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2-Acetylaminopropionic Acid

    • Product Name 2-Acetylaminopropionic Acid
    • Alias N-Acetyl-DL-alanine
    • Einecs 204-812-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    560103

    Chemical Name 2-Acetylaminopropionic Acid
    Molecular Formula C5H9NO3
    Molecular Weight 131.13 g/mol
    Cas Number 56-10-0
    Appearance White to off-white crystalline powder
    Melting Point 180-184°C
    Solubility Soluble in water
    Pka 2.16 (carboxylic acid), 9.13 (amino group)
    Iupac Name 2-acetylaminopropanoic acid

    As an accredited 2-Acetylaminopropionic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 500g package of 2-Acetylaminopropionic Acid comes in a sealed, amber glass bottle with a tamper-evident cap and clear labeling.
    Shipping 2-Acetylaminopropionic Acid is shipped in secure, tightly sealed containers to prevent contamination and moisture exposure. It should be packed according to safety guidelines for chemical substances, clearly labeled, and transported under cool, dry conditions. Handle with care, avoiding direct contact, and follow all relevant transport regulations for safe delivery.
    Storage 2-Acetylaminopropionic acid should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from incompatible substances such as oxidizing agents. Protect it from moisture and direct sunlight. The storage temperature should ideally be kept at room temperature (20–25°C). Always follow proper chemical safety protocols and consult the Safety Data Sheet (SDS) for additional storage recommendations.
    Application of 2-Acetylaminopropionic Acid

    Applications of 2-Acetylaminopropionic Acid in Industrial Manufacturing

    As the actual manufacturer of 2-Acetylaminopropionic Acid, we maintain strict control over material quality and downstream supply. The compound serves as a critical intermediate in several specialized sectors, each with distinct compliance, usage, integration, and final product requirements. Below, we detail application scenarios validated by industrial practice and regulatory oversight.

    1. Pharmaceutical Intermediates for Chiral Drug Synthesis

    2-Acetylaminopropionic Acid is widely used in the synthesis of non-proteinogenic chiral amino acid side chains for active pharmaceutical ingredient (API) manufacture. It provides a key building block for beta-lactam antibiotics and select antiviral agents, where optical purity and traceability are crucial. Process engineers in pharmaceutical plants incorporate the material during stage-gating amid multi-step synthesis, often integrating through amidation and deprotection stages. GMP compliance and batch release testing are mandatory throughout. Sophisticated control over ratio and purity underpins downstream API yield and crystallinity.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) monographs where applicable
    • European Pharmacopoeia (Ph. Eur.) guidance for raw materials
    • FDA 21 CFR Part 210/211 for drug substance production

    Typical usage ratio

    • 5–25 mol% relative to target API batch, with adjustment according to process yield and contaminant profiles; exact ratio defined by patented synthetic routes.

    Downstream process integration

    • Added at amidation or acylation stages following base-catalyzed protection.
    • Demands rigorous in-process control and HPLC monitoring post-reaction for enantiomeric excess.
    • Integrated in closed system reactors to avoid contamination.

    Final product types

    • Beta-lactam antibiotic APIs (e.g., cefadroxil intermediates)
    • Non-standard amino acid derivatives for antiviral pharmaceuticals
    • Advanced intermediates for peptidomimetic drugs
    • Pharmaceutical reference standards for chiral analysis

    2. Peptide Synthesis for Research and Diagnostic Kits

    This compound sees frequent use in the manufacturing of custom peptides for use in pre-clinical research and commercial diagnostic enzymes. Biotech plants leverage its stability and reactivity within Fmoc- or Boc-based solid-phase peptide synthesis (SPPS). Equipment operators dose the compound during the elongation steps of peptide chains, triggering controlled coupling reactions. Assays and diagnostic kit manufacturers further extend its value by verifying sequence integrity and purity in final products through LC-MS and MALDI-TOF methods, strictly following ISO and GLP requirements for batch traceability.

