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2,6-Diaminopyridine

    • Product Name 2,6-Diaminopyridine
    • Alias 2,6-Pyridinediamine
    • Einecs 202-988-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    309345

    Chemical Name 2,6-Diaminopyridine
    Molecular Formula C5H7N3
    Molecular Weight 109.13 g/mol
    Cas Number 141-86-6
    Appearance White to pale yellow crystalline solid
    Melting Point 145-148 °C
    Boiling Point 273 °C at 760 mmHg
    Solubility In Water Soluble
    Density 1.23 g/cm³
    Flash Point 170 °C
    Pka 6.80
    Synonyms 2,6-Pyridinediamine, 2,6-PDA
    Odor Aromatic

    As an accredited 2,6-Diaminopyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2,6-Diaminopyridine, 100g, is packaged in a sealed amber glass bottle with a secure screw cap, labeled with safety information.
    Shipping 2,6-Diaminopyridine is shipped in tightly sealed containers, protected from moisture and light, and complies with relevant chemical transport regulations. It is classified as a hazardous material, so it should be handled and transported by authorized carriers with appropriate hazard labeling and documentation. Storage during shipping should avoid heat, ignition sources, and incompatible substances.
    Storage 2,6-Diaminopyridine should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and acids. Protect it from moisture and direct sunlight. Store at room temperature and ensure proper labeling. Use appropriate precautions to avoid inhalation, ingestion, and contact with skin or eyes during handling.
    Application of 2,6-Diaminopyridine

    Applications of 2,6-Diaminopyridine in Industrial Manufacturing

    2,6-Diaminopyridine serves as a highly functional intermediate in specialized industries requiring consistent quality and precise technical application. Our manufacturing expertise ensures that product characteristics remain stable throughout large-scale supply, delivering reliability and efficiency across advanced chemical processing sectors. Below, we detail major industrial scenarios where downstream utilization of this chemical plays a critical operational role along with segment-specific standards, practices, and product integration.

    1. Hair Dye Intermediate for Oxidative Coloring Formulations

    Large-scale hair color producers in the personal care industry use 2,6-Diaminopyridine as a primary intermediate in manufacturing permanent oxidative hair dyes. Its electron-donating amine groups support the generation of stable, long-lasting color molecules during the dyeing process, contributing to shades ranging from light brown to dark black. QC measures in manufacturing strictly control purity to avoid off-color byproducts and to comply with international cosmetics regulations.

    Industry compliance standards

    • EU Regulation (EC) No 1223/2009 on Cosmetic Products
    • USA FDA Title 21 CFR Part 73 (listing of color additives for hair dye)
    • Japan's Standards for Cosmetics (MHLW Notification)
    • ISO 22716 Cosmetics—Good Manufacturing Practices (GMP)

    Typical usage ratio

    • 0.1%–2.0% of total dye cream formulation, adjusted according to required shade intensity and shade combination strategy

    Downstream process integration

    • Used in the pre-neutralization phase for preparing dye base intermediates, followed by oxidative coupling (hydrogen peroxide or similar oxidizers) mixed into the cream or gel matrix

    Final product types

    • Permanent oxidative hair color creams
    • Resistant grey-coverage hair gels
    • Professional salon-use coloration kits
    • Consumer home dyeing products

    2. Pharmaceutical API Intermediate: Synthesis of Anti-Hypertensive Agents

    The pharmaceutical sector incorporates 2,6-Diaminopyridine as a core building block for the synthesis of certain active pharmaceutical ingredients (APIs), especially within the quinoline or pyridine derivative classes used in anti-hypertensive therapies. Downstream API manufacturers demand strict traceability, batch-to-batch consistency, and impurity profiling, often requiring customized synthesis support to fulfill DMF and pharmacopoeia registration dossiers.

    Industry compliance standards

    • EU GMP Directive 2017/1572/EU for Medicinal Products
    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • USP–NF and EP monographs (where applicable)
    • US FDA DMF (Type II) for intermediate registration

    Typical usage ratio

    • Applied as a limiting reactant, usually 0.5–1.5 molar equivalents based on synthesis pathway; usage level defined by target molecule yield and synthesis efficiency parameters

    Downstream process integration

    • Introduced at initial condensation synthesis stage for API backbone construction, followed by purification, crystallization, and salt formation steps unique to each drug substance

    Final product types

    • Anti-hypertensive drug APIs (e.g., pyridine-based hydrochloride salts)
    • Intermediates for nervous system modulators
    • Specialty pharma-grade intermediates for proprietary molecule discovery

