear, down to operators’ logs, vessel IDs, and analysis sheets. Several years ago, we swapped out an older batch drying step for one that uses inert gas—direct response to user requests for lower residual solvents. Since that shift, customer feedback has shown less risk of contamination in sensitive catalytic applications.

    There’s a difference between product made with stable, practiced parameters and samples thrown together for speed. Our trained crew runs every batch, every week; the people behind the controls know the difference between standard out-turn and problems that can show up in subtle texture or flow differences. We don’t produce just for inventory but coordinate with end-user schedules, which makes the workflow more predictable all around.

    Real Uses, Real Value for Synthesis

    2-Amino-4-Methoxy-Benzoic Acid does more than round out a catalog; it plays a direct role as an intermediate in pharma, dyes, agrochemical, and specialty material routes. Production chemists look for reactivity at both the amine and carboxylic sites. This molecule slots into derivative making, such as amides, esters, and heterocycle syntheses where side-chain modification makes all the difference.

    In our experience, customers use our product in both drug discovery and scale-up. Several generic drug houses and R&D organizations work with these batches for the construction of bioactive benzamides or substituted heterocycles. The para-methoxy function on the benzene ring affects both electronic properties and solubility, which opens paths unavailable with analogs lacking this group. We have also supplied material for fine-tuned azo-dye intermediates and pigment precursors, particularly for applications sensitive to minor isomeric impurities or color variables.

    By staying close to feedback from the labs that actually use the substance, we refine not just the chemical, but support documentation, packaging, and shipping protocols. Our scale makes flexibility possible; whether a client needs 25 kilograms for a pilot plant or hundreds for regular supply, we keep both drums and smaller packs moving through clean, certified rooms.

    Specifications That Matter in Practice

    We track assay values consistently at 99% and above, collected via titration and NMR, not just nominal manufacturer figures. Particle size checks run in-house with calibrated sieves and microscopy, as clumping or over-fine particles can cause major handling issues out on the user’s end. Residual solvent always draws concern, so our process documentation details every drying cycle, down to vacuum level and exposure time. Internal lot registry offers a concrete trail, which keeps things tight for return customers who need batch repeats or have regulatory checks on record.

    During development, we put in place better protocols for handling dust and minimizing cross-contact: stainless steel lines, scheduled deep cleaning, and periodic swab testing. Our approach to quality comes from frustration with unreliable supplies in our earlier years; now, our pre-shipment samples allow clients to verify actual performance in their own systems ahead of large purchases.

    Factory Control Means Real Consistency

    Production does not thrive on assumptions. Each line operator receives training on current good manufacturing practices. Every significant parameter—temperature, pH, solvent choice—gets backed up with actual run-date logs. We store originals of every QC and analytical report for several years, as regulatory processes can stretch across seasons or budgets.

    Almost all chemical users have ended up dissatisfied after receiving inconsistent material from brokers or repackers. Direct-from-plant manufacturing closes the loop on these stories. We see that the avoidance of intermediaries trims confusion, compresses timelines, and gives the technical buyers somebody responsible for every single ton or box. If a challenge comes up in a big synthesis, the response reaches the operator and the technical supervisor together—not a third-party account rep who knows only what the paperwork shows.

    Comparisons to Similar Para-Amine Benzoic Derivatives

    Many chemists know the trade-offs among the common substituted benzoic acids. Compare 2-Amino-4-Methoxy-Benzoic Acid with plain 2-Aminobenzoic Acid or its hydroxy analogs, and a few patterns stand out. The methoxy group in the para position changes polarity and hydrogen bonding, which often leads to better solubility in common organic media and easier purification later in multistep routes. We see more requests for our product in processes that need high loading, as options with less favorable solubility usually hit a wall in thickening or precipitation.

    More, the methoxy group offers a handle for further transformation, whether through O-demethylation or protection. Certain dye pathways, for instance, run smoother with this group present at the 4-position, because the electron-donating effect helps direct substitution to the right place. That fine control has real value for researchers and pilot engineers. Over years at the bench, teams learn to trust suppliers who provide the same results again and again.

    Impurity profiles distinguish direct-from-factory materials from low-cost commodity alternatives. We run full impurity spectrum checks (including related isomers and residual starting materials) for every lot over 10 kilograms. Picking up a drum from us, users know they are not inheriting random by-products or leftover contaminants from prior syntheses, which sometimes drift into mixed third-party sources.

