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2-(4-Tert-Butylphenyl)Ethanol

    • Product Name 2-(4-Tert-Butylphenyl)Ethanol
    • Alias 4-t-Butylphenylethanol
    • Einecs 248-265-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    493578

    Chemical Name 2-(4-Tert-Butylphenyl)Ethanol
    Molecular Formula C12H18O
    Molecular Weight 178.27 g/mol
    Cas Number 25655-41-8
    Appearance Colorless to pale yellow liquid
    Boiling Point 269-271°C
    Density 0.956 g/cm³
    Refractive Index 1.505
    Solubility In Water Slightly soluble
    Smiles CC(C)(C)c1ccc(CCO)cc1
    Purity Typically ≥98%
    Storage Temperature 2-8°C (refrigerated)
    Synonyms 4-(1,1-Dimethylethyl)phenylethanol
    Flash Point 119°C

    As an accredited 2-(4-Tert-Butylphenyl)Ethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100g of 2-(4-Tert-Butylphenyl)ethanol, sealed with a screw cap and safety label detailing hazards.
    Shipping 2-(4-Tert-Butylphenyl)Ethanol is shipped in tightly sealed containers to prevent leakage and contamination. It is transported as a non-hazardous liquid, kept away from strong oxidizers and direct sunlight. Proper labeling and documentation are provided, complying with relevant transportation regulations for safe and efficient delivery.
    Storage 2-(4-Tert-Butylphenyl)ethanol should be stored in a cool, dry, and well-ventilated area, away from direct sunlight, ignition sources, and incompatible substances such as strong oxidizers. Keep the container tightly closed when not in use. Recommended storage temperature is at or below room temperature (20–25°C). Store in a clearly labeled container, preferably made of glass or compatible plastic.
    Application of 2-(4-Tert-Butylphenyl)Ethanol

    Applications of 2-(4-Tert-Butylphenyl)Ethanol in Industrial Manufacturing

    2-(4-Tert-Butylphenyl)Ethanol functions as a specialized intermediate across several sectors. The material's aromatic structure and defined alcohol functionality support its use in coatings, polymer synthesis, fragrance compounds, pharmaceutical intermediates, and electronic chemical manufacturing. Each scenario outlined reflects actual industry practice, process requirements, and final applications.

    1. High-Performance Coating Additives

    In advanced coatings, including industrial alkyd and polyurethane systems, formulators use this alcohol derivative to modify gloss, flexibility, and UV resistance. Introduction occurs after polymer pre-dissolution or as part of cross-linking additives in solvent-based paint production. The tert-butylphenyl group stabilizes the resin matrix, improving weathering and surface protection without contributing significant VOCs. Compatibility with multiple resin chemistries enables precise property adjustment for high-value coatings applied to metal, machinery, and infrastructure substrates.

    Industry compliance standards

    • ISO 12944 (Corrosion protection of steel structures by protective paint systems)
    • ASTM D3023 (Standard Practice for Determination of Resistance of Factory-Applied Coatings on Wood Products to Stains and Reagents)
    • REACH registration compliance (Europe) for chemical substances
    • China GB/T 25251 (General technical requirements for anti-corrosive paints)

    Typical usage ratio

    • 0.5% – 2.5% by total formulation weight for industrial coatings, depending on resin type and UV stability requirements

    Downstream process integration

    • Added during resin blending or pigment dispersion stages after initial solvent charging
    • Introduced under controlled agitation to ensure perfect miscibility
    • QC checks confirm absence of phase separation before scale-up
    • Post-addition viscosity and gloss measured for batch release

    Final product types

    • OEM machinery coatings
    • Protective pipeline paints
    • Marine anti-corrosion systems
    • Architectural metal primers

    2. Fragrance and Aroma Chemicals Manufacturing

    Manufacturers of aroma chemicals utilize 2-(4-Tert-Butylphenyl)Ethanol as a fixative and intermediate for synthesizing musk and woody notes in perfumery. Its stability in acidic and mildly basic media allows efficient transformation into ethers or esters for fragrance compositions. The structure imparts substantial persistence in top and middle notes, and direct use in compounded fragrances confers tenacity to fine perfumes, household and personal care products. Processing requires strict control over reaction purity to preserve olfactory properties in downstream formulations.

