Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing sales7@sinochem-nanjing.com 3389378665@qq.com
Follow us:

2,6-Bis(Hydroxymethyl)-P-Cresol

    • Product Name 2,6-Bis(Hydroxymethyl)-P-Cresol
    • Alias 2,6-Bis(hydroxymethyl)-4-methylphenol
    • Einecs 225-146-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    820365

    Cas Number 7326-44-9
    Molecular Formula C9H12O3
    Molecular Weight 168.19 g/mol
    Iupac Name 2,6-Bis(hydroxymethyl)-4-methylphenol
    Appearance White to off-white crystalline powder
    Melting Point 115-118°C
    Solubility In Water Slightly soluble
    Density 1.21 g/cm³
    Purity Typically ≥98%
    Synonyms 2,6-Bis(hydroxymethyl)-p-cresol; 4-Methyl-2,6-bis(hydroxymethyl)phenol
    Storage Temperature Store at 2-8°C
    Pka Phenol group ~10
    Smiles CC1=CC(=C(C(=C1)CO)O)CO
    Ec Number 230-651-2

    As an accredited 2,6-Bis(Hydroxymethyl)-P-Cresol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, sealed plastic bottle containing 100 grams of fine, off-white powder with hazard and identification labels for 2,6-Bis(Hydroxymethyl)-P-Cresol.
    Shipping 2,6-Bis(Hydroxymethyl)-P-Cresol is typically shipped in tightly sealed, corrosion-resistant containers to prevent moisture absorption and contamination. Packages are clearly labeled according to chemical regulations, and transported under ambient temperature with proper documentation. Handling precautions are observed to ensure safety, with compliance to international shipping laws and hazardous materials guidelines where applicable.
    Storage Store **2,6-Bis(Hydroxymethyl)-p-cresol** in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizing agents. Keep the container tightly closed and protected from moisture and light. Use chemical-resistant containers, and label appropriately. Ensure access is restricted to trained personnel; always follow standard laboratory protocols for chemical storage and handling.
    Application of 2,6-Bis(Hydroxymethyl)-P-Cresol

    Applications of 2,6-Bis(Hydroxymethyl)-P-Cresol in Industrial Manufacturing

    As a direct manufacturer of 2,6-Bis(Hydroxymethyl)-P-Cresol, we focus on established industrial value chains where this key chemical delivers defined structural or functional roles within end-use processes. Below we detail verified downstream application sectors supported by data on formulation, process integration, standard compliance, and final product outcomes.

    1. Phenolic Resin Production for Laminates and Molding Compounds

    Producers of specialty phenolic resins integrate 2,6-bis(hydroxymethyl)-p-cresol as a tailored crosslinker and chain extender to modulate cure profiles, molecular weight, and final network density. Its unique substitution pattern supports precision formulation of high-performance resin matrices, especially for PCB laminate and molding compound manufacturers specifying tight control over mechanical, dielectric, and thermal properties. Direct feeding at the resin kettle pre-polymerization stage ensures homogeneous dispersion and effective participation in methylene bridge formation.

    Industry compliance standards

    • EN 438 (High-Pressure Decorative Laminates)
    • UL 94 (Flammability Testing of Plastic Materials Components)
    • IPC-4101 (Base Materials for Printed Boards Standards – phenolic variants)
    • ISO 9001:2015 (Quality Management Systems for Resin Manufacture)

    Typical usage ratio

    • 2 – 7% w/w of total phenolic content, adjusted for target crosslink density and flow cure characteristics

    Downstream process integration

    • Charged at batch start with phenol and formaldehyde or during staged addition to tune viscosity and pre-polymer stability

    Final product types

    • Printed circuit board (PCB) base laminates (FR-2, XPC, phenolic paper)
    • Phenolic molding powders (electrical, automotive components)
    • Decorative, HPL, and compact laminates

    2. Stabilizer Component in Antioxidant Formulations for Lubricant and Polymer Manufacturing

    Downstream formulators in the lubricant and polyolefin industries utilize this molecule as a functional group-bearing phenolic antioxidant, often in custom blends with thioesters and phosphites. The bis(hydroxymethyl) substitution provides increased thermal stability and persistence, supporting extended oxidative protection in high-temperature service environments. Physical incorporation precedes final compounding or is introduced in pre-blend stabilizer packages for masterbatch addition.