    End User Safety and Accountability

    Our safety practices start with workers handling the chemical, from PPE and controlled weigh-outs to sealed storage. The safety data sheet—drawn from real readings and historical operating records—travels with every shipment. Each customer gets an unbroken documentation chain, which means nobody receives an unlabeled drum or a repacked bag with missing batch info. This minimizes downstream accidents and helps maintain a clear record in the event of incidents or audits.

    We also keep backup retained samples for every batch, so user complaints or quality questions can be answered with lab re-checks. Over the years, this policy has saved clients time investigating process stops; testing a retained batch sometimes clears up whether a cause comes from the raw material or local conditions.

    Legitimate end use, compliance with local rules, and correct handling all rest on direct manufacturer accountability. We do not ship to brokers without clarity on destination or use. Our documentation follows updated standards, so users with pharmaceutical, food-contact, or regulated manufacturing always know the data supports their needs.

    Sustainability and Waste Reduction

    Chemical production creates waste and resource challenges, both at the process stage and downstream. Our continuous improvement program looks for ways to reduce solvent use and cut down freshwater draw—closing loops on rinse processes and capturing evaporated organics. As we scaled up, condensers and solvent recovery systems brought down our emissions profile. Powder loss on unseen filter bags used to be significant; now, targeted filter upgrades mean better yield and less landfill.

    We also record energy use per kilogram of output, and our staff participate in annual refresher sessions. The site maintains stack and liquid effluent checks according to local requirements. Resource savings matter to us not because they look good on paper, but because those costs end up reshaping pricing and supply for everyone.

    Feedback and Real-World Problem Solving

    Open lines with customers help not just the buyer, but our whole technical team. We’ve handled requests for custom packaging—smaller double-lined bags for high-humidity settings, larger containers for centralized storage at multinational sites. Timely and accurate delivery keeps projects on-track, and over time, the trust built up with repeat users means problems get aired early.

    In some cases, clients have flagged unforeseen problems: changes in reactivity when switching from a competitor’s material, unexpected residue in combustion, or discoloration after storage in humid conditions. We tackled these through back-and-forth sample analysis and process review, rather than handwaving blame away. One major improvement came when a pharma partner shared data on post-chromatography yield using our product versus competitors. Their higher yield traced back to our product’s lower trace metals and consistent crystal size. This kind of feedback cycles back into plant operations and even tweaks to cleaning schedules and storage hardware upgrades.

    Years in the field have taught us that no lot, no shipment, and no process stays unexamined for long. Client discoveries, supplier audits, joint trouble-shoots—these reviews press us to keep tightening the process for both longtime and first-time buyers.

    Keeping Supply Reliable in a Changing Market

    The chemicals market sees constant swings in feedstock cost, transport disruptions, and regulatory curveballs. Our direct-from-factory approach helps buffer these shocks by keeping stocks managed based on forecasted end-customer need, rather than speculative oversupply. Advance notice and frequent updates with our partners mean we rarely have to turn down a returning client for lack of product.

    We manage supply chains actively, with backup suppliers for key raw materials and in-house lab checks for any incoming change. Price stability depends on these safeguards; single-point failure in supply can derail production timelines across the globe. We also carefully inspect any secondary materials—from packaging films to external drums—since quality failures in these can undo the entire point of careful chemical processing upstream.

    Close relationships across regions mean that if a customs block or new regulation appears, we deal directly with the affected parties. Quick shipment adjustments and honest status reports have prevented major headaches for our partners, whether in API synthesis, specialty colorant manufacture, or research applications.

    Looking Ahead: Innovation Rooted in Experience

    We believe in investing further in process improvements, not just for compliance, but to unlock even better physical characteristics for this compound. R&D teams actively compare in-house modifications, such as alternate catalysts, green solvents, or continuous-flow adaptations aimed at lowering by-product formation. Feedback from our clients indicates where we should direct these resources; we do not chase unproven process shortcuts or untested sources.

    Each year, we revisit packaging, storage, and analytical standards to keep pace with evolving needs. Investment in new filtration and packaging lines has reduced handling time and exposure risk, which means fresher, cleaner product for users as well. Plans include extending real-time data access for users to authenticate batch data and assay reports—bringing even more transparency and easing external audits.

    Direct, hands-on manufacturing means our staff feels a personal stake in every kilogram shipped. This approach means more than a certificate of analysis; it shows up in the way we handle problems, talk openly with customers, and follow through on process refinements year by year. 2-Amino-4-Methoxy-Benzoic Acid offers value because its production rests on attention to real-world needs and steady improvement, batch after batch.