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2-Amino-4-Chlorobenzoic Acid

    • Product Name 2-Amino-4-Chlorobenzoic Acid
    • Alias 2-Amino-p-chlorobenzoic acid
    • Einecs 219-057-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    554095

    Product Name 2-Amino-4-Chlorobenzoic Acid
    Cas Number 87-09-2
    Molecular Formula C7H6ClNO2
    Molecular Weight 171.58 g/mol
    Appearance Off-white to light yellow solid
    Melting Point 220-224 °C
    Solubility In Water Slightly soluble
    Purity Typically ≥ 98%
    Synonyms 4-Chloroanthranilic acid
    Density 1.47 g/cm³ (approximate)
    Smiles c1cc(ccc1N)C(=O)O
    Inchi InChI=1S/C7H6ClNO2/c8-4-1-2-5(9)6(3-4)7(10)11/h1-3H,9H2,(H,10,11)
    Storage Conditions Store at room temperature, tightly sealed, in a dry place
    Hazard Classification Irritant

    As an accredited 2-Amino-4-Chlorobenzoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, sealed HDPE bottle containing 100 grams of 2-Amino-4-Chlorobenzoic Acid, labeled with chemical name, CAS number, and hazard warnings.
    Shipping 2-Amino-4-Chlorobenzoic Acid is shipped in tightly sealed, chemical-resistant containers to prevent contamination and moisture exposure. Transport is conducted according to standard hazardous material regulations, ensuring proper labeling and documentation. The chemical should be stored away from incompatible substances and handled only by trained personnel wearing suitable protective equipment during shipping and handling.
    Storage 2-Amino-4-chlorobenzoic acid should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from strong oxidizing agents. Keep it protected from moisture and direct sunlight. Properly label the container and store it at room temperature. Avoid inhalation, ingestion, and contact with skin or eyes. Use appropriate personal protective equipment when handling.
    Application of 2-Amino-4-Chlorobenzoic Acid

    Applications of 2-Amino-4-Chlorobenzoic Acid in Industrial Manufacturing

    2-Amino-4-Chlorobenzoic Acid is a critical intermediates in chemical synthesis, supporting advanced downstream production in the pharmaceutical, agrochemical, and dye manufacturing industries. Our manufacturing expertise ensures precise specification control and allows flexible integration into commercial-scale processes. Below, we provide a detailed overview of established application scenarios, each with relevant compliance frameworks, formulation guidelines, integration points, and end-use categories.

    1. Pharmaceutical Synthesis: Cephalosporin Antibiotic Intermediates

    Manufacturers in the pharmaceutical sector use this material primarily as a building block for cephalosporin-class beta-lactam antibiotics. The compound typically enters the multistep synthesis phase where side chain modifications are required, especially for drugs like cefaclor and cefazolin. The strict requirements for traceability and purity necessitate close adherence to pharmaceutical standards and batch documentation, especially given regulatory scrutiny in regulated markets. The material’s reactivity profile allows for direct amide coupling or esterification in protected conditions.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Part 210/211
    • European Pharmacopoeia (Ph.Eur.) monograph for intermediates
    • US Pharmacopeia (USP) reference standards for process validation

    Typical usage ratio

    • 0.85–1.1 molar equivalents relative to cephalosporin core, adjusted for target yield and impurity profile; ratio optimized per specific drug side chain engineering.

    Downstream process integration

    • Incorporated during the nucleophilic substitution or amidation step within the cephalosporin synthesis cascade, often post-beta-lactam ring closure and prior to final derivatization/purification.

    Final product types

    • Cephalosporin antibiotics (e.g., cefaclor API, cefazolin API)
    • Sterile injectable antibiotic formulations
    • Oral solid dosage antibiotic tablets and capsules
    • Bulk pharmaceutical intermediates for further processing

    2. Agrochemical Synthesis: Herbicide Intermediate

    Downstream agrochemical manufacturers utilize this acid as a core intermediate in the synthesis of certain selective herbicides, especially those based on benzoic acid frameworks. Its unique amino and chloro substitution pattern enables the introduction of specific functional groups for weed-selective activity. Process control at this stage focuses on minimizing halogenated byproducts and optimizing yield in catalytic condensation reactions.

