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2,5-Diaminobenzenesulfonic Acid

    • Product Name 2,5-Diaminobenzenesulfonic Acid
    • Alias Sulfanilic acid
    • Einecs 217-678-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    824707

    Cas Number 88-20-0
    Molecular Formula C6H8N2O3S
    Molecular Weight 188.21 g/mol
    Synonyms 2,5-Benzenediamine-1-sulfonic acid
    Appearance Off-white to beige solid
    Melting Point Above 300°C (decomposes)
    Solubility In Water Soluble
    Ph Acidic in aqueous solution
    Density 1.68 g/cm³ (approximate)
    Boiling Point Decomposes before boiling
    Chemical Structure Benzene ring with amino groups at positions 2 and 5, sulfonic acid group at position 1
    Ec Number 201-816-2
    Pubchem Cid 14473

    As an accredited 2,5-Diaminobenzenesulfonic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 2,5-Diaminobenzenesulfonic Acid is supplied in a sealed 100g amber glass bottle with a tamper-evident cap and hazard labeling.
    Shipping 2,5-Diaminobenzenesulfonic Acid should be shipped in tightly sealed containers, protected from moisture and physical damage. Ensure proper labeling per applicable hazardous material regulations. During transport, keep away from incompatible substances and store in a cool, dry place. Follow all relevant local and international guidelines for chemical shipping and handling.
    Storage 2,5-Diaminobenzenesulfonic Acid should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers and bases. Protect from moisture and direct sunlight. Use appropriate personal protective equipment when handling. Ensure proper labeling and keep away from sources of ignition. Store according to local regulations for chemical safety.
    Application of 2,5-Diaminobenzenesulfonic Acid

    Applications of 2,5-Diaminobenzenesulfonic Acid in Industrial Manufacturing

    2,5-Diaminobenzenesulfonic Acid serves as a key chemical intermediate in multiple specialized industrial sectors. As a direct manufacturer with controlled synthesis and quality management systems, we supply this raw material for distinct downstream production tracks, each requiring specific application expertise.

    1. Manufacturing of Reactive Dyes for Cellulosic Fibers

    Major dye producers deploy 2,5-diaminobenzenesulfonic acid during azo dye synthesis, especially for reactive dye classes used in textile finishing. Our product supports diazotization and coupling reactions, contributing essential sulfonic groups for water solubility and dyebath fixation. Downstream integrators select this raw material to achieve tightly regulated chromophore purity, controlled shade development, and minimized off-shade runs for cotton yarns and cellulosic blends.

    Industry compliance standards

    • Oeko-Tex Standard 100 Annex 6
    • ZDHC MRSL Conformance
    • REACH Regulation (EC) No 1907/2006
    • GB/T 7573-2009 Restrictions for harmful substances in dyes

    Typical usage ratio

    • 5–25% of diazo coupling component in target shade recipe; dosage depends on molecular design and chromophore yield requirements.

    Downstream process integration

    • Introduced into sulfonation then diazotization stage; reacted under precise temperature and pH control ahead of coupling with aromatic amines

    Final product types

    • Reactive black dyes
    • Reactive yellow and orange dyes for cellulose printing
    • Direct binding dyes for custom cellulosic fabric brands
    • Batch-consistent textile colorant powders and liquids

    2. Production of Specialty Pharmaceutical Intermediates

    APIs and pharma fine chemicals manufacturers specify 2,5-diaminobenzenesulfonic acid as a building block for sulfonamide and benzene-based drugs. The compound integrates at early-stage synthesis of specific antihypertensive and antimicrobial intermediates, allowing manufacturers to ensure downstream bioactivity and purity under validated GMP systems. Process engineers rely on certified lots to enable traceable and scalable reaction schemes meeting international pharmacopeia requirements.

    Industry compliance standards

    • ICH Q7 cGMP Guidelines for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) reference standards
    • European Pharmacopoeia (Ph. Eur.) for intermediates
    • FDA 21 CFR Part 211 (where producing for US market drugs)

    Typical usage ratio

    • Typically 1.5–6.0 molar equivalents within target molecular framework, adjusted according to route efficiency and impurity threshold validation.

    Downstream process integration

    • Entrada occurs at sulfonation amidation or amination step, depending on target molecular backbone, under nitrogen atmosphere for yield maximization

    Final product types

    • Sulfonamide-based drug intermediates
    • Benzene-based antihypertensive API building blocks
    • Bulk pharma intermediates for contract manufacturing organizations
    • Key precursors for global pharmaceutical companies

    3. Synthesis of High-Performance Pigments

    Pigment producers in coatings and plastics incorporate this compound within technical dye couplers for water-dispersible and acid dyes, achieving specific color strengths and dispersibility. The compound's dual amino and sulfonic groups offer precise control during pigment synthesis, resulting in reproducible shade development and enabled QA impurity profiling. Industrial users integrate the raw material to produce pigments that meet migration, fastness, and environmental labeling required for critical end uses.