    Industry compliance standards

    • ASTM D4652 (Testing for Antioxidant Content in Lubricating Oils)
    • FDA 21 CFR 177.1520 (Indirect food additives: Polyolefins)
    • REACH registration for polymer antioxidants
    • API Lubricant Specifications

    Typical usage ratio

    • 0.05 – 0.3% w/w for lubricant base oil stabilization; up to 0.15% w/w for polyolefin antioxidant packages, subject to regulatory migration limits

    Downstream process integration

    • Direct addition to lubricant formulation tanks or polymer compounding extruders; co-blending with synergist stabilizers before final extrusion or blending

    Final product types

    • Hydraulic and turbine oils
    • Plastic pellets and masterbatches (PE, PP, ABS)
    • High-durability films and molded plastic goods for food contact or industrial applications

    3. Intermediate for Active Pharmaceutical Ingredient (API) Synthesis

    Pharmaceutical intermediates manufacturers employ 2,6-bis(hydroxymethyl)-p-cresol in the multi-step preparation of certain cresol-derived active molecules and complex benzylic ethers. Its dual hydroxymethyl groups offer sites for selective etherification, esterification or further protective group chemistry. Entry into cGMP-compliant synthetic routes occurs under controlled, validated conditions, with all reactors, solvents, and filtration media specified for pharma-grade production.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • EU GMP, Part I and II (Pharmaceutical GMP)
    • USP-NF and Ph. Eur. for intermediate quality and residual solvents
    • DMF (Drug Master File) submission (where applicable)

    Typical usage ratio

    • Stoichiometric or slight excess relative to target API core, varying 1.0–1.2 mole equivalents, balancing conversion, and downstream isolation needs

    Downstream process integration

    • Bench-scale to commercial-scale GMP synthesis reactors; charged prior to alkylation, acylation, or condensation reactions

    Final product types

    • Pharmaceutical intermediate bulks (cGMP grade)
    • Specialty APIs (certain cresol derivatives or precursor compounds)
    • Key protected intermediates for onward multi-step synthesis

    4. Monomer or Chain Extender for Thermosetting Urethane Systems

    Producers of cast or spray-applied polyurethane and polyisocyanurate foams exploit the dual hydroxymethyl structure as a reactive chain extender or minor monomer, providing select cross-linking in rigid or semi-rigid foam systems and enhancing dimensional stability. This addition helps balance friability and compressive strength in insulation foams and construction panels, while maintaining good processability on both discontinuous and continuous production lines.

    Industry compliance standards

    • ASTM C1029 (Specification for Spray-Applied Rigid Cellular Polyurethane Thermal Insulation)
    • EN 14315-1 (Thermal insulation products for buildings - Factory made rigid polyurethane foam (PUR) products)
    • ISO 9001:2015 (Production Quality Systems for Polyurethane)
    • REACh, GHS (Chemical Safety and Product Labeling)

    Typical usage ratio

    • 0.5 – 2% w/w of total polyol or chain extender portion in rigid foam formulations, modulated for reactivity and cure rate depending on system design

    Downstream process integration

    • Pre-dissolved in polyol blend, dosed on-the-fly prior to mixing with isocyanate stream during foam formation or panel lamination

    Final product types

    • PIR and PUR insulation board
    • Spray-applied building insulation foams
    • Pre-formed rigid foam blocks and construction sandwich panels

    5. Curing Agent and Structural Modifier in Epoxy Coatings

    Specialty epoxy coating formulators use this phenolic ingredient as a curing accelerator and secondary structural modifier to modulate gel times, hardness, and adhesion on metal or composite surfaces. Its bifunctional groups participate in condensation with epoxy resins, improving film integrity and chemical resistance—essential for heavy-duty industrial and marine applications. Addition during pre-mix or as a separate stage in the two-component hardener package helps optimize final coating performance.

