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2,6-Dimethylpyrazine

    • Product Name 2,6-Dimethylpyrazine
    • Alias 2,6-Dimethyl-1,4-diazine
    • Einecs 209-026-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    697538

    Cas Number 108-50-9
    Molecular Formula C6H8N2
    Molecular Weight 108.14 g/mol
    Iupac Name 2,6-dimethylpyrazine
    Appearance Colorless to pale yellow liquid
    Boiling Point 166-168 °C
    Melting Point 5 °C
    Density 1.063 g/cm³ at 25 °C
    Solubility In Water Moderately soluble
    Odor Nutty, roasted, cocoa-like
    Refractive Index 1.524 at 20 °C
    Flash Point 54 °C (closed cup)

    As an accredited 2,6-Dimethylpyrazine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 2,6-Dimethylpyrazine, sealed with a screw cap and labeled with hazard and product information.
    Shipping 2,6-Dimethylpyrazine should be shipped in tightly sealed containers, protected from heat, sparks, and open flame. It must be clearly labeled and handled as a chemical substance. Use appropriate packaging per regulatory guidelines (e.g., DOT, IATA), and transport in compliance with applicable local, national, and international regulations.
    Storage 2,6-Dimethylpyrazine should be stored in a tightly closed container in a cool, dry, well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Avoid exposure to heat and direct sunlight. Proper labeling and segregation from food and drink are recommended to prevent contamination. Always follow appropriate chemical storage regulations and institutional guidelines.
    Application of 2,6-Dimethylpyrazine

    Applications of 2,6-Dimethylpyrazine in Industrial Manufacturing

    2,6-Dimethylpyrazine serves as a specialty flavor and functional intermediate for several regulated industrial sectors, supporting distinctive aroma compounds, performance additives, and advanced materials. Below are real downstream applications with detailed use practices and compliance parameters.

    1. Food Flavor Formulation: Savory and Snack Seasonings

    Food ingredient formulators employ 2,6-Dimethylpyrazine for imparting roasted, nutty, and cereal-like notes in savory seasonings. This material acts as a critical impact compound to reproduce authentic appetizing profiles in processed foods. Specialists dose the material under strict regulatory limits, ensuring compliance with food safety authorities. It enters production at the blending step, processed with liquid or powder matrices. End applications include ready-to-eat snacks, seasoning blends, and instant noodle sachets.

    Industry compliance standards

    • U.S. FDA 21 CFR 172.515 (Flavoring Substances and Adjuvants)
    • EU Regulation (EC) No 1334/2008 (Flavorings and food ingredients with flavoring properties)
    • GB 2760-2024 National Food Safety Standard for Food Additives (China)
    • Japanese Food Sanitation Act (Flavoring Materials List)

    Typical usage ratio

    • 0.1–10 ppm in finished product (exact dosage based on substrate and potency target)
    • Lower thresholds required for direct flavor top-notes
    • Formulators reference sensory panels for batch optimization
    • Adjustment required for fat/oil-based or dry blends

    Downstream process integration

    • Added during seasoning premix blending
    • Can be dissolved in carrier solvents or adsorbed on carriers
    • Direct addition to spray drying feed tanks for flavor encapsulation
    • Subject to final finished product QC and allergen traceability protocols

    Final product types

    • Corn chips and extruded snacks
    • Roasted nut seasonings
    • Cooked meat flavor bases
    • Instant soup powder blends

    2. Coffee and Cocoa Aroma Enhancement in Beverage Industry

    Beverage compounders include 2,6-Dimethylpyrazine in flavor systems for soluble coffee and cocoa products, mimicking the natural pyrazines released in controlled Maillard reactions. This raw material participates in top-note flavor balancing, with parameters controlled for beverage stability and compliance with beverage additives legislation. It is introduced at the flavor compounding or pre-mix stage and scrutinized for beverage matrix compatibility. Finished goods include drink powders, ready-to-drink coffees, and barista syrups.

