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2-Amino-4-Chlorophenol-6-Sulfonic Acid

    • Product Name 2-Amino-4-Chlorophenol-6-Sulfonic Acid
    • Alias 4-Chloro-2-hydroxyaniline-6-sulfonic acid
    • Einecs 228-725-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    678450

    Chemical Name 2-Amino-4-Chlorophenol-6-Sulfonic Acid
    Molecular Formula C6H6ClNO4S
    Molar Mass 223.64 g/mol
    Appearance Light brown to beige powder
    Melting Point Decomposes above 240°C
    Solubility In Water Soluble
    Cas Number 88-93-7
    Ph Acidic in aqueous solution
    Storage Conditions Store in a cool, dry place away from sunlight
    Synonyms 4-Chloro-2-hydroxyaniline-6-sulfonic acid
    Ec Number 201-864-9
    Usage Intermediate for dyes and organic synthesis
    Hazard Statements Irritant to skin, eyes, and respiratory tract

    As an accredited 2-Amino-4-Chlorophenol-6-Sulfonic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, high-density polyethylene bottle containing 100 grams, clearly labeled as 2-Amino-4-Chlorophenol-6-Sulfonic Acid, with hazard warnings.
    Shipping 2-Amino-4-Chlorophenol-6-Sulfonic Acid is shipped in tightly sealed, chemical-resistant containers to prevent contamination and moisture exposure. The package is labeled according to hazardous material regulations and handled with care, ensuring compliance with safety standards. Transport is conducted by certified carriers, with documentation accompanying the shipment for secure and traceable delivery.
    Storage 2-Amino-4-Chlorophenol-6-Sulfonic Acid should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area. Keep it away from heat, moisture, and direct sunlight. Store separately from incompatible substances such as strong oxidizing agents. Use recommended safety procedures, including the use of gloves and eye protection, to avoid direct contact during handling.
    Application of 2-Amino-4-Chlorophenol-6-Sulfonic Acid

    Applications of 2-Amino-4-Chlorophenol-6-Sulfonic Acid in Industrial Manufacturing

    2-Amino-4-Chlorophenol-6-Sulfonic Acid is a specialty chemical mainly used as an intermediate in the synthesis of high-value dye and pigment compounds, as well as in select pharmaceutical intermediates and specialty agrochemical preparations. Our facility manufactures this compound to tight process and analytical standards, aligning with specific needs of downstream industries where traceability, purity and composition have a direct impact on finished product quality and regulatory acceptance. Below we detail several core application areas based on actual industrial practice.

    1. Azo Dye Intermediates for Reactive Textile Dyes

    Textile dye manufacturers use 2-Amino-4-Chlorophenol-6-Sulfonic Acid as a diazo component to produce azo-based reactive dyes, especially for cotton, viscose, and blended fabrics. Its unique electronic characteristics support vivid coloration and high washfastness, making it valuable in dye production requiring both shade brightness and chemical durability. Secondary amine and sulfonic acid functionalities improve dye solubility and fixation properties in aqueous dye baths during textile processing.

    Industry compliance standards

    • OEKO-TEX® Standard 100: Class I–IV for harmful substances in dyed fabrics
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • REACH Annex XVII and SVHC requirements for aromatic amines
    • GB/T 22864-2009 (China national standards for dye production)

    Typical usage ratio

    • 18–35% (wt/wt) as intermediate in diazo component, adjusted for target chromophore and substrate
    • Formulation may shift by ±5% based on dye bath reactivity and strength needs

    Downstream process integration

    • Enters initial diazotization coupling stage; coupled with coupling components, isolated, and standardized into commercial dye formulations
    • Integrated directly into aqueous synthesis reactors with automated feed controls

    Final product types

    • Reactive dyes for cellulose fibers (e.g., Turquoise Blue, Navy, Black dye grades)
    • Direct application powders, granules, and ready-dye liquids
    • Dye concentrate pastes for textile mills

    2. Acid Dye Intermediates for Wool and Leather Finishes

    Producers of acid dyes employ this sulfonic acid as a key intermediate for synthesizing colorants used on protein fibers such as wool, silk, and for leather finishing. It provides anchoring sites for acid mordanting, resulting in dyes with deep tone, migration control during dyeing, and strong resistance to perspiration and light exposure, essential for finished garment and upholstery performance.