    Industry compliance standards

    • ASTM D823, D4541 (Coating Performance & Adhesion Testing)
    • ISO 12944 (Corrosion Protection of Steel Structures by Protective Paint Systems)
    • RoHS, VOC directives for low-emission formulations
    • ISO 9001:2015 (Coatings Manufacturing Quality System)

    Typical usage ratio

    • 1 – 4% w/w based on total binder solids, altered to meet target cure time and hardness requirements of the intended specification

    Downstream process integration

    • Incorporated into epoxy curing agent/hardener blends or charged into millbase during initial pre-dispersion step

    Final product types

    • Chemical and marine environment protective coatings
    • Heavy-duty metal primers and topcoats
    • Industrial floor coatings, corrosion-resistant linings

    6. Chemical Intermediate for Specialty Surfactant Synthesis

    Manufacturers of nonionic surfactants select this molecule for controlled synthesis of phenolic ethoxylates and downstream surface-active agents. The specific substitution pattern enables reproducible oxyalkylation, offering desirable cloud points, foam stability, and solubilization properties tailored for use in textile, agrochemical, or cleaning product formulations. Raw material addition occurs before controlled ethoxylation stages, typically under alkaline catalysis in jacketed reactors.

    Industry compliance standards

    • REACH registration for surfactant intermediates
    • ISO 9001:2015 (Management Systems for Surfactant Manufacture)
    • SAICM (Chemicals Management)
    • OECD Guidelines for Testing of Chemicals

    Typical usage ratio

    • 1 – 5% w/w in base charge for ethoxylated surfactant synthesis, adjusted for degree of alkoxylation and final HLB target

    Downstream process integration

    • Charged with phenolic or cresol feed, reacted with ethylene oxide or propylene oxide under temperature and pressure control; downstream neutralization and purification

    Final product types

    • Nonionic phenol ethoxylate surfactants
    • Emulsifiers for agrochemical and textile sectors
    • Detergent and industrial cleaning agents
    Free Quote

    Competitive 2,6-Bis(Hydroxymethyl)-P-Cresol prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to sales7@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: sales7@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    Understanding 2,6-Bis(Hydroxymethyl)-P-Cresol from a Manufacturer's Standpoint

    Introduction to a Reliable Intermediate

    For years, we have relied on consistency, purity, and reliability in our own batches of 2,6-Bis(Hydroxymethyl)-P-Cresol. Among its many identifiers, this compound also goes by its recognized CAS number, 1526-24-3, and its chemical formula: C9H12O3. As direct manufacturers, we encounter all the upstream steps: careful raw material selection, vigilant batch processing, and a level of traceability many downstream users never see. The white crystalline powder produced at our plant displays a steady melting point, generally observed near 112-115°C.

    Our chemists trust its pronounced dual hydroxymethyl groups—each attached to the aromatic cresol ring—delivering high reactivity and valuable chemical flexibility. What motivates attention is not only the ease of handling and formulation, but the way these functional groups open pathways for downstream synthesis. Making this product, we’ve gained firsthand knowledge of how tiny tweaks in processing conditions influence end-use, especially for demanding fields such as high-grade resins and adhesives. There’s a temptation to describe this compound in generic terms, but its story is specific, tangible, and earned batch by batch.

    Technical Profile and Why Our Batches Stand Apart

    Our team understands that each kilogram bears the imprint of upstream solvent purities, reaction kinetics, and labor behind the scenes. Impurities, like unreacted precursors or side-products, quickly show themselves in such specialized intermediates. For our process, the attention given to precise temperature control and purification methods, including repeated recrystallizations and checking for residual phenol, brings clarity in the final powder. The specifications repeatedly confirmed in our quality control lab typically include a purity above 99.0% by HPLC, a moisture content below 0.5%, and an ash value less than 0.05%. We often cross-check batch lots for trace metals using ICP-OES, even if not always demanded by clients, because we built our best processes by solving root causes, not just symptoms.

    Other forms float around the global market—some produced in low-volume pilot plants, some sourced from large commodity lines. The difference in direct production becomes obvious when comparing solubility, batch reproducibility, and contaminant profiles. We track our internal yields, often running a spot check for byproducts such as 2,6-dimethylphenol or incomplete hydroxyalkylation fragments. Batches not meeting our threshold get reprocessed, not sold. Direct buyers regularly mention the issues of off-spec lots from intermediaries dumping on export markets—yellowish hues, odd melting ranges, or powder caking early in transit. Our direct controls lessen blind spots.