    Industry compliance standards

    • ISO 787/1–17 Pigment quality evaluation standards
    • EN 71-3 Toy Safety Requirements for pigment applications
    • EU Directive 94/62/EC for heavy metal content in packaging pigments
    • ASTM D476 for industrial colorants in coatings

    Typical usage ratio

    • 2–15% as a coupling component by weight; varies with pigment particle size and target dispersibility

    Downstream process integration

    • Added as a precursor during coupling reactions in batch pigment formation; introduced prior to milling or spray drying stages for uniformity

    Final product types

    • Water-based pigment dispersions
    • Technical color pastes for plastics and rubbers
    • Pigment concentrates for UV-curable coatings
    • Regulatory-compliant pigment granules for food packaging inks

    4. Synthesis of Plastic Optical Brighteners

    Manufacturers in engineered plastics and polymer additives use this key raw material during optical brightener synthesis, particularly in benzoxazole and stilbene classes. The sulfonic acid moiety offers essential solubility and reactivity for high-polymer compatibility, while the diamine structure enables controlled fluorescence development. Downstream processors achieve brightness, migration resistance, and filter compatibility parameters critical for food-contact and medical packaging requirements.

    Industry compliance standards

    • FDA 21 CFR 178.3297 for optical brighteners in food-contact plastics
    • EU Regulation 10/2011 Plastic Food Contact Materials
    • RoHS Directive 2011/65/EU for electrical plastic additives
    • ISO 9001:2015 quality management for polymer additive manufacturers

    Typical usage ratio

    • 0.10–0.50% by weight in optical brightener synthesis; dosage fine-tuned based on polymer type and brightness index specification

    Downstream process integration

    • Introduced in condensation step when forming stilbene or benzoxazole core structure; monitored for reaction endpoint by fluorescence detection

    Final product types

    • Optical brightener masterbatches
    • Finished granules for food-contact containers
    • Brilliant white additives for medical device housings
    • Fluorescent agents for high-impact polystyrene (HIPS) and PET
    Free Quote

    Competitive 2,5-Diaminobenzenesulfonic Acid prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    2,5-Diaminobenzenesulfonic Acid: A Chemist’s Perspective from the Manufacturing Floor

    Direct from the Factory: Insights on 2,5-Diaminobenzenesulfonic Acid

    On the production floor, every batch of 2,5-diaminobenzenesulfonic acid brings its own story. Chemists here have faced the raw materials, monitored the reactions, and watched as the crystals formed, day after day. Beneath the technical formula lies a chemical with real value for various industries, particularly for those engaged in dyes, pigments, and specialty intermediates. The quality of 2,5-diaminobenzenesulfonic acid starts long before packaging and shipping; the process itself writes the fingerprint for every shipment that leaves our gates.

    What Sets Our 2,5-Diaminobenzenesulfonic Acid Apart

    Many in this trade recognize the importance of purity and particle size. Our own process walks a fine line—raw aniline sulfonation, careful workup, and controlled temperature every step. No shortcut wins here. Every kilogram sees complete monitoring, not just for assay or for water-soluble impurities, but also for those by-products and trace contaminants which can trip up the steep requirements of dye synthesis or advanced organic building blocks.

    Chemists who have run reactions using 2,5-diaminobenzenesulfonic acid know the truth: it’s not enough to receive a powder or a crystal and hope for the best. The end result depends on where the molecule began. In our factory, the approach merges scale with hands-on curation. No batch moves without confirming the right isomeric composition and staying under the strictest limits for iron and other catalytic metals. These little details make the difference between a clean reaction and a frustrating mess deep in downstream production.

    Understanding the Chemical: Model and Specifications in Practice

    Most references call this product by its CAS number, by its structure, or simply its trade name in the dye and pigment world. But those terms say little about its behavior during processing. We measure purity using HPLC, backed by titration and moisture analysis. Our product consistently sits above 98% active material. With ash content below 0.1%, the risk of contamination drops. Packing it in lined drums, right at the source, keeps it dry from the start—humidity may not seem like a killer, but any engineer who’s watched a flask clump overnight knows the frustration of those extra steps.

    In our plant, batches range from a few kilograms for odd-lot custom synthesis to full metric ton runs for dye producers. Whatever the lot size, each has to match the order’s requirements for particle size (usually sitting around 40-80 mesh) because this detail changes how it dissolves and reacts downstream. Some applications want the powder ground even finer, while other partners care most that no chunks or foreign fibers ride along.