    Industry compliance standards

    • OECD Principles of Good Laboratory Practice (GLP)
    • FAO/WHO Specification Requirements for Pesticide Active Ingredients
    • EU Regulation (EC) No 1107/2009 (Plant Protection Products)
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), Safety Data Sheet (SDS) compliance

    Typical usage ratio

    • 0.9–1.05 molar equivalents per target herbicidal active structure; final loading optimized based on desired alkylation or acylation route in downstream conversion.

    Downstream process integration

    • Introduced during the primary condensation or esterification step, forming the core benzoic acid structure of the herbicide molecule; typically blended in jacketed reactors for temperature and pH-controlled synthesis.

    Final product types

    • Pre-emergent and post-emergent selective herbicide technical concentrates
    • Water-dispersible granules for field application
    • Emulsifiable concentrates
    • Bulk herbicidal intermediates for further downstream reactions

    3. Specialty Dyes and Pigments Manufacturing

    Producers in the dye manufacturing industry incorporate this compound as a diazo coupling component for the synthesis of azo dyes and optical brighteners. The amino group contributes to high dye affinities and fastness properties, while the para-chloro substitution facilitates controlled color tone adjustments during the sulfonation or subsequent coupling stages. Consistency of input material and strict process control are critical to achieve reproducible shade and purity in final pigment dispersions.

    Industry compliance standards

    • REACH Regulation EC 1907/2006 (Annex XVII – restrictions on azo colorants)
    • OEKO-TEX® Standard 100 for textiles
    • ISO 105 series (Color Fastness Testing)
    • Global Organic Textile Standard (GOTS) for dye intermediates

    Typical usage ratio

    • 10–25% by mass in dye precursor batches depending on desired chroma, solubility, and application system; altered based on the particular coupler and dye class being synthetized.

    Downstream process integration

    • Employed during the diazotization or coupling step after primary sulfonation; typically processed in batch reactors with in-line monitoring for color consistency and reaction endpoint.

    Final product types

    • Disperse and acid dyes for polyester and wool fabric
    • Direct dyes for paper and leather
    • Fluorescent optical brighteners for detergents and plastics
    • Specialty pigment pastes and dispersions

    4. Photographic Chemicals: Color Film Coupler Intermediate

    Photographic chemistry firms employ this material in the synthesis of cyan and magenta couplers used in photosensitive film and color paper emulsions. Its aromatic structure allows efficient coupling in controlled halogenation and alkylation reactions, critical for achieving color-accuracy and shelf-life in negative film production. The stringent performance criteria tied to light stability and chemical inertness mandate high-purity sourcing and detailed trace impurity analytics.

    Industry compliance standards

    • ISO 9001:2015 (Quality Management Systems for specialty chemicals)
    • ANSI IT9.3 and ISO 18909 (Photographic Image Stability Standards)
    • Relevant safety and chemical purity benchmarks per downstream customer technical agreements
    • RoHS for non-toxicity in photographic applications (where applicable)

    Typical usage ratio

    • Ranged from 5–15% by mass in coupler precursor batches; dependent on film sensitivity, layer thickness, and emulsification formula requirements.

    Downstream process integration

    • Fed into the organic synthesis stage prior to final coupling and dispersion into film-coating emulsions; often executed in closed vessels with controlled heating/cooling cycles.

    Final product types

    • Color film emulsion coupler concentrates
    • Color-negative photographic films for camera and medical use
    • Photographic color paper and developer chemicals
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    Certification & Compliance
    More Introduction

    Introducing 2-Amino-4-Chlorobenzoic Acid: Direct from the Manufacturer’s Point of View

    A Chemical Plant Perspective on 2-Amino-4-Chlorobenzoic Acid

    2-Amino-4-Chlorobenzoic Acid always grabs the attention of process chemists and buyers alike, not only because of its specific functional groups—amino and chloro—positioned on the benzoic acid ring, but for what it realistically offers on the production floor and downstream applications. Our plant has put years into refining the synthesis route for this compound, keeping batch purity consistent across every ton. Unlike generic traders, we see the full arc from raw material drum to finished acid, and that means every characteristic—color, particle profile, melting range, even the scent during grinding—matters on a practical scale.

