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2-Acetyl-3-Methylthiophene

    • Product Name 2-Acetyl-3-Methylthiophene
    • Alias 2-AMT
    • Einecs 242-017-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    818294

    Name 2-Acetyl-3-Methylthiophene
    Cas Number 13679-70-4
    Molecular Formula C7H8OS
    Molecular Weight 140.20 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 231-233 °C
    Melting Point -19 °C
    Density 1.12 g/cm³
    Refractive Index 1.568
    Flash Point 97 °C
    Smiles CC1=CSC(C1)=O
    Synonyms 3-Methyl-2-acetylthiophene
    Solubility Slightly soluble in water
    Purity Typically ≥98%

    As an accredited 2-Acetyl-3-Methylthiophene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 2-Acetyl-3-Methylthiophene is packaged in a 100 mL amber glass bottle with a secure screw cap and hazard labeling.
    Shipping 2-Acetyl-3-Methylthiophene is shipped in tightly sealed containers, protected from light and moisture. It should be handled as a flammable liquid, compliant with relevant hazardous materials regulations. During transit, it is packed with cushioning material and appropriately labeled according to UN and DOT guidelines to ensure safe and secure delivery.
    Storage 2-Acetyl-3-Methylthiophene should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Keep the container tightly closed and protected from direct sunlight. Store in a chemical storage cabinet, preferably dedicated to flammable or organic chemicals. Properly label the container and follow standard safety precautions during handling and storage.
    Application of 2-Acetyl-3-Methylthiophene

    Applications of 2-Acetyl-3-Methylthiophene in Industrial Manufacturing

    As a direct manufacturer, we supply 2-Acetyl-3-Methylthiophene of high chemical purity for advanced industrial applications across multiple specialized downstream sectors. Below, we outline the main application areas, specific downstream integration points, compliance frameworks, process details, and typical finished products made using our material.

    1. Pharmaceutical Intermediate Synthesis

    In the pharmaceutical industry, 2-Acetyl-3-Methylthiophene serves as a valuable intermediate for the synthesis of active compounds, especially in the production of thienopyridine-based drugs. Formulators use it during targeted condensation reactions to build key bicyclic structures required for certain antiplatelet medications and anti-inflammatory agents. Quality assurance teams must check thorough removal of residual starting materials to meet finished API purity targets. Process engineers closely control reaction conditions—temperature, time, and solvent profile—to maximize throughput without sacrificing selectivity.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • EU GMP for APIs
    • US FDA 21 CFR Part 211
    • Chinese Pharmacopoeia (for qualifying intermediates for export drug production)

    Typical usage ratio

    • 0.2–2.5 molar equivalents in stepwise synthesis; ratio adjusted per downstream target API, route, and scale

    Downstream process integration

    • Used during multi-step synthetic route to thienopyridine derivatives
    • Introduction at heterocyclic ring-forming step, preceding coupling and subsequent purification
    • Monitored for complete conversion to target intermediate before further processing

    Final product types

    • Key intermediates for clopidogrel or ticlopidine family
    • Specialty thienopyridine APIs
    • Custom pharmaceuticals based on modified thiophene skeletons

    2. Aroma and Fragrance Ingredient Manufacturing

    Flavor and fragrance companies employ 2-Acetyl-3-Methylthiophene as a potent odorant with roasted, sweet, and nutty notes. It finds use in low dosages for specialty blends that mimic cooked food aromas, as well as high-impact flavorings for beverages and processed foods. Formulators use precision dosing by weight or in solution, as even minor deviations affect final product profiles. Our material meets industry requirements for absence of prohibited contaminants like heavy metals, amines, and phthalates.

    Industry compliance standards

    • IFRA Code of Practice (for fragrance use)
    • US FDA 21 CFR §172.515 (Synthetic flavoring substances)
    • EU Regulation (EC) No 1334/2008 (Food flavorings)
    • Japan Food Additive Standards

    Typical usage ratio

    • 0.002–0.05% w/w in fragrance compositions; up to 1 ppm in finished food flavoring

    Downstream process integration

    • Blended during final fragrance compounding or food flavor formulation
    • Diluted in ethanol, propylene glycol, or triacetin as carriers for better dispersion
    • Subjected to GC–MS profiling and sensory evaluation during QC

    Final product types

    • Coffee, cocoa, and nut flavorings
    • Roasted meat or savory snack seasonings
    • Perfume top and middle notes for edible and personal care fragrances
    • Specialty e-liquid flavors

    3. Agrochemical Active Ingredient Production

    Agrochemical producers implement 2-Acetyl-3-Methylthiophene as a sulfur-containing intermediate for building select insecticide and fungicide molecules. It acts as a sulfur and aromatic group donor during the cyclization or coupling reactions that form bioactive heterocycles. Manufacturers require tight batch-to-batch control of impurity levels to satisfy downstream product registration demands. Application engineers manage supply logistics for integration into continuous or batch agrochemical synthesis workflows.