    Industry compliance standards

    • IFRA Code of Practice for fragrance ingredient safety
    • European Union Cosmetics Regulation (EC) No 1223/2009
    • REACH Annex XVII (restrictions on certain aromatic compounds)
    • Food Chemicals Codex standards for non-food fragrance applications

    Typical usage ratio

    • 0.1% – 1.0% in compounded fragrance concentrates, with exact dosage based on GC-MS retention and panel testing of persistence

    Downstream process integration

    • Undergoes etherification or acetylation for specialty aroma compounds
    • Employed as fixative directly in blending tanks after initial mixing of volatile bases
    • Gas chromatography validates finished aroma profile consistency per batch
    • Purity and odor threshold monitored in pre-distribution QC

    Final product types

    • Luxury fine fragrances
    • Personal care scents (shampoo, lotion, body wash)
    • Home air fresheners and candles
    • Laundry fabric conditioners and detergents

    3. Polymerization Intermediate for Engineering Plastics

    This compound serves as a functional monomer or chain modifier in the production of advanced polymers such as polyesters, polycarbonates, and specialty acrylic resins. The phenylethanol scaffold introduces bulky side groups, influencing polymer glass transition temperature, impact resistance, and dimensional stability. Manufacturers use it to control molecular weight and architecture in reaction vessels under strictly anhydrous, catalyst-regulated environments. The compound’s influence on polymer microstructure supports applications where long-term material integrity is essential, such as in electrical housings and automotive engineering plastics.

    Industry compliance standards

    • UL 94 (Flammability of Plastic Materials)
    • ISO 9001 (Quality management for manufacturing and processing)
    • IEC 60695 (Fire hazard testing for electronics)
    • RoHS 2011/65/EU (For lead and hazardous substance restrictions)

    Typical usage ratio

    • 0.3% – 1.2% by monomer weight for copolymerization, with precise proportion set by target molecular weight and finished part performance

    Downstream process integration

    • Added to polymerization reactor along with principal diacids/diols or acrylic monomers
    • Monitored under inert gas during thermal or catalytic polymerization
    • Compositional analysis by GPC and NMR before polymer pelletization
    • Post-reactor compounding for color and flame retardancy adjustment

    Final product types

    • Electronic device casings
    • Automotive internal modules
    • Specialty film and sheet products
    • Engineering-grade plastic components

    4. Pharmaceutical Intermediate for API Synthesis

    As an intermediate for active pharmaceutical ingredients, the compound participates in the synthesis of CNS-active, anti-inflammatory, or cardiovascular drug classes. The alcohol functionality provides a convenient handle for alkylation, esterification, or oxidation, yielding core structures used in patented and generic formulations. Batch protocols demand strict GMP documentation, validated cleaning procedures, and traceable lot documentation. Analytical methods such as HPLC and NMR confirm absence of related impurities in every synthetic step. In this application, full backward traceability is maintained from the supplied raw material through to final API lot release.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • USP, Ph. Eur., and ChP monographs for APIs
    • FDA 21 CFR Part 210/211 (USA Drug Manufacturing)
    • EDQM CEP (Europe)

    Typical usage ratio

    • Stoichiometric amount per batch; proportional to desired conversion, with excess minimized to control downstream purification cost. Usually in the range of 1:1 – 1.2:1 molar ratio versus key reactant.

    Downstream process integration

    • Charged in reaction step as primary alcohol intermediate
    • Transferred to downstream reactors for alkylation or oxidation
    • Product transitions through filtration, crystallization, and column purification
    • Final product subjected to full analytical QC and impurity profiling

    Final product types

    • Anti-inflammatory drug substances
    • Cardiovascular medication APIs
    • CNS-targeted pharmaceuticals
    • Proprietary drug intermediates for final formulator

    5. Electronic Chemicals and Functional Materials

    Producers of electronic chemicals employ this intermediate as a performance modifier in high-purity photoresist and dielectric compositions. Its controlled reactivity and steric hindrance minimize ion migration and improve chemical resistance of film layers. Usage targets microfabrication of semiconductors, LCDs, and printed circuit boards, where sub-ppm metallic and particulate contamination limits apply. Cleanroom-compatible packaging and in-line purification are routinely specified to meet rigorous device fabrication standards. Analytical validation covers both finished material and parent batches to ensure device-level performance consistency.

