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HS Code |
586376 |
| Chemical Name | 2-Amino-3-nitropyridine |
| Molecular Formula | C5H5N3O2 |
| Molecular Weight | 139.11 g/mol |
| Cas Number | 4214-76-0 |
| Appearance | Yellow to brown crystalline powder |
| Melting Point | 163-166°C |
| Solubility | Slightly soluble in water |
| Density | 1.51 g/cm³ |
| Purity | Typically ≥ 98% |
| Pubchem Cid | 23220 |
| Synonyms | 2-Amino-3-nitropyridin, 3-nitro-2-aminopyridine |
| Smiles | c1cc(c(nc1)N)[N+](=O)[O-] |
| Inchi | InChI=1S/C5H5N3O2/c6-5-4(8(9)10)2-1-3-7-5/h1-3H,(H2,6,7) |
| Storage Conditions | Store at room temperature, in a tightly closed container |
As an accredited 2-Amino-3-Nitropyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The 100g 2-Amino-3-Nitropyridine is supplied in a tightly sealed amber glass bottle with a printed hazard label and product details. |
| Shipping | 2-Amino-3-Nitropyridine is shipped in tightly sealed, chemical-resistant containers to prevent contamination and exposure. It is handled as a hazardous material, complying with relevant transport regulations. The packaging is clearly labeled, and shipment includes necessary safety documentation. Protect from moisture, heat, and incompatible substances during transit. |
| Storage | 2-Amino-3-nitropyridine should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition, heat, and incompatible materials such as strong oxidizing agents. Protect from moisture and direct sunlight. Label the container clearly and keep it in a secure chemical storage cabinet, following standard laboratory safety protocols. |
Applications of 2-Amino-3-Nitropyridine in Industrial ManufacturingAs a direct producer of 2-Amino-3-Nitropyridine, we support multiple chemical manufacturing industries that depend on this intermediate for demanding downstream syntheses. Below, we outline established industrial tracks and technical specifications related to its real-world uses. 1. Active Pharmaceutical Ingredient (API) Synthesis2-Amino-3-Nitropyridine functions as an essential building block within complex pharmaceutical syntheses, particularly in the creation of anti-infective, oncology, and neurological APIs where substituted pyridine scaffolds are required. Manufacturers utilize our material to construct pyridine ring systems via nucleophilic substitution, reductive amination, or heterocycle assembly, ensuring strict compliance with regulated impurity profiles and traceable batch records. Downstream producers integrate our intermediate during the early or middle synthesis steps, optimizing yields according to target compound complexity. Finished pharmaceuticals often include anti-tubercular agents, kinase inhibitors, and experimental CNS modulators, each subject to specific regulatory filing and validation. Industry compliance standards
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2. Agrochemical SynthesisProducers of high-value crop protection agents leverage our 2-Amino-3-Nitropyridine for the development of advanced herbicides and fungicides. Due to its unique electronic and steric attributes, the molecule acts as a pyridine core for formulations requiring strong biological activity. Downstream use typically involves its conversion to aminopyridine derivatives or the introduction of complex side chains via Buchwald-Hartwig or Ullmann-type couplings, supporting selectivity and regulatory documentation. Landed plant protection products undergo stringent toxicological and residue scrutiny, with production requiring certification against safety and environmental benchmarks. Industry compliance standards
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3. Dye and Pigment Intermediate ProductionOur 2-Amino-3-Nitropyridine enables colorant manufacturers to introduce nitro and amino functionalities within pyridine dye structures, especially for specialized azo and heterocyclic pigment products. This raw material supplies the electronic donors necessary for deep color formation and fastness. Downstream facilities integrate the compound in initial condensations and diazotization reactions, taking care to reduce nitro content fully to avoid stability issues in finished dispersions. Final colorant products target applications in plastics, fibers, printing inks, and performance coatings, subject to international heavy metal and amine content regulations. Industry compliance standards
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4. Electronic and Photonic Material SynthesisProduction of advanced organic semiconductors and photonic functional materials incorporates 2-Amino-3-Nitropyridine as a precursor for substituted pyridine moieties, which support charge transport and specific wavelength absorption. Downstream manufacturers require high-purity input to ensure electronic consistency and avoid charge traps. Processing steps include selective amination, cyclization, and subsequent attachment of electron-withdrawing groups to modulate final device characteristics. Integration demands analytical confirmation of residual solvents and ionic contaminants, essential for optoelectronic device reliability and adherence to RoHS and industry-specific trace metal limits. Industry compliance standards
