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2,6-Dimethyl-4-Hydroxybenzaldehyde

    • Product Name 2,6-Dimethyl-4-Hydroxybenzaldehyde
    • Alias 4-Hydroxy-2,6-dimethylbenzaldehyde
    • Einecs 208-966-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    480468

    Chemicalname 2,6-Dimethyl-4-Hydroxybenzaldehyde
    Molecularformula C9H10O2
    Molecularweight 150.17 g/mol
    Casnumber 3377-61-1
    Appearance White to off-white crystalline powder
    Meltingpoint 146-150°C
    Boilingpoint Unknown or Decomposes
    Solubilityinwater Slightly soluble
    Density 1.14 g/cm3
    Synonyms 2,6-Xylenol-4-carbaldehyde
    Smiles CC1=CC(=CC(=C1O)C=O)C
    Inchi InChI=1S/C9H10O2/c1-6-3-8(5-10)9(11)4-7(6)2/h3-5,11H,1-2H3
    Storageconditions Store at room temperature in a tightly sealed container
    Purity Usually ≥98%

    As an accredited 2,6-Dimethyl-4-Hydroxybenzaldehyde factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 2,6-Dimethyl-4-Hydroxybenzaldehyde is packaged in a 25-gram amber glass bottle with a secure screw cap and hazard labeling.
    Shipping 2,6-Dimethyl-4-Hydroxybenzaldehyde is shipped in tightly sealed containers to prevent contamination and moisture exposure. It should be kept cool, dry, and away from direct sunlight. Compliant with chemical transport regulations, the package includes safety labeling and documentation, ensuring safe handling and delivery to laboratories or industrial sites.
    Storage 2,6-Dimethyl-4-hydroxybenzaldehyde should be stored in a tightly sealed container, protected from light and moisture, in a cool, dry, and well-ventilated area. Keep away from sources of ignition, heat, and incompatible substances such as strong oxidizers. Ensure proper labeling and restrict access to authorized personnel. Store at room temperature unless otherwise specified by the manufacturer.
    Application of 2,6-Dimethyl-4-Hydroxybenzaldehyde

    Applications of 2,6-Dimethyl-4-Hydroxybenzaldehyde in Industrial Manufacturing

    As a direct manufacturer of 2,6-Dimethyl-4-Hydroxybenzaldehyde, we serve specialized sectors that require reliable chemical raw materials for advanced production. Below, we outline core downstream application scenarios where this ingredient delivers concrete value according to real industrial needs, formulated standards, and process criteria.

    1. Pharmaceutical Intermediates for Active Pharmaceutical Ingredient (API) Synthesis

    Pharmaceutical manufacturers select this compound as a building block in the synthesis of specific APIs, particularly in the assembly of specialty intermediates used in anti-inflammatory and central nervous system drugs. Chemical engineers integrate this benzaldehyde derivative into multi-step reaction sequences, allowing precise control over target molecule structure while maintaining compliance with regulatory frameworks at every stage.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • Current Good Manufacturing Practice (cGMP) as per 21 CFR Part 210/211
    • European Pharmacopoeia (Ph. Eur.) and United States Pharmacopeia (USP) if final API is monographed
    • REACH Registration for chemical safety in the EU market

    Typical usage ratio

    • 0.5%–2% of target molecule substrate weight, precise scale based on molecular stoichiometry of reaction scheme; proportion calculated according to the yield percentage in condensation or alkylation reactions

    Downstream process integration

    • Added directly into the reaction vessel during intermediate formation, typically at the condensation or alkylation stage, followed by controlled purification and isolation steps

    Final product types

    • API intermediates for sulfonamides and substituted aromatic pharmaceuticals
    • Final APIs for specific CNS-acting compounds where aromatic aldehyde scaffolds are required
    • Prescription drug ingredients where regulatory monographs list derivatives prepared using this raw material

    2. Fragrance Ingredient Manufacture for Flavor and Fragrance Industry

    Manufacturers in aroma chemicals utilize this molecule to develop aldehydic and phenolic notes within high-value fragrance bases. Its distinct odor profile allows perfumers and compounders to craft complex aroma accords for both fine fragrance and technical perfumery, applying precise formulation techniques under regulatory scrutiny for human sensory products.