    Industry compliance standards

    • ISO 13485 Medical Devices Quality Management for diagnostic reagent production
    • Good Laboratory Practice (GLP) for research-use-only (RUO) materials
    • OECD Guidelines for Testing of Chemicals in analytical kit production

    Typical usage ratio

    • 1–10% w/w per total amino acid load in SPPS resin, with adaption for chain length; selection based on target sequence complexity.

    Downstream process integration

    • Incorporated at controlled steps during peptide chain assembly via automated synthesizers.
    • Requires direct coupling with activating agents (e.g., HATU, DIC).
    • Material feed and solvent systems undergo pre-validation for every batch.

    Final product types

    • Custom research peptides for in vitro screening
    • Enzyme-linked immunosorbent assay (ELISA) substrates
    • Diagnostic peptide markers embedded in commercial kits
    • Labeled peptides for mass spectrometry calibration

    3. Agrochemical Synthesis for Selective Herbicides

    2-Acetylaminopropionic Acid functions as a targeted intermediate in the supply chain for selective post-emergence herbicides, particularly those acting on amino acid biosynthetic pathways in plants. Agrochemical manufacturing plants introduce the compound during early condensation or alkylation reactions, proceeding under tightly controlled thermal and solvent conditions to ensure desired isomeric purity. Process protocols incorporate rigorous hazard analysis and adherence to environmental emissions regulations throughout scale-up. Material selection criteria stem from regulatory-defined residue limits and downstream crop safety evaluations.

    Industry compliance standards

    • FAO/WHO Manual on Development and Use of FAO and WHO Specifications for Pesticides
    • REACH (EC) No 1907/2006 Registration, Evaluation, Authorisation and Restriction of Chemicals
    • ISO 9001 Quality Management for agrochemical formulation plants

    Typical usage ratio

    • 1.2–3.5% w/w of total reaction mass, adjusted according to target herbicide structure and impurity profile mandated by registration dossiers.

    Downstream process integration

    • Loaded at the initial condensation step; involvement in side-chain assembly of active herbicide precursors.
    • Requires integration in jacketed reaction vessels under inert atmosphere.
    • Subject to intermediate QC sampling for residue qualification.

    Final product types

    • Selective post-emergence herbicide technicals for cereal crops
    • Ready-to-use granular herbicide blends
    • Emulsifiable herbicidal concentrates
    • Intermediates for further transformation into pro-herbicides

    4. Specialty Material Modification in Polymer Additives

    Producers of performance polymers and specialty plastics use 2-Acetylaminopropionic Acid to modify surface and bulk properties in engineering resins. The raw material participates in side-chain functionalization of polyamide and polyurethane series, providing increased hydrophilicity, anti-fouling attributes, or enhanced dye affinity. Manufacturing lines meter the acid during polycondensation or chain-extension steps, with the reaction route aligning to internal R&D protocols and material compatibility assessments. Extensive focus is placed on compliance with both industrial and end-user safety directives when applying to components that may contact food or sensitive technologies.

    Industry compliance standards

    • EU Regulation (EU) No 10/2011 on plastic materials intended to come into contact with food
    • ISO 10993-5 Biological evaluation for medical-grade polymers
    • RoHS Directive 2011/65/EU for restriction of hazardous substances
    • ASTM D638 for physical testing of polymer specimens

    Typical usage ratio

    • 0.2–2.5% w/w based on total monomer feed, with precise dosage set after evaluating polymer performance and target regulatory limits for migration or extractables.

    Downstream process integration

    • Charged into reaction vessels during resin melt or solution polymerization steps.
    • Requires in-line viscosity and FTIR spectroscopy monitoring for batch reproducibility.
    • Commonly followed by melt extrusion or solvent casting based on application.

