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2,6-Dichlorophenylhydrazine Hydrochloride

    • Product Name 2,6-Dichlorophenylhydrazine Hydrochloride
    • Alias 2,6-Dichlorophenylhydrazine hydrochloride
    • Einecs 258-628-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    406193

    Chemical Name 2,6-Dichlorophenylhydrazine Hydrochloride
    Cas Number 5348-75-6
    Molecular Formula C6H6Cl2N2 · HCl
    Molecular Weight 215.51 g/mol
    Appearance Light yellow to beige crystalline powder
    Melting Point 225-230°C (decomposition)
    Solubility In Water Slightly soluble
    Storage Conditions Store at 2-8°C, protected from light and moisture
    Synonyms 2,6-Dichlorophenylhydrazine hydrochloride
    Purity Typically ≥ 98%
    Hazard Classification Irritant
    Inchi Key ZHJZHZRNBYULAQ-UHFFFAOYSA-N

    As an accredited 2,6-Dichlorophenylhydrazine Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 10g package contains 2,6-Dichlorophenylhydrazine Hydrochloride in a tightly sealed amber glass bottle with clear hazard labeling.
    Shipping 2,6-Dichlorophenylhydrazine Hydrochloride should be shipped in tightly sealed, chemically resistant containers, protected from moisture and light. It must be labeled as a hazardous chemical and transported according to relevant local, national, and international regulations, preferably via ground shipping, and kept at a controlled room temperature to ensure safety and product integrity.
    Storage 2,6-Dichlorophenylhydrazine Hydrochloride should be stored in a tightly sealed container, away from light, heat, moisture, and incompatible substances such as strong oxidizers and acids. Keep it in a cool, dry, well-ventilated area, preferably in a chemical storage cabinet. Clearly label the container and ensure access is restricted to trained personnel. Follow all relevant safety regulations and guidelines.
    Application of 2,6-Dichlorophenylhydrazine Hydrochloride

    Applications of 2,6-Dichlorophenylhydrazine Hydrochloride in Industrial Manufacturing

    2,6-Dichlorophenylhydrazine hydrochloride serves specialized roles in chemical manufacturing, pharmaceutical research, dye synthesis, and agrochemical intermediates. As a direct manufacturer, we supply this compound to professionals who demand controlled quality, precise specifications, and documented compliance across advanced industrial processes.

    1. Pharmaceutical Intermediate Synthesis

    Pharmaceutical manufacturers frequently use 2,6-Dichlorophenylhydrazine hydrochloride as an intermediate in the synthesis of targeted active pharmaceutical ingredients (APIs), especially within certain anti-tuberculosis, antipyretic, or central nervous system agents. This compound reacts during specific coupling steps to introduce dichlorinated phenylhydrazine moieties, which are critical for structure-activity relationships in various drug analogues. Controlled addition into condensation reactions ensures correct molecular configuration and purity, directly influencing the pharmacological profile of the final API.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP/NF Monographs – conformance to USP35 where applicable
    • European Pharmacopoeia (Ph. Eur.) specifications for intermediates
    • REACH Annex IV listing and proper registration for European supply chains

    Typical usage ratio

    • 0.5–2.0 molar equivalents per target intermediate
    • Adjustment depends on hydrazine reactivity and purification route; excess minimal, typically below 5% over stoichiometric requirement

    Downstream process integration

    • Charged during reductive amination or hydrazine condensation reactions
    • Introduced into pressure vessel or glass-lined reactors, directly following base-catalyzed hydrolysis or ester precursor addition
    • Routine inclusion in step four to six of multi-stage API manufacturing

    Final product types

    • Rifampicin analogues (anti-tuberculosis class)
    • Pain management compounds
    • Experimental CNS-active molecules
    • Other specialty pharmaceutical intermediates

    2. Azo Dye and Pigment Manufacture

    Within specialty textile and pigment dye industries, this compound serves as a key coupling component for the creation of dichlorinated azo dyes. Through diazotization and subsequent coupling with phenol, naphthol, or other aromatic substrates, formulators achieve precise hue and chemical stability in industrial dyeing operations. Stringent in-process controls ensure consistent colorimetric properties and batch reproducibility, especially for export-grade pigment production.

