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2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride

    • Product Name 2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride
    • Alias DADH
    • Einecs 217-421-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    678837

    Productname 2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride
    Casnumber 56-06-4
    Molecularformula C4H7ClN4O2
    Molecularweight 178.58
    Appearance White to off-white powder
    Meltingpoint 285-290°C (dec.)
    Solubility Soluble in water
    Purity Typically ≥98%
    Storagetemperature 2-8°C
    Synonyms 2,5-Diamino-4,6-pyrimidinediol hydrochloride
    Ph Approximately 3.5-5.5 (1% solution in water)

    As an accredited 2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 50g bottle features a tightly sealed, amber glass container labeled “2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride,” including hazard warnings.
    Shipping 2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride is shipped in tightly sealed containers to protect from moisture and light. The chemical is handled in accordance with all safety and regulatory guidelines, including proper labeling and documentation. Shipments are typically sent at ambient temperature unless otherwise specified by the manufacturer or Material Safety Data Sheet (MSDS).
    Storage Store **2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride** in a tightly closed container, in a cool, dry, and well-ventilated area away from moisture, heat, and incompatible substances such as strong oxidizers. Protect from light. Handle under inert atmosphere if sensitive to air or moisture. Use appropriate personal protective equipment and follow standard laboratory safety procedures during storage and handling.
    Application of 2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride

    Applications of 2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride in Industrial Manufacturing

    2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride serves as a key intermediate in several specialized manufacturing sectors because of its unique chemical structure and reactivity. Our industrial-grade product supports high-value downstream formulations in personal care, colorant synthesis, pharmaceutical intermediates, and veterinary actives. We maintain close alignment with global compliance requirements and supply consistent, traceable quality to direct manufacturers in these fields. Below, we detail real-world application scenarios and relevant integration information.

    1. Hair Dye Intermediate for Oxidative Color Formulations

    This compound functions as an essential coupling agent in the production of permanent hair colorants, specifically for oxidative dye formulations. Color houses and personal care manufacturers utilize it to achieve select shades ranging from brown to black and to stabilize color consistency throughout the oxidation process. The additive enters the formulation stage where dyestuff precursors interact with oxidizers during manufacturing, producing final colorants with reliable, reproducible shade intensity and durability.

    Industry compliance standards

    • EU Cosmetics Regulation (EC) No 1223/2009—Annex III restrictions for hair dye substances
    • U.S. FDA 21 CFR Part 73—Listing of Color Additives for Cosmetics
    • Japan MHLW Standards for Cosmetics—Ingredient registration and safety thresholds
    • IFRA Cosmetic Ingredient Guidelines

    Typical usage ratio

    • Generally 0.2%–1.0% by weight in dye cream base, adjusted based on target shade and compatibility with other dye precursor inputs.

    Downstream process integration

    • Added at the blending stage with other dye precursors and stabilizers before final emulsification or homogenization.
    • Subjected to homogenization and pH adjustment for optimized reactivity with hydrogen peroxide developer systems.

    Final product types

    • Permanent oxidative hair dyes (cream, gel, or liquid)
    • Professional salon hair colorant kits
    • At-home boxed hair coloring systems

    2. Pharmaceutical Intermediate for Antiviral Nucleoside Analogs

    Our chemically pure grade serves pharmaceutical companies developing nucleoside analogs, as the pyrimidine ring structure enables precise modifications for active pharmaceutical ingredient (API) synthesis, particularly for certain antiviral therapies. The material is often reacted in the nucleobase-building phase, allowing for selective functionalization before subsequent sugar moiety attachment in multi-step flow or batch synthesis facilities.

    Industry compliance standards

    • EU GMP Guidelines (EudraLex Volume 4)—APIs and intermediates
    • USP–NF (United States Pharmacopeia–National Formulary)—Intermediate quality referencing
    • ICH Q7—Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 211—Current Good Manufacturing Practice for Finished Pharmaceuticals

    Typical usage ratio

    • Up to 1.5 molar equivalents per reaction batch, dependent on process stoichiometry and specific nucleoside substitution patterns.

    Downstream process integration

    • Used as a pyrimidine building block during the nucleobase assembly stage before glycosylation and API finalization.
    • Subject to multi-step organic synthesis and intermediate purification under GMP controls.

