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2-Amino-2-Thiazoline Hydrochloride

    • Product Name 2-Amino-2-Thiazoline Hydrochloride
    • Alias 2-Amino-2-thiazolinium chloride
    • Einecs 220-975-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    730554

    Product Name 2-Amino-2-Thiazoline Hydrochloride
    Cas Number 156-56-9
    Molecular Formula C3H7ClN2S
    Molecular Weight 138.62
    Appearance White to off-white crystalline powder
    Melting Point 205-210°C (dec.)
    Solubility In Water Freely soluble
    Purity Typically ≥ 98%
    Storage Temperature 2-8°C
    Synonyms 2-Amino-2-thiazolinium chloride
    Density 1.38 g/cm³ (approximate)
    Canonical Smiles C1=CSC(=[NH2+])N1.[Cl-]

    As an accredited 2-Amino-2-Thiazoline Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 25g 2-Amino-2-Thiazoline Hydrochloride is supplied in a tightly sealed, amber glass bottle with a tamper-evident cap.
    Shipping 2-Amino-2-Thiazoline Hydrochloride is typically shipped in tightly sealed, moisture-resistant containers to prevent degradation. It is transported under ambient temperature, following standard chemical safety protocols. Proper labeling and documentation compliant with regulatory guidelines are ensured to avoid hazards during transit. Handle and store in a cool, dry, well-ventilated area upon receipt.
    Storage 2-Amino-2-Thiazoline Hydrochloride should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from sources of moisture and incompatible substances, such as strong oxidizing agents. Store it at room temperature, protected from light and humidity. Ensure container is clearly labeled, and access is limited to trained personnel to avoid contamination and degradation.
    Application of 2-Amino-2-Thiazoline Hydrochloride

    Applications of 2-Amino-2-Thiazoline Hydrochloride in Industrial Manufacturing

    As a dedicated manufacturer, we supply 2-Amino-2-Thiazoline Hydrochloride for established downstream sectors where its unique structure and reactivity play a functional role. On this page, we detail key application scenarios across chemical synthesis, pharmaceutical intermediate production, fine chemical processing, and specialty reagent manufacturing, focusing on how this material directly supports customer formulations, compliance requirements, and industrial-scale production workflows.

    1. Synthesis of Thiourea-Based Pharmaceutical Intermediates

    Manufacturers of thiourea derivatives utilize 2-Amino-2-Thiazoline Hydrochloride as a selective precursor during the preparation of advanced intermediates for cardiovascular and anti-hypertensive APIs. Integrators require a precisely controlled molar ratio to avoid excessive by-product formation, and must demonstrate traceability to pharmacopeial standards. The compound enters the process during condensation steps with isothiocyanate or carbonyl reagents. Finished products include key intermediates used in the synthesis of Imidazoline derivative drugs.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP-NF Monographs for Pharmaceutical Intermediates
    • EDQM CEP compliance for controlled starting materials
    • ISO 9001:2015 Quality Management Systems

    Typical usage ratio

    • 0.8–1.0 molar equivalent relative to target aldehyde or isothiocyanate substrates, with final ratio adjusted based on end-use API impurity profile

    Downstream process integration

    • Added during intermediate stage of batch synthesis after initial activation of carbonyl reactants
    • Purification via recrystallization or liquid-liquid extraction post-reaction

    Final product types

    • Thiazoline-carboxamide intermediates
    • API precursors for Imidazoline pharmaceuticals (e.g., Antihypertensive agents)
    • Custom drug development intermediates

    2. Raw Material for Cyclic Thioether Compound Production

    Producers of cyclic thioether building blocks leverage 2-Amino-2-Thiazoline Hydrochloride as a core synthon for aggregating thiazoline and thiazolidine frameworks applied in crop protection and fine chemical synthesis. Quality assurance requires conformity with food or agri-chemical registration dossiers and trace elemental criteria. The compound acts as a ring-introducing agent via nucleophilic addition and subsequent cyclization with dihalide or oxo-functional reactants, leading to thioether derivatives for downstream formulation.