    Physical and Chemical Profile: What We Actually Produce

    This compound falls under the CAS number 876-50-6, and inside our plant, crystalline solids consistently exhibit an off-white, sometimes very pale yellow tone—never gray, never wet to the touch. In-house controls confirm a melting point ranging around 201 to 205°C, signaling to our QC team that synthetic workup and isolation hit their target. HPLC and GC tests, run before every batch release, report our minimum purity at 98.0%. With tighter controls, some lots read above 99.2%, and that level of certainty doesn’t grow on trees. Trace analysis covers common contaminants like residual solvents and organic impurities; chloride levels sit tight within pharmacopeial guidelines. Even particle size distribution falls within a range that aids in downstream processes; suppliers talking about "fluffy light powder" show they don’t actually make it.

    Actual plant workers smell the batch, gauge flow, and check if the crystalline texture fits the order spec. Packaging moves fast, but not before an in-person sign-off. We pack this acid in sealed fiber drums or lined polyethylene bags, depending on customer request, and aim to keep water content far below one percent by weight. Why does this matter? Over time, traces of moisture or chlorine leeching from second-rate drums corrode everything from IBC valves to transfer lines. Only controlled packaging with verified materials prevents batch loss, especially for exporters sitting on docks for weeks.

    Core Applications: Where Quality Really Counts

    Our team gets questions every season about which industries value this compound most. The truth is: the whole story points to dye intermediates, high-performance pigments, active pharmaceutical intermediates, and sometimes veterinary formulations. Customer priorities keep changing, but the majority demand tight tolerances—especially those synthesizing specialty dyestuffs, azobenzene derivatives, and certain anti-inflammatory pharmaceutical APIs. Forget the sales fluff about "potential"—demand exists where manufacturing tolerances fail elsewhere.

    Many R&D groups tap our product for its ortho-amino and para-chloro substitution, which brings unique reactivity to coupling reactions, halogenations, and amidations. Chlorine at the para position resists easy removal in subsequent steps, granting a predictable chemical backbone for downstream functionalization. The amino group, being an excellent directing group in electrophilic aromatic substitution, boosts selectivity in condensed phase reactions. For customers feeding synthesis robots or pilot plants, batch-to-batch consistency saves dozens of man-hours and knocks down troubleshooting cycles. That kind of reliability traces itself to how we load acid chlorides and catalysts at the plant, not to anything a middleman can rearrange.

    Solid Manufacturing Experience: The Difference Real Factories Deliver

    We have seen plenty of imported samples and off-grade material from general traders. They arrive with mismatched labels, unknown synthetic byproducts, or off-odors that fail even simple TLC spot checks. Big pharmaceutical or dye customers don’t simply want “2-amino-4-chlorobenzoic acid” labeled on a bag—they need structural purity with little deviation, time after time. Years back, lax purification led some resin plants to clogged pipes thanks to polymeric byproducts left from shoddy isolation steps. Today, our columns and re-crystallization cycles squeeze out those issues, verified at each campaign.

    We continually invest in analytical capacity. Each month brings in more requests for new analytical markers as regulations tighten, especially in Europe and North America. Our internal standards for iron content, residual halide, and total organic volatility keep our material ready for even the strictest downstream audits. These aren’t lab tricks—they result from the effort put into industrial controls and day-to-day plant management. By working shoulder-to-shoulder with partner firms, from process engineers to logistic crew, we build feedback into every production run. Every rejected lot gets broken down—was it raw material variance, purification drift, or mixing kinetics? Lean operations mean not just cost-saving, but deeper control. That gets passed on to the buyer.

