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2,6-Dichloroisonicotinonitrile

    • Product Name 2,6-Dichloroisonicotinonitrile
    • Alias 2,6-Dichloro-4-pyridinecarbonitrile
    • Einecs EINECS 401-330-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    145144

    Chemical Name 2,6-Dichloroisonicotinonitrile
    Molecular Formula C6H2Cl2N2
    Molecular Weight 173.00 g/mol
    Cas Number 356783-16-9
    Appearance White to light yellow crystalline powder
    Melting Point 87-89°C
    Solubility Slightly soluble in water
    Density 1.5 g/cm³ (approximate)
    Purity Typically >98%
    Smiles C1=CC(=NC(=C1Cl)Cl)C#N
    Inchi InChI=1S/C6H2Cl2N2/c7-4-1-6(9)10-2-5(4)8/h1-2H

    As an accredited 2,6-Dichloroisonicotinonitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 2,6-Dichloroisonicotinonitrile is packaged in a sealed, amber glass bottle with a tamper-evident cap and chemical labeling.
    Shipping **Shipping Description for 2,6-Dichloroisonicotinonitrile:** This chemical should be shipped in accordance with local, national, and international regulations. It is typically packed in sealed containers to prevent moisture or air exposure, labeled as a hazardous material. Proper documentation, cushioning, and protective packaging must be used to prevent leakage or breakage during transport.
    Storage 2,6-Dichloroisonicotinonitrile should be stored in a cool, dry, well-ventilated area, away from sources of ignition, moisture, and incompatible substances such as strong oxidizing agents. Keep the container tightly closed and properly labeled. Store in a chemical storage cabinet, preferably for hazardous substances, and avoid exposure to direct sunlight. Use PPE when handling and ensure access to safety equipment.
    Application of 2,6-Dichloroisonicotinonitrile

    Applications of 2,6-Dichloroisonicotinonitrile in Industrial Manufacturing

    As a direct manufacturer specializing in high-purity chemical intermediates, we deliver 2,6-Dichloroisonicotinonitrile for defined downstream production sectors where stringent regulatory standards, controlled formulation requirements, and traceable processing are paramount. The following applications reflect established industrial usage based on real formulation demands and sector-specific compliance frameworks.

    1. Agrochemical Intermediate for Pyridine-based Crop Protection Synthesis

    Pesticide and active ingredient manufacturers apply this raw material as a core intermediate in the synthesis chains for selected chloropyridine-based herbicides and insecticides. Chemical engineers dose the material during multi-step assembly of active technical grade APIs, prioritizing impurity control to meet international maximum residue limits for end-use crop protection products.

    Industry compliance standards

    • ISO 9001:2015 Quality Management System for agrochemical production
    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • European Regulation (EC) No 1107/2009 for Plant Protection Products
    • China GB 2763-2021 Maximum Residue Limits for Pesticides

    Typical usage ratio

    • Usage ranges from 8–15% by total batch mass in technical synthesis; precise ratio depends on downstream molecule structure and targeted impurity profile in final active substance

    Downstream process integration

    • Early-stage intermediate addition to closed-automated halogenation or cross-coupling reactors
    • Sequential batch charging for condensation and cyclization steps
    • Purification via crystallization or distillation prior to technical product isolation

    Final product types

    • Technical grade herbicides, such as chloropyridine derivatives
    • Insecticide actives for foliar and soil protection formulations
    • Formulated crop protection liquids, wettable powders, and granules

    2. Pharmaceutical Building Block for Antiviral and Antitumor APIs

    Our material enters pharmaceutical synthesis pipelines as a specialized intermediate for the development of complex pyridine-core drugs, including select antiviral and antitumor active pharmaceutical ingredients. Process chemists rely on stringent lot-by-lot analytical testing and full material traceability to support US, EU, and Japanese pharmacopoeial registration and downstream GMP compliance requirements.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • U.S. Pharmacopeia (USP)
    • European Pharmacopoeia (Ph. Eur.)
    • Japan Pharmacopoeia (JP)

