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HS Code |
813388 |
| Product Name | 2-Amino-3-Bromo-5-Methylpyrazine |
| Cas Number | 857407-41-5 |
| Molecular Formula | C5H6BrN3 |
| Molecular Weight | 188.03 |
| Appearance | Off-white to light yellow solid |
| Melting Point | 83-87°C |
| Purity | Typically ≥ 97% |
| Solubility | Slightly soluble in organic solvents |
| Storage Temperature | Store at 2-8°C |
| Smiles | CC1=CN=C(N=C1Br)N |
| Inchi | InChI=1S/C5H6BrN3/c1-3-2-8-5(7)4(6)9-3/h2H,1H3,(H2,7,8) |
| Synonyms | 3-Bromo-5-methylpyrazin-2-amine |
As an accredited 2-Amino-3-Bromo-5-Methylpyrazine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
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Among organic compounds, pyrazines often stand out in the worlds of pharmaceuticals, agrochemicals, and research. 2-Amino-3-Bromo-5-Methylpyrazine stands as a fine example of how thoughtful modifications on a small molecular frame open up new realms of utility. Its value lies not just in being a brominated and aminated pyrazine, but in how this particular arrangement starts to shift reaction opportunities and outcomes.
Born from my own time spent working with heterocyclic compounds—those aromatic rings that seem so simple but surprise you with complexity—I've learned that seemingly modest changes in molecular structure can dramatically change a compound's usefulness. Here, you’re looking at a pyrazine core with a methyl group in the 5-position, an amino group at the 2-position, and a bromine atom at the 3-position. Each of these features plays a role in directing reactivity, solubility, and suitability for synthesis.
Structural tweaking changes everything. The amino group attaches to the ring in a spot that makes it a strong point for further reactions—especially towards functionalizations suited for the next link in a synthetic chain. The bromine, being an excellent site for reactions like palladium-catalyzed cross-coupling, adds serious versatility. The methyl group isn’t just decorating the ring: it shapes electronic distribution and solubility, and sometimes even influences crystal packing in the solid state.
In pharmaceutical research, these functions are not just neat for organic chemists—they translate directly into drug design choices. Many advanced molecules rely on tricky intermediates like this pyrazine because these groups direct further reactions and make it possible to build out libraries of analogues quickly. The careful placement of bromine and amino moieties is not an accident, and anyone who's spent late nights nudging a reluctant reaction to completion knows just how big a difference the right backbone can make.
A common question I hear from colleagues: “Why not just use a more basic aminopyrazine or bromopyrazine? Why pile on the complexity?” In practice, the answer comes down to both selectivity and speed. The extra methyl group offers a subtle but reliable tweak in the molecule’s electronic profile, steering reactions in your favor. It often improves compatibility with organic solvents and influences solubility—what you end up with is an intermediate that doesn’t just serve a single process, but forms a building block for a whole panel of SAR (Structure-Activity Relationship) studies in medicinal or crop protection chemistry.
I remember working with 2-aminopyridines and constantly running into issues with over-alkylation and uncontrollable side products. Switching to a methylated pyrazine ring where bromine sits at the right spot cleared a surprising amount of trouble out of the way. Anyone developing a chemical library for hit-to-lead optimization understands the sigh of relief when side reactions back off, letting the project move forward.
2-Amino-3-Bromo-5-Methylpyrazine finds use across several fields. Its most celebrated role sits in lead compound development for pharmaceutical companies. The position of the amino group streamlines further derivatization—the kind of transformations that create candidate drugs with higher selectivity, better absorption, or fewer side effects. The bromine atom brings in the opportunity for Suzuki or Buchwald-Hartwig cross-couplings, enabling introduction of complex side chains or aryl groups with relative efficiency. The methyl group helps fine-tune physical properties or even enhance blood-brain barrier permeability depending on the final compound.
Combinations like this aren’t just about the molecule as it arrives, they’re about what you can do with it later. Pyrazines with just a bromine or a methyl group usually offer limited synthetic handles. Adding an amino group unlocks portals to ureas, amides, sulfonamides—structures you find in countless FDA-approved drugs. When mentorship guided me in early research, we always aimed to keep a handful of strong “linchpin” molecules in our cabinet—compounds ready for almost any transformation. This product belongs in that toolkit.