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5. Chemical Catalyst Ligand ManufactureSpecialty catalyst producers utilize 2-Amino-3-Nitropyridine as an intermediate in the synthesis of pyridine-derived bidentate and tridentate ligands. These ligands play critical roles in homogeneous catalysis for fine chemical and pharmaceutical production, including palladium- and platinum-catalyzed C–C and C–N bond formations. Manufacturers graft functional arms onto the pyridine core via site-selective amination or nitro-to-amino reduction, with stringent documentation of ligand purity and metal content. Downstream processes must validate ligand loading parameters for batch-to-batch consistency, and end-users require technical confirmation of ligand stability via NMR and HPLC. Industry compliance standards
Typical usage ratio
Downstream process integration
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Walking through our plant each morning, I see how specialty intermediates like 2-Amino-3-Nitropyridine shape the backbone of fine chemical development. In an industry built on consistency and depth, every batch tells a story of people, raw materials, and hard-learned expertise. Over decades, our approach has always focused on improving purity, ease of handling, and real reliability — not marketing spin. Getting 2-Amino-3-Nitropyridine right isn't theoretical, and it doesn't rely on buzzwords. It comes from what happens at the reactors, in the packing rooms, and out on the loading docks when an order has to be turned fast, and right. We take pride in keeping this compound at a quality level that meets global customer needs — researchers, pharmaceutical process teams, agrochemical formulators, and dye specialists alike.
Every chemist who’s run a pilot process or scaled up a synthesis route understands the difference between the name on paper and the reality from a factory drum. 2-Amino-3-Nitropyridine — model designation 3-NP-2A for internal tracking — often plays a pivotal role as a building block. Because of its dual functional groups, researchers value it for smart linking in heterocycle construction, targeted pharmaceutical intermediates, specific pigment scaffolds, and crop science actives. Our product consistently clocks in above 99% purity by HPLC, because any less, and you’re washing money down the drain during downstream purification. We use nimble batch processes and proprietary crystallization controls, which let us maintain low impurity profiles lot after lot, something that matters if you worry about trace byproducts affecting biological screens or color properties.
Specifications mean little if the material can’t be processed efficiently. We've made sure that our 2-Amino-3-Nitropyridine stays flowable, cream-pale in color, and resists caking — whether stored for two weeks or two years. Standard packaging includes 25 kg fiber drums for R&D and 200 kg bulk units for process scale-up, with inner linings that guard against moisture ingress. Manual sampling remains an ongoing practice in quality inspection. Each shift learns to check for off-odors or sign of yellowing, subtle changes that flag issues before they reach your loading dock.
Over years, our client conversations shape how this chemical is delivered and what additional documentation we provide. Real-world end users are not academic search engines; they’re blending, reacting, dosing, and responding to tough timelines. Pharmaceutical groups, for example, will request a full characterization suite: NMR, MS spectra, elemental analysis, and water content. For a dye manufacturer or pigment lab, light reflectance and purity define acceptance. Agrochemical developers regularly ask about byproduct profiles and shelf-stability in hot, damp climates.
In actual scale-up runs, handling characteristics often overshadow theoretical "spec" sheets. Fine, free-flowing material, easy to weigh, transfers well through isolators, and cleans up better if a spill happens. We’ve worked with customers on batch-to-batch traceability, open impurity lists, and detailed COA customization — not every partner asks for this, but when your downstream route hangs on 0.1% variance, every detail matters. Simple promises can’t replace open QC records and real human process knowledge. A well-documented production log can resolve half the sourcing headaches our customers face. We've seen synthetic failures hinge on a difference as small as residual moisture or trace organic solvent left over from an upstream step. We track these systematically, based on lessons from hard-earned production experience.