    Applications that Value Predictable Quality

    2,6-Bis(Hydroxymethyl)-P-Cresol enters supply chains for a narrow but vital group of industries. Over the past decade, leading demand consistently traces to high-performance phenolic and epoxy resins. The functional hydroxymethyl groups on the aromatic ring create sites for crosslinking, which in turn raises molecular weight and improves final polymer properties. More than once, we’ve consulted with end-users developing molded plastics, protective coatings, and advanced adhesives, each requiring reliable crosslink density across every batch.

    In our resin manufacturing partnerships, clients often report that sameness in molecular weight distribution and reactivity directly impact flow profiles, curing rates, or end-use stability. Adhesive formulators describe how inconsistent material grades undermine batch quality, especially where the 2,6-bis(hydroxymethyl) substitution pattern confers not just reactivity but also subtle control over hardening rates and final modulus. Our task—never losing sight of end-user performance even as we stand upstream.

    Use of the compound extends even further, into stabilizer manufacturing. Some specialty plasticizers and antioxidant preparations incorporate 2,6-Bis(Hydroxymethyl)-P-Cresol as a precursor. Here, oxidative stability of the core ring system pairs with the flexibility brought by the twin hydroxymethyl groups. The industry has counted on the compound as a cost-effective, high-performance alternative to more complex or heavily regulated aromatic compounds. Our hands-on experience shows that even tiny changes in moisture content or trace acid can alter downstream stability in polymerization settings.

    How We Approach Purity and Traceability

    Producing specialty chemicals means learning from every batch, every outcome, and sometimes, every failure. Our plant processes demand full traceability, with batch numbers following each drum from reactor to final client. We record every deviation—no matter how minor—in processing temperatures, reagent origins, and storage humidity. Quality proves cumulative; a single shortcut anywhere upstream often echoes in client complaints and costly recalls.

    We invest time in documenting both successful and failed syntheses. For each run, we log precise reactive conditions for condensation, time under catalyst, and downstream drying steps. Drifts in any standard operational parameter typically show up as slight losses in particle size control, off-odor, or increased levels of high-boiling impurities. The best feedback loop comes from running regular GC-MS scans on both product and all potential side reactions, tightening our profiles as global requirements shift.

    In a crowded field, the real proof emerges with repeat orders. Some customers have returned for over five years running, not because anyone at our end overpromises but simply because our record holds steady, and we stand available whenever there’s an anomaly to investigate.

    Comparing Against Other Raw Materials

    Having processed both p-cresol and more substituted phenols, our chemists routinely compare properties at the bench and in pilot lines. Single-methyl substituted phenols rarely match the unique behavior of the 2,6-disubstituted backbone; the pair of hydroxymethyls alters molecular symmetry, making the compound more compatible with certain thermosetting reactions.

    Traditional phenol or p-cresol derivatives remain valuable but offer less versatility for direct cross-linking. Many resin applications need extra modification steps or co-monomers when using basic phenol derivatives, which injects additional cost, variable side reactions, and time. With 2,6-Bis(Hydroxymethyl)-P-Cresol, the production cycle often runs leaner: fewer side products, tighter reactivity under common catalysts, and less post-reaction cleanup. In most instances, our direct users spend less time troubleshooting inconsistent polymer flows when sticking with our material, reducing total manufacturing downtime.

    Differences in handling also come to the fore. Unlike some substituted phenols, this compound tends not to release offensive odors in the workshop. Its stable powder form allows easier transport and storage, and we monitor packaging integrity closely during shipment, rotating stock and keeping clear records on temperature exposure. Issues such as clumping, surface moisture accretion, or color shift have forced multiple process upgrades on our side over the years. Without these hands-on lessons, we would not be able to confidently supply the high-purity grade that specialized customers now expect.

    Some manufacturers dilute raw material lots to meet minimum export requirements, hoping customers won’t notice subtle process failures until compounds sit in a tank or warehouse for weeks. We reject this approach, preferring repeat business over risky one-off shipments. Buyers have told us that provenance matters—brands and clients seeking consistency want to avoid ambiguous sourcing as global suppliers shift with cost curves. As manufacturers, we bring the perspective that specification sheets alone never tell the whole story.

