Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing sales7@sinochem-nanjing.com 3389378665@qq.com
Follow us:

2,6-Dibromo-4-Nitrophenol

    • Product Name 2,6-Dibromo-4-Nitrophenol
    • Alias BRN 110377
    • Einecs 218-860-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    134947

    Name 2,6-Dibromo-4-Nitrophenol
    Cas Number 609-17-4
    Molecular Formula C6H3Br2NO3
    Molecular Weight 312.90
    Appearance Yellow crystalline powder
    Melting Point 191-194°C
    Solubility In Water Slightly soluble
    Density 2.39 g/cm³
    Synonyms 2,6-Dibromo-4-nitro-phenol
    Pubchem Cid 13091
    Smiles C1=C(C=C(C(=C1Br)O)Br)[N+](=O)[O-]
    Inchi InChI=1S/C6H3Br2NO3/c7-3-1-4(8)6(10)2-5(3)9(11)12/h1-2,10H
    Storage Conditions Store at room temperature, protect from light

    As an accredited 2,6-Dibromo-4-Nitrophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 2,6-Dibromo-4-Nitrophenol, with hazard labeling, tightly sealed cap, and product information.
    Shipping **Shipping Description for 2,6-Dibromo-4-Nitrophenol:** Ship in tightly sealed containers, protected from light and moisture. Store and transport under cool, dry conditions. Handle according to standard chemical safety regulations. Clearly label as a hazardous material—potentially harmful and environmentally toxic. Comply with relevant local, national, and international shipping guidelines for hazardous chemicals.
    Storage 2,6-Dibromo-4-nitrophenol should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizing or reducing agents. Protect from light and moisture. Clearly label the storage area, and ensure only trained personnel have access to minimize exposure risk. Use appropriate secondary containment.
    Application of 2,6-Dibromo-4-Nitrophenol

    Applications of 2,6-Dibromo-4-Nitrophenol in Industrial Manufacturing

    2,6-Dibromo-4-nitrophenol serves as a specialty intermediate in select chemical manufacture, supporting demanding synthesis requirements in specialty dyes, advanced agrochemical formulations, pharmaceutical intermediates, and high-performance pigment production. Its unique brominated phenolic structure enables targeted substitution reactions and precise molecular modifications essential for these specialized fields.

    1. Dye Intermediate for Azo and Polycyclic Dye Manufacture

    In the colorant industry, 2,6-dibromo-4-nitrophenol is used as a halogen-rich precursor in the synthesis of complex azo and anthraquinone dyes where precise electron-withdrawing effects enhance tinctorial properties, lightfastness, and solvent resistance. Its introduction typically occurs during the diazonium coupling phase, where controlled substitution improves chromophore stability and facilitates later sulfonation and metallization steps. Color houses adjust the input ratio based on targeted hue intensity and bath exhaustion requirements, ensuring regulatory compliance for textile and plastics coloration.

    Industry compliance standards

    • OEKO-TEX ECO PASSPORT chemical input requirements
    • REACH Annex XVII and SVHC restrictions (Europe)
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • EN 71-3:2019 safety requirements for toy colorants

    Typical usage ratio

    • 0.2–3.0% by weight in dye intermediate batch, with adjustment according to shade depth and substituent yield targets

    Downstream process integration

    • Added during selective bromination or nitration step post-condensation; participates directly in diazo coupling or anthraquinone ring functionalization prior to finishing and salt formation

    Final product types

    • Disperse, reactive, and acid dyes for polyester, nylon, and acrylic fibers
    • Specialty printing inks for plastics and synthetic polymers
    • Colorant preparations for textile auxiliaries and masterbatches

    2. Intermediate for Agrochemical Active Ingredient Synthesis

    Agrochemical manufacturers use 2,6-dibromo-4-nitrophenol as a halogenated nucleus in the production of select fungicides and herbicide intermediates, where the specific halogen/nitro substitution pattern confers enhanced bioactivity and persistence. The compound enters the synthetic pathway during nucleophilic aromatic substitution for constructing target pesticide cores, often in multistep processes prior to esterification or amide coupling. Its dosing is optimized for downstream reaction yield, minimizing waste and maximizing conversion efficiency per QSAR-driven design.