    Typical usage ratio

    • Utilization between 2–7% by mole equivalent in multi-stage API syntheses; amount adjusted based on molecular complexity and final impurity tolerances

    Downstream process integration

    • Nitrile intermediate charging during key cyclization or substitution reactions
    • Reaction step monitored by HPLC and LC-MS for real-time yield control
    • Material handled in GMP-approved reactor trains with validated cleaning protocols

    Final product types

    • Pharmaceutical raw APIs for oral or injectable antivirals
    • Building blocks for antitumor agents with pyridine ring structures
    • Regulatory submission samples for clinical manufacturing

    3. Specialty Intermediate for Dye and Pigment Synthesis

    Colorant manufacturers adopt this material within specific synthetic dye and pigment pathways to introduce dichloro functional groups onto aromatic frameworks, producing unique chromophore shades and enhancing light fastness properties. The chemical is dosed under tightly controlled conditions to ensure predictable shade reproducibility and environmental safety in waste stream management.

    Industry compliance standards

    • ISO 9001:2015 for colorant production
    • REACH Regulation (EC) No 1907/2006
    • Oeko-Tex Standard 100 (for textiles applications)
    • GHS labeling and SDS compliance

    Typical usage ratio

    • Formulations include 5–10% by weight during intermediate formation; proportion varies according to targeted pigment structure and batch scale

    Downstream process integration

    • Entry point at first step of halogenated pyridine condensation in pigment synthesis
    • Controlled addition to batch or continuous flow lines for dye chromophore assembly
    • Subsequent coupling or metallization stages to expand color range

    Final product types

    • Specialty organic pigments for plastics masterbatch
    • High-performance dyes for digital textile inks
    • Functional colorant dispersions for coatings and polymers

    4. Fine Chemical Intermediate for Electronic and Photonic Materials

    Manufacturers in the electronics and photonic sectors require specialty dichloroisonicotinonitrile derivatives as advanced intermediates when engineering optoelectronic materials, OLED intermediates, and selective semiconductors. The raw material is employed in fine-tuned feed ratios to control electronic properties, minimize ionic contamination, and satisfy downstream device performance benchmarks.

    Industry compliance standards

    • IEC 61249-2-21 for materials in electronic equipment
    • RoHS Directive (EU) 2011/65/EU for restriction of hazardous substances
    • ISO 14001 Environmental Management System
    • IPC-4101 for base materials in printed circuit boards

    Typical usage ratio

    • Implemented at 3–6% by mass as a reactive intermediate; ratio altered in line with targeted photonic or conductive layer properties

    Downstream process integration

    • Feeding to precursor synthesis step for OLED or display active layer production
    • Integrated under inert atmosphere in dry, moisture-controlled reaction units
    • Material subjected to high-purity filtration and IC/ICp-MS analysis post-reaction

    Final product types

    • Intermediate chemicals for organic LED and display production
    • Fine chemicals used in photoresists and imaging resins
    • Specialty components for printed electronics

    5. Intermediate for Veterinary Drug Synthesis

    Producers of veterinary pharmaceuticals use dichloroisonicotinonitrile as a core intermediate in synthesis routes for targeted pyridine-based veterinary actives. Each batch is incorporated with strict process validation and analytical support to demonstrate compliance with regulatory dossiers and guarantee safe, traceable inclusion in final veterinary medicine products.