    Final product types

    • High-performance engineering polyamides for automotive parts
    • Hydrophilic polyurethane coatings for water-contact equipment
    • Specialty fiber additives for medical textile applications
    • Plastics with improved printability and dye uptake for consumer goods
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    Certification & Compliance
    More Introduction

    Understanding 2-Acetylaminopropionic Acid: Our Approach to Reliable Chemical Production

    Direct from the Manufacturer: What Sets Our 2-Acetylaminopropionic Acid Apart

    Manufacturing 2-Acetylaminopropionic Acid has taught us that chemical quality begins with process discipline and ends with knowing how subtle changes can shape outcomes. We work with 2-Acetylaminopropionic Acid for its consistent demand in pharmaceutical and biochemical research. Every batch reflects a balance of reliable raw materials, controlled reaction conditions, and in-house purification steps. Our production never gets outsourced or handed off; everything stays under our roof, so we witness every phase from synthesis to final analysis. Experience shows impurities are never just numbers on a certificate—they affect crystallization, stability, and downstream use.

    This compound, recognized by its systematic structure and straightforward acylamino derivative of propionic acid, finds its core usages in custom peptide synthesis, as a reference standard, and in several lab-based applications. We noticed early on that differing purity demands meant no single “model” fits every request. We offer both regular-lab and high-purity grades, and these correspond not only to stricter impurity profiles, but also tighter controls on moisture and trace organics. Strict management of batch records and analytical runs mean that when users compare our regular grade to our premium pharmaceutical-intermediate grade, the distinction is more than label-deep: we back it with chromatography, reference spectra, and repeatable test results.

    2-Acetylaminopropionic Acid seldom comes up as a household name, but researchers and formulation chemists respect what dependable materials can do for reproducibility. Our team engages directly with feedback from academic labs, contract research users, and R&D teams. Some want to dissolve it for reaction substrates, others for calibration standards. Dissolution rates and pH handling come up routinely, so we track solubility curves and measure ionization under buffered conditions. This helps in fields like peptide coupling, where minor contaminants can stall a whole synthetic route. Our more experienced clients trace batch lot numbers back through their own results—and we think that kind of accountability should define specialty chemical manufacturing.

    A routine week in our plant involves lining up vacuum filtration, batch reflux, and careful monitoring of pH and temperature controls—each parameter learned through years of handling 2-Acetylaminopropionic Acid batches. We learned early on that relatively small mistakes ruin homogeneity and create headaches for downstream recrystallization. We chose to invest in continuous in-line monitoring, plus regular checks under both HPLC and NMR. Trace solvents and side products need attention, and this keeps the specification real, not just a theoretical target.

    It’s not just about ticking boxes for assay and melting point; users of our 2-Acetylaminopropionic Acid ask for evidence beyond numbers. We keep vials from every lot so customers can request re-testing months or even years later. Reliable identification—backed by spectral data—counts more than anything else in materials with a defined structure. That’s why we log every run, keep thorough chromatic baselines, and share them when requested.

    The Differences You Can See: How Our Product Divides from Others

    Most labs have come across 2-Acetylaminopropionic Acid as a raw reagent or standard, but not every batch on the market meets the same expectations. Through direct experience, we know that some market offerings get bottled by third-party blenders or resellers—these often show up with inconsistent color, residual solvent odors, or vague batch records. Unlike resellers, we operate our own reactors, so we never lose track of a lot. Every process improvement gets tested on-site, and batch-specific data never comes from outside labs we can’t audit. If 2-Acetylaminopropionic Acid arrives at your lab with inconsistent melting or unexpected spots on a TLC plate, you feel the difference immediately. We’ve worked with quality teams who run into delays from crude inter-batch blending—waiting on a reliable lot can stall a research project fast.

    Our specification roots itself both in literature precedents and in the lessons learned after working alongside formulation chemists. Purity matters, but users ask for defined water content, consistent particle size, and clarity on ionic composition, especially in the context of analytical standards. Large distributors might label batches as “meets standard,” but our experience shows that reporting on minor volatile impurities or low-level inorganics, even when the guidelines don’t require it, prevents downstream problems. End-users who run liquid or gas chromatography comment that drifting background can trace right back to converter solvents—so we publish residual solvent levels openly.