    Industry compliance standards

    • OEKO-TEX Standard 100 chemical input assessment
    • Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH Regulation EC No 1907/2006)
    • Global Organic Textile Standard (GOTS) Section 2.4 – Input chemical traceability
    • ISO 9001:2015 certified dyehouse quality systems

    Typical usage ratio

    • 1.1–1.3 equivalents in diazo coupling step
    • Concentration adjusted for target molar absorptivity and dye stability; precision critical for tone reproducibility

    Downstream process integration

    • Added immediately post-diazotization when aromatic amine-based diazonium salts form
    • Reacts under controlled pH, typically 4.5–6.0, with ice bath cooling or jacketed reactor for exotherm management
    • Ensures dichlorinated ring closure in high-stability pigment synthesis

    Final product types

    • Disperse dyes for synthetic fibers
    • High-purity azo pigments for plastics
    • Specialty ink formulations
    • Textile dye batches for export garment finishing

    3. Agrochemical Building Block Integration

    In crop protection chemistry, 2,6-dichlorophenylhydrazine hydrochloride acts as a vital hydrazine source for constructing heterocyclic scaffolds. It enables the preparation of hydrazone or pyrazole intermediates, which subsequently feed into selective herbicide or fungicide pathways. Agrochemical formulators prioritize controlled reactivity and impurity profile to limit residuals in final commercial products registered under strict regulations.

    Industry compliance standards

    • FAO/WHO specifications for technical active ingredients
    • ISO 9001:2015 production documentation for traceability
    • EPA 40 CFR Part 158 (US) – Test guidelines for chemical composition and residue
    • Chinese National GB standards for pesticide purity and impurity limits

    Typical usage ratio

    • 0.9–1.0 molar equivalents in hydrazone ring formation
    • Optimized based on downstream cyclization yield and impurity carryover limits; over-addition not advised due to regulatory trace testing

    Downstream process integration

    • Dispensed into reactors containing diketone or keto-ester for hydrazone formation
    • Integrated at early intermediate stage — typically second or third major synthetic step
    • QC sampling follows each batch for raw impurity tracking based on supplier CoA

    Final product types

    • Precursor for pyrazole-based herbicides
    • Intermediate for triazole fungicides
    • Building block for phenylhydrazone pesticide API
    • Specialty intermediates for custom agrochemical synthesis

    4. Fine Chemicals and Research Synthesis

    Academic labs and specialty fine chemicals producers rely on 2,6-dichlorophenylhydrazine hydrochloride for preparing custom hydrazine derivatives and advanced materials. Its unique substitution enables structure–activity studies, new catalyst development, and the production of small-batch reference molecules where electronic effects of ring chlorination matter significantly in reactivity and selectivity.

    Industry compliance standards

    • ISO/IEC 17025:2017 accreditation for chemical analysis
    • Hazard Communication Compliance: OSHA 29 CFR 1910.1200 (US) for SDS/labelling
    • Transport compliance per UN Recommendations on the Transport of Dangerous Goods
    • GLP (Good Laboratory Practice) for intermediates in regulated studies

    Typical usage ratio

    • 0.5–1.5 equivalents depending on the lab-scale synthesis or batch size
    • Scaling adjusted for research, analytical, or pilot requirements; excess often avoided due to cost and environmental disposal

    Downstream process integration

    • Dosed directly into custom glassware under inert gas
    • Applied in multi-step custom syntheses, often as early or central step for hydrazide or new functional material formation
    • Used in controlled-pH or redox coupling protocols

    Final product types

    • Hydrazone-based analytical standards
    • Precursors for new catalyst compounds
    • Small-batch heterocyclic libraries
    • Custom high-value laboratory reagents
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    Certification & Compliance
    More Introduction

    2,6-Dichlorophenylhydrazine Hydrochloride: Proven Reliability from the Manufacturer's Bench

    Experience and Consistency in Chemical Manufacturing

    Every day in the manufacturing plant, precision matters. Our team has worked with 2,6-Dichlorophenylhydrazine Hydrochloride for over a decade, shaping process parameters based on actual production feedback rather than just technical theory. What started as a small-batch operation has grown into scaled, controlled production, guided by close attention to how input quality, humidity, and handling procedures affect the final yield and purity. Every kilo tells its story, and over years of observing batch differences, we’ve learned that sticking to proven methods and constant monitoring of crystallization—especially with strict control of cooling rates—makes a fundamental difference in achieving a stable, pure final product.

    The Importance of Batch Purity and Why It Matters

    Our product has a chemical formula of C6H6Cl2N2·HCl, recognized by the deep yellow crystalline appearance that marks correctly produced batches. Minute changes in synthesis temperature or reagent quality generate visible shifts in color and flow, signaling off-spec material even before titration or HPLC confirms it. Our lab team automatically rejects those batches. Many underestimate how sensitive hydrazine derivatives respond to subtle contaminants, which can throw off downstream performance in fine chemical synthesis. As direct manufacturers, we bear the consequences of impurities, so tight quality thresholds are not negotiable. Trace analysis happens on every lot, not just on paper but as a matter of real-world necessity, because our customers require predictable outcomes in their own plants and research labs.