    Industry compliance standards

    • VICH GL3 (GMP for Active Pharmaceutical Ingredients)
    • European Pharmacopoeia (Ph. Eur.) Monographs for veterinary use
    • US FDA Guidance for Industry #201 Veterinary Drug Residue—Chemistry
    • China Veterinary Pharmacopoeia

    Typical usage ratio

    • Synthesis phase employs 4–9% by mole equivalent; specific loading based on proprietary synthesis design and desired residue limits

    Downstream process integration

    • Incorporation at condensation or cyclization step in veterinary API formation
    • Comprehensive in-process monitoring and material identity confirmation
    • Downstream purification using high-vacuum isolation and HPLC validation

    Final product types

    • Raw active veterinary pharmaceutical ingredients
    • Finished veterinary tablets, suspensions, and injectable formulations
    • Registration samples for dossier filing in major veterinary markets
    Free Quote

    Competitive 2,6-Dichloroisonicotinonitrile prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 2,6-Dichloroisonicotinonitrile: Quality You Can Rely On

    Where Applied Knowledge and Practical Chemistry Meet

    Every step in creating a consistent batch of 2,6-Dichloroisonicotinonitrile demands focus, from sourcing raw materials to the pressure in the reactor. Our team works long hours to perfect every run, not just for a certificate, but for the peace that comes with knowing our partners downstream will open a drum and find exactly what they expected — no surprises. Chemists and technicians at our plant see the molecule for what it truly is: a platform ready for building other compounds, essential in more than one synthesis pathway. We craft each batch to specifications suited for challenging syntheses, especially when reproducibility and purity shape the outcome for agrochemical or pharmaceutical intermediates.

    Model and Specifications Matter: Building Trust Molecule by Molecule

    Our standard product delivers a high purity, free from common residual solvents or byproducts that frequently slip through elsewhere. Moisture content must remain minimal, because with sensitive nucleophiles downstream, every trace of water can start side reactions that put an entire day’s work at risk. Particle size affects how the compound handles and dissolves, so we monitor it, not to advertise a number, but to avoid headaches during transfers or weighing. Chloride content and residue on ignition get controlled to support catalysts or reactions prone to inhibition. We don’t watch these numbers to meet regulations – we do it because we’ve dealt with rework and reject piles ourselves.

    On the shop floor, chemists rely on our efforts: single-digit ppm impurities, low moisture, and a product that pours well. Shipping quality starts hours before packaging. Whether the order calls for drums or bags, every package comes off the line with a spec sheet that tracks batch traceability and analytic results. No two customers run identical processes, and while we can tailor granulation or carrier solvents under special orders, we see more results when we focus on keeping our main grade predictable and reproducible.

    The Real Uses Beyond the Labels

    2,6-Dichloroisonicotinonitrile slots into synthetic schemes where the pyridine ring’s position and halogen pattern act as crucial handles for further modification. In the last decade, demand has risen especially from agriculture products, with crop protection compounds drawing on the versatility of this intermediate. In a pharmaceutical context, this nitrile often feeds into libraries of heterocyclic scaffolds. The molecule’s reputation centers on how well it holds up under coupling and cyclization steps. No manufacturer enjoys calls about byproducts or residual contaminants that foul sensitive reactions, so purity and batch consistency have become the currency of real partnerships.

    Some of our clients adapt continuous flow chemistry or microreactor setups; quality requirements become stricter, since the automation tolerates even less batch variation. Others work by batch, blending this intermediate into a larger kettle synthesis, yet both groups expect shipments to retain precisely the attributes agreed upon — every drum, every time. Our direct relationship with these users means we hear quickly if particle size slows down filtration, or if trace chlorides gum up a catalyst bed. We address issues by adjusting parameters upstream, having invested in pilot-scale kettles to validate every process tweak.

    What Sets Authentic Material Apart

    It’s easy to promise high purity, but fewer suppliers detail the impurity profile or back their words with third-party chromatographic data. Ours is published because we continue to see users struggle with off-color, poorly soluble alternatives sourced elsewhere. By limiting side reactions during chlorination and maintaining strict controls during drying and packaging, unwanted halides and breakdown products remain in check. Our specifications go past typical minimums not because regulations dictate it, but because we’ve taken calls from plant managers halfway around the globe whose production targets rely on batch-level reliability, not marketing claims.