    Industry compliance standards

    • FAO/WHO Specifications for Pesticides
    • EU Regulation (EC) No 1107/2009 (Plant Protection Products)
    • US EPA Active Ingredient Registration Data Requirements (40 CFR Part 158)

    Typical usage ratio

    • 0.15–1.0 molar equivalents per step, scale based on downstream pesticide formulation

    Downstream process integration

    • Charged as a key precursor in base-catalyzed condensation or aromatic substitution
    • Followed by further functional group modification and AI isolation
    • Integrated with batch sequencing for scale-up to commercial quantities

    Final product types

    • Broad-spectrum fungicide technical concentrates
    • Systemic insecticide actives based on thiophene structures
    • Ready-mix agrochemical formulations for crop protection

    4. Specialty Electronic and OLED Material Synthesis

    Electronics and optoelectronic firms source 2-Acetyl-3-Methylthiophene for chemical construction of advanced thiophene-based monomers and oligomers. These intermediates contribute essential electronic properties—charge mobility, bandgap tuning—to organic light-emitting diode materials and conductive polymers. Production chemists run stringent purification and analytical confirmation, including HPLC and NMR identity checks, before forwarding to device manufacturers. Ensuring absence of metal contaminants and low water content supports application in high-purity electronics standards.

    Industry compliance standards

    • IEC 61249-2-21 (Material standards for electronic components)
    • JEITA ET-7304 (Testing methods for organic electronic materials)
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals, for export within the EU)

    Typical usage ratio

    • 10–30 wt% of total monomer mix; adjusted based on target charge transfer characteristics

    Downstream process integration

    • Initiates monomer synthesis via Friedel-Crafts acylation and subsequent polymerization
    • Feeds downstream continuous flow or batch reactors for custom oligomer production
    • Subjected to controlled precipitation and drying pre-device integration

    Final product types

    • OLED emission layer materials
    • Photovoltaic conductive polymers
    • Organic semiconductors for display panels
    • Specialty inks for flexible electronics
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    Certification & Compliance
    More Introduction

    2-Acetyl-3-Methylthiophene: An Experienced Manufacturer’s Perspective

    Understanding the Heart of 2-Acetyl-3-Methylthiophene Production

    When talking about 2-Acetyl-3-Methylthiophene, we’re addressing a compound familiar to those who rely on precise flavor and fragrance chemistry. Years of hands-on experience in the lab and on the plant floor have underscored one truth for us: richness of aroma and the nuance of a finished product begin here, in the technical choice and reliability of the starting materials. This molecule, C7H8OS by formula, stands out for those looking to deliver authentic meaty, roasted, or onion notes in foods, beverages, or aroma compositions. Its chemical fingerprint offers more than an ingredient—it brings a solution honed by direct technical skill all the way from pilot reactors to scaled-up vats.

    Essential Details That Matter in Application

    Let’s get specific about what our team considers when producing this compound. Batch after batch, quality shows up in purity and reproducibility. Our 2-Acetyl-3-Methylthiophene aligns with GC purity exceeding 98%, checked against recognized analytical standards for every lot we dispatch. If you walk through our production facility, you’ll see our team calibrating HPLC and GC instruments, not just as a formality, but because even a trace impurity can throw off the taste in finished seasoning blends or misalign with food safety requirements. Consistency is king, and that’s where hands-on manufacturing brings its value: knowledge built over years can adapt a process quickly when raw material variations pop up or a customer asks for a tighter specification.

    This chemical appears as a pale yellow liquid, carrying both the signature bready, roasted touch and a sulfurous dimension. The odor sets it apart from generic sulfur compounds. That’s why flavorists and perfumers often prefer it—they need depth, not just a blunt sulfur punch. The boiling point sits around 200°C, allowing for flexible use in both low and high-temperature processes without rapid loss to evaporation or decomposition. The density ranges between 1.09 and 1.12 g/cm3, important for fine-tuning dosing systems in continuous lines.

    We bottle this compound in UN-approved drums and jerry cans, mindful of stability during transit and on-the-floor use. Despite its robustness, our storage protocols call for cool, well-ventilated warehouses, since exposure to air or heat over long periods slowly alters its aroma profile. Teams down the line rely on manufacturers who understand that these practical storage lessons translate directly into product integrity by the time it reaches your blend tanks or filling machines.