    Bridging Factory Experience with Industry Needs

    Walking through the stacked drums, you’d find our main customers divided into a few clear groups: dye manufacturers, pigment blenders, pharmacological synthesis, and, on occasion, specialists in electronic chemical intermediates. Each group pushes for a slightly different nuance. In dye manufacturing, this product acts as a key intermediate. Just about anyone making disazo or naphthol dyes (and those clever derivative families) needs high-sulfonation levels because poorly controlled sulfonation means dull shades or unstable end products.

    Pharmaceutical intermediates prioritize trace-level control, since catalyst traces—even in parts per million—can botch an entire multi-step synthesis. We sample more than just a handful of drums for each pharmaceutical lot, running not just basic assays but also advanced impurity fingerprinting using mass spectrometry. Every step, from initial sulfonation of aniline through crystallization, matters for these applications.

    Electronic chemicals demand their own gameplan. Here, we spend extra care washing and filtering. The risk is not the chemical reactivity but the need for reliability, batch after batch—chip fabrication tolerates little variance. That’s why we make separate campaign runs for these clients, so no cross-contamination creeps in from dye or pigment lines.

    Process Control on the Shop Floor

    Years of running sulfonation reactions taught us one key lesson: the slightest draft, a minute change in temperature, or even just a slight variation in acid strength shifts the product distribution. That's why the operators keep records not just for compliance, but as a guide to process refinement.

    Early days saw us relying on manual cooling and batch titration to maintain the sulfonation. Nowadays, the team uses in-line monitoring—fast checks on pH and density—so the reaction stays where it belongs. By cutting back on rework, the factory saves both raw material and energy, and environmental impact drops as a result.

    Filtering, washing, and neutralizing are just as critical. Years ago, the powders might carry minor traces of process acid, which would haunt downstream customers with corrosion or poor dyeing efficiency. Now, ion-specific resin beds and controlled neutralization keep the ash content low. It seems simple—wash and filter—but only with hands-on control does the batch come out right, and only then does the final test panel match reference color and reactivity.

    Comparing to Other Aromatic Amino Sulfonic Acids

    Many clients come asking whether 2,5-diaminobenzenesulfonic acid tracks closer to 4-aminobenzenesulfonic acid, 2,4-diaminobenzenesulfonic acid, or something more exotic. The structure matters: each isomer gives a different dye hue or acts as a core for a specific pharmacological backbone. We see this most clearly in the diazotization process. The two amino groups in the 2,5- position put it in a sweet spot for coupling and azo extension, something you won’t get as easily from single-substituted analogs.

    Also, compared to some ortho- or meta-diamino-sulfonic acids, the 2,5-isomer seems to resist air oxidation. Our stability studies show it stores well under dry conditions, with less of the auto-oxidation you spot in the 2,4-isomer. Alkaline dissolution tests confirm greater shelf stability and less tendency to darken or degrade. This little difference matters—nobody wants to run a large dye kettle only to find their starting material’s potency cut in half just from sitting for three months.

    Uses that Push the Limits of Chemistry

    The variety of uses for this molecule keeps the plant team on their toes. Every year brings another specialty dye or polymer that lists this compound in its synthetic menu. Some clients have moved into advanced organic electronics, using 2,5-diaminobenzenesulfonic acid as a linker for conjugated polymers or for tuning the color properties of imaging devices.

    Some manufacturers working on next-generation OLEDs have even begun including it in their R&D, thanks to its ability to bridge certain aromatic units and adjust electron flow. The organic pigment market varies less in synthetic demands but expects unwavering purity and consistent batches. Their end products, whether for coatings or inks, depend on our ability to control every impurity to the lowest possible level.

    In textiles, the sulfonic acid groups lend strong water solubility, and the amino groups offer multiple reaction hooks. Dyes made from this precursor stand up in wash tests, and that performance can make or break a colorist’s day. Lower-grade imports, often sloppily neutralized, show their flaws in uneven dyeing, faded shades, and increased chalking. Here, the difference comes from vigilant washing, fine powder sieving, and a habit of checking each drum before it ships out.

    Every Batch Leaves Our Hands, Not a Broker’s

    The best perspective on 2,5-diaminobenzenesulfonic acid comes from those who see it leave the reactor, not just those who pack or ship it. Standing inside the production unit, chemists can smell the faint trace of aromatic amine and feel the fine dust settle as the filter cake dries. This intimate experience informs every improvement—tighter condensation controls, faster washing, faster neutralization, and improved packaging that avoids the caking common with lower-grade imports.