    Some minor byproducts plague other versions on the market, particularly where aggressive chlorination leads to ring cleavage or unwanted substitution — often invisible until late-stage reactions. In the early days, we found these problems ourselves, learning that patience at the purification stage makes the difference between “good enough” and “trusted partner for five years running.” We adjusted drier temperatures, improved inline sensors, and trained operators to track even subtle changes in product smell and color. We have no patience for reprocessing or scrap caused by problems upstream.

    Why Specifications Keep Changing: Not Every Process Looks Alike

    One truth that stays consistent: clients keep refining their own processes, pushing boundaries with automated systems or more stringent final product specs. Instead of clinging to a static grade sheet, we collect real-world feedback about how our batches interact with other reagents, solvents, and catalysts. If a residue or trace contaminant stalls a downstream reaction, we figure out where it’s coming from, make adjustments, and send samples ahead of full-scale deliveries.

    We know some partners look for options with reduced environmental footprints or meet tight emissions targets during synthesis. Our facility underwent upgrades to solvent recovery and emissions control, but also to support requests for alternative drying techniques that cut process energy while keeping purity undisturbed. In each case, these changes come from conversations with users who invite us into their workflow, rather than just as a vendor. We’ve grown to see quality as a moving target, adapting tools, training schedules, and even lab methods to keep up with what matters outside our gates.

    Proof in Every Drum: Deep Roots in Quality Control

    A reliable batch begins long before material ever reaches a drum or bag. Raw material selection gets tighter every year, with suppliers required to share more detail about their own process impurities. Traceability follows each step: from mixing to chlorination, washing, and isolation. Each intermediate tank and dryer load gets samples drawn and tracked, with retention samples stored for years to protect our users in case an old batch needs investigation. Customers rarely see those behind-the-scenes routines, but our operators and analysts know that skipping a step never pays in this business.

    We run full GC-MS, HPLC, and elemental analyses not because an auditor is watching, but because experience taught us the pain of a process that drags down a client’s line. Some specifications — like solubility in certain organic solvents — become critical for specific end products, so we often test additional parameters for advanced clients even if the spec isn’t printed on the main certificate. Issues from dusty samples or poor flow behavior led us years ago to lock down not only particle size, but bulk density and flowability, especially for clients using pneumatic transfer or automated feeders.

    Clients reaching out with complaints almost always give us a chance to get even better; we’ve invested in remote monitoring and rapid-response testing to catch trends early, correcting for weather shifts or raw material variability. Once, a single off-spec impurity led a key client to halt production until a cause was found. Our troubleshooting team didn’t stop until they not only fixed the current lot, but traced back to an upstream alteration in a supplier’s delivery window. That memory shapes our follow-through today.

    Differences Set by Verification, Not Hype

    Competitors often treat this product as a bulk commodity, leaving out the controls needed for research-scale or medical intermediate applications. By going further on quality verification, we secure long-standing relationships rather than chasing one-off sales. Buyers who depend on simple resellers often find themselves left with more variability, especially as traders blend lots or ship on extended timelines that stress shelf life or introduce off-spec contamination. By contrast, our model puts production squarely under one roof, every batch managed and certified from start to finish by the same hands that built the process.

    We run regular shipment audits — opening drums at random on arrival at key client sites — to back up our claims on stability, moisture retention, and ease of handling. If there’s a shipping hiccup or a storage challenge in a humid warehouse, we hear about it, and our materials science group looks at desiccant choice or fresh lining in packaging. Small changes, learned over years, keep product handling and storage trouble-free outside of pristine lab conditions.

    The Role of Real Communication in Meeting Customer Goals

    In our business, a successful relationship grows less from contracts and more from regular check-ins about how well the product performs in each new campaign. We set up joint studies when users ask how changes in the upstream process translate on their lines. Open lines of feedback, combined with a thorough change notification system, mean clients avoid costly surprises. It’s routine for our engineering and R&D leads to join virtual meetings with users halfway around the world, bringing together on-the-ground experience with technical troubleshooting.