    Industry compliance standards

    • International Fragrance Association (IFRA) Standards and Guidelines
    • EU Regulation (EC) No 1223/2009 for cosmetic ingredient safety
    • Regulation (EC) No 1334/2008 on flavorings and certain food ingredients
    • Hazard Communication Standard (OSHA HCS 29 CFR 1910.1200) for workplace safety

    Typical usage ratio

    • 0.01%–0.15% (100–1500 ppm) in fragrance oil concentrate, adjusted for odor threshold and end-use application; final levels set by organoleptic evaluation and IFRA maximum allowed limits

    Downstream process integration

    • Dosed during compounding of fragrance oil concentrates under controlled temperature stirring, followed by quality control GC-MS validation and stability assessment

    Final product types

    • Compound fragrances for fine perfume blends
    • Fragrance additives in soaps and personal care
    • Air care and home care aroma compositions (e.g., diffusers, detergents, scented candles)

    3. Stabilizer and Intermediate in UV-Absorber Production for Polymer Additives

    Producers of polymer additives incorporate this compound as a key precursor in the synthesis of benzotriazole-type and hydroxyphenyl-s-triazine UV stabilizers, crucial for prolonging polymer life under UV exposure. It enters the value chain during targeted condensation reactions, enabling downstream manufacturers to achieve stability in transparent plastic applications.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems for polymer additive production
    • US FDA 21 CFR 177.1520 for indirect food contact polymers (where applicable)
    • EU Regulation (EC) No 1907/2006 (REACH)
    • ASTM D5208 for evaluating the resistance of plastics to UV light

    Typical usage ratio

    • 0.5%–2.5% by weight in UV absorber active composition; incorporated according to desired light stability and polymer compatibility requirements

    Downstream process integration

    • Fed into synthesis reactor at intermediate stage for condensation with triazine or benzotriazole moieties, followed by purification, micronization, and blending with carriers for masterbatch production

    Final product types

    • Hindered phenol UV-absorber additives for polycarbonates
    • UV-stabilizer concentrates (masterbatch) for polyethylene, polypropylene, and PVC
    • Light-stabilized transparent films and molded plastic articles

    4. Key Aromatic Intermediate for Agrochemical Syntheses

    Agrochemical formulators apply this raw material in the production of specialty herbicides and growth regulator ingredients. Its reactivity and substitution profile support the formation of robust aromatic scaffolds necessary for the bioactivity and stability of modern crop protection agents, with integration points in proprietary multi-step processes targeting specific regulatory endpoints.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • OECD Guidelines for the Testing of Chemicals
    • US EPA Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)
    • ISO 9001-certified quality systems for agrochemical intermediates

    Typical usage ratio

    • 1%–5% w/w of batch formulation; proportion determined by specific synthetic pathway and molar yield ratios in key condensation or formation steps

    Downstream process integration

    • Charged into the reaction stream during aromatic core formation, typically before heterocycle introduction or chlorination; followed by workup and distillation for intermediate or technical concentrate isolation

    Final product types

    • Synthetic intermediates for phenoxy-substituted herbicides
    • Technical grade crop protection chemical actives
    • Plant growth regulator scaffolds used in field formulations

    5. Fine Chemicals Manufacturing: Analytical Reagents and Specialty Dyes

    Producers of analytical reagents and specialty dye intermediates specify this material for its defined purity and reactivity, enabling controlled synthesis of chromogenic agents and sensor dyes. Quality control teams demand traceability and clear origin, integrating the raw material within batch records and synthesis documentation as required for downstream QC and validation.

    Industry compliance standards

    • ISO 17025 for analytical reagent manufacturing
    • GHS/CLP labeling under Regulation (EC) No 1272/2008
    • ASTM E284 and E1627 standards for colorimetric reagent performance
    • RoHS Directive (2011/65/EU) for chemical components in analytical instruments

    Typical usage ratio

    • 0.2%–2% based on target dye intensity or test reagent sensitivity; set by titration against known analyte under standardized assay conditions

    Downstream process integration

    • Introduced during the core chromophore coupling or aldehyde derivatization stage, followed by crystallization, purification, and formulation into reagent kits or colorant powders

    Final product types

    • Chromogenic reagents for laboratory and industrial colorimetric assays
    • Specialty dyes used in plastics and molecular sensor strips
    • Analytical standards for quality assurance laboratories and chemical manufacturers
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    Certification & Compliance
    More Introduction