Comparing this pyrazine with standard bromomethylpyrazines or aminomethylpyrazines illustrates the edge you get. Regular 3-bromo-5-methylpyrazine lacks the nucleophilic punch of the amine, limiting modulation of polarity or hydrogen bonding in targets. Conversely, 2-amino-5-methylpyrazine skips out on halogen-based coupling routes, boxing your approach into fewer options. The real advantage blossoms when collaborating across disciplines—medicinal chemistry, radiolabeling, and even chelator synthesis for diagnostics all tap into these multiple functionalities.
Solving problems in synthesis goes beyond picking reagents off a shelf. Working on heterocycle-rich projects has shown me that good intermediates have to be both robust and adaptable. There are always roadblocks; too often, a single functional group gets in the way of further progress. For example, certain deprotection or reductive amination steps falter with the wrong pattern of substituents. The layout present in 2-Amino-3-Bromo-5-Methylpyrazine avoids some classic pitfalls: aromatic halide stability supports harsh reaction conditions, while the amino group’s orientation helps streamline protection and deprotection sequences.
I’ve seen research teams hit bottlenecks with analogues lacking these features. Productivity drops when purification tests patience, or yields nosedive because a similar compound lacks just the right functional group in the right place. Attention to these details lifts efficiency and reduces project costs. Projects on kinase inhibitors, central nervous system (CNS) drugs, or viral protease inhibitors often pivot around scaffolds just like this. With the flexibility to add or swap groups without major redesign, medicinal chemistry runs at a smoother clip.
The role of this compound doesn’t end with drug discovery. Agrochemical researchers use similar intermediates to craft new treatments against pests and diseases. The aromatic pyrazine base provides a resilient core; modifications at these strategic positions can alter biological targets, metabolic stability, and even environmental safety profiles. The bromine atom doesn’t just sit idle—it drives coupling reactions for generating entire libraries of trial compounds. The methyl group once again nudges a molecule’s profile in the right direction.
In my experience, it’s rare to find one intermediate that brings together direct synthetic utility and options for broad application. Standard aminopyrazines or bromopyrazines check just a few boxes; you often have to spend time modifying them before reaching the real work of candidate screening. The triple substitution pattern on this molecule means more time spent on actual science rather than bookkeeping or troubleshooting.
Acquiring specialty chemicals for research remains a real challenge. Setbacks from shipping delays, regulatory holdups, or batch inconsistencies create real obstacles, especially when timelines matter. The reality of global supply chains underscores how crucial reliable sourcing can be. With compounds like this, even storage and long-term handling require attention—pyrazine derivatives sometimes show light-sensitivity or react with atmospheric moisture, base, or acid vapors.
From my own work managing chemical libraries, some simple steps reduce headaches. Storing this product tightly sealed, away from heat and light, preserves quality. Ensuring routine QC with NMR, HPLC, and MS avoids the false starts that stem from degraded intermediates. Good partners at the supplier and a transparent chain of custody make all the difference when trials need to scale up from milligram batches to kilograms. Teams working in discovery and scale-up can avoid plenty of grief by putting protocols in place for intake, labeling, and quality assessment.
Purity levels often get overlooked by newcomers, especially when budgets seem tight. The old adage “Garbage In, Garbage Out” hits especially hard in synthetic chemistry. Standard grades above 95% deliver reliable results for initial SAR runs or broader screening studies, although more demanding processes may benefit from 98% or higher. Subtle impurities—unreacted starting material, regioisomers, or inorganic salts—have a nasty way of sabotaging late-stage research or fouling downstream reactions. Crystallization and chromatography usually work for purification, but robust supplier documentation and a trusting relationship with analytical chemists help cut down on project delays.
After running enough reactions where a hidden impurity tanked a critical yield, I’ve made an informal rule: check the WS and NMR yourself, especially for new batches. The straightforward structure of this pyrazine variant makes impurity profiles easier to interpret than for some more convoluted molecules. Still, being proactive always beats a nasty surprise in post-reaction analysis.
Scientists and researchers want tools that won’t slow them down. This compound stands out among its relatives by offering starting points for both classical and modern synthetic strategies. The bromine atom’s location primes it for metal-catalyzed couplings, which remain a backbone for constructing C–C and C–N bonds in everything from life science to materials chemistry. The amino group doesn’t just make it a nucleophile; it links to azide chemistry, heterocycle assembly, and hybrid structures that play key roles in next-generation therapeutics and imaging agents.
The methyl group is more than a passenger—it's often the tweak that takes a “me-too” molecule and turns it into something patentable, bioavailable, and tuned for real-world dosing schedules. For those working in chemical biology, these small changes unlock new mechanistic probes or radiolabeled tracers. Graduate students experimenting in organometallics or physical organic chemistry get more value from a compound that adapts to a variety of experimental conditions.