    Industry compliance standards

    • SEMI C3 (Specifications for High-Purity Chemicals)
    • JEITA standards for electronic chemicals
    • ISO 14644-1/2 (Cleanroom particulate control)
    • RoHS and REACH compliance for restricted substances

    Typical usage ratio

    • Typically 0.05% – 0.2% by weight for surface modification in photoresist blends; adjusted based on lithographic resolution and etch rate requirements

    Downstream process integration

    • Added into bulk lithographic resin dissolve stage
    • Pre-filtration through 0.1-micron filter prior to cleanroom QC sampling
    • Blended in nitrogen-purged tanks with automated parameter control
    • Final process QA includes residue analysis and pattern transfer qualification in trial wafers

    Final product types

    • Photoresists for semiconductor wafer manufacturing
    • LCD circuit patterning fluids
    • Dielectric insulating materials
    • Printed circuit board resist layers
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    Certification & Compliance
    More Introduction

    2-(4-Tert-Butylphenyl)Ethanol: A Core Component Backed by Experience

    Introduction from the Manufacturer’s Perspective

    Producing 2-(4-Tert-Butylphenyl)Ethanol over the years, we have come to understand the precise needs and persistent challenges faced by those working at the intersection of chemical synthesis, specialty intermediates, and materials science. This compound stands out for its reliability and performance in diverse applications across industries that demand strict batch consistency and high purity.

    Proven Experience with Model and Specifications

    Our 2-(4-Tert-Butylphenyl)Ethanol, routinely referenced in technical circles as p-tert-butylphenylethanol, carries the confidence of tightly controlled manufacturing conditions. We monitor every stage from raw material verification, through reaction efficiency, to final purification and packaging. Over years of scaling up, we have refined both our batch and continuous processes to ensure optimal yields and minimal impurities. Customers working in high-end specialty chemistry, fine fragrance intermediates, and advanced coatings depend on this consistency. Our preferred physical format is a crystalline solid, typically offered in white to off-white powder or low-melting flakes, always tested for color, purity, and residual solvents.

    Consistently we supply material with a purity greater than 99% by gas chromatography, confirmed by melting point, IR, and NMR analyses. Moisture content never exceeds critical application thresholds. For sensitive downstream processes, we employ an additional recrystallization step, which brings impurity profiles down below levels that could disrupt catalytic or formulation processes. As an original manufacturer, we maintain archives of every batch, ready for review by our partners, often going far beyond regulatory requirements.

    Practical Uses and Real-World Value

    Throughout our years producing and delivering 2-(4-Tert-Butylphenyl)Ethanol, we have worked side by side with R&D teams as they seek intermediates for next-generation products. This compound’s unique structure, a combination of bulky tert-butyl protection with a reactive phenyl-ethanol moiety, allows for particular flexibility in synthesis. Perfume houses utilize this structure to introduce desirable musk and powdery back notes; the strong, lipophilic tert-butyl group slows volatility and delivers persistence in finished compositions. Analytical labs call for this alcohol as an internal standard, due to its chemical shift, inertness to common reaction pathways, and sharp signal in chromatographic methods.

    Coating manufacturers have approached us, needing an alcohol with both steric bulk and aromatic compatibility for resin modification, enhancing solvent resistance and finish in final applications. The detailed records we keep allow customers to predict reactivity and compatibility without guesswork. Though similar in backbone to plain phenylethanol, the tert-butyl substitution shifts both solubility and reactivity, opening routes not possible with standard analogues. Chemical researchers in academia choose our product as a starting material for custom ligand design, exploiting electron-donating properties for tailored catalysis work. In the pharmaceutical sector, medicinal chemists have incorporated 2-(4-Tert-Butylphenyl)Ethanol into candidate molecules, appreciating both the stability and tunable functional group transformations the structure permits.

    Differences Compared to Similar Intermediates

    Years of exchanges with both industry and academic buyers have given us clear insight into why 2-(4-Tert-Butylphenyl)Ethanol has become a staple in certain synthetic routes while being passed over for others. Standard phenylethanol, widely available and less expensive, lacks the additional hydrophobic bulk and reduced side-reactivity. This makes our compound more desirable in cases where unwanted reactions with base or nucleophiles must be minimized. Even subtle changes in structure can cause dramatic differences in melting behavior, solubility in non-polar solvents, volatility, and chemical transformation options. We have seen partners switch from unmodified phenylethanol to our variant after troubleshooting unexpected side reactions, only to find that one methyl group’s presence was enough to prevent rearrangements or over-oxidation.

    Testing across several years shows that our carefully produced 2-(4-Tert-Butylphenyl)Ethanol demonstrates exceptional stability under both ambient and accelerated aging conditions. It resists discoloration and remains within tight assay ranges even after long-term storage, which has proven critical for companies that need reliable shelf life and batch repeatability. Other producers sometimes offer a comparable molecular structure, but with looser controls on tert-butyl group purity or final crystallization step. End users have reported inconsistencies and trace byproducts that disrupt downstream processes. Making the compound in-house, controlling each variable, closes the loop—ensuring the absence of troublesome trace organics, chlorinated species, or catalytic residue.