    Final product types

    • Pharmaceutical antiviral intermediates
    • Finished antiviral nucleoside APIs after downstream modification
    • Bulk intermediates for further modification in contract API synthesis networks

    3. Colorant Precursor for Direct Textile Dye Manufacturing

    Textile dye producers employ this compound for synthesizing specialty dyes, especially for protein-based fibers like wool and silk. The unique diamino and dihydroxy pattern on the pyrimidine skeleton provides reactive sites for chromophore extension, imparting specific shade ranges and wash-fastness to the final dye materials. Manufacturers typically react the material during diazotization or condensation stages to yield custom dye molecules for technical textiles.

    Industry compliance standards

    • OEKO-TEX Standard 100—Restrictions on hazardous amines in textile dyes
    • ZDHC MRSL (Manufacturing Restricted Substances List)—Textile chemical input control
    • REACH Regulation (EC) No 1907/2006—Substance Registration and Authorization
    • ISO 9001:2015—Textile dye QC systems

    Typical usage ratio

    • 1%–2.5% by weight in chromogenic precursor batch; dosing depends on targeted color intensity and compatibility with other reactants.

    Downstream process integration

    • Introduced during the initial synthesis stage as a base reactant for azo, sulphur, and other direct dye classes.
    • Integrated prior to dye condensation, often under controlled-temperature reactions to ensure proper coupling or diazotization yield.

    Final product types

    • Direct textile dyes for wool, silk, or synthetic blends
    • Customized dye intermediates for technical yarns
    • Non-migratory textile printing colorants

    4. Synthesis of Veterinary Drug Actives

    In animal health compound manufacturing, this pyrimidine derivative functions as an intermediate for the synthesis of certain veterinary actives—specifically, those requiring modified nucleobase analogs with selective reactivity for antiparasitic or immunomodulator drug classes. The raw material enters the veterinary drug pipeline early, allowing for targeted derivatization to introduce side groups relevant for biological efficacy in finished actives.

    Industry compliance standards

    • VICH GL3 (Veterinary ICH) GMP Guidelines
    • EU Regulation (EU) 2019/6 on veterinary medicinal products
    • US FDA Guidance for Industry #61—Veterinary Drug GMP
    • China Veterinary Pharmacopoeia

    Typical usage ratio

    • Utilized at 0.5–1.2 mole equivalents depending on the intended veterinary medicinal analog’s structure; dosage adjusted for process yield and required purity in downstream transformations.

    Downstream process integration

    • Charged as a starting reactant during the nucleobase assembly stage, enabling further functionalization and side-chain introduction prior to final API crystallization.
    • Processed under strict process controls in CGMP-compliant veterinary production lines.

    Final product types

    • Veterinary APIs for parasiticides and immunomodulators
    • Bulk actives prepared for formulation into injectable or oral veterinary medicines
    • Precursor compounds for contract animal health synthesis partners
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    Certification & Compliance
    More Introduction

    2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride: A Real-World Approach from the Manufacturer’s Floor

    Part of Our Own Daily Lineup

    On any regular day inside our factory, we see plenty of compounds flow out the door, but few get as much attention from the production team as 2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride. The folks in the plant know it by its batch numbers, by its distinctive odor, and by the kind of demand cues that show up as emails, phone calls, and the notes we take on the plant whiteboards. People outside our facility sometimes forget what it means to actually take raw materials and shape them into a consistent pyrimidine derivative, then keep that bar high for repeat orders. This is the stuff we do ourselves, day after day.

    Our Account of Quality in Practice

    Model numbers matter most when they reflect the specifics of a substance and the way it performs in its end-use. Our batches of this pyrimidine hydrochloride come at high purity, and on more than one occasion, a research or pharmaceutical client asks about minute details—particle size, loss on drying, or solubility in various solvents. Whether it's a clear solution request or a need for finer crystals ready for direct compounding, we keep that dialogue going directly with the labs using it, not through a sales intermediary. Our sampling and analysis crew keeps records running back many years. Dust in the air near the dryer means the team pays close attention, because the right granule formation doesn't happen by itself. It comes from handling and experience on our watch.

    For Us, Usage Grows out of Real Orders

    Watching this product move through the building tells a story you can’t read off a datasheet. Our customers come from pharmaceutical and diagnostic research, along with makers of specialty reagents, who all have their own checklists for what matters in a pyrimidine compound. It doesn't surprise anyone here when a new inquiry is really about figuring out whether this molecule will play well in enzyme assays, dye intermediates, or similar applications. Over the years, we’ve seen project managers walk in with a request for a kilogram, then soon after, for ten times that. Their requests usually follow a round of successful trials—not the other way around.