    Comparison shouldn’t stop at purity. For pharmaceutical use, we go beyond minimum compliance, running additional screens for likely genotoxic impurities, and submitting reference samples for outside proficiency testing. These steps don’t just check regulatory boxes—they help our customers avoid re-validation. On technical grades, we watch for practical matters: powder flow for automated dosing, clump resistance in storage, and color stability across the supply chain. There’s little room for ambiguous labeling or undocumented alterations between production and customer delivery in our operation.

    Why Usage Context Matters: Lessons from Working with Our Customers

    Diverse applications of 2-Acetylaminopropionic Acid taught us that controlled sourcing supports every project downstream. In peptide chemistry, the presence of even minor side-products easily complicates deprotection and coupling cycles. Some clients working on enzyme inhibition research find that background reactivity from a single misplaced peak causes significant setbacks, so we keep a standard of rigorous subtraction, running deeper impurity profiles whenever unusual signals arise. Diagnostic labs sometimes use our compound as part of standardization or reference tests; these orders require full documentation, and we learned long ago to keep both digital and archived paper records accessible for regulatory review.

    Not all usage fits neat categories. Contract manufacturers purchase our higher grade to avoid risk of cross-contamination in their own multi-step syntheses. Startups operating in the specialty pharma space tend to order smaller quantities with more frequent re-testing, so we adapted our batch reservation and lot tracing accordingly. This adds complexity on our end but keeps end-users supplied with exactly matched lots for trial, scale-up, and pilot production.

    Customers depend on our transparency not because it’s an industry slogan, but because once the material leaves our hands, control over outcomes relies on the confidence they have in the data provided alongside the shipment. We include full chromatograms, spectra, and identity confirmation for each lot. It’s a routine, not a special request, because we learned from feedback it helps labs avoid error-prone analysis and shortens time-to-result.

    Common Challenges and How Direct Chemical Manufacturing Faces Them

    Producing 2-Acetylaminopropionic Acid in a real plant means adapting to variables, not just offering certificate-based compliance. Raw materials fluctuate in purity; temperature control sometimes slips in older equipment; trace humidity creeps in during open-handling or weighing. Where mass producers might average out issues, we address them batch-to-batch.

    Quality hinges on human judgment as well as instrumentation. Questionable test values don’t get ignored; our analysts repeat runs, hunt outliers, and revise processes if results look off-pattern. We set up a closed feedback loop connecting operations with downstream users—if a customer’s chromatogram flags an unexpected impurity, we go back to our retained samples and dig deeper.

    Traditional challenges meet practical solutions. Static charge from powder handling can skew weighing, so we modified our setup to control the local environment. Cross-contamination once meant delayed shipping and costly recalls. We redesigned transfer bins and added equipment that can be fully dismantled for cleaning. Our batch coding system limits the risk that a lot goes astray.

    Resilient supply is a theme we hear from experienced buyers in pharmaceutical, chemical, and life sciences R&D. Even the most reliable compound becomes a bottleneck if delivery stops. We keep safety inventory on hand, invest in redundant filtration, and keep supplier scoresheets for those who provide our starting materials. If we see a trend in stockout risks—like global events causing disruptions—we adjust our schedule and inventory protocols.

    Environmental factors factor into long-term supply. Energy usage, waste volume, and reuse of solvent all get tracked and reported. We trim what we can from process water use and recover solvents for reprocessing, keeping output consistent but mindful of regulatory landscapes changing beneath our feet. All documentation and process logs stay audit-ready because government and customer scrutiny only builds trust with facts, not with promises.

    The Technical Path and How We Evolved Alongside 2-Acetylaminopropionic Acid Demand

    Our product history with 2-Acetylaminopropionic Acid starts with classic batch chemistry but advances each year as market needs shift toward more robust analytical documentation and lower process residues. We’ve moved from simple melting point and NMR identity checks to fuller impurity profiling, including GC for trace volatiles and moisture analysis by Karl Fischer titration. Years of batch logbooks fill our archives—a source of collective memory for every tweak, side-reaction, or process adaptation that yielded better purity or yield.