    Learning through Industry Collaboration

    Our factory lines rarely work in isolation. Many innovations have come from listening to downstream engineers or researchers, catching process frustration long before it becomes a complaint or lost order. For instance, one client producing electronics coatings uncovered a subtle haze forming during curing, traced under joint lab study to a trace stabilizer impurity in an upstream batch. After months sharing analytical results, we pinpointed a step in our dehydration phase as the culprit—a fix only possible with open collaboration and process transparency.

    These direct exchanges form the backbone of progress in chemical manufacture. Not every problem proves so technical. Sometimes, expected logistics delays or packaging errors can ripple downstream. We instituted changes to moisture barrier bagging, trace temperature loggers inside our bulk shipments, and datalog integrity checks that clients can access remotely. Every improvement lowers the likelihood of complaints, reprocessing costs, or unnecessary returns. For specialized industrials, direct lines to the source—unfiltered by layers of resellers—make all the difference.

    Challenges and Forward Steps

    While demand stays steady in established sectors, regulatory and environmental standards never remain stationary. Restrictions on phenolic compounds in certain market areas, as well as restrictions on non-renewable feedstocks, demand that we continually rethink our process inputs. We test greener catalyst systems, alternative solvent cycles, and tighter waste minimization practices in partnership with accredited laboratories. The fact remains: the highest-purity, most consistent output results from diligent adaptation, not from standing still.

    Clients occasionally question whether recycled sources or alternative substitutes could fill the same performance space. Nothing replaces the twin hydroxymethyl group positioning for certain polymer specifications. At times, we’ve trialed small-scale runs with renewable aromatic precursors, though genuine bio-based conversion for this compound remains an emerging research area rather than a large-scale solution. Current output continues to come from traditional, rigorously controlled manufacturing, where every new batch incorporates analytical feedback, pilot plant data, and new performance standards.

    Commitment to Responsible Manufacturing

    Responsible chemical production extends beyond just analytical numbers. Into our plant, we have built protocols for safe handling, waste minimization, and emissions monitoring that meet both local directives and broader voluntary programs. Since powdered phenolic intermediates can pose dust and exposure hazards, operator training, containment, and air scrubbing feature in every stage of our process. By sharing best practices across our production team—from shift engineers to quality control specialists—mistakes become lessons, and continuous improvement becomes routine.

    In the spirit of continual improvement, we run annual reviews benchmarking our emission records against peers, seeking incremental gains in water and solvent usage. Experiences such as product recalls, rejected shipments, or failed post-shipment audits shape our sense of what actually works on the ground. It is easy to promise care in product stewardship; what matters is verifiable action, every time, for every lot.

    How Feedback Shapes Our Process Control

    Our approach repeatedly improves under scrutiny, sometimes through direct client site visits. It is not uncommon for client regulatory teams to audit our line, examining everything from calibration logs to batch retention records—even spot-checking old rejected lots. These exercises, while time-consuming, have built a knowledge base that guides our daily business. For example, feedback from a specialty coatings customer led us to automate and tighten digital logs of every weigh tank used in on-shift production, closing gaps in traceability and speeding up batch release to clients.

    Analytical precision, while essential, grows effective only through steady hands in day-to-day production. Old lessons, such as letting a dryer run past recommended hold time, can show up in small particle agglomerates or slower dissolution times for key clients downstream. Every improvement, from replacing a valve to retraining a technician, feeds reliability. The focus stays on the compound, grounded in direct manufacturing responsibility.

    Final Thoughts on Sector Needs

    Those sourcing 2,6-Bis(Hydroxymethyl)-P-Cresol for high-performance materials want two things above all: absolute reliability and clear producer accountability. On our side, manufacturing means not just filling drums and ticking off checklists, but absorbing hard feedback, testing changes, and standing directly behind every batch code shipped. End-users in resin, polymer, and stabilizer lines have shaped our methods, demanding high purity, consistent handling, and transparent process records. This partnership built on facts, not promises, ensures the compound keeps meeting rising demands in an evolving chemical landscape.

    With each batch that leaves our facility, we stay grounded by the reality that these molecules may end up in critical electronics, construction resins, or advanced surfaces requiring absolute quality and safety. There’s no substitute for firsthand accountability, deep process expertise, and a willingness to keep listening to those shaping new applications and higher standards. The story of 2,6-Bis(Hydroxymethyl)-P-Cresol thus connects every bag of starting material to a complex chain of people, processes, and final products, each step making a difference consumers rarely see but always rely on.