    Real Differences from Similar Products

    A chemist fresh out of grad school might not see the difference between 2-amino-4-chlorobenzoic acid and its isomers or related aminobenzoic acids, at least not beyond the position of the substituents on the ring. The truth lies in how those positions dictate the pathway and safety profile during actual production.

    We manufacture 2-amino-4-chlorobenzoic acid with the amino group ortho to the acid and the chlorine at para. Compare this to 4-amino-3-chlorobenzoic acid, where even a single position switch can disrupt reactivity—resulting in less convenient coupling for dyes and more waste product when aiming for certain pharmaceutical intermediates. Most off-brand traders sell a vague “chloroaminobenzoic acid” blend, leaving end users with inconsistent yields, unpredictable waste, and headaches for their EHS reporting teams.

    The key to high-value production continues to be strict separation protocols and cleaning standards. Running multiple isomers on the same line without a full cleanout invites cross-contamination, and we never accept lines without full separation. On our watch, the old practice of running miscellaneous organics through shared reactors died years ago. Reports from competitors who take those shortcuts show repeat cases of out-of-spec batches, recalls, and even regulatory action.

    Traceability saves time and reputations. Every lot number can get traced back through batch records and process books—temperature, catalyst, flow rates, operator comments. Transparency breeds confidence and we put every claim to the test with real, on-demand data. That’s not marketing, that’s the reality of delivering chemical intermediates to markets where margin for error sits close to zero.

    Practical Usage and Handling Insights from Daily Production

    Few articles or promotional blurbs talk much about the reality of handling this acid inside a manufacturing facility. Our teams have learned, sometimes the hard way, that its fine particle profile means good practice in dust control and localized ventilation. Strong enough hood systems and maintained ducts prevent chemical exposure and layer the work zone with a safety net. All handling equipment uses corrosion-resistant alloys, preventing interaction between the acid and iron that can spark off-color contamination. Bags leave the plant with triple-line seals to keep out moisture and warehouse gremlins.

    Inside the formulation stage, operators discover the advantage of our product’s reliable solubility in basic and hot water conditions. No more worrying about unmixed clusters creating sludge at the bottom of reactors. Our feedback loop with customers has taught us that when moisture content stays low, process chemists adjust fewer parameters in their recipes, saving time with filtration and drying. We favor practical fixes over textbook theory: drying rooms set with monitored dehumidifiers, calibrated weights for each shift’s work, infrared dryers with real-time output checks.

    Market Challenges and Solutions from the Manufacturer’s Bench

    Supply volatility and price swings may frustrate trading desks, but for a plant manager, the worst enemy is inattentive raw material sourcing and outdated process documentation. A single contaminated drum can turn a month of production upside down. Our risk assessments, built over years of chemical supply chain headaches, point straight to robust supplier vetting and in-person audits. Rather than appointing a procurement agent and hoping for the best, we assign senior chemists to visit upstream suppliers. Shipments get tested before they even get to site, catching out-of-spec content before it costs weeks in lost time and wages.

    Export hurdles call for proper documentation and real preparation for event-based disruptions. Not every logistics crew welcomes a drum of amino chloro acids, especially under evolving regulatory frameworks in the EU, US, or Asia-Pacific. Our compliance unit partners with local agencies to pre-vet every new regulation, avoiding costly rejections at customs. We focus on paperwork precision with every batch. Employees receive regular training on the patchwork of international quality and transport rules. In-house compliance saves more than effort; it saves the entire consignment from sit-time, storage bills, and expiry risk.

    Continuous Improvement: Lessons from Plant to End-User

    Improvement isn’t just an annual slogan. Each process revision—whether it’s an optimized crystallization or a tweak to the filtration stage—gets tested first, reviewed in internal audits, then rolled out in live production. End-user feedback throws the spotlights on recurring pain points, especially in pigment and pharmaceutical lines. Collaborative troubleshooting, not just sample trading, turns those pain points into actionable process tweaks. We gather monthly input on solubility shifts, flow errors in large reactors, and post-formulation purity. These lessons cycle right back into our plant operations guidebooks and technician next-shift notes.