    Industry compliance standards

    • Codex Alimentarius General Standard for Food Additives (GSFA)
    • FDA GRAS Notice (Generally Recognized as Safe substance)
    • European Flavour Association (EFFA) Regulatory Guide
    • China’s Food Ingredients National Standard (GB standards)

    Typical usage ratio

    • 0.05–5 ppm in ready-to-drink beverages
    • Adjust based on base coffee/cocoa strength and target aroma profile
    • Higher concentrations permitted in syrup or concentrate
    • Batch dosage refined using GC-MS flavor profile analysis

    Downstream process integration

    • Mixed into flavor bases prior to addition to beverage matrices
    • Homogenized with other volatile flavor actives
    • Stability checked during pasteurization or UHT steps
    • Final QC for off-note/volatile loss post-packaging

    Final product types

    • Instant coffee granules
    • Ready-to-drink cappuccino beverages
    • Flavored coffee syrups
    • Instant cocoa drink mixes

    3. Pharmaceutical Impurity Marker and Process Intermediate

    Pharmaceutical manufacturers utilize 2,6-Dimethylpyrazine as both a synthetic building block in heterocyclic active pharmaceutical ingredient (API) synthesis and an analytical impurity marker. It is subject to detailed traceability under cGMP guidelines, with specification control from incoming raw material through to the API or excipient validation. The compound is introduced at early-stage intermediates in controlled reactor systems.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • Ph. Eur., USP, JP (relevant monographs for starting materials and impurities)
    • 21 CFR Part 211 Current Good Manufacturing Practice for Finished Pharmaceuticals
    • China NMPA Drug Registration and Technical Review Standards

    Typical usage ratio

    • Variable: parts per thousand to percent range in reaction intermediates
    • Ratio determined by stoichiometry of specific API process route
    • Residual pyrazines monitored to pharmacopeial impurity limits (typically ≤ 0.1%)
    • Documented in DMF with analytical justification

    Downstream process integration

    • Charged to API synthesis reactor during heterocyclic ring formation
    • Monitored using validated HPLC/GC methods post-synthesis
    • Controlled purge/removal during purification/filtration
    • Final trace impurity analysis documented for batch release

    Final product types

    • Heterocyclic API intermediates
    • Synthetic process APIs (subject to registration dossier)
    • Pharmaceutical impurity markers (for QC reference)
    • Excipients in regulated applications (subject to validated limits)

    4. Tobacco Product Flavors and Aroma System Development

    Tobacco product formulators incorporate 2,6-Dimethylpyrazine in selected flavor systems, where it generates the signature roasted and nutty aroma notes in cigarette blends, pipe tobacco, and reconstituted sheet additives. Usage levels are regulated and require precise dosing based on blend and intended regional legislative frameworks. The compound is applied during slurry blending or flavor addition prior to final product shaping and curing.

    Industry compliance standards

    • US Tobacco Control Act (for ingredient reporting and use in finished products)
    • EU Tobacco Products Directive 2014/40/EU
    • ISO 12863 Tobacco — Standardized non-fire standard ignition propensity test
    • China’s GB/T 5606 National Standard for Cigarette Manufacturing

    Typical usage ratio

    • 0.5–15 ppm in finished tobacco blends
    • Lower levels for pipe or dark air-cured applications
    • Adjusted based on blend type, final aroma intensity, and regulatory status
    • Processed under ingredient declaration and batch documentation

    Downstream process integration

    • Added in flavor slurry during blended tobacco preparation
    • Applied in wet/dry phase before sheet reconstitution or tobacco shredding
    • Volatility checked during curing and packaging
    • Tracked in finished goods database for inspection

    Final product types

    • Filtered and non-filtered cigarette products
    • Pipe tobacco blends
    • Reconstituted tobacco sheets
    • Flavored cigar wraps