    Our view starts on the warehouse shelf and ends wherever science and innovation take the compound. It’s more than just a step in a synthetic sequence. Some projects lean on it for its reactivity, some for its ability to form stable intermediates during the process of making photographic agents or catalytic compounds. The teams that actually use this compound do not want pretty packaging; they look for clean, reproducible outcomes. Behind each batch, people here scrub glassware, maintain reactors, and run HPLC readouts because every step adds up later, in a lab or in a factory somewhere on the other side of the world.

    Why Details Set Us Apart

    Experience in manufacturing shows up in the small things—batch notes, the feel of filtered crystals, and knowing to look at the off-odors before shipment leaves our doors. Unlike agents who negotiate based on speculation or resellers who handle dozens of substances through thin information, we stick to direct experience. We learn which step in the drying process affects residual solvent levels, or which temperature swings during crystallization result in better yields, because we perform those steps ourselves. Our records of successful shipments and customer feedback offer a timeline of improvements that serve every repeat client.

    Direct manufacturing puts discipline at the center of production. Adhering to quality standards is not a box-ticking exercise, but a hands-on practice that starts with selecting trusted raw material suppliers—ones we have dealt with for years—and bringing the same vigilance to every new intake of ingredients. Our shift chiefs know, by practice, how the color of the filtrate indicates reaction completion. Analytical reports come with signatures from real staff. None of this happens at a distance. Our documentation is audited internally before leaving the building.

    Differences Learned Through Practice, Not Theory

    We hear about substitutes and analogues all the time. Our chemists and production planners have handled enough pyrimidine derivatives over the years to talk about them with confidence. 2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride stands apart from other pyrimidine compounds because it brings two amino groups and two hydroxyl groups, which give it a distinct reactivity profile—making it a preferred building block for targeted synthesis routes. This is not abstract chemistry, but a lesson learned from seeing which chemicals stand up during process scale-up. Other pyrimidines we’ve worked with may lack one or more of these groups, changing their solubility or limiting downstream transformation.

    There’s a big difference between what’s theorized on paper and what happens on the plant floor. Some competing products might show comparable purity on a certificate, but produce unwanted by-products when scaled up, or come with fine-dust contaminants that escape attention until the customer tries using them in sensitive formulations. We deal with these realities directly. Our on-site QC lab picks up these issues well before the drums are closed. Several clients have told us they noticed improved performance during their own production after making the switch from generic material to our batch, and we keep looking for further refinements with every cycle.

    Traceability and Transparency Go Hand in Hand

    No process is perfect, and we accept that by keeping detailed batch-level records. In any manufacturing setup, traceability covers more than a paper trail; it anchors our ability to answer questions quickly, follow up on feedback, and stamp out variability. We encourage customer audits and third-party inspections, not because it’s a checklist requirement, but because those visits lead to better understanding on both sides of the dock. More than once, a suggestion from a user lab has led us to a modification in drying time or a change in vessel cleaning protocol. Real transparency grows out of a willingness to let your process be seen, questioned, and improved from the outside as well as the inside.

    Some buyers come with nothing but trust—they rely on reputation and testimonials. Others run parallel analytical checks after every delivery, and share those findings with us. Every one of these interactions shapes how we look at our own process. We’ve put extra weight on sharing not only the final purity numbers but also an account of how the lot was made, right down to the raw material origins if needed. Our confidence comes from being able to track, resolve, and adapt on the fly, not simply because an inspection agency says so.

    Labor and Know-How Matter

    We don’t see chemical manufacturing as simply adding value to a commodity, but as practicing an evolving craft. Skilled operators bring a sense of ownership to the process that a third-party supplier rarely matches. Some of our staff can pinpoint a batch’s vintage by the nuances in texture, moisture content, or a shift in pH—not because they read about it, but because they pulled those samples themselves for years. Our maintenance teams steady the equipment through seasonal shifts that affect humidity and temperature, knowing full well how those change the crystal habit of a pyrimidine salt.

    This attitude stretches right through our process improvement cycles. Regular brainstorming sessions between production techs and lab analysts yield modifications that stick: one such effort resulted in a steadier product yield through controlled solvent feeds, which cut drying variation by a notable margin. We've found that investing in hands-on expertise saves time and resources down the line. The workflow we follow came from years of mistakes, tweaks, and constant improvement, not from instruction manuals. Bringing in new hires isn’t a plug-and-play affair—they need time to learn the lessons the experienced crew have internalized.

    Market Shifts Shape Our Decisions

    Demand for specialty pyrimidines doesn’t move in straight lines. Sudden spikes come from new research directions, breakthroughs in diagnostics, or innovations in materials science. We react not just by ramping up capacity, but by re-examining which steps are most prone to bottlenecks. Each time a customer’s project pivots, supply patterns change, and with them, so do our batch schedules, cleaning regimes, and raw material ordering habits. The ability to pivot rapidly and re-allocate capacity is a product of system discipline and a staff culture that accepts and adapts to surprise orders.