    Industry compliance standards

    • EN ISO 20105 (Textiles - Tests for color fastness to perspiration, water, and light)
    • Leather Working Group Restricted Substances Requirements (LWG RSL)
    • REACH Annex XVII for migration of aromatic amines/leather chemicals
    • ASTM D5033-06 (Standard for leather colorfastness testing)

    Typical usage ratio

    • 12–28% (wt/wt) based on molar stoichiometry of the targeted acid dye core
    • Dosing tailored according to target depth of shade and end-use exposure rating

    Downstream process integration

    • Participates in coupling steps with naphthol or other aromatic partners during acid dye synthesis
    • Follows multi-stage purification for application in high-performance dye lots

    Final product types

    • Acid dye granules and powders for woolen yarn and fabric dyehouses
    • Lake pigments for leather finishing emulsions
    • High-lightfastness dyes for technical textile goods (carpets, upholstery)

    3. Pharmaceutical Intermediate for Sulfa Drug Syntheses

    Chemical manufacturers involved in the synthesis of sulfonamide antibiotics and related APIs employ 2-Amino-4-Chlorophenol-6-Sulfonic Acid as a building block during benzene ring functionalization. The compound's substitution pattern enables regioselective transformation steps in proprietary synthesis routes for anti-infective agents. Quality consistency and metal ion purity are critical due to stringent pharmacopoeial regulations and GMP batch traceability demands in pharmaceutical environments.

    Industry compliance standards

    • ICH Q7 GMP Guide for Active Pharmaceutical Ingredients
    • USP-NF (United States Pharmacopeia - National Formulary) reference monograph standards for intermediates
    • Ph. Eur. 2.4.8 (European Pharmacopoeia: Sulfonic group intermediates)
    • 21 CFR Part 211: cGMP regulations for finished pharmaceuticals

    Typical usage ratio

    • 15–27% (w/w), with adjustment based on the specific synthetic pathway, yield optimization, and impurity profile controls
    • Stringent upper limits if employed as a sole precursor

    Downstream process integration

    • Introduced during ring substitution, amide formation, or condensation steps—often under strictly controlled, low-contaminant conditions
    • Subject to in-process analytical verification (HPLC, IR, elemental analysis)

    Final product types

    • Bulk intermediate grades for sulfonamide-class APIs
    • Precursors in multi-step syntheses of second-generation antibiotics
    • Pharma grade intermediates tailored for contract manufacturing organizations (CMOs)

    4. Agrochemical Intermediate for Selective Herbicide Synthesis

    Agrochemical producers use 2-Amino-4-Chlorophenol-6-Sulfonic Acid as a precursor in the synthesis of certain heterocyclic-ring sulfonylurea herbicides and related selective weed control agents. Chemical reactivity and substitution patterns of this material permit the construction of stable, crop-safe herbicide actives while supporting residue compliance limits in field applications. Trace impurity management and formulation homogeneity are of primary concern for compliance and efficacy in downstream blending.

    Industry compliance standards

    • FAO/WHO Specifications and Evaluations for Plant Protection Products (FAO/WHO CODEX standards)
    • ISO 9001:2015 for agrochemical ingredient production
    • OECD Principles of Good Laboratory Practice (GLP) for active substance synthesis
    • U.S. EPA FIFRA (Federal Insecticide, Fungicide, and Rodenticide Act) registration for active substances

    Typical usage ratio

    • 8–22% (wt/wt) as a key intermediate, modified for targeted herbicide molecule potency and compatibility with co-formulants
    • Ratio determined by target molecule and synthesis step yields

    Downstream process integration

    • Reacted in condensation or cyclization steps for sulfonylurea ring construction
    • Feedstock for integrated intermediate production, prior to downstream granulation or wet-milling

    Final product types

    • Selective post-emergence herbicide actives (e.g., for wheat, maize, rice applications)
    • SC (Suspension Concentrate) and WG (Water Dispersible Granule) formulations for farm use
    • Bulk active ingredient for proprietary blend pesticides

    5. Intermediate for High-Performance Pigments

    Manufacturers of specialty pigments employ this compound in the synthesis of certain high-performance azo and phthalocyanine pigment molecules. Its specific functional groups facilitate coupled pigment particles with outstanding thermal stability and lightfastness, which are crucial for automotive, plastic coloring, and industrial coating applications demanding extended outdoor durability and weather resistance. The raw material must meet strict particle size, color index, and trace impurity benchmarks to ensure resulting pigment batch reproducibility.