    3. Precursor in High-Performance Polymer Additives

    Polymer manufacturing facilities employ 2,6-Diaminopyridine in the synthesis of advanced engineering polymer additives, especially as a monomer source for aromatic polyamides and specialty polyimide resins. Its incorporation introduces favorable electronic properties, enhancing resistance to thermal and chemical environmental factors, and is vital in electronic-grade film production for circuit substrates.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 (Substance Registration)
    • RoHS Directive 2011/65/EU for Electrical/Electronic Equipment
    • IEC 61249-2-21 (Materials for Printed Boards)
    • ISO 9001:2015 for Quality Management of Polymer Processing

    Typical usage ratio

    • For polymerization: 1–3 wt% as a co-monomer relative to total monomer batch; actual inclusion ratio set by property targets for film flexibility and thermal stability

    Downstream process integration

    • Dosed into the polycondensation reactor during backbone chaining stage, followed by extrusion, film-casting, and high-temperature annealing relevant to specialty polymer production

    Final product types

    • Polyimide electrical insulation films
    • Wire and cable coating polymers
    • PCB (Printed Circuit Board) grade prepregs and laminates
    • High-performance composite resins

    4. Synthesis Intermediate for Agricultural Chemicals (Herbicides & Plant Regulators)

    Agrochemical producers incorporate 2,6-Diaminopyridine as a precursor in the synthesis of specific pyridine-based herbicidal active ingredients and growth regulators, which depend on effective ring activation for plant selectivity and degradation behavior. Process controls prioritize consistent molecular reactivity and minimal side-product formation, fulfilling regulatory dossiers and field performance requirements.

    Industry compliance standards

    • FAO/WHO Specification for Pesticides
    • China "GB 2763" Maximum Residue Limits for Pesticides
    • US EPA Pesticide Registration Guidelines
    • ISO 9001:2015 Agrochemical Manufacturing Certification

    Typical usage ratio

    • 0.2–1.0 molar equivalents as a nucleophilic reactant depending on the downstream synthetic route and required yield of finished actives

    Downstream process integration

    • Charged into the heterocyclic ring-formation step within multi-step synthesis of active ingredient, followed by catalyst treatment and post-purification for formulation inclusion

    Final product types

    • Pyridine-based herbicide actives
    • Plant growth regulator intermediates
    • Final technical-grade pesticide concentrates
    • Ready-to-use formulated agrochemicals
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    Certification & Compliance
    More Introduction

    Introducing 2,6-Diaminopyridine: A Reliable Tool for Advanced Synthesis

    In our many years producing specialty chemicals, we’ve consistently witnessed how subtle adjustments to structure open the door to entirely new applications—something 2,6-Diaminopyridine makes obvious. As a manufacturer, the aim remains simple: deliver purity, consistency, and performance batch after batch, responding directly to the high standards set by research teams and process operators. In our facility, each drum of 2,6-Diaminopyridine reflects an ongoing investment in clean synthesis routes, careful quality control, and a respect for what customers actually experience when working with this compound.

    What 2,6-Diaminopyridine Brings to Chemical Synthesis

    2,6-Diaminopyridine is more than a raw material; it’s become an indispensable intermediate for a variety of chemical processes. Its molecular structure—C5H7N3, featuring two amino groups at the 2 and 6 positions of the pyridine ring—offers a foundation for flexibility. This specific pattern impacts reactivity and downstream utility. We see 2,6-Diaminopyridine used widely in pharmaceutical research, especially for synthesizing active pharmaceutical ingredients and specialty dyes. Demand also comes from fields like rubber vulcanization accelerators, polymer crosslinking, and specialty materials, thanks to its unique balance of basicity and nucleophilic character.

    The grades we supply undergo rigorous internal analytics. Using HPLC and GC-MS, we routinely measure purity levels above 99%. Moisture, ash, and residual solvents are regularly checked. By sticking to strict protocols, we spare customers the cropped yields or side reactions that can ruin an ambitious project. We never rely on trading intermediaries; every batch comes directly from our plant, using protocols honed through years of feedback from polymer developers, pharma researchers, and pigment formulators. We know that on-the-ground support matters as much as paperwork when someone’s process is on the line.

    Choosing Between 2,6-Diaminopyridine and Other Isomers

    Not all diaminopyridines behave the same way, even though they share the core pyridine ring. Laboratory teams familiar with substituent effects appreciate this distinction. 2,6-Diaminopyridine’s arrangement puts the two amino groups as far apart as possible on the ring, changing both electronic properties and steric accessibility compared to 2,4- or 3,5-diaminopyridines. This matters, for example, in regioselective reactions—one reason the textile dye industry often sticks with this compound for certain classes of azo and anthraquinone dyes, avoiding side products seen with other isomers.