Some buyers want the lowest price, and they'll take shipments in whatever form arrives, but this approach bites back. Over time, customers who started out with cheaper, inconsistent material shifted to our supply because of fewer quality holds, improved handling at their own sites, and overall cost reduction due to less labor on reworking or extra purification. There’s a world of difference between a manufacturer blending from in-house synthesis and one who simply repacks material from outside — traceability can drop fast in the latter case. We manage every synthesis from starting pyridine derivatives to final drum sealing, and this hands-on path makes our quality control process more transparent and accountable. Our batch logs, retained samples, and open-door policy allow technical teams from our customers to audit, sample, and advise on adjustments to fit their process — something a typical trading company never provides.
Contaminant risk varies widely depending on source process. Some global suppliers use nitro substitution routes involving metal catalysts, risking traces of forbidden heavy metals which pharmaceutical clients flag instantly. We ensure our method avoids these pitfalls, tested by external labs to back up our own results. Even end-users outside regulated spaces, such as pigment or agrochemical teams, benefit from cleaner starting intermediates in terms of less downstream filtration and lower risk of unexpected byproducts. These practical results build loyalty far more than spec sheet claims.
Many in the lab and process world think of 2-Amino-3-Nitropyridine as a “specialty” item, but behind the scenes, the material shapes reactions and finished goods in surprising ways. Medicinal chemistry uses this building block to design kinase inhibitors, antimicrobial agents, and CNS actives due to the unique orientation of its amino and nitro groups. In the dye and pigment arena, it builds base colors with high fastness and distinct hues — all depending on purity and lot consistency. In crop science, it often gets incorporated into actives meant for leaf or soil application, demanding robust, shelf-stable forms that withstand wide temperatures and humidity swings.
Smaller scale innovators, especially startups or university research teams, usually order our 2-Amino-3-Nitropyridine for custom syntheses, pilot trials, or method validation prior to large commercial runs. In these cases, technical support means as much as the product itself. Our on-site chemists consult daily on solubility tips, extraction tricks, recommended solvents for tricky steps, and proper filtration setups — advice built up from seeing thousands of kilograms go through real-world reactions, not just bench-scale work. It’s common to troubleshoot issues that pop up with certain reagents or temperature controls and offer insights on improving final yield or isolating critical intermediates.
The specialty chemical sector never stands still, and requirements evolve as regulations tighten or new application fields emerge. The demand for pharmaceutical-grade intermediates comes with rising scrutiny on trace solvent, undefined byproducts, and allergen cross-contamination. We've responded by investing in closed-system synthesis, additional filtering, vapor recovery, and real-time impurity profiling, so our partners see clean, legally-compliant material. In pigment and agrochemical development, physical storage and caking present practical headaches — we regularize our product form to avoid bridge-forming and keep particle size optimal, whether the order is 1 kg or 1 ton. Shelf-life extension techniques limit risk for slower-moving stockpiles and global logistics delays.
Logistics and customs shifts have also forced adaptations. Increasing global shipping scrutiny, fire safety ordinances, and local import preferences mean packaging isn't just an afterthought. We offer compliance-friendly documentation, GHS labeling, child-proof drums, and clear photographic records. These steps reduce hold-ups at border checks and keep downstream lines running, especially for critical, made-to-order production lines. We’ve faced supply chain shocks, from port closures to rail strikes, and responded by building up multiple transport routes and backup stock near key customer clusters. Our strategic stocking helps partners buffer against market volatility without compromising on quality or traceability. The ability to shift quickly matters far more to customers than any theoretical "supply chain optimization" pitch. It's about solving their daily challenges, not presenting slides showing abstract risk matrices.
Many in the intermediate sector talk about “continuous improvement,” but our story is built from generations of practical lessons — not just modern catchphrases. Quality audits don’t end after ISO or industry certification paperwork. They run through weekly on-floor checks, annual synthesis reviews, and every customer feedback call. Our technical and operations teams share feedback openly, learning from customer complaints about off-color material, slow dissolution rates, or unexpected residue in their reactors. Every such report becomes a new control point or training subject. The field judges quality through results, not paperwork. Long-term customers have stayed with us because we’ve admitted mistakes, fixed real sourcing issues, and worked openly to prevent recurrence — a direct, honest relationship wins more trust than hiding behind a reseller’s generic guarantees.