    Supporting Innovation Through Reliable Supply

    After years shipping 2-(4-Tert-Butylphenyl)Ethanol to more than a dozen countries, trends in feedback have revealed the importance of documentation and logistical planning. Our customers, working under pressure to deliver innovation, rely on our logistical team to anticipate customs, temperature control, and compliance issues. A single missed impurity report can delay a research program or knock weeks off a critical pilot-scale run. Our scale allows for both small research lots and bulk shipments, and our packaging formats are selected based on years of dialogue. Chemists have told us how easier handling—whether in foil-lined drums, vacuum-sealed bottles, or nitrogen-purged containers—has made workflows more efficient and safer.

    In fragrance projects, especially, the necessity of batch-to-batch aromatic consistency has become clear. A faint off-note or slight shift in character renders a perfumer’s work unusable; we run extra GC-MS analysis on each lot to validate olfactory purity. In specialty coatings, technicians have highlighted reduced variability in cure times and mechanical properties when shifting to our material versus previous suppliers. Across the board, short learning cycles and dependable supply chains mean more resources are dedicated to creation rather than troubleshooting raw materials.

    Addressing Challenges and Continual Improvements

    Producing 2-(4-Tert-Butylphenyl)Ethanol at scale isn’t free from challenges. Occasionally, raw material sources present minor fluctuations, especially for the tert-butyl precursors. Having robust requalification processes in our quality lab, we can spot and isolate unexpected variability before it impacts product. Chromatographic fingerprinting, physical property testing, and multi-step purification are routine here. Teams have learned from batches that veered towards the edges of spec; by tracking these lessons, processes have been honed to avoid recurrence.

    Sustainability questions are constant from customers pushing for greener supply chains. In response, we have implemented solvent recycling, byproduct minimization, and low-waste workup strategies. Every gram matters. Regular plant audits, both internal and from third-party experts, keep us working to higher standards. While regulations evolve toward stricter tolerances and disclosure, our technical package for 2-(4-Tert-Butylphenyl)Ethanol now includes traceability for every lot, and we’re transparent about methods used, rather than relying on generic certificates of analysis.

    Transporting chemical intermediates, particularly those destined for fine fragrances or electronics, has called for strategic thinking on contamination risk and environmental impact. Continuous investment into packaging resilience and improved labelling means reduced risk of cross-contamination or misidentification. Future plans include developing bio-based syntheses for precursor aromatic compounds, aiming to drop net carbon impact. Our connections with both multinational clients and local startups spark new ideas for responsible supply.

    Quality Assurance Beyond Compliance

    Long-term experience shows that quality isn’t static—it evolves with the needs of our customers. By directly manufacturing 2-(4-Tert-Butylphenyl)Ethanol rather than relying on external job shops, we retain control over both critical and subtle quality attributes. Each analytic method, from titrations to GC-MS and NMR, was validated in-house to confirm that it truly reflects the parameters important to end users. Batches never leave our site before passing multi-method identification, impurity quantification, and functional application checks. For clients in the fragrance sector, these include organoleptic panels; for specialty chemistry, reaction suitability checks are performed before release.

    Our technical team includes chemists with decades of hands-on experience, many of whom have managed both lab- and plant-scale operations. Frequent contact with users identifies shifts in global standards—whether tightening aromatic amine thresholds, seeking halogen-free declarations, or requesting new forms suited for automated metering. With this feedback loop, upgrades to process and product are constantly incorporated, not just maintained.

    Technical Consultation and Collaborative Progress

    Many of our team members have walked into a customer’s laboratory or pilot plant to address challenges up close. No two end uses for 2-(4-Tert-Butylphenyl)Ethanol look exactly alike. Academic customers often push the boundaries by using the alcohol as a launching point for complex supramolecular assemblies and catalysts. Process engineers in coatings expect rapid technical response to questions about reaction speed, contamination risks, or alternative purification options. Through direct visits and digital consultations, our technical support bridges the manufacturing floor and the application space.

    Users have described frustration when other suppliers delivered product with unpredictable polymorph content, resulting in inconsistent solubility or processing. Accurate control over crystallization conditions at our facilities, learned through years of repeated runs, results in a more reliable physical state. Lessons learned on the shop floor feed back into better methods, tighter specification ranges, and easier transitions for partners developing new products.

    Product