    Many times, a new synthetic route or process change on the user’s end raises questions about reactivity with low-level side components or new solvents. Instead of sending a revised COA and moving on, we send technical teams to study those reactions, often adapting a portion of our pilot facility to trial the process tweak and see what happens at scale. This hands-on collaboration fuels every upgrade — from raw input selection to how we validate process control. In practice, it means clients trust their timelines and avoid disruptions from unwelcome surprises in a drum.

    Pushing for Sustainable and Reliable Chemistry

    Environmental targets get tighter every year. Meanwhile, users rely on a reliable supply of crucial intermediates. To bridge the gap, we invested in process upgrades that cut solvent losses and emissions, not only to check a box but because solvent fumes and dust translate into both environmental and workplace risk. Recovery systems now route solvent streams back into closed circuits, keeping workers safer while supporting responsible stewardship. Most importantly, our on-site lab checks every batch for byproducts that can signal runaway reactions or process inefficiency, delivering feedback right to the process engineers before shipping.

    Several clients came to us wanting to lower their environmental burden for customer-facing products, asking for greener profiles or enhanced sustainability documentation. By pulling in external audits and participating in industry consortiums, we benchmark our own practices and keep pushing for safer alternatives, including updated reagents and milder conditions during manufacturing. This philosophy keeps us transparent — not only about product specs but also about how each kilogram reaches the user, and the story behind it.

    Direct Experience: The Value of Long-Term Production History

    We started making this compound in response to custom projects — requests that never fit neat catalogs, sometimes calling for tons, sometimes a single pilot run. Early years meant figuring out the hard way why batch size or agitation scheme made some material easier to filter and dry. Putting in the hours on the ground, we learned to trust real data over wishful thinking, collecting feedback during every campaign to make each next batch a step better. Some users run high throughput, counting on uninterrupted supply; others build value in small campaigns over many months. Both approaches ask for traceability, and our long record of keeping every lot sample archived builds confidence for demanding users.

    We keep product development open, running pilot campaigns on new variants or grades if a user comes with special needs. While most rely on the trusted main specification, a few require tighter control or a special impurity profile, especially in sensitive pharmaceutical or diagnostic applications. Instead of spinning up a new brand or creating layers between user and operator, we keep the process in-house and talk one-on-one about what will solve the problem at hand.

    Supporting Advanced Research and Scale Production

    Research labs and scale-up teams both need more than a shipped drum. Detailed batch records, in-person technical exchange, and a demonstrated willingness to adjust are all part of the experience. Our best partnerships grew from a willingness to send small custom samples or open the plant’s doors for joint development, giving researchers and engineers a direct role in refining specs. Confidence grows with each successful synthesis, proven by fewer reprocessing steps or less downtime.

    As research fields shift, established partnerships help everyone adapt to new regulatory guidelines, greener chemistry, and evolving application requirements. By engaging early, sharing analytic data, and validating changes on pilot lines, we stay out in front of predictable supply and quality challenges. Decades of method development and real-world troubleshooting mean we support customers through changes — the opposite of anonymous, mass-market supply.

    Takeaway: Performance You Can Build On

    2,6-Dichloroisonicotinonitrile’s value comes not just from the synthetic transformations it enables but also from predictable performance thanks to decades of focused experience. By controlling every step, listening to end users, and constantly refining both process and product, we’ve turned a simple molecule into the backbone of countless innovations across industries. Users understand, sometimes only after costly errors elsewhere, why the origin and handling of chemical building blocks set the trajectory for every new product. We build confidence with facts, experience, and a willingness to keep improving. The real difference lies in the details: verified quality, direct partnership, and a relentless drive to solve the practical problems that turn ideas into results. Each drum tells its own story — and every order keeps shaping our approach for the better.