    We learned to listen to customers who ran into quality issues after buying other sources. Sometimes, it was incomplete drying, sometimes a single major side-product left from incomplete washing. Organic synthesis is unforgiving, and labs reported full runs getting scrapped. Over time, we became proactive—checking for common side-substituents that can arise from incomplete acylation, or from contaminated reagents. Owning the full value chain means modifying locks, interlocks, and scheduling so one production never contaminates another.

    Research applications also demand flexible logistics. Product re-shipping, recall, or re-testing takes priority over volume. Smaller pack sizes, vacuum-sealed containers, and tamper-evident packaging all stemmed from industry requests, and from our own field audits that revealed just how easily damage can occur in transit. Our solution: adapt shipping protocols, batch sizes, and internal labeling so that every box, drum, or vial maintains the traceability expected at regulatory audit.

    We study international guidelines on reference material handling, adapting labeling and production logs to match wherever shipment lands. As regulatory frameworks evolve, so does our approach to producing 2-Acetylaminopropionic Acid—flexibly scaling lot sizes up or down to fulfill R&D orders, pilot runs, or repeated confirmations for validated analytical tests.

    Why Direct Manufacturing Changes the Conversation on Quality

    Working hands-on in chemical production changes the way a team views responsibility. We are not just filling an order; each run represents both our reputation and the culmination of hard-won process experience. Customers approach us with challenging questions about trace elements, regulatory compliance, or the subtleties of chromatographic background—questions we can answer with direct references to the process, raw material records, or in-house analytical data. We do not rely solely on standard templates, since each batch tells a detailed story.

    We learned to say yes to lot-specific documentation, to open audit requests, and to rapid troubleshooting when a peculiar test result shows up, because these actions reflect the expectations of seasoned chemists and regulators. Quality ceases to be an abstract concept and becomes instead the track record built by every hour in the lab, each equipment upgrade, and all the logbook notes written over years of production.

    Traceability is non-negotiable in our operation. By keeping every process in-house—from sourcing through final QC—we offer more than just “compliant” lots. Every certified vial comes from a chain of custody we can verify, defend, and supplement with spectra or method detail upon request. This approach has resolved many issues quickly when a regulatory or research user called for additional data or an unusual secondary standard.

    Our direct experience shapes how we handle and report stability, shipping risk, and even storage. A simple missed step—like incomplete drying—can put a whole run out of specification for high-purity applications. By running stability tests under a range of conditions, we collect data that allows us to give realistic advice on storage, transit, and secondary repackaging.

    Closing Thoughts on 2-Acetylaminopropionic Acid from the Perspective of Practical Manufacturing

    Chemical manufacturing remains a business of details, full of lessons learned from thousands of production hours and feedback from professionals who depend on each compound’s consistency. 2-Acetylaminopropionic Acid forms a small but critical part of modern chemical research and development. Our commitment as a direct manufacturer translates into a partnership, not just a transaction. Every analyst, every batch log, and every QC technician under our roof contributes to turning a theoretical structure into a reliable lab material.

    Having seen results from dozens of customer projects, we know that an authenticated lot of 2-Acetylaminopropionic Acid can make or break a multi-month R&D campaign. Producing it in-house, controlling every purification step, allowing traceability from raw material to finished lot number—these principles grow out of real-world needs, not from generic descriptions. When customers ask for evidence, context, or tailored batch support, our operation responds from direct experience—supported by data, records, and an open line of communication right back to the production floor.

    Years of hands-on manufacturing mean we recognize that quality never comes from shortcuts or marketing gloss. Instead, confidence in scientific outcomes grows from each process decision, each check on impurities, and the willingness to engage with users at every stage of the production journey.