    Industry compliance standards

    • OECD Guidelines for the Testing of Chemicals - Pesticides and Industrial Chemicals
    • FAO/WHO Specifications for Plant Protection Products
    • ISO 17025 Laboratory Accreditation for Analytical Control
    • REACH Regulation (EC) No 1907/2006 (for European chemical registration)

    Typical usage ratio

    • 10–15% w/w of total stage reactant mass; precise ratio adjusted to manage unreacted amine content and achieve target cyclization yield

    Downstream process integration

    • Introduced during initial cyclization or ring-closing step after mixing with dihalide substrates
    • Subsequent removal of hydrochloride byproduct via filtration or pH adjustment

    Final product types

    • Cyclic thioether intermediates used in fungicide or nematicide manufacture
    • Building blocks for specialized thiol-containing monomers

    3. Precursor in Heterocyclic Dye Intermediate Synthesis

    In dye and pigment industries, companies require heterocyclic ring systems to achieve specific colorimetric and stability properties, often relying on thiazoline cores. 2-Amino-2-Thiazoline Hydrochloride provides targeted nucleophilicity for condensation reactions with aryl aldehydes or dicarbonyl reagents, forming the foundation for vivid and non-fading colorants. Recipe control is critical to ensure batch-to-batch consistency in chromophore generation.

    Industry compliance standards

    • DIN EN ISO 9001:2015 for colorant manufacturing
    • European Regulation (EC) No 1272/2008 (CLP) for classification, labelling, packaging of substances
    • ZDHC (Zero Discharge of Hazardous Chemicals) requirements for textile supply chains
    • EN 71-3 Safety of Toys (for dyes used in toy manufacturing)

    Typical usage ratio

    • 5–12% by weight of total dye formulation, adjusted based on targeted chromophore intensity and solubility requirements

    Downstream process integration

    • Introduced during condensation or coupling reactions as a ring-precursor
    • Colorant crystallization controlled via pH and solvent selection

    Final product types

    • Heterocyclic dye intermediates for textile and polymer coloration
    • Coloring agents for printing inks and writing instruments
    • Organic pigments for plastics and specialty coatings

    4. Specialty Analytical Reagent Manufacturing

    Producers in the analytical chemistry sector use 2-Amino-2-Thiazoline Hydrochloride in the formulation of selective derivatization agents for detecting nitrile, aldehyde, or certain alkyl halide functionalities in advanced analytical workflows. Downstream users require precise documentation of trace impurities and must satisfy metrological traceability for high-purity applications. The material is typically used during synthesis of calibration standards or detection reagents in controlled lab environments.

    Industry compliance standards

    • ISO 17034:2016 General requirements for reference material producers
    • USP Reference Standards (for analytical characterization)
    • OECD GLP Principles for test facility operations
    • ISO/IEC 17025:2017 for chemical analysis laboratories

    Typical usage ratio

    • 0.02–0.1 mmol per gram of sample matrix, set as per detection limit and sensitivity requirements of the analytical method

    Downstream process integration

    • Used as a derivatization agent during sample preparation stage
    • Reacts with functional group targets under mild conditions to form analysis-ready complexes

    Final product types

    • High-purity derivatization reagents for chromatography
    • Analytical standards for quantitative chemical assays
    • Detection kits for environmental or pharmaceutical quality control
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    Certification & Compliance
    More Introduction

    2-Amino-2-Thiazoline Hydrochloride: Insights From the Plant Floor

    What Sets Our 2-Amino-2-Thiazoline Hydrochloride Apart

    Bringing 2-Amino-2-Thiazoline Hydrochloride to life inside a chemical plant demands focus on detail and a lean operation. Over the years, we’ve learned that clear product quality stands above industry noise. Every batch carries a signature that only a producer could recognize — the sharp crystalline structure, high purity, and trusted consistency. Operators here can spot a well-run reaction long before instruments deliver confirmation. Confidence in the reaction vessels spills over into confidence at the loading dock. Steady hands and vigilant eyes track purity, color, and flow rates, catching even minute variations that impact the final outcome for clients using this intermediate.

    Why Quality Control Starts Long Before Synthesis

    Reliable production of 2-Amino-2-Thiazoline Hydrochloride relies on controlled sourcing. We insist on verifying every lot of raw material, measuring water content, particle fineness, and clocking every drum arriving in our yard. Not every supplier stands up to cold winter deliveries; some lose integrity en route. Our relationships with longstanding upstream partners help us lock in those finer quality details. Every minor deviation shows up in the reactor — a lesson learned from experience. As the material enters our process, experienced operators check viscosity, pour properties, and color with the sort of scrutiny born of pride and necessity. These small steps let us avoid costly adjustments downstream.

    Synthesis Demands Hands-On Expertise and a Mind for Safety

    In our experience, the synthesis of 2-Amino-2-Thiazoline Hydrochloride thrives under tight temperature and time controls. Operators track exothermic peaks, and slight off-gassing gets noticed along the way. Each batch goes through scheduled sampling across the reaction timeline. Titrations confirm progress, and the operators — some with decades behind the glass panels — adjust feeds as aromas and colors evolve. Evacuation protocols kick in if thresholds cross. This level of fine-tuned management shows itself in clean, uniform product from batch to batch.