    5. Advanced Materials and Electronics: Precursors for Molecular Synthesis

    Manufacturers of advanced electronic materials utilize 2,6-Dimethylpyrazine as a ligand precursor and building block in the synthesis of metal-organic frameworks and related specialty organic compounds. The compound is integrated into strictly monitored chemical synthesis lines under quality management systems. It enters either as an initial charge to high-pressure reactors or as a solution phase reagent, depending on downstream compound design.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems (applied to specialty chemical manufacturing)
    • REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals—EU)
    • TSCA Inventory Listing (US, for use in R&D and industrial synthesis)
    • China MEE Environmental Hazardous Chemical Registration

    Typical usage ratio

    • 0.2–3.0 molar equivalents, depending on the coordination structure or organic framework design
    • Stoichiometry adjusted for scale and final product form
    • Material excess managed via recovery and recycle protocols
    • Quality controlled by NMR and elemental analysis of intermediates

    Downstream process integration

    • Dosed at initial synthesis step or as a ligand in complexation reactions
    • Blended in inert or controlled moisture environments
    • Thermal or catalytic activation monitored by in-line IR or MS
    • Managed by batch process control documentation

    Final product types

    • Metal-organic framework powders
    • Organic semiconductor intermediates
    • OLED material precursors
    • Fine chemical intermediates for electronics
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    Certification & Compliance
    More Introduction

    2,6-Dimethylpyrazine: Shaping Flavors from the Factory Floor

    Our Direct Experience with Production

    2,6-Dimethylpyrazine belongs to a family of pyrazines that play a central role in flavor and aroma chemistry. Speaking as a chemical manufacturer with direct experience in production, the journey from raw materials to finished 2,6-Dimethylpyrazine speaks volumes about its distinct characteristics. We handle volumes of requests from food and beverage companies with specific goals in mind: natural flavor enhancement, improved aroma profiles, and consistent, reliable performance in applications ranging from snacks to tobacco products.

    Producing 2,6-Dimethylpyrazine relies on a batch process using carefully sourced methylated precursors, pure solvents, and high-standard catalysts. Our reactors run under stringent temperature controls to ensure each molecule forms correctly, minimizing unwanted byproducts. Purity levels often exceed 99%, and each kilogram reflects hours of hands-on monitoring by our technical team. This high purity ensures that the product integrates without overwhelming or distorting formulations.

    Key Characteristics: What Sets It Apart

    This compound brings a nutty, roasted aroma reminiscent of freshly baked bread or toasted seeds. It has a low odor threshold, so even a fraction of a gram in a kiloliter of flavor formulation creates a distinct impact. The sensory notes are sharper and more defined than what you see with other methylpyrazines. As a result of our processes, color stays pale to light yellow and remains stable with time under appropriate storage. Careful fractionation steps during purification lock in consistency from batch to batch.

    2,6-Dimethylpyrazine tends to stand out against other pyrazines, such as 2,3- or 2,5-Dimethylpyrazine. The positioning of the methyl groups changes the interaction with both other ingredients and end receptors. Customers working with meat analogs or roasted snack coatings regularly tell us that the 2,6 configuration imparts a rounded, complex note that doesn’t get muddied when processed under high-heat or during shelf life testing. Shelf stability in both liquid and powder premixes comes directly from the purity and absence of reactive residuals.

    Common Applications: Purpose Drives Production

    Requests for 2,6-Dimethylpyrazine largely come from sectors demanding strong flavor enhancement without using synthetic masking agents. The bakery industry uses this pyrazine to simulate the toasted notes of fresh crust and roasted grain. In coffee and cocoa formulations, it deepens the perception of roast while balancing bitterness. The snack sector credits it for delivering that familiar, mouth-watering aroma that draws consumers to freshly popped popcorn, roasted nuts, or seasoned chips. It recurs in tobacco product flavoring, synthetic meats, and even pet food coatings, always seeking to replicate a familiar “roasted” comfort.