    Our own experience highlights another point: solubility and ease of handling sometimes vary even among related pyridine diamines. The 2,6-variant typically dissolves more easily in polar solvents, which translates to cleaner workups and faster filtration in the lab and plant. Over the years, we’ve seen customers report better color strength and cleaner yields when they swap in 2,6-Diaminopyridine, especially in multi-step syntheses. Trying to cut corners with substitutes often leads to chain reactions in quality control, so we stick with what works and communicate those details directly to our partners.

    Production and Quality Control—Lessons from the Plant Floor

    Synthetic chemistry only tells part of the story. After years spent on formulation work and process improvement, we’ve learned how small changes in upstream materials or crystallization temperatures create headaches downstream. That’s why our chemists stay hands-on throughout the entire production life cycle. We start with high-purity starting materials, paying attention to supplier traceability and in-house inspection. During nitration and reduction, tight controls over pH, temperature, and flow rates prevent overreduction or colored side products.

    Safety teams emphasize equipment cleaning between runs, preventing cross-contamination with other pyridine derivatives. Environmental controls—scrubbers, waste neutralization, filtered ventilation—minimize worker exposure and maintain compliance with regional and international standards. Standard protocols incorporate trace metals analysis and batch archival. We do this for more than compliance; years of collaborative troubleshooting with downstream customers have proved that even minor contamination, like iron or chloride, can sabotage otherwise robust synthetic plans. As a company run by chemists, we focus on engineering-out surprises.

    Where 2,6-Diaminopyridine Keeps Providing Value

    Some compounds drop in and out of fashion, but certain core intermediates hold their place due to proven performance. In our records, 2,6-Diaminopyridine appears again and again in requests for new pigment precursors, emerging cancer therapeutics, or process improvement efforts from established firms. The reason often comes down to reliability. In the colorant sector, for example, this compound underpins the synthesis of numerous violet and blue dyes with strong washfastness and lightfastness. In pharmaceutical programs, teams turn to it to build important drugs or probe molecules; the diamino groups make it a versatile building block both for heterocycle construction and direct coupling.

    We’ve partnered with polymer R&D teams seeking crosslinkers that provide specific resilience or thermal profiles. 2,6-Diaminopyridine often ends up at the core of these programs due to its clean reactivity and absence of problematic byproducts. We maintain steady production schedules even in spot markets, backing every order with sample retainers and open access to our technical support crew. Many customers tell us our transparency—down to details around drying cycle temperatures or exact impurity profiles—helps prevent expensive process hiccups during scale-up or validation.

    From the Lab to Full-Scale Manufacturing

    A lot of 2,6-Diaminopyridine out there traces back through complex supply chains. Over the years, we’ve responded to frustrated researchers dealing with off-color, poorly dissolving materials sourced elsewhere. Even minor shifts in particle size or residual moisture affect reproducibility when moving from flask to reactor. In our own plant, we’ve made design choices to limit these variables. Milling and packaging occur under nitrogen or low-humidity air. Drum materials are selected to prevent leaching and static pickup.

    Our technical team consults directly on transition projects, offering up-to-date analysis sheets and blending options for those who need bespoke dispersibility. Sometimes we deliver in custom particle sizes, although our standard product often works for most applications. For larger-volume purchasers, we arrange periodic site audits and are fully open about our batch history, as our customers rely on having a clear chain-of-custody back to synthesis. Feedback from process engineers and QC inspectors has led us to tighten specs far beyond the basic regulatory minimums, because a blocked filter or an unexpected impurity causes more trouble than just wasted time.

    Common Challenges Customers Face—and Some Practical Solutions

    Drawing on years of feedback, we keep a close eye on recurring pain points for users of 2,6-Diaminopyridine. Poor flow during dispensing, uncertain batch color, or minor differences in odor usually indicate either process drift or contamination. We’ve tackled these issues by setting up redundant in-line filtration and micro-sieving, as well as switching to closed transfer systems. Constant communication with everyone who handles our chemical, from truck drivers to lab analysts, has helped root out sources of error like moisture pickup or mislabeled secondary packaging.

    In other cases, customers face regulatory questions about potential trace impurities or want help with REACH or GHS documentation. Because we keep full control over our ingredient sourcing and batch blending, our support staff can provide precise, real-world composition data at short notice. We don’t outsource hazardous materials paperwork or delegate it to a sales office. By working across time zones and offering direct chemist-to-chemist dialogue, we streamline what can become a bureaucratic burden for innovators and compliance teams alike.