Across all sectors, data transparency matters. Buyers want to know not just what’s in the drum, but how it got there. We keep clear batch histories, traceable from raw pyridine feedstocks to the final seal, and regularly release residual solvent and impurity chromatograms with shipments, even if not every customer requests them. This transparency, built over many years, builds reliability far faster than short-term pricing games or generic QA statements from third parties or unknown blenders. Our plant teams take pride in the material leaving their hands, and their pride shows up in the consistency that experienced customers notice after just a few shipments.
Production of specialty intermediates like 2-Amino-3-Nitropyridine involves handling potentially hazardous reagents and managing chemical waste streams responsibly. Environmental controls aren’t just regulatory box-checking for us; they safeguard our teams and communities. We run continual air and water monitoring, use closed system charging during key steps to limit emissions, and train staff in spill prevention and emergency response. We’ve moved away from less sustainable oxidants and shifted raw input purchasing to verified, auditable sources, specifically to reduce knock-on contamination risk and boost the safety profile of final material.
Workplace safety adapts as new risks emerge in both handling and long-term exposure. Our practical adjustments, such as anti-static flooring, enhanced respiratory protection in certain areas, and updated training in chemical transfer, all follow hard-won experience, not just outside audits. We integrate first-responder feedback into our incident protocols. Near-miss reporting brings real improvements — whether that's a redesigned transfer chute, a faster eyewash installation, or a post-shift problem-solving huddle to spot a better handling sequence. Years of working directly with reactive, sometimes finicky intermediates like this one have refined our plant routines far more than any standard checklist could. We've learned every step affects quality, worker safety, and the final customer — so nothing gets skipped, no matter the pressure for fast turnaround.
Customers across pharmaceuticals, crop science, and pigment manufacturing find value in a partner who not only delivers quality product but also understands downstream risks and can talk them through on a technical basis. We've supported teams as they validate new routes requiring tight impurity profiles, or who need custom drum packaging to fit local regulations, or who face urgent adjustments due to unexpected plant stoppages. Instead of relying only on sales staff, our technical experts work hand-in-hand with customer chemists to pinpoint and solve real hurdles, whether it’s solubility, particle control, or just the logistical demands of running a multi-site operation.
Our product fits into a broad spectrum of applications because we understand both the molecular details and large-volume process realities. This hands-on engagement extends well beyond the shipping dock — it’s about building capability in our clients to run leaner processes, reduce failures, and hit regulatory goals. We keep refining our protocols as clients develop more advanced, selective syntheses where old tolerances no longer fit. This flexibility and direct communication set the foundation for supplier relationships lasting decades. Our plant visits, open documentation trail, and direct technical support make us more than just another vendor storing drums in a warehouse. We're linked into customers' actual process goals.
After producing and supplying 2-Amino-3-Nitropyridine over many years, we remain convinced that persistent improvement — not only in product purity but also in handling ease, batch transparency, and shared technical problem-solving — sustains long-term progress. Where the industry once emphasized production speed or lowest cost, experience has shown that stability and clear information yield higher overall value for end-users. The compound remains a workhorse in modern synthesis and process development, valued most by those who’ve been burned by inconsistent or poorly-documented raw materials on an important project. We’ve responded by deepening our technical bench, adapting processes to customer feedback, and strengthening our order execution to absorb shocks in an unpredictable supply chain.
We believe the future will demand even greater clarity from manufacturers — not just chemical traders — and closer integration between upstream suppliers and downstream users. Stronger communication, better logistics, and more open technical dialogue will continue to matter as regulation grows and customers demand more detailed answers to tough synthesis or formulation questions. Those demands keep pushing us to improve every step, from purchasing raw inputs to testing every completed batch and delivering to the customer on time and fully in-spec. That's a challenge, but also the source of growth and pride for every member of our team.