    In these applications, less stable compounds either dissipate during processing or shift into unpleasant off-notes when exposed to oxygen and light. Our ongoing investment in finished product validation makes sure the volatility and reactivity of 2,6-Dimethylpyrazine stays minimized, allowing food scientists and flavorists to use lower dosages while achieving pronounced sensory effects.

    Production Challenges and Safety Commitments

    Handling pyrazines at an industrial scale brings unique operational challenges. Off-odors from raw intermediates can disrupt baseline air quality in the plant, so we installed closed-system transfers and vapor-phase recovery to tighten the cycle. This avoids cross-contamination with other products and recycles a higher portion of starting materials. Each lot leaves our site with strict quality documentation—including GC-MS spectra for trace impurity analysis and logs of batch controls.

    Experience tells us plant safety cannot be compromised. Pyrazine production involves some exothermic steps; we train every technician to anticipate runaway reactions and install real-time monitoring sensors. Our incident data shows that routine investment in equipment calibration and employee skill building prevents hazardous releases and supports our insurance profile. Downstream users often comment on the “clean” nature of our 2,6-Dimethylpyrazine, a direct result of rigorous containment and continuous improvement in the production environment.

    Environmental Impact and Sustainability

    Our manufacturing facility keeps environmental responsibility in focus. Process water recycling, emission scrubbing, and solvent recovery practices go beyond regulatory minimums. The parent chemicals used in 2,6-Dimethylpyrazine manufacture come from established suppliers who demonstrate full chain-of-custody and environmental compliance. We publish summary lifecycle analyses and meet with local stakeholders twice annually to keep the community updated on plant performance.

    Our engineering team routinely audits solvent usage, adjusting conditions to favor greener alternatives where feasible. The waste stream from pyrazine purification—mainly consisting of trace organics and neutral salts—undergoes multiple treatment steps before off-site disposal. We minimize single-use packaging and support returnable logistics options for bulk shipments. This approach resonates with the growing expectation from our customers, especially those in the European and North American food sectors, to know the full environmental story behind every kilogram shipped.

    Differences from Other Pyrazines

    Much of the demand for 2,6-Dimethylpyrazine comes from its relationship to other methylated pyrazines. The three main positional isomers—2,3-, 2,5-, and 2,6-Dimethylpyrazine—differ at a molecular level that leads to meaningful distinctions in their odor profiles, threshold concentrations, and application performance. The 2,3- and 2,5-isomers carry more dry, earthy or musty notes, often overpowering delicate formulations. They lack the sweet, bready edge 2,6 brings, an attribute that’s especially prized in simulating the “fresh from the oven” appeal.

    Our regular customers share their trial data, which backs what our sensory teams observe: 2,6-Dimethylpyrazine shapes a more lasting, nuanced taste and bouquet—even after baking, boiling, or frying cycles. Where cheaper, impure sources sometimes bring sulfuric or acrid off-notes, our in-house purification steps remove these. That reliability keeps product launches on schedule and eliminates troubleshooting stages downstream.

    Regulatory and Safety Expectations

    As a hands-on producer, we track the evolving regulatory scene closely. 2,6-Dimethylpyrazine appears on various food additive lists and faces usage limits depending on geography. Our compliance team reviews both finished goods standards and in-process handling rules. Every shipment exits with a purity report and trace contaminant log that aligns with current requirements from the US, EU, and East Asian authorities.

    Our safety data sheets lay out exposure concerns, handling rules, and storage recommendations based on the latest toxicology reviews. Customers in the flavor and fragrance fields rely on this level of transparency to support their own safety documentation and pass ingredient audits. Real-world accidents stemming from pyrazine mishandling underscore the real risk: inhalation and skin contact, especially with concentrated forms, demands diligence in PPE and ventilation on every production run. We constantly reinforce safe handling culture across both our workforce and our downstream clients.