    Energy management keeps growing in complexity, too. We track every kWh spent on isolation and drying. Lowering energy draw lowers cost and shrinks our carbon mark. Installation of reclaim systems and heat exchangers let us recover value where old running systems just burned off precious steam and coolant. For a commodity acid, this pinches at tight margins and gives our buyers a fair price when underlying costs keep rising. Putting operators in the same room as process engineers for lean workshops strips away layers of inefficiency. Safety and savings travel hand in hand.

    Working Smarter from Sourcing to Final Shipment

    Long-term contracts with customers mean more than a handshake and a price sheet. We see repeat business from firms who value supply security and procedural transparency. The old ways—batching blindly, trusting every retail order—risk failed due diligence and lost market standing. Our teams invest in digital batch tracking and electronic documentation, with easy access portals for approved customers. This helps keep dialogue honest; every batch gets matched to its analytical history and process notes, without relying on long paper trails.

    One of the benefits of being an actual manufacturer is setting standards, not just following them. We set our own acceptance criteria for each batch issued—not just for purity, but also for color, pourability, dusting tendency, and pack integrity. Our QA division tracks feedback on every shipment. These direct data points let us push for better not just with internal diagnostics, but with routine upgrades and better feedstock selection at the procurement stage. Our partners know they aren’t getting relabeled, brokered, second-sweep acid—they receive product that’s traceable to a real batch, with all records open for review.

    Sustainability and Waste Reduction in Bench-Scale and Full-Scale Runs

    Reducing waste and managing volatile emissions require more than compliance checks. We include solvent capture units and acid recovery units on every line. This lets us reclaim process acids for re-use, trimming both cost and environmental load. Water used in purification never leaves the plant untreated. Bioreactors and secondary treatment stages break down any organic residues before water heads back out the gate. These investments aren’t just regulatory requirements; they keep us a step ahead as governments phase in stricter controls.

    Our in-house training programs lead workers through every protocol—waste segregation, emergency washes, leak detection, drum closure checks—giving them ownership of plant safety and sustainability. When a new regulation drops, operators and EHS managers synchronize to re-map compliance. We maintain a feedback network with industry advocacy groups and regulators, updating our plant processes before enforcement seasons hit. Losing batch material to regulatory lapses is a rookie move—veterans know how to play the long game.

    End-User Dialog and Real-World Troubleshooting

    Open lines mean more than just a sales phone number. Our application engineers consult with customer site managers, tracking order performance and troubleshooting where the reaction chemistry falls short. Regular calls solve more problems than any PDF manual—customers relay bottlenecks, strange colorations, or reaction hold-ups, and we flag every issue for process review. Sometimes a fix comes down to a slight pH adjustment or a tweak in mixing speed. Having the actual manufacturer in your corner makes a difference when the batch cost is on the line. Mistakes by third-party resellers always take longer to resolve, with everyone passing the blame along. By dealing direct, we sort things out on the spot.

    Customers appreciate that every query receives attention from someone who’s actually managed a reactor or overseen a drying room, not just filed procurement paperwork. Our teams close feedback loops, making sure improved technical data and shipping guides reach the next customer in line. With plant leadership invested in day-to-day problem solving, every customer outcome benefits, no matter if they handle ten kilos or a ten-ton order.

    Supporting a Growing Future: Generational Investment in Manufacturing

    The present and future of quality chemical supply don’t rest on quietly churning out the same compound each campaign. Our focus grows with every inquiry, every performance issue flagged and solved. Research partners lean on us for scale-up trials, blending troubleshooting, and sustainability audits. We invest profits in equipment upgrades, operator training, and greener process improvements. Manufacturing 2-amino-4-chlorobenzoic acid doesn’t offer shortcuts; only patient investment and responsive production systems win respect, both from buyers and regulators.

    Emerging applications in advanced materials and specialty pharmaceuticals continue to push the need for ever-cleaner, precisely specified material. Our willingness to collaborate, adapt, and share technical insight means we keep pace with those demands. Markets grow more demanding each year, but real factories with skin in the game—not brokers—rise to meet those new technical standards, delivering both consistency and accountability.