    Purity: A Real-World Concern

    For years, we’ve fielded requests for “lab grade” purity while keeping one eye on scale-up consistency. Industrial requirements rarely match academic ideals. Every client comes with a different need: some demand minimum detectable impurities for pharmaceutical research, others lean toward cost performance in bulk processes. Persistent trials helped us lock in the sweet spot — purity levels that stand up to both chromatographic analysis and demanding downstream processes, without pushing costs through the roof. Feedback from users points toward ease of solubility and the absence of secondary crystallization during storage. Neither comes by accident — decades of batch records build this reliability.

    Understanding the Specifications

    Within the plant, numbers are more than technical markers. When we talk about the molecular formula (C3H6N2S·HCl) or the expected melting point, these points matter most to engineers establishing new applications or running compliance testing. Typical output here runs to a purity of 98% or above, monitored lot by lot. Physical qualities like fine powder appearance and a distinctly sulfurous aroma remain benchmarks for our experienced staff. For those working with automated material handling, consistent particle size and free-flowing nature of our product means no lost time breaking clumps or coaxing material through feeders. These seemingly small manufacturing details matter every day for people one or two steps downstream.

    Beyond the Standard: Usability and Performance

    Working alongside researchers and process chemists, we listen for practical feedback. In pharmaceutical synthesis, 2-Amino-2-Thiazoline Hydrochloride serves as an intermediate, especially where heterocyclic ring structures require precise placement of sulfur and nitrogen. Process developers comment on our product’s ability to dissolve quickly without residue clogging filters or reacting vessels. Others come back, year after year, for repeat orders with identical physical characteristics. For chemical synthesis, batch-to-batch consistency and freedom from trace metals prevent repeated troubleshooting steps. Commercial success in this space comes not from generic claims but from solving the small frustrations that disrupt large-scale synthesis.

    Contrast With Other Chemicals or Grades

    Many clients ask how our 2-Amino-2-Thiazoline Hydrochloride stacks against other common thiazoline intermediates. Some products in the market show yellowish tints or variable powder density. Direct experience shows us that instability under ambient humidity causes clump formation over time, reducing usefulness in automated dosing or when preparing solutions. Other grades, pressed for price, sacrifice purity and lead to residual byproducts disrupting sensitive reactions. We have received samples from competitors that show visible dark specks or generate strong, unpleasant odors, both of which indicate incomplete purification or degraded material. Our process rejects these subpar lots before any such product reaches our warehouse.

    From our vantage point in manufacturing, we favor neither theoretical purity nor the lowest price point at the cost of compatibility or user safety. Some suppliers push higher yields with shortened reaction times, but this method often leads to compromised product lifespan during storage. We lean on slower, controlled crystallization and multiple filtration steps. These choices bring extra labor time but pay off by giving clients a trouble-free handling experience. Plant staff check samples after months of storage for consistency in moisture pick-up and physical handling. Reliability across the calendar marks the difference between specialty chemical production and broad commodity trading.

    Applications: What We’ve Learned From End Users

    Real-world usage often tells the clearest story. Many clients synthesize advanced pharmaceutical compounds from our 2-Amino-2-Thiazoline Hydrochloride, while others focus on building-block synthesis for agrochemical development. Over the years, we’ve shipped to both bench-scale research and high-volume continuous operations. Plant operators often select this intermediate for its compatibility with a range of solvents and the ease with which they can introduce it to multi-step synthesis sequences. One critical property, highlighted in frequent user requests, is the product’s minimal tendency to form secondary salts during aqueous reactions — an advantage born of strict process control and thorough washing during finishing.

    In lab-scale research, we see requests for small, well-packaged aliquots, which we accommodate with special filling lines. In contrast, large chemical companies benefit from our ability to load bulk drums or lined IBCs without cross-contamination worries. Every sector points toward the fundamental need for clear labeling, traceability, and rapid documentation. Our records stretch back decades, and we consistently handle compliance documentation for analysts or regulatory affairs professionals in the pharmaceutical and agricultural sectors.

    Form Handling in Plant Settings

    Handling and storage lie at the core of day-to-day practical use. To ensure safe arrival and easy use, our facility engineers design packaging around the realities of moisture uptake and electrostatic charge. Operators on the floor refill production hoppers, monitor silo condensation, and notice the flow of powder into mixing tanks. They’ve learned where clogs can form and which transfer machines best maintain product integrity without dust release. For smaller facilities, ease of resealing and clear package labels reduce waste and provide more consistent usage data batch after batch. These nuts-and-bolts lessons, logged over years of operation, drive every improvement we make to packaging.