    Industry compliance standards

    • EN 71-3 (Safety of toys: migration of certain elements in colorants)
    • ISO 18451-1:2019 (Pigments and extenders—Terminology)
    • ASTM D3134-98 (Standard for organic pigment quality assurance)
    • REACH registration for pigment chemicals

    Typical usage ratio

    • 18–32% (w/w) as azo coupling partner; actual ratio defined by chromophore strength and desired pigment shade intensity
    • Altered according to application in plastics vs. paints due to different thermal requirements

    Downstream process integration

    • Undergoes diazotization/coupling or cyclization reactions, followed by milling and dispersal into polymer or coating bases
    • Processed in pigment synthesis reactors equipped with controlled particle-size reduction

    Final product types

    • Azo pigment powders for plastics coloration (PP, PE, PVC)
    • High-durability pigment preparations for automotive topcoats and OEM paints
    • Coloring agents for powder coatings, inks, and high-performance masterbatches
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    Certification & Compliance
    More Introduction

    2-Amino-4-Chlorophenol-6-Sulfonic Acid: Insight from the Manufacturer Floor

    Rooted in Chemical Craftsmanship

    Years of hands-on work in chemical manufacturing build a different relationship with specialty compounds like 2-Amino-4-Chlorophenol-6-Sulfonic Acid. The lab tests are one thing, but watching fresh batches come off production lines, smelling the sharpness in the air, seeing the yellowish solid settle in the trays—these moments drive home what makes this molecule such a steady performer in our industry. Chemists come to recognize that the compound carries its own personality. Getting each batch right has refined our ability to deliver consistency with tight sulfonation and amination controls, so users down the line can expect results that don’t sway from drum to drum.

    The Specifics that Matter: Model and Specifications

    Every sack of our 2-Amino-4-Chlorophenol-6-Sulfonic Acid bears a unique lot number that links back to its origin, process notes, and reagent traceability. The backbone of this compound—structurally identified as C6H6ClNO4S—combines a sulfonic acid group at position six, an amino group at position two, and a chlorophenol core at four. This linkage creates opportunities for downstream synthesis and reactivity in dye intermediates and pharmaceutical actives.

    We manufacture this product as an off-white to pale yellow crystalline solid, providing standardized purity specifications—often reaching 98% or higher, measured by HPLC. Strict monitoring guarantees that moisture content, heavy metal impurities, and inorganic salts fall beneath industry thresholds. Subtle differences in particle size can even affect processing for sensitive end uses, so our grinding and sieving steps have evolved to achieve repeatable flow in automated equipment without introducing static or clumping hazards.

    From Shop Floor to Real-World Application: Beyond a Statistic

    Most customers think of 2-Amino-4-Chlorophenol-6-Sulfonic Acid first as a dye intermediate, especially in the making of high-performance azo and triarylmethane colors. The sulfonic group brings that essential solubility for aqueous dye baths, the amino group improves affinity for fiber and substrate, and the chlorinated ring pushes colorfastness and shade control a degree higher. Textile processors look for more than just a molecule that works in the test tube—they want a raw material that blends into bulk synthesis without bringing down yield or requiring special purification downstream.

    Our shop gets steady calls from R&D scientists in pigment manufacturing, looking for batch-specific data. In their experience, tiny upticks in an impurity can shift the hue or solid-liquid separation behavior in the next synthetic stage, costing both time and money. We handle each inquiry by pulling QA records that map out the batch’s analytical profile—not just to satisfy protocol, but because our teams know, from firsthand error and success, that real-world synthesis is less forgiving than textbook chemistry. Product traceability offers reassurance each order traces directly back to its manufacturing conditions—with evidence to back every promise.

    A Distinct Edge in Key Sectors

    Dye houses, pigment formulators, and specialty chemical plants rely on intermediates like this not only for their established tyrosine's and reactivity but for repeatability in bulk runs. The edge our process provides lies in uncompromising control over starting phenol quality, precise chlorination, and rigorous filtration at the sulfonation stage. At scale, each step involves real people—operators overseeing reaction tanks, engineers monitoring temperatures and flows, and processors examining the checkpoint chromatographs for any off-notes. These touches add up to less batch-to-batch drift, more consistent shade formation, and cleaner overall conversion in downstream factories.

    Used in synthetic dye routes, 2-Amino-4-Chlorophenol-6-Sulfonic Acid serves as a building block where side-reactions could spoil color clarity or yield. Sulfonation at the six position boosts water compatibility, so the intermediates and finished dyes remain dispersible under a wider range of processing conditions, translating into fewer surprises on the production line. Chlorine at position four brings a measure of oxidative stability—less tendency to break down or shift with repeated exposure to light and washing.