    Introducing 2,6-Dimethyl-4-Hydroxybenzaldehyde: A Chemical Manufacturer’s Perspective

    Getting to Know 2,6-Dimethyl-4-Hydroxybenzaldehyde

    People in our industry tend to know a few things right away about 2,6-Dimethyl-4-Hydroxybenzaldehyde. The name rolls off the tongue for most of us, and the CAS number pops up in memory the moment someone brings up benzaldehyde derivatives. In our shop, we’ve spent years fine-tuning the production of this specialty aldehyde, with its two methyl groups at the 2 and 6 positions and that defining hydroxy group at the 4. The white to slightly yellow crystalline solid emerges from our reactors after a careful orchestration of temperature, solvent selection, and precise timing—methods that have seen plenty of revision as we strive for better yields and better purity with each run.

    When chemists on the production floor refer to the model they’re working with, they mean the run conditions, the batch sizes, and the actual methods behind the scenes. On paper, the compound lands firmly at C9H10O2, and in our operation, we aim consistently for a purity over 99%, with water content and metal contamination pushed below the lowest industry benchmarks. We use gas chromatography and HPLC side by side—no one sticks with just one technique anymore, not with the kind of accuracy our customers expect.

    It’s tempting to think 2,6-Dimethyl-4-Hydroxybenzaldehyde is an obscure chemical, tucked away in a catalog, only rolling off the production lines when a new client comes knocking. That misconception falls apart the moment you look at where it actually gets used. In day-to-day business, most of our product flows straight into the hands of fragrance manufacturers, specialty resin producers, and advanced pharmaceutical labs. It often appears as a starting intermediate, where its unique shape and electron distribution set it apart from its more familiar cousin, plain vanillin.

    Real-World Applications: The Stories Behind the Science

    Experience has taught us that fragrance chemists prefer 2,6-Dimethyl-4-Hydroxybenzaldehyde for more than its pleasant, slightly herbal and woody note. The two methyl groups and that 4-position hydroxy allow it to act as a foundation for designing complex scents that demand longevity and subtlety. I’ve walked through scent labs where our material ends up in fine fragrance bases, not just for its smell but because it brings stability that’s often missing from simpler benzaldehyde derivatives. One customer mentioned their search for a fixative that doesn’t oxidize or discolor, and our 2,6-dimethyl-4-hydroxyblenzaldehyde emerged as a solution.

    There’s also a steady demand from resin and polymer researchers. Early on, we observed that introducing ortho methyls on the benzaldehyde structure changes the way it reacts in polymerization, often increasing thermal stability in resulting compounds. It remains true that our product finds favor among specialty adhesive developers and those pushing the limits of high-performance coatings, where the aldehyde brings about cross-linking efficiencies that are tough to match.

    Pharmaceutical use tells another story entirely. In our own background as a manufacturer, we field regular questions about batch consistency, trace metal level reports, and bioburden assessments. Many research labs rely on high-purity 2,6-Dimethyl-4-Hydroxybenzaldehyde for synthesizing more complex molecules, especially those that form the backbone for new drug candidates. Safety and traceability standards keep rising, and we spend long days making sure our downstream partners get paperwork and test samples that meet the strictest bar.

    Some buyers eye 2,6-Dimethyl-4-Hydroxybenzaldehyde for its place in the synthesis of UV absorbers and additives for polymers. Our R&D department has spent months working hand in hand with plastics manufacturers on the East Coast, who need a key intermediate that won’t degrade under exposure to heat or light. The ortho methyls really do the heavy lifting here, blocking undesired side reactions and preventing yellowing in end products.

    From time to time, specialty dye producers reach out with technical questions about impurity profiles and trace color bodies. It’s always a balancing act: keeping production lines efficient while never compromising on clarity. These conversations aren’t just about numbers; the right spectral fingerprint can mean the difference between a mill run that passes or fails.

    Specifications Reflecting Real Production Challenges

    Examining our typical specifications, we tighten up purity well beyond general industry standards. Everyday production means countering the formation of related isomers and carefully monitoring for byproducts in every batch—especially since traces of 2,4-dimethyl or 3,5-dimethyl analogues may slip through in less controlled environments. Dealing with these issues doesn't call for shortcuts. Our team goes after contaminants with high-performance filtration, repeated recrystallizations, and solvent systems honed through years of testing.