    Industry compliance standards

    • Good Manufacturing Practice (GMP) for Active Ingredients (European Commission Regulation (EU) 2017/880)
    • US EPA Pesticide Registration Guidelines
    • ISO 9001:2015 for agrochemical intermediate production
    • Chinese GB 2763-2021 Maximum Residue Limits for Pesticides

    Typical usage ratio

    • 0.4–1.2 molar equivalents, precisely calculated per molecular stoichiometry and reaction step yield in multicomponent synthesis

    Downstream process integration

    • Fed into nucleophilic substitution or coupling reaction following initial aromatic activation; undergoes transformation during construction of heterocyclic agrochemical cores prior to final granulation or emulsification

    Final product types

    • Bromonitro-substituted triazole fungicides
    • Precursor building blocks for pyridyl-based herbicides
    • Agrochemical actives for industrial crop protection

    3. Pharmaceutical Intermediate for Antimicrobial and Antineoplastic APIs

    Within pharmaceutical synthesis, this compound is introduced as a key building block for specific APIs requiring halogen-rich phenolic scaffolds, especially in antimicrobial or cytotoxic drug discovery platforms. Chemical process engineers implement it at intermediate stages such as oxidative coupling, preparing derivative moieties required for subsequent functionalization. Its precise addition supports process reproducibility, impurity control, and compliance with cleanroom-grade production standards for APIs targeting regulated international markets.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • USP <797> and Ph. Eur. regulations for pharmaceutical intermediates
    • FDA 21 CFR Part 210/211 for finished pharmaceuticals
    • EDQM CEP/ASMF documentation requirements

    Typical usage ratio

    • 5–30 mmol per mole of final API, calibrated by desired substitution level and side-product management

    Downstream process integration

    • Salt or ester form enters synthetic route after initial acylation; enables stepwise coupling, oxidation, or hydrogenation prior to API crystallization or micronization

    Final product types

    • Specialty antimicrobial API intermediates for parenteral formulations
    • Cytotoxic compounds for oncology research
    • Diagnostic marker molecules for laboratory use

    4. Functional Pigment Precursor for High-Performance Coatings

    Coating and pigment producers utilize this molecule as a functionalized raw material in the synthesis of brominated organic pigments where resistance to UV and chemicals is critical, such as in marine, automotive, and industrial paint systems. It is incorporated during specific coupling or condensation polymerization reactions to establish color stability under harsh service conditions. Consistent input and monitoring facilitate batchwise color uniformity that meets performance and end-use regulatory requirements.

    Industry compliance standards

    • ASTM D01 for organic pigment performance
    • ISO 9001:2015 for pigment quality management systems
    • RoHS Directive (2011/65/EU) for restricted substances in coatings
    • AP(89)1 Council of Europe for coatings in contact with food

    Typical usage ratio

    • 0.8–2.7% w/w in pigment precursor reaction mix, controlled for pigment yield and shade formulation

    Downstream process integration

    • Introduced post-alkylation in the pigment precursor stage; used prior to chlorination or sulfonation during high-temperature polymer colorant synthesis, followed by filtration and finishing

    Final product types

    • High-fastness organic pigments for coatings
    • Marine and automotive paint colorants
    • Industrial powder coating additives
    Free Quote

    Competitive 2,6-Dibromo-4-Nitrophenol prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to sales7@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: sales7@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    2,6-Dibromo-4-Nitrophenol: A Commitment to Consistent Quality and Reliable Performance

    Understanding the Chemicals We Make: Centering Experience in 2,6-Dibromo-4-Nitrophenol Manufacturing

    Production does not stop with an order fulfilled and a shipment on the road. In chemical manufacturing, especially for specialty compounds like 2,6-dibromo-4-nitrophenol, reliability takes shape over years of refinement, feedback, and direct application knowledge. Each batch we produce reflects our understanding—from source material scrutiny to final characterization. 2,6-dibromo-4-nitrophenol is not just a formula to us; it’s a commitment. Precision in process brings quality that scientists and engineers recognize each time they engage with our product, whether probing its molecular structure in a research lab or scaling synthesis for new materials.

    Key Features and Distinguishing Factors

    Many compounds carry a handful of halogen substitutions, but 2,6-dibromo-4-nitrophenol stands apart through its unique combination. Its two bromine atoms, set at meta positions, create clean cutting points for further chemical modification. The nitro group at the para position balances reactivity and stability, making it valuable in syntheses where controlled transformation matters. Over the years, we’ve honed techniques to minimize impurities, avoid excessive discoloration, and deliver consistent melt-point performance—small details that matter in analytical chemistry or fine organic synthesis.

    Standard product comes as a yellow solid, often crystallized in forms easily handled and weighed, allowing customers to scale from milligram to kilogram with confidence. Our own control procedures, developed over years of lab and plant experience, seek out minor byproducts and catch them before a lot ever reaches a drum. Solubility profiles remain true from lot to lot, which means chemists do not fight flaky residues or inexplicable losses during work-up. That consistency doesn’t come from documentation alone—it results from listening to partner labs, learning what works and what doesn’t in day-to-day use.