    Raw materials don’t always show up as planned, especially during global supply chain stress. It becomes essential to have trusted sources and reserve stocks. A well-managed inventory helps us maintain promised lead times and keep batch chemistry consistent. We archive weather, delivery, and supply reports with the same seriousness as batch logs, because even small disruptions in logistics have consequences downstream.

    Mistakes Teach as Much as Successes

    No one running a genuine manufacturing plant hides from setbacks. More often than customers realize, problems crop up on the shop floor: unexpected side-reactions, clogs in filtration, or misread instrument values. We make it a point to share these events within our teams, treating them as case studies for further improvement. Our company has logged and discussed every deviation, bottleneck, or failed batch, using these as tools for training new hires and benchmarking process improvements. Changes in shelf life, humidity shifts, minor color fluctuations—all of these get evaluated.

    Building this level of resilience means putting as much attention into post-delivery feedback as into pre-shipment checks. Our long-term partners tell us when their processes break down, and our own production history reveals patterns worth correcting. Each failure drills down the value of documentation over improvisation, teamwork over guessing, and ownership over blame. Growth as a real producer does not come from avoiding mistakes, but from using them to build stronger teams and better products.

    Safety and Responsibility: A Lived Reality

    A factory setting leaves no room for complacency with substances like 2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride. Personal protective equipment isn’t reserved for special circumstances; it forms the baseline for every shift, every hour. Regular drills, hazard reviews, and staff-level safety brainstorming not only drive home a sense of discipline, but they help us spot small inefficiencies before these turn into risks. We commit resources to safer storage, improved ventilation, and hands-on training.

    We always keep an ear out for environmental best practices and adjustments in regulatory standards. Cleaning effluent, dust control, and solvent reclamation play daily roles in our routines. Nothing lands in the waste streams by default. Raw materials, intermediates, finished products—each runs through a set of disposal guidelines written from experience. Teams know what to look for, and nobody bypasses protocol for the sake of speed. All those little steps build into the ongoing safety record of our facility, and that is something we share with anyone who wants to know, from customers to regulatory officers.

    Supporting Research and Scale-Up

    Academic and industrial R&D labs shape a big part of the demand for 2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride. Our technical support team keeps the conversation open with researchers and project leaders who value responsiveness as much as reliability. Questions from these clients range from solubility adjustment techniques to raw data from previous lots, and we keep those records on hand, ready to share. The connection between our plant operations and R&D partners is direct—nobody has to go through layers of sales handlers or chase down information.

    Technical service isn’t something we delegate. Every round of scale-up, formulation, or downstream application information travels directly between our experts and the people running trials in the field or at the bench. In one case, a client traced impurities back to a specific lot of starting material: we could supply exact process conditions and analytical readouts for the batch in question within 24 hours, not because of a scripted protocol, but because of our accessible records and commitment to real dialogue. Over time, this level of engagement shapes how quickly we can adapt a batch for a client seeking a slightly different particle size or solvent profile.

    The Long View: Building a Culture, Not Just a Product Line

    From where we stand, chemical manufacturing means something deeper than just quoting specs and shipping drums. Each product connects to the story of how it is made, kept clean, tracked, shared, and improved. 2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride reflects that mindset. Its reputation, among repeat clients and within our own workforce, comes from this cumulative effort. We remain in touch with changing research trends, supply disruptions, and evolving industrial practices not by looking outward, but by making our own house as stable and flexible as possible.

    This is a competitive market, filled with claims of quality, precision, and reliability. The mark of a real manufacturer isn’t a glossy brochure but the willingness to answer uncomfortable questions about failure and improvement. It’s in the discipline to follow every batch from raw material intake to final delivery, in adopting real-time suggestions from the field, and in recognizing the hands-on experience of those who actually run the facility. Many companies can show you a certificate; fewer can walk you through each stage of the process in real detail. We choose the latter.

    A Product—and a Process—We Stand Behind

    Our days move to the rhythm of melting points, filtration times, the thump of drum lids, and hands-on troubleshooting. As a team, we stake our claim on doing real chemistry, not simply buying and forwarding what someone else made. The product gets better every season, not just because we upgrade equipment or tweak a protocol, but because the people making it keep learning, keep testing, and stay open to improvement. That’s where our confidence in 2,5-Diamino-4,6-Dihydroxypyrimidine Hydrochloride comes from. We make it. We track it. We support it. Day in, day out.