    Product Stability in Storage and Transit

    Transporting 2-Amino-2-Thiazoline Hydrochloride across climates, from humid subtropical regions to dry continental winters, presents challenges. Our shipping department tracks transit conditions, learning which times of year and which freight forwarders best protect our product’s stability. Strict in-house storage protocols — temperature, atmospheric pressure, and light exclusion — help us replicate those benefits for users storing product for months on end. Quality rotas run regular stability tests, trialing older inventory and monitoring for clumping, color change, or loss of free-flowing characteristics. Once, a winter shipment indicated trace water accumulation inside drums. Immediate corrective action at the filling stage led to revised protocols and shared learnings with the field team. End users now remark on the product’s shelf life and reliable performance regardless of location.

    Safety Experience From Our Operators’ Perspective

    Nothing matters more on the production line than safety. Workers here stay up-to-date on safe handling practices, supported by site managers who insist on routine hazard reviews. Each process step pulls from experience — not only theoretical hazard statements but stories told over lunch about spills, dust containment, or accidental exposure. Cleaning schedules and real-time process monitoring get woven into the daily rhythm. Proper PPE and ventilation systems built into every room reduce incidents and product loss. When safety improves, morale rises, and absenteeism drops. This direct connection between quality and workplace safety shapes our approach to every aspect of production.

    Traceability and Documentation Backed by Experience

    Compliance documentation proves its worth in the trenches of bundled audits and supply chain verifications. Our team keeps complete records by digital and paper backup. At any time, we pinpoint batch lineage, production logs, and region of origin for raw materials reaching back years. Quality managers organize regular self-inspections, ensuring records match ground-level reality for every packaged lot. For pharmaceutical and agricultural users, this transparency removes uncertainty when building or expanding new processes. Regulatory authorities often request full test data, including residual solvent analysis, for multiple years at a time. We deliver these details, matching our in-house test results with independent third-party verification whenever requested.

    Troubleshooting: Shared Solutions Across Industries

    Operating on the manufacturing front lines delivers repeated reminders that challenges can crop up anytime along the supply chain. One year, a sudden spike in humidity inside a shipping container increased product clumping for several shipments. Reaching out to downstream users, we learned which clumping caused process delays and which went unnoticed. Adjustments to liner thickness and desiccant sachet type followed, and future issues dropped sharply. Communication remains open with every recurring customer for just these situations. Working groups from both our plant and customer sites regularly discuss any product performance anomalies, building solutions rooted in both practical plant experience and rapid feedback cycles.

    Collaborating on Tailored Solutions

    Every new client brings fresh process requirements. Some request custom particle sizes to fit unique feeders, while others push for improved filtration profiles in target applications. Sales and technical support teams coordinate directly with production engineers to adjust process parameters in real time. All changes get validated in trial batches and shared for customer approval before scaling up. Regular workshops and plant tours cement relationships, letting users see firsthand how operational excellence translates into the finished material.

    Product Integrity: Protecting Customers’ Interests

    The market sees fluctuations in both raw material cost and product availability. Maintaining reliable production floors means acting early, securing multiple supply lines, and building buffer stocks. Difficult times — raw material slowdowns, freight disruptions — test these preparations. Varied lot testing, drum tracking, and production contingency plans have prevented order shortfalls across regional and global customers. Each crisis leads to process improvements. Plant supervisors maintain frequent review sessions to update staff on lessons learned and revisit older incidents. By emphasizing transparency and traceability, we have built trust that holds through unpredictable circumstances.

    Open Door to Further Innovation

    Chemical manufacturing never stands still, especially for specialty intermediates like 2-Amino-2-Thiazoline Hydrochloride. Collaboration with universities, participation in industry-standard panels, and close ties to innovation clusters have opened doors to better catalysts, greener process routes, and energy-saving protocols. As customer applications shift toward lower carbon footprint or greener chemistry mandates, plant managers and R&D teams share feedback on process optimization. Years of operation taught us that change becomes sustainable only when each level of production, from operators to senior engineers, gets involved early and sees clear benefits. Continued dialogue ensures the needs of research labs, pilot plants, and full-scale industrial users remain in focus.

    Continuous Learning Grounds Our Commitment

    Motivated by daily interactions with people who depend on our product, everyone at the facility brings their own pride and expertise to the floor. Some draw from years of practice on packaging lines, others from nuanced control over reaction environments. Peer-to-peer training, frequent in-house upskilling, and a shared commitment to transparency drive not just compliance, but steady improvement. Each improvement feeds back into the next run: higher yield, purer product, fewer batch hiccups, easier handling. This cycle of learning and applied experience protects customer relationships, supports ongoing process improvement, and reaffirms our commitment as experienced, hands-on manufacturers of 2-Amino-2-Thiazoline Hydrochloride.