    Why Solubility and Handling Shape User Experience

    Anyone who has prepared solutions with 2,6-Dichlorophenylhydrazine Hydrochloride knows that consistency in solubility at room temperature influences application throughput. Our fine crystalline cut offers regular bulk density and smooth handling, minimizing dust and static compared to granulated alternatives. This saves time at the bench and lowers risk, especially for operators running repetitive dissolutions for screening or synthesis. Several years ago, an adjustment to the drying protocol made a noticeable improvement in moisture stability, cutting out problematic caking that competitors still wrestle with. Stories from the synthesis line illustrate that small details—like whether the material forms clumps over time—help shape the pace of research and production down the chain.

    Applications in Synthesis: Where Performance Is Tested

    Chemists working with pharmaceuticals, dye intermediates, and reference standards often need hydrazine hydrochloride compounds that perform without introducing background interference. Many of our industrial clients use this product in the preparation of dichlorophenylhydrazones, where inconsistent purity has derailed pilot campaigns in the past. One memorable case involved a pharmaceutical lab that traced an anomalous impurity peak in their HPLC to a competitor’s hydrazine hydrochloride, setting them back weeks. This scenario served both as a warning and a lesson for us—internal batch retention and record-keeping have since doubled in rigour. Researchers need repeatable results; as manufacturers, our job is to keep a tight grip on batch-to-batch comparison and feedback loops.

    Technical Specifications Shaped by Real-World Requirements

    In the factory, the technical specification is more than a document. It forms the baseline for active process decisions. Our standard purity exceeds 98%, measured by titrimetric and chromatographic methods, reflecting what chemists expect for intermediate-level work. Moisture limits sit under 0.5%, monitored continuously in the packing line through Karl Fischer titration. The distinct hydrochloride counterion ensures higher stability against atmospheric water, giving this product an edge in storage and transit when compared to freebase hydrazines. These specs do not come from wishful targets but from practical trial and error, informed by years of customer notifications and our own cross-department incident reviews.

    Comparison: How Our Product Stands Apart

    There are differences in the market. Some manufacturers prioritize volume, opting for faster but less precise batch crystallizations. We have taken a different route—slower, staged precipitation method, followed by controlled drying. This gives a tighter lot-to-lot purity window. On the market, product from alternative crystallization processes tends to show broader particle size and more variable color, often with a faint chemical odor. Our process minimizes byproducts, which means end-users don’t have to fight with unexplained peaks in downstream spectral analysis. From direct conversations with clients, the feedback consistently praises the ease of dissolution and reliable reactivity, critical to success in both kilogram-scale pilot work and gram-level fine synthesis.

    Model: Evolving Based on Process Results

    We identify our batches through an internally developed lot system, which grew out of a need to track not just shipment dates but the entire process flow. Previous attempts to align model numbers with only the synthesis approach failed to capture key handling and drying differences. After multiple customer requests for validation documentation, we began cross-correlating our model codes with spectrographic signatures, ensuring every batch is traceable to a reproducible process. This system has roots in both chemical engineering and day-to-day troubleshooting by operators who understand how changes to reagent pH or mixing speed filter through into final product quality.

    End-Use Feedback Shapes Direction

    Direct manufacturer-client communication frequently reveals where a product’s limits become evident. In the case of 2,6-Dichlorophenylhydrazine Hydrochloride, labs running highly sensitive syntheses sometimes report difficulties sourcing a variant that maintains full specification over longer storage times. Based on this, our technical team launched a study on atmospheric stability across multiple storage conditions—a pointed lesson that storage conditions are just as important as synthesis steps. Because these conversations lead to better outcomes, we prioritize them over anonymous surveys. Each return shipment or technical complaint prompts a root cause investigation handled by both chemists and process engineers, so response cycles are short, and lessons are built directly into training programs for plant operators.

    Meeting Regulatory and Analytical Demands

    Years of supplying this compound to regulated industries have led to tighter documentation and enhanced traceability. End-users, especially in regions with heightened oversight, often require batch-level data for specification controls and independent lab verification. We maintain on-site reference libraries with retained samples and digital logs, all mapped to our internal manufacturing model codes. Periodic external audits reinforce process discipline. Our experience has shown that regulatory requests change over time, so flexibility in document preparation and continuous operator training keep us ahead of changing requirements. Attention to detail—down to how samples are labelled—makes a critical difference in passing audits with no findings.

    Innovation from Ground-Level Operations

    Improvements in this compound’s physical form have consistently come from feedback and iterative problem solving on the plant floor. An example: an operator noticed that minor tweaks to agitator blade geometry led to better solids dispersion, shortening drying times by several hours per batch. Innovations like this do not originate from upper management memos, but from the day-to-day realities of people who see the effects of minor mechanical changes on the actual product in the barrel. Encouraging this form of process innovation means lower energy use and marginally improved lots, benefits that show up most in the reduced number of customer complaints and returns.