    Downstream, users in API manufacturing see more than a reagent: purity levels affect crystallization habits, filtration speeds, and even the safety of final tablets or powders pressed for pharmaceuticals. Each gram showing up in those end uses draws its quality directly from practices here at the plant—attention to solvent selection, cleanliness of reaction vessels, and zeal in final purity testing.

    What Sets Us Apart—Manufacturer’s Perspective

    It’s one thing to offer a product by catalog number. It’s something else entirely to know how 2-Amino-4-Chlorophenol-6-Sulfonic Acid behaves through every season, every subtle tweak to upstream ingredients, every recalibration of the supply chain. Our QC teams learned the hard way that ambient humidity, pressure fluctuations, and even the tiniest difference in water deionization can mean the difference between a reliable batch and a pile of off-spec rework. Staying tuned to those details keeps the rest of the supply chain functioning, with no costly fit-ups or troubleshooting for the buyer.

    Other producers may deliver acceptable material by standard; our practice roots itself in regular batch stability testing across months and years. We put aside product from each run and run it through simulated processing—reproducing the same dye synthesis steps our clients use. Reading the reaction rates, monitoring side reactions, and watching for precipitate formation before shipment let us spot and solve potential pitfalls before the material leaves our plant.

    These deeper checks back industry claims that our lots meet, or outpace, the strictest performance and safety targets. Buyers aiming for challenging colors or pharmaceutical intermediates don’t want the anxiety of troubleshooting basic input materials. They expect the manufacturer to bear that burden, which we do by scrutinizing each parameter that could drive unpredictability downstream.

    Comparisons to Related Molecules

    Our experience working with 2-Amino-4-Chlorophenol-6-Sulfonic Acid reveals specific strengths when compared to similar halogenated or aminated phenol sulfonates. In our labs, we’ve tested alternatives like 2-Amino-5-Chlorophenol-4-Sulfonic Acid and basic p-chlorophenol sulfonated variants at different positions. Adjustment to substitution patterns can degrade solubility, dull the intensity of resulting colors, and escalate the requirements for purification and waste handling.

    We’ve seen clients attempt to substitute with non-chlorinated or differently-sulfonated amino phenols in pursuit of cost savings or regulatory simplification. Feedback usually points to lower color yield, irregular shade build, or even legal headaches related to process patents. The sulfonic placement at the six position in our product shapes a dependable profile—greater dye bath compatibility, better interaction with metal ions, and easier discharge treatment downstream.

    We back these observations with process data from our own production. Over hundreds of runs, product loss through side reactions typically undercuts the claimed economic advantage of using "simpler" intermediates. The structure of 2-Amino-4-Chlorophenol-6-Sulfonic Acid strikes a realistic balance: enough functionalization to handle demanding reactions, not so over-engineered to make processing excessively costly.

    The difference in chlorination also matters. Chlorine at the para position—opposite the amino—gives a distinct push on bath stability without veering into over-chlorination, which can introduce environmental and waste compliance headaches. Our waste treatment teams record a far more manageable effluent profile using this model than with multi-chlorinated analogs, keeping regulatory reporting less onerous over the long haul. That real-world lesson underscores why controlling substitution counts as more than a theoretical exercise.

    Managing Challenges on the Line

    No manufacturing journey runs without hiccups. During periods of unusual humidity, we’ve fought extra clumping, leading to slower feeds on automatic dosing lines. Mechanical sifting and direct feedback to process operators help to prevent downstream blockages, but we don’t trust fixes to luck. Beyond moisture, we’ve had to rein in batch temperature drift—climb much above target and side-chain decomposition creeps in, clouding up the final product with color bodies that complicate downstream dye purification.

    We take customer complaints seriously. Years ago, an end user in fiber dyeing flagged a drifting absorption profile, which on further study traced to undetected microcontaminants in an acid-wash stage. It led to installation of new in-line spectral analyzers and retraining across shifts. That costly episode still reminds us that tiny deviations can travel a long way through the supply chain, morphing into quality issues at the point of final use. Many businesses may cite certifications and batch analysis, but in our plant, that kind of lesson changes the checks and walks we make every day.

    We also keep a close dialogue with downstream users about upcoming changes—regulatory shifts in permitted impurities, requests for tighter particle fraction ranges, or new solvent restrictions in Europe and North America. If a customer must innovate on their process in response to environmental guidelines, we work out batch trials under simulated new specs, retooling some of our steps rather than forcing end customers to absorb all the transition pain.