    Moisture presents its own set of headaches. Keeping water content below 0.1% sometimes eats into throughput, but we’ve learned from bitter experience that a little relaxation on drying translates to headaches down the line for customers—especially for those using our 2,6-Dimethyl-4-Hydroxybenzaldehyde in reactions with sensitive organometallics. Others may try to get away with vibrating dryers and skip final filtration. We stick with controlled vacuum drying and tight atmospheric seals.

    Trace metal analysis hangs over every batch report, too. Even trickle levels of iron or copper can kick-start unwanted catalytic reactions in downstream chemistry. We throw extra effort behind removing contact with metallic surfaces and replace batch-contacting equipment if a spike shows up in the data. The test results often go out alongside the shipment, not just buried in a certificate of analysis.

    Handling and packaging may sound less exciting, but they deserve an honest mention. Even the toughest material won’t stay in spec if storage isn’t up to scratch. Our bins lock tight against atmosphere and moisture, lined with inert films, and we keep them out of sunlight as a rule. Bulk orders often get double heat-sealed and boxed for shipment, and smaller volumes for research customers leave our building in amber glass flasks—proven over the years to keep aldehydes in top shape during transit.

    Distinguishing 2,6-Dimethyl-4-Hydroxybenzaldehyde from Other Substituted Benzaldehydes

    People sometimes lump 2,6-Dimethyl-4-Hydroxybenzaldehyde in with vanillin, salicylaldehyde, or the simpler tolualdehydes. Actually, those structural tweaks make a world of difference in downstream use. The extra methyls close off reactive sites on the ring, lowering the risk for unwanted side reactions when customers put our product through their synthetic routes. A polymer chemist from Pennsylvania explained that even a subtle structure change flips their product yield from 60% to over 90%, explaining why they demand our tightly controlled syntheses.

    High-performance polymer and pharmaceutical developers see in our product a rare combination of high reactivity where it matters—with the aldehyde and phenol functions easily participating in condensation or coupling reactions—yet strong resistance to degradation elsewhere. Compare that to unsubstituted hydroxybenzaldehydes, which often break down or discolor under modest heat or UV exposure. The feedback from plastics and resin customers keeps coming: methylation at the 2 and 6 positions blocks auto-oxidation and ring-opening. These features add shelf life for storage-sensitive intermediates and preserved optical clarity for finished goods.

    Cost and supply risk also diverge from the rest of the benzaldehyde family. Some derivatives depend on more volatile raw material prices; our sourcing team stays nimble, contracting for stable supplies of starting toluenes and phenols, and setting up backup purchase agreements. Early on, we moved away from relying on a single aniline supplier—after a years-ago scare that held up production for nearly a month. Since then, the supply for 2,6-Dimethyl-4-Hydroxybenzaldehyde has been more robust than many other substituted aldehydes.

    That difference makes its way to customers too. Many have called us in a panic after their old supplier switched to a 3,5-dimethyl isomer without warning—resulting in flawed batch outcomes and costly scrapping of material. We know that not all products with similar names behave the same way in the lab or in manufacturing plants. That’s why our quality control crew checks not only for purity but also for the characteristic proton NMR fingerprint, differentiating ours at a glance from structurally similar impurities.

    Experience Backed by Consistency and Innovation

    Not every production plant runs the same process, and not every batch of 2,6-Dimethyl-4-Hydroxybenzaldehyde will hit the same numbers unless the manufacturer watches every lever. Our chemists remember back to the days before automated process controls, when shifts ended with manual tests and anxious eyes scanning TLC plates for strays. Now, we rely on a digital backbone to check purity and yield in real time, but the instincts of the team—developed over decades—mean we catch anomalies far sooner than untrained eyes. Several years ago, a pre-Christmas surge caught the market off guard, yet we maintained output without disruption, largely because we hadn’t overlooked the value of experienced staff on the line.

    Whenever sourcing partners or end users come to visit, we open our production records without hesitation. Notifying customers well in advance of any process tweaks avoids a world of misunderstanding down the road, especially for regulated pharmaceutical or flavor applications. We haven’t forgotten the lessons of batches past where communication gaps cost everyone time and money. Our internal policy: transparency wins over speed. That has cemented long-term customer partnerships and built trust with auditors from the pharmaceutical and food industries.