    Where 2-Acetyl-3-Methylthiophene Shines: Usage and End-Market Stories

    Decades of direct customer feedback have shown that 2-Acetyl-3-Methylthiophene punches far above its weight in the food industry. The molecule adds roasted, meaty accents that mimic browned onions or fried meat—a function no simple sulfur compound can perform. That’s why instant soups, bouillon powders, and snack seasonings often feature it at surprisingly low dosage rates amid dozens of other flavor molecules. The trick lies in its top note, which interacts with proteins during cooking or shelf life, rounding out both aroma and taste.

    Beyond its flavor role, perfumers use it to deepen green, earthy compositions or bring complexity to synthetic tobacco accords. The sulfur note, more refined than plain thiophenes or simple mercaptans, lends a subtle, enduring presence. Chemical engineers in our facility watch for off-notes that less experienced producers sometimes miss. Over-oxidation or carryover from upstream synthesis can introduce harshness—an issue that gets caught well before filling, because our operation has seen firsthand the effect of feedback from major flavor houses demanding better.

    Some specialty applications have education value too. A few years ago, a key customer wanted to reduce added salt but retain a full, savory character in snack seasonings. Traditional thiazole compounds gave a salty-umami effect but turned harsh at high usage. 2-Acetyl-3-Methylthiophene, blended in precise microgram concentrations, created the illusion of cooked meats without bitterness or off-flavors—the win came from understanding both the chemistry and the culinary goal, something that comes with manufacturing and reformulation experience.

    The molecule’s role in analytical chemistry rounds out its versatility. Labs tracking off-flavors in food packaging or trouble-shooting smokey notes in roasted products sometimes turn to authentic standards of 2-Acetyl-3-Methylthiophene for instrument calibration. Our production experience gives those teams confidence that reference standards will match the molecular profile found in real-world samples.

    The Subtle Differences: What Sets 2-Acetyl-3-Methylthiophene Apart

    Anyone working with thiophenes or sulfur aroma chemicals recognizes the danger in lumping these compounds together. Over the years, our production runs of methylthiophene and thiophene itself—chemicals occupying a similar space—have taught some key lessons about their differences in behavior and performance. Methylthiophene often brings a simple, burnt-rubber aroma, overwhelming finished products unless used with caution. By contrast, 2-Acetyl-3-Methylthiophene offers roasted, nutty warmth layered with savory notes, allowing formulators to dial in complex flavors without masking adjacent components.

    We found another difference in process compatibility. 2-Acetyl-3-Methylthiophene tolerates moderate heating during flavor cooking steps, resisting rapid loss that plagues simpler sulfur compounds. In baking and extrusion environments, this reduces volatility-related waste—a cost factor that only becomes clear after years of watching loss rates and customer returns. The acetyl group not only modifies aroma but also stabilizes the molecule against harsh processing.

    Across the fragrance industry, comparisons with similar sulfur aromatics make the point even sharper. Sulfur-furan and sulfur-thiazole compounds punch dramatically, but their profiles often veer toward the medicinal or the cabbage-like. 2-Acetyl-3-Methylthiophene balances assertiveness with roundness, explaining its long-standing role in creating familiar, mouthwatering savory profiles in consumer goods. Chefs and flavorists can rely on it for authenticity because generations of product launches and production scale-ups have shown that its profile is both instantly appreciated and hard to replicate with cheaper substitutes.

    The difference also appears in formulation stability. Some competitors occasionally encounter phase separation or incompatibility with emulsifiers when loading up other sulfur chemicals. The solution has come through repeated pilot runs at our facility using 2-Acetyl-3-Methylthiophene, which integrates smoothly into aqueous, oily, or dry blends with little need for extra process steps. This doesn’t just represent a lab finding—it’s a bridge to reliable, industrial-scale output that customers count on batch after batch.

    Tackling Issues Through Experience

    Problems in aroma chemical manufacture don’t come from textbooks—they walk into your receiving bay and eat into your yield. Our facility came to this conclusion after years spent chasing batch-to-batch uniformity and fighting upstream supplier shifts. Many flavor manufacturers have experienced shifts in aroma profile or shelf life because their supplier switched to a cheaper, less refined process. By controlling every step, from raw material qualification to careful cleanup and polishing, we deliver what is expected—which, in the real world, means fewer complaints, less rework, and consistent cost structure.