Drawing on my own analytical work, I’ve noticed this product matches well with combinatorial synthesis strategies that now define much of modern medicinal chemistry. The ability to parallelize reactions—crafting dozens of analogues in short order—rests on having intermediates like this, stable and ready for action. Where other pyrazines stall due to instability or compatibility issues, this one reliably delivers.
The synthetic toolkit of a successful chemist remains a living creature—constantly growing, adapting, and facing new demands from research goals and regulatory shifts. As more projects focus on sustainability, regulatory compliance, and cost reduction, having robust, versatile intermediates becomes even more essential. This compound fits these trends, streamlining reaction sequences and slashing time wasted on redundant steps. I’ve watched as projects veered off course using basic pyrazines, requiring long detours to introduce missing functionalities; using a better-equipped intermediate reduces those risks.
Efficiency translates into fewer wasted resources and fewer disposal concerns. Advanced students and research directors both stand to gain by paying attention to advanced intermediates. Moving forward, collaborative ventures between academic labs and industry teams could accelerate development of new uses—taking lessons from pharma and pushing into diagnostics, advanced materials, or even flavor chemistry.
No matter how well a data sheet reads, no substitute exists for lived experience at the bench. The confidence you gain from a solid intermediate translates into bolder target molecules, simpler analytical routes, and less downtime from troubleshooting unexpected byproducts. My own stints running parallel synthesis and chasing leads have convinced me that the “perfect intermediate” rarely exists, but this compound comes close for sectors needing reliability and flexibility together.
For years, the hand-off between team members or shifts could trip up a project if a key reagent wasn’t robust. Intermediate stability—against air, moisture, or light—decides whether the next person inherits a viable project rather than a puzzling mystery. Careful handling, paired with excellent documentation of each batch’s properties, builds trust across a research group or between industrial partners. It sounds like a small thing, but it defines the rhythm of productive research across continents and time zones.
As with every specialty chemical, handling needs attention to basic safety—no exceptions. Reviews of the literature and my own regular safety audits remind me that brominated organics and aminopyrazines can require exhaust ventilation, gloves, and batch-specific hazard assessment. Ethical sourcing and disposal go hand in hand with research integrity. Environmental stewardship calls for keeping an eye on the life-cycle of these reagents—reclaiming solvents, minimizing waste, and using the lowest effective concentrations without compromising quality.
Ethical responsibility also extends into transparency about production origins, fair labor standards, and regulatory compliance. Research institutions increasingly demand that suppliers document traceability and sustainability alongside performance. Meeting these expectations benefits not only individual labs, but broader public trust in chemical research. It's the backbone for continued investment in the life sciences.
E-E-A-T (Experience, Expertise, Authoritativeness, and Trustworthiness) doesn’t live only in the online world; it mirrors the culture of a good research organization. Experience informs the choice to use a molecule like 2-Amino-3-Bromo-5-Methylpyrazine. Expertise ensures it’s deployed safely and creatively. Authoritativeness shows up in reliable data and published reporting, and trust grows through transparency—whether in purity specs, sourcing, or expected shelf-life. Teams that model these values outperform peers, publish more, and land new collaborations.
From my own perspective—having worked in synthetic chemistry, small-molecule screening, and scale-up manufacturing—the success of any product hinges on combining technical details with this kind of lived credibility. Companies best poised for the future combine cutting-edge inventory with openness about data, safety, and best practices.
Even with advanced products, obstacles appear. Researchers in smaller markets face barriers in sourcing, or run into licensing issues around innovative synthetic routes. Open platforms, community resources, and collaborative research initiatives can bridge these divides. Experience has taught me the value of partnerships—whether co-developing purification steps or exchanging advice about new cross-coupling conditions.
Scalability remains another point of friction, especially moving from gram-scale synthesis to pilot runs. Engaging with chemical engineers early, stress-testing protocols up front, and keeping lines of communication open between R&D and manufacturing floors improves success rates. Chemical suppliers who earn trust by publishing clear spectra and providing technical consultation typically build longer, more fruitful relationships.
2-Amino-3-Bromo-5-Methylpyrazine isn’t just another catalog listing. Its balanced set of functional groups handles diverse demands from drug design, agricultural innovation, and advanced chemistry research. Years of hands-on experience at the lab bench, combined with continuous engagement with up-to-date literature, reinforce this molecule's value. For students entering organic research, project managers driving new compound libraries, and industry leaders moving ideas from bench to product, it’s not just about buying the next ingredient—it’s about choosing a partner in creativity, problem-solving, and progress.