    Innovation plays just as much a part. We invest right at the level where new catalyst systems shave hours off reaction times, or better solvent recovery systems reduce waste. Some competitors seem content to run the same process year after year, but the waste costs alone tell a different story in the financials by the end of the fiscal period. Customers stand to benefit, too, as lower trace contaminants result and the environmental impact declines.

    Every year, requests come in from researchers seeking non-standard cuts of 2,6-Dimethyl-4-Hydroxybenzaldehyde: higher purities, different forms, or alternatives meeting certain biobased or renewable benchmarks. We listen closely, and respond where practical, but never allow expedience to lower our established safety or consistency standards. For us, improvement happens on the shop floor, in the QA lab, and through honest feedback from those using our product at scale.

    Facing Challenges, Finding Solutions

    No chemical manufacturing operation runs trouble free. Tackling those challenges head on strengthens both process and relationships. Raw materials shift in cost and availability, forced by global trends outside any one company’s control. We counter this with diversified supply contracts, and, where needed, scaled-up inventory for key intermediates, so we aren’t left scrambling at the first hint of disruption.

    Waste handling requirements continue to burn through operating budgets, especially as regulations tighten near urban plants. Early on, our leadership invested in in-house solvent recovery and better distillation techniques, long before mandates forced the issue. Today, we recover and reuse around 93% of the solvent from 2,6-Dimethyl-4-Hydroxybenzaldehyde production, translating into savings and stronger environmental performance. Inspectors who visit our operation often leave impressed by a waste tank that sits nearly empty compared with competitor operations.

    Safety holds a permanent spot on the agenda. Aldehydes demand alert handling. We undertake regular training for our workers, frequently updating protocols and conducting actual emergency drills without warning. Over the last decade, we’ve slashed reportable incidents, partly by making safety a measure of professional pride. Lab coats and eyewash stations are just the surface—routine PEL monitoring and air filtration upgrades protect both our team and visitors. When new research reveals a risk we didn’t spot earlier, we adjust.

    Documentation can be the unseen bottleneck, if it lags behind the rest. Our paperwork trails stretch from raw material arrival through every step of the production line, reinforced with digital sign-offs and backup systems offsite. This traceable path means auditors, whether coming from a fragrance maker or a regulatory agency, can nail down the exact composition and origin of every lot—even those produced years ago. It makes life easier for customers during compliance checks, and builds in confidence for those looking to enter more tightly regulated international markets.

    Adapting to global changes in environmental and trade policy means regular reevaluation of every phase of our production and trading strategy. We work with partners around the world to stay ahead of shifting import/export duties and ingredient restrictions. In the last two years, we have worked with three major clients transitioning their formulations, due to updated food safety frameworks. Our technical support stays on hand, even after a shipment lands, ready to adjust documentation or clarify synthesis pathways so production lines keep running.

    Looking Ahead: The Future of Specialty Aldehyde Manufacturing

    In our decades of experience, staying relevant has meant more than just keeping up with the status quo. Emerging applications in biotechnology, advanced materials science, and green chemistry place higher demands on both the versatility and sustainability of our product line. Research collaborations continue to surface novel uses for 2,6-Dimethyl-4-Hydroxybenzaldehyde, from advanced photoinitiator systems to next-generation antioxidant precursors.

    Meeting these new challenges draws not just on existing chemical expertise, but on willingness to share knowledge, adapt logistics, and continually test safety and quality boundaries. Our approach reflects a grounded confidence: every drum and flask embodies our commitment to accuracy, reliability, and flexibility. This perspective grows from hands-on experience, shaped by the real successes and obstacles faced every day on the manufacturing floor.

    Aldehyde chemistry holds many surprises, but the value of 2,6-Dimethyl-4-Hydroxybenzaldehyde remains undeniable in tough synthetic environments—and in the creative hands of formulators crafting products across countless fields. Our operation stands behind this key intermediate, with a steady focus on safety, traceability, and support that reflects both our history and our future goals.

    For every request or challenge that comes our way, the goal remains unchanged: supply pure, reliable, and well-characterized 2,6-Dimethyl-4-Hydroxybenzaldehyde, produced by a team that values both science and the people who depend on it.