    Upholding Integrity in Production Flow

    Every batch of 2-Amino-4-Chlorophenol-6-Sulfonic Acid ties directly to our core values—traceability, authenticity, and accountability. Walk through our plant and you’ll spot operators logging every reagent delivered, checking for contaminants at receipt, and physically inspecting reaction tanks before each run. This all matters more than ever. Global supply chains keep tightening quality standards, and any short-cut in the first step only makes headaches for everyone further along. Over the years, we've witnessed how the temptation to shortcut, even in minor protocols, can create months of rework for users trying to interpret whether a color tone variation stems from ingredient drift or from unexpected plant-level reactions.

    We run annual training updates that focus not only on new technology but on mistakes made—misreadings that led to trace contamination, or mis-timed temperature drops that left unwanted side-products behind. Our team rotates between stations so no one loses sight of the bigger process. They all know the ripple effect their choices have on textile finishers, pigment dispersers, or pharmaceutical blenders relying on our batch declarations. This culture of shared responsibility has the greatest impact on maintaining trust up and down our network of buyers and users.

    The Demand for Transparency and Responsiveness

    In the current climate, transparency beats tradition. Buyers request COAs rich with every possible data point—residual solvent load, trace byproduct analysis, exact melting point readings, detailed storage recommendations. Rapid, honest responses matter more than rehearsed marketing speak. Our sales and technical teams field real-world questions: Can we tweak particle size to suit a slower mixer? How do we guarantee no banned chlorinated dioxin residues? Clients value more than a purity number—they depend on full accountability anchored in real, reproducible data.

    Increasingly, customers ask for insight into our waste management procedures, green chemistry integrations, and audit trails. We’ve invested in automated batch tracking and open communication about what goes into our product and what comes out as waste. While regulatory authorities set minimum reporting thresholds, we push for voluntary, detailed disclosures that exceed compliance—providing greater peace of mind for those incorporating our intermediates into textile, pigment, or fine chemical supply lines where recalls or off-spec runs are costly and highly disruptive.

    Regular factory visitors will see the process from raw reagent qualification to final crystallization and packaging. We encourage site tours, spot sampling, and third-party testing, putting our entire operation under the microscope because reputational risk outweighs the price of absolute transparency. Supply chain security runs deeper than paperwork: it’s a daily effort backed by a manufacturing team whose pride comes from producing nothing they wouldn’t use themselves in their most sensitive projects.

    Moving Forward Through Experience—Real Solutions, Not Platitudes

    Looking at the future, demand keeps growing in both quantity and complexity. Newer dye routes, advanced pigments, and stricter pharmaceutical requirements stretch the limits of what 2-Amino-4-Chlorophenol-6-Sulfonic Acid must deliver in each context. Anticipating shifts, we’ve routed more resources to in-process analytical controls, so we spot impurities faster and isolate reaction drifts before they grow into problematic trends. We don’t just rely on formula—our teams routinely simulate process variations in pilot runs, testing for robustness under realistic upsets.

    Environmental pressure is another front. Responding to more stringent waste protocols, we have continuously reworked our extraction and disposal processes, trimming effluent toxicity and reusing spent solvents wherever practical. The finished product remains clean because upstream waste is tightly managed. These process improvements feed back directly to users in textile and pigment manufacturing, who themselves bear increasing regulatory scrutiny.

    From time to time, R&D partnerships with key clients test out alternative reaction routes, seeking incremental improvements in yield or reductions in energy usage. Sometimes progress comes from surprising adjustments—minor tweaks to pH buffering, or fresh catalyst grades that shave fraction points off impurity rates. Our stance remains that incremental improvement is the surest safeguard—not chasing showy, untested changes, but building reliability batch by batch.

    Years of direct hands-on production have taught us that manufacturing 2-Amino-4-Chlorophenol-6-Sulfonic Acid isn’t just about matching a molecular formula or compiling compliance paperwork. It’s about fostering habits, investing in staff, and upholding purposeful transparency—so anyone downstream gets a product they can trust to perform the same, every time, with no hidden surprises lurking at the end of a long logistics chain. If something needs solving—for a customer’s unique process or a regulatory squeeze—we work the problem head-on with the people who touch the product every day, never hiding behind abstract quality promises. Experience on the plant floor says it best: reliability comes from the details, and in our operation, those details have always come first, for as long as we’ve made this compound.