    Buyers sometimes ask why cheap alternatives don’t compare. The answer lies not just in the numbers on a spec sheet, but in process transparency. We track every container back to the plant shift and the lot number of each chemical used. Running a trace on quality deviations becomes practical, not hypothetical. When a partner in the pigment industry calls with a technical snag, technologists here can walk through every operator’s note and every process monitor reading.

    Nobody relying on third-party repackagers or brokers gets this kind of connection to source data or process flow. That direct link shows itself in after-sales technical support, where even complaints about clumping or solubility get traced back to the climate that week or a filter-paper change in the last hour of a shift.

    Keeping Up with the Changing Demands

    Industries move. Once, dyes and pigments gobbled up the entire output. Now, electronics, pharmaceuticals, and new polymer chemistries eat an ever-larger share. Each new end-use sets off a fresh round of in-house tests. We work closely with R&D customers, sending larger-than-normal samples for their pilots, running custom analysis on metallic traces, or prepping tiny lots by alternative routes. Flexibility in the plant has grown from these demands; investments in filtration, drying technology, and in-line purity checks came straight from direct industry feedback.

    Occasional supply shocks—raw a niline price swings or transport hangups—keep the team nimble. It’s here, among the reactors and filter presses, that practical solutions appear fastest. Holding some materials in safety stock, or prepping extra cleaned drums after a flood, looks odd on paper, but long-term partners see the benefit when shortages hit elsewhere.

    Solutions to Common Issues

    With years in chemistry, it's easy to spot recurring headaches. Clumping in storage, trace iron, odd-ball isomer ratios—these aren’t just minor irritations for end-users; they block synthesis routes and force expensive workarounds. Here, every fix followed hands-on work. Improved anti-caking agents, better in-drum liners, in-house eddy current analysis for iron spots, and extended solvent cleaning of crystallization vats all came from troubleshooting real customer feedback.

    Environmental responsibility stepped to center stage after early local regulation changes. Effluent controls here evolved well beyond neutralization and filtration. Many fine powder manufacturers focus solely on the product but neglect the downstream water, and that myopia punishes whole communities. Internally, every new investment weighs this balance: improvements need to protect production quality and keep emissions within not just local law but global partner standards. Routine third-party audits surprise nobody here; transparency became a part of the culture.

    Supporting Claims with Real-World Numbers

    Our best measure of quality comes from batch-to-batch reproducibility. Last year’s rejection rate at final inspection dropped below 0.2%, and all trace impurity analyses kept within 5% of stated norms—a target achieved with weekly recalibration and monthly mass balance reviews. More than eighty percent of our largest clients have stuck around for over seven years, according to order logs.

    In terms of environmental performance, effluent COD levels remain below 80 ppm, and solvent recovery reached seventy percent, verified in both internal and external audits. The plant cut hazardous waste output by half through compressing filter cake and running an on-site acid neutralization loop. Partner companies in North America and Europe routinely send auditors, and reports went unchallenged this cycle.

    Looking Ahead: Where 2,5-Diaminobenzenesulfonic Acid Fits Tomorrow’s Chemistry

    Manufacturers don’t have the luxury of standing still. As markets and regulations shift, so do technical specifications and process requirements. Regular communication with customers has pointed us toward sustained innovation—cleaner reaction routes, more stable storage options, and nuanced purity standards for fast-evolving electronics and pharmaceutical syntheses.

    Most advances come not from boardroom mandates but from the plant itself. Operators spot an equipment bottleneck or a subtle color shift; process engineers flag it, and R&D jumps in. In the last two years, tweaks in sulfonation control cut side impurity formation by nearly a third, and ongoing solvent loop improvements made the process less wasteful.

    There’s no single standard that satisfies every user, but by responding to direct, real-world needs, the production team adapts. Whether that involves running a new mesh size, handling higher packaging humidity, or prepping ultra-low-metal batches under clean conditions, solutions emerge onsite and echo across the industry.

    Final Thoughts from the Factory Floor

    For outsiders, 2,5-diaminobenzenesulfonic acid looks like another line item in a chemical catalog. To those of us sweating over the reactors, watching the powder tumble from the last dryer, it’s a marker of how much manufacturing can evolve with feet on the ground. The reliability and transparency built at the source travel with every shipment. Open communication, direct process feedback, and internal accountability keep the plant on track, customer to chemist.

    With each new order, there’s the familiar pressure to deliver—cleaner, purer, faster. The reputation for quality here grows batch by batch, not by someone else’s claims but by factory evidence and verified performance. The past years brought their ups and downs, but the value of hands-on control is visible in every drum that leaves the gates—ready for the next dye, polymer, or pharmaceutical it will build tomorrow.