    Another challenge comes from handling, since 2-Acetyl-3-Methylthiophene’s pungency calls for tailored ventilation and transfer processes. Loading lines include vapor management steps, protecting both operators and neighboring materials from cross-contamination. Our teams undergo regular on-the-floor training because preventing a single misdirected drum spill pays back through reduced insurance claims and smoother production. Those lessons don’t appear in glossy pamphlets but come from lived experience met with a technical fix.

    Market shifts toward traceability and transparency pushed us years ago to introduce comprehensive batch tracking and in-house analytics. Our customers expect material that matches both legal requirements and their own house profiles—not just in paperwork, but in actual, demonstrated sample-to-sample comparison. Full spectrum chromatographic profiling, retained samples, and rapid root cause analysis when any deviation pops up ensure that trust remains solid, shipment after shipment.

    2-Acetyl-3-Methylthiophene in the Greater Supply Chain

    Food safety regulations, authenticity testing, and flavor trends keep reshaping supply chains. Producers who don’t keep pace with traceability, labeling, and safety certification don’t just lose market share—they risk blocking their customers from export or new launches. We update material data sheets along with all relevant compliance documents according to both local and international standards, and we actively participate in audits requested by multinational customers.

    Downstream partners rely on our ability to scale up or dial back output based on forecast accuracy. That requires more than a large reactor; it means storage planning, logistics, and robust scheduling systems built around real-world market data. With many years spent battling raw material shortages, port delays, or packaging shifts, our company keeps adequate buffer stocks and multiple outbound options to maintain service, season after season. That’s the value proposition manufacturers can bring that pure traders cannot—it comes from risk management tested by actual interruptions and real production cycles.

    Supporting Sustainable Solutions

    Sustainability isn’t a buzzword on our shop floor. Volatile organic sulfur compounds require thoughtful waste management and emissions control. Air scrubbers, solvent management, and effluent treatment plants all run in parallel with production lines, keeping environmental impact as low as practical. Our technical staff monitor not only product output but also side-streams, implementing both classic and emerging filtration and capture methods. Long-term, this reduces both regulatory risk and operating cost, but the initiative stems from direct experience managing community relations and local compliance audits.

    Where possible, we’ve shifted to greener starting materials—reducing the petrochemical footprint for certain product lots. This doesn’t just check a box for certification; it delivers product that aligns with the expectations of multinational buyers and regulatory bodies increasingly interested in chain-of-custody and carbon disclosure. Our main insight is simple: early, transparent dialogue with downstream partners makes ramping up sustainable variants viable both technically and commercially.

    Future Directions and Industry Impact

    Trends in plant-based foods, clean labels, and premium savory products have all raised the standard for sulfur-containing aroma chemicals. The pressure on manufacturers is to achieve cleaner, more authentic tastes with fewer off-notes and fuller documentation. Our process chemists test new purification stages and alternative catalytic routes each quarter, updating systems not because it’s expected, but because the margin for error narrows as end consumers become more discriminating.

    Recent projects explored using 2-Acetyl-3-Methylthiophene in next-generation vegan meat analogues and high-protein snacks. The challenge came in mimicking ‘roast’, ‘broth’, and ‘umami’ without crossing into bitterness or sticking sulfurous notes. Our direct, long-term collaboration with R&D teams helps dial in flavor targets, rather than passing off a technical data sheet and walking away. Many of those launches use custom concentrations adjusted by processing temperature, matrix, and application—all supported with application lab trials to stress-test shelf stability and taste evolution.

    For clients interested in high-purity specialty grades, we continue to expand our micro-batch capabilities. These lines run under dedicated process conditions, separate from multi-ton lots destined for commodity food applications. The investment pays off for fragrance and fine aroma customers who seek signature notes that will differentiate their product on competitive shelves. Through hundreds of such projects, expertise grows not through guesswork but through accumulated, hands-on results.

    Closing Insights from the Manufacturing Floor

    Chemicals like 2-Acetyl-3-Methylthiophene may not get front-page stories, but they shape aroma experiences people encounter daily. The mark of a strong manufacturer lies in the willingness to adapt, troubleshoot, and refine—not simply in scaling up a recipe but in living through evolving regulations, market shifts, and product launches. Our perspective roots itself in repeat experience, learning from both the easiest and hardest production runs. Every batch leaving the plant carries a margin of quality built not by automation alone, but by technical vision turned habit, project after project.

    As new sectors and product types emerge, we see our role expanding not just as a supplier but as an embedded technical partner. Trust between manufacturer and formulator grows every time a challenge is met directly. 2-Acetyl-3-Methylthiophene may only occupy a fraction of a recipe, but its impact punches far above its percentage—one more reminder that in specialty chemicals, capability and deep technical care are the true differentiators.