    Specifications That Matter Where it Counts

    We rely on specifications drawn from deep experience, not just theoretical purity claims. Typical content of active ingredient surpasses 98%, with most lots exceeding that. Trace halogenated byproducts can sabotage a synthetic route, so we screen for those using dedicated chromatography paired with UV or MS detection. Moisture content sits below 0.5%, measured by Karl Fischer titration rather than guesswork. Color, often overlooked in technical sheets, tells its own story; slight deepening signals possible oxidative changes, best caught before they cause off-spec reactivity later on.

    Particle size often dictates success in solid-phase reactions or fine dispersions. Customers working in analytical applications see the difference firsthand. We have responded by tuning grinding and sieving operations to deliver uniformity without excess fines. You can expect most of our product to pass a 60-mesh, but not break down into dust, which cuts transfer losses and simplifies weighing for low-scale synthetic work. Each batch receives full analytical support: NMR spectra confirm the skeleton, IR checks functional group integrity, and materials are always HPLC-profiled to pinpoint possible co-eluted impurities.

    Applications Developed By and For Experienced Chemists

    Few chemicals enjoy a one-size-fits-all status in research or industry, and 2,6-dibromo-4-nitrophenol is no exception. Its value comes to light in several fields. Primarily, it serves as a robust intermediate—its halogens and nitro group unlocking options for sequential substitution, Suzuki couplings, or nucleophilic displacement. In our experience, research groups often leverage its scaffold for new pharmaceutical explorations or dye development. The position of the bromines means transformations can be both predictable and selective, a property organic chemists prize when chasing new molecular architectures.

    Environmental testing labs make use of it as part of standard reference solutions, given its stability against hydrolysis and straightforward detection by spectroscopic methods. Some polymer manufacturers incorporate it for specialty monomer development, taking advantage of its electron-withdrawing characteristics to fine-tune the properties of more complex frameworks. Over the past decade, we have watched regulatory changes nudge research toward greener options—this molecule often fulfills that need thanks to its well-mapped degradation profile and manageable waste footprint compared with heavier halogenated analogs.

    Differences That Matter Compared to Other Phenol Derivatives

    Lab users and production chemists routinely ask: what sets this compound apart from cousins like 2,4-dibromo-6-nitrophenol, monochlorinated derivatives, or the simpler 4-nitrophenol? Direct experience reveals three primary factors. First, the dual bromine arrangement on the aromatic ring offers an extra handle—making selective cross-coupling simpler and often cleaner than with single-halogen compounds. Synthesis planning benefits: fewer side paths, less unpredictable isomerization, more robust yields. Second, the nitro group’s electron withdrawal tempers excessive reactivity, which means less risk of runaway side reactions and easier purification downstream.

    Other suppliers sometimes offer similar phenols, but close examination shows practical differences. Impurities originating from over-bromination or from unreacted starting materials often show up in off-brand or hastily made product. These interfere with both analytical signals and reaction selectivity. Our approach, developed through long relationships with repeat customers, centers on eliminating those contaminants through extra washing and re-crystallization—an additional step some skip for the sake of margin, but one we view as essential for the end-user’s workflow.

    Handling characteristics also set 2,6-dibromo-4-nitrophenol apart. The crystalline form discourages clumping, which benefits both weigh-out and transfer. Similar nitrophenols, especially those with only one bromine atom or those without a para-nitro group, don’t always behave as predictably—they may cake or create issues at joints or endpoints, eating up precious time and resources in large or small production settings. By focusing on the practical ways companies and labs use these materials, we build in the features that customers have told us, year after year, make the work flow more smoothly.

    Keys to Reliable Sourcing: Our Approach Learned Over Decades

    We have always believed that the route from raw material to finished product should serve customers with clarity and accountability. These ethics matter most when supply chains tighten or critical projects rest on timely, repeatable deliveries. Over the years, we have built up direct purchase channels for essential brominating and nitrating agents to limit variability upstream—small steps, but vital ones.

    Quality control in our facility mirrors this attention; analysts who have spent years with these compounds notice the faintest shifts in color or flow. That experience lets us trouble-shoot long before a batch ever reaches customers. Analytical transparency means we publish our typical ranges for melting point (usually around 170-175°C), residual solvents (kept below 0.1% by weight), and halogen-free material (confirmed by combustion analysis). This creates reliability where it counts: no guesswork, and no surprises for the end user.

    For companies sourcing for scale-up projects, this kind of stability can make or break a development timeline. From our vantage point as a manufacturer, we have a clear view of how small deviations in QA can have outsize consequences externally. We invest both in the stability of our own supply and in technical staff whose experience and judgment keep standards high. The tight feedback loop between batch production and customer lab results ensures that problems get nipped in the bud before they can cascade into costly project delays or troubleshooting cycles.

    Supporting Our Industry Partners with Direct Knowledge

    Technical documentation tells only part of the story—the rest comes from fielding questions and adapting to unique requests. Over the past decade, we have worked with clients needing not only varying purity levels, but also adjustments in particle size, packing format, and even custom analytical profiling. Such requests might not sound like much on a datasheet, but they have made the difference in successful analytical campaigns, robust pilot-scale syntheses, or clean downstream coupling reactions.

    Open communication brings benefits on both sides. Often, researchers find something unexpected during application—a solubility hiccup, a minor instability—that never appears in generic technical bulletins. Because we work directly with end users, we troubleshoot, dial in improvements, and incorporate new best practices into subsequent batches. This two-way street not only benefits individual clients, but also strengthens the reliability of our material for the wider scientific community.

    Sourcing directly from the plant that made the batch streamlines problem resolution and ensures a feedback loop. Colleagues and customers alike know they can speak directly with chemists and operators who understand every detail of product origin and preparation. This immediate access to knowledge creates market trust, not simply through slick branding, but by delivering consistent, documented outcomes.

    Building Trust Through Technical Transparency

    Markets often reward speed or price, but in our experience, sustainable partnerships in specialty chemicals grow from honesty and technical transparency. We routinely document thorough batch records, retain analytical samples, and keep communication lines open for as long as clients have questions or concerns. That culture of openness extends to admitting limitations; if a requested purity grade or particle size distribution falls outside our quality comfort zone, we explain why and offer guidance on what can be delivered reliably.

    In our view, cutting corners—by skipping critical washes or masking minor color changes—serves nobody in the long run. Some partners value nothing more than knowing exactly what they are getting and how it behaves over time. Consistency in 2,6-dibromo-4-nitrophenol manufacturing is not some abstract ideal, but an obligation, born from repeated hands-on work with demanding chemistries. This is where our accumulated experience finds its true worth: guiding adaptation, preparing for shifts in sourcing, and keeping our promises to people who need this compound to meet their own high standards.

    Paths to Improvements: Listening and Learning With Every Lot

    No manufacturing process stands still. Throughout years of experience with 2,6-dibromo-4-nitrophenol, we have seen new research demands—finer particle sizes for microfluidics work, even stricter controls on trace metal content to meet pharmaceutical precursor rules, and tighter packaging specs for easier sampling. Our response has been hands-on. Rather than treating such requests as disruptions, we treat them as instructions toward better product and deeper service.

    Often, a customer points out a problem first noticed by technicians at the point of use: a batch clumped after long storage, or a faint aroma suggested trace decomposition, or workup yields dipped without clear explanation. Solutions come not from generic answers, but from careful review and targeted process changes. We add sieving steps, adjust drying cycles, change packaging, or invest in better detection equipment. Over time, such focused changes accumulate, and lot-to-lot consistency tightens still further. This mindset—continuous improvement, always learning—is how we keep product performance ahead of expectations and ahead of copycats.

    Our conviction rests on living up to the rigorous standards set by our longest-term, most demanding partners. Their work in research, production, and quality control offers the toughest and most valuable tests. By listening and acting on feedback from those closest to the chemistry, we refine what goes into every bottle and drum, making 2,6-dibromo-4-nitrophenol not just another entry in a catalogue, but a reliable tool, trusted over many projects and research cycles.

    Looking Ahead: Meeting Tomorrow's Challenges in Synthesis and Quality

    We do not take confidence for granted in specialty chemicals manufacturing. Each new regulatory wave, application trend, or supply chain disruption brings demands for change and higher standards. In 2,6-dibromo-4-nitrophenol manufacturing, this means watching emerging analytical standards—lowering detection thresholds for impurities, preparing for alternative halogen sources, or building in traceability from precursor to packaged final product. The ability to adapt has always separated enduring manufacturers from transient traders; we shape our investments accordingly.

    As technology opens new uses for phenolic intermediates, we stay close to the scientific community, monitoring breakthroughs in green chemistry or data-guided synthesis. This relationship keeps our products not just qualified, but specifically valued for modern research and development. Our goal is to be more than a supplier; we aim to be a trusted source of insight, reliable performance, and continuous innovation. Each new lot, each partnership, gives us the opportunity to renew that commitment and uphold the standards that define specialty chemical manufacturing at its best.