    Practical Lessons from Long-Term Supply

    Years of direct production have taught us the hard realities of supply chain interruptions. When global methylamine prices swing, factories without stable sourcing see wild fluctuations in pyrazine availability. We maintain on-site reserves of key inputs and stagger purchase contracts across multiple fiscal quarters to cushion our customers from supply shocks. In past years, weather-related disruptions at chemical plants upstream created bottlenecks for several pyrazine types, but redundant supplier vetting prevented order backlogs.

    Customers value predictability as much as sensory character. We’ve responded by building capacity for both large-lot and just-in-time shipments. Each tote or drum ships with full provenance records, connecting batch numbers from raw materials through final packing, so food safety teams or auditors can track every detail. End users save countless hours of troubleshooting by accessing our archived production runs and test data.

    Technical Support and Collaborative Development

    No two customers treat pyrazines in exactly the same way. Some run small-batch innovation kitchens, while others operate 24/7 industrial lines. Our technical service engineers spend time in both settings, learning where dosage levels hit the sweet spot or where volatility in high-temperature processes creates losses. We’ve worked closely with flavor houses to model reaction rates during Maillard-type browning, optimizing concentrations for both lab-scale and commercial trials.

    Collaboration often uncovers new uses. Breweries seek gentle nutty accents in specialty ales, while non-dairy cheese developers ask for improved melt stability during reheating. We feed this feedback into our R&D cycle, sometimes tweaking reaction times or rebalancing purification pressures to fit new requirements.

    The relationship with customers often goes beyond selling; it involves troubleshooting, reformulating, and even reverse-engineering competitors’ lot inconsistencies. Our reputation for technical competence rests on hundreds of such encounters and the cumulative trust built from on-the-ground results.

    Building Reliable Value: What Our Experience Means for Users

    Choosing 2,6-Dimethylpyrazine from us brings a direct pipeline to the factory source. There are no extra hands in the transaction; there’s no dilution in the quality, accountability, or technical support customers receive. Each inquiry triggers a dialogue with manufacturing engineers who know the compound—right down to the batch quirks and minor impurity profiles from different production days.

    Customers highlight several recurring benefits. The absence of foreign odor residues, the persistent “toasted” notes during storage, and the rock-solid reproducibility for batch-matched launches matter greatly in new product rollouts. Our technical team monitors both market trends and scientific advances, adopting new reactor technologies, catalyst approaches, and purification materials promptly.

    Feedback loops never close. We treat every complaint, defect report, or unexpected test result as a chance to refine our process and customer service. Our plant runs pilot reactor loads based on early adopter feedback and partners with universities for advanced aroma chemistry validation. Where other producers may push volume, we focus equally on performance and long-term sensory durability.

    Future Outlook and Industry Evolution

    Market demand for clean-label, authentic-tasting flavor compounds grows every year. Chefs and product developers want less synthetic taste and more natural appeal, driving innovation in both fermentation-derived and traditionally manufactured pyrazines. We watch the scientific literature closely for enzymatic breakthroughs, brewing new sample batches of bio-catalyzed intermediates and screening sensory panels. While most industrial 2,6-Dimethylpyrazine remains petrochemical in origin for now, the shift to bio-based methods remains on our radar.

    New product categories—plant-based meats, snacks for health-conscious consumers, “low and slow” cooking styles—create openings for nuanced flavor additions like 2,6-Dimethylpyrazine. Our customers routinely experiment with encapsulation systems and matrix combinations that bring out unique properties of the molecule. We invest in both classic quality systems and exploratory research to keep our offerings relevant as culinary science advances.

    Long-term partnerships thrive on both reliability and technical evolution. We keep lines open to emerging regulatory demands, green chemistry opportunities, and feedback from production and R&D personnel at all stages. Our direct role as a manufacturer—not as a middleman or trader—means the conversation about 2,6-Dimethylpyrazine continues after each order, through every experiment, and across each new product launch.