    Packaging and Care in Transit

    Handling hydrazine derivatives requires thoughtful packaging. Our site shifted to reinforced polyethylene liners after observing product caking and fine dusting with older, unlined drums. We implemented a continuous monitoring process for warehouse humidity, cutting spoil rates by over a third. Close tracking of these physical incidents, with regular reporting and intervention led by our onsite warehouse supervisor, forms the basis for these adaptations. When a major client reported signs of moisture ingress two years ago, our shipment system was redesigned—feedback had an immediate effect, and the lessons were documented in internal protocols and in the training of new hires.

    Direct Manufacturing: Advantages in Customer Response

    Manufacturing on-site affords us a direct understanding of the production chain. Delays do not result from waiting on outsourced partners but are a matter of plant scheduling and raw material logistics, which our own team controls. Clients frequently request custom batch sizes; with direct oversight of scheduling, the plant manager reallocates reactors as needed. Adjustments, such as changing output for pilot campaigns or providing sample-sized lots for R&D, can take less than a week with minimal fuss. Outsourcing this flexibility almost always introduces risk, with more variables and less transparency.

    Sustainability: Adapting Processes to Modern Demands

    Awareness of environmental requirements in chemical synthesis has led to incremental but important changes in how we approach waste streams. Disposal of mother liquors containing chlorinated byproducts once required off-site incineration, but years of process development enabled partial recycling, cutting hazardous waste volumes by over 20 percent. We replaced some process water with on-site distilled recovery, a suggestion from our plant’s shift supervisor who tracked input-output balances closely. These sustainability measures arise out of both regulation and internal motivation; auditing waste streams happens monthly, and lessons learned filter through to both batch costs and environmental compliance paperwork.

    Challenges in Industry Supply

    Unpredictable global demand for fine hydrazine intermediates puts pressure on raw material sourcing. Fluctuations in supply and cost of chlorinated benzenes occasionally create hurdles for smooth production planning. Experience has shown that maintaining trusted supplier relationships and building reasonable buffer stocks lessens risk. One plant shutdown in a neighboring region led us to revisit both our dual-sourcing and emergency supply plans, lessons that would not be as visible in a purely transactional distribution model. These realities of direct manufacturing mean facing both macroeconomic and micro-level interruptions with contingency built into logistics by design.

    Supporting Analytical Workflows and Research Needs

    Academic labs and pilot plants often need reliable materials on short notice. Over time, we have built out a support network grounded in technical agility, not just stock availability. Scientists working on reaction mechanism studies rely on receiving the same product profile for comparison testing, not just a broad “specification match.” Upstream, the plant chemistry team works in tandem with lab contacts to troubleshoot solubility or unusual byproduct reports with fast analytical backup. This level of direct engagement, rare among non-manufacturers, creates a climate of trust that translates into multi-year supply agreements and collaboration on method development for both quality control and downstream use.

    Adapting to Market Shifts with Process Improvements

    Growth in demand for hydrazine compounds in both research and industry occasionally outpaces infrastructure. New reactor installations at our own site over the past two years responded directly to forecasted increases in market pull for advanced intermediates. The challenge of modernizing plant utilities brings opportunities to trial new temperature control logic and finer evacuation systems, which feed into improved batch reproducibility. Through direct trial and error—not generic engineering guidelines—operators and engineers shaped the evolution, sharing detailed results so each production run learns from the last. Efficiency gains go back into the business, with lower defect rates and shorter lead times, benefiting all users.

    Listening to the End User: Continuous Quality Improvement

    Long-term clients regularly share technical observations and needs, often spotlighting ways our product meets or falls short of their requirements. Perhaps the most important lesson has been the need for fast, clear lines of communication between the plant and end-user. Whether it's an obscured analytical signal or an unexpected physical shift under new reaction conditions, the feedback loop closes only when every comment reaches those empowered to make manufacturing adjustments. Direct engagement prompts process changes that not only solve acute problems but also help fill in the gray areas that generic specifications inevitably miss.

    Conclusion: Lessons From the Manufacturing Floor

    Experience as a direct manufacturer of 2,6-Dichlorophenylhydrazine Hydrochloride brings a practical, hands-on perspective to challenges and improvements in chemical supply. Every change in formulation or process, from agitation geometry to packaging adjustments, shapes the end product in real, measurable ways. Conversations with technical users refine not just product specs but the daily habits and protocols within our plant. Reliability, safety, and performance start with transparent, flexible production — qualities that only direct, ground-level manufacturing allows us to deliver. By focusing on facts from our own process lines and listening to feedback from the field, we keep quality and consistency as cornerstones for every shipment leaving our site.