    Challenges have also come up around controlled substance regulation. Although 2,6-Diaminopyridine itself remains widely available for research and industrial use, we track evolving legal frameworks in all the regions we ship to. In response, we’ve added extra paperwork tracking and verification to help our clients move material between jurisdictions without unnecessary risk. It’s another way direct communication—rather than passing paperwork through several desks—helps prevent accidental compliance gaps.

    Environmental Responsibility in Production

    Our experience shows that environmental impact and sustainable sourcing aren’t just checkboxes—they shape operational choices every season. We run solvent recovery units, recirculate cooling water, and use advanced waste minimization routines throughout the 2,6-Diaminopyridine process. Light-colored, low-odor material signals not just high-purity chemistry but also responsible waste management upstream. We’ve dropped older oxidizers in favor of greener alternatives, and constantly adjust our effluent treatment plant based on test results rather than assumptions. We prioritize local sourcing for raw materials and shipping, reducing unnecessary freight emissions.

    Our regulatory compliance staff hold regular reviews with local authorities to keep ahead of shifting expectations around emissions and occupational exposure limits. Third-party audits back up our numbers, and we keep public-facing results available—both for our customers and as part of being present in our local community. While green chemistry goals keep evolving, we expect growing demand from clients who want not just results but real transparency around production, labor practice, and community safety. Many buyers now ask about lifecycle impact or supplier audit trails, and we have the structure in place to give clear answers, not just generic reassurances.

    Where Performance Meets Practicality: What Sets Our 2,6-Diaminopyridine Apart

    Anyone sourcing chemical intermediates looks for three things: reliability, value, and support. 2,6-Diaminopyridine brings all three when it’s made to tight tolerances, using stable upstream sources, and packed fresh from synthesis. Our batches have a long record of passing third-party verification, holding up to demanding process audits in Europe, Asia, and North America. We deliver powder and crystalline forms, with strict controls on particle size distribution, and make sure each drum includes the analysis sheet detailing impurities and moisture content—information rarely volunteered by volume traders who don’t touch the factory floor.

    We encourage regular dialogue with QC staff, process chemists, and buyers at every stage, because specifications sometimes shift mid-project and rigid approaches rarely help. Some groups want a slightly narrower melting range for use in a continuous reactor. Others seek packaging in small lots for parallel trials across project teams. Over time, this flexibility in packaging and documentation has brought in new partners who left competitors tired of off-the-shelf answers to unique problems.

    From specialty pigment houses to global pharma labs, the need for faithfully produced 2,6-Diaminopyridine spans the spectrum. Beyond its documented reactivity and compatibility, our approach adds value by rooting every process in actual plant experience, subject to everyday realities of cost control, safety, and partnership. We see every batch as a test of our resolve to deliver what was promised, with each lesson—mistake or success—informed by real customer collaboration. Years of learning by doing, without shortcuts or unnecessary intermediaries, have kept both our product and our plant in top working order.

    Commitment to Knowledge Sharing

    Supporting users rarely stops at filling an order; the real challenge comes as researchers and line operators troubleshoot new or legacy processes with our 2,6-Diaminopyridine. We run regular feedback forums, invite on-site QC visits, and maintain an open-door policy for customer tours. Many improvements in purity control, packaging, and even logistics arose from customer stories—like a plant manager tracing a subtle color shift back to a change in our upstream solvent grade. We credit level communication, openness about process changes, and constant willingness to share production details for sustaining trust.

    For technical users, we maintain document libraries and data sheets, sharing crystallographic, thermal, and handling data verified in our own labs. Our technical support teams are led by chemists with PhDs or decades of industrial experience, never generic call-center staff. That depth means we speak the same language as research leads and development chemists, tackling both routine and advanced queries. Some of the best innovations—like our anti-caking improvements—began as technical calls, not spec-sheet wishes.

    Looking Forward: The Future of 2,6-Diaminopyridine Production

    As new applications for 2,6-Diaminopyridine emerge across pharmaceuticals, materials science, and specialty chemicals, we continue investing in more efficient, scalable production paths. We see promise in biocatalytic routes and greener reducing agents. Every production season brings new data, both from our in-house team and from the field. We balance customer needs for ever-tighter impurity specs with the environmental demands of modern chemical practice. By staying open to feedback and always owning our production data, we prepare to meet the expectations of tomorrow’s chemical innovators.

    At its core, this is a story of adaptation and reliability. 2,6-Diaminopyridine earned its place through proven reactivity, consistency, and adaptability—reinforced by a manufacturing crew that stands behind every lot, answers every question, and treats each client’s challenge as their own. Years from now, as industries keep shifting, the principles learned and shared around this simple molecule will still guide our approach. By being present at every step, from synthesis through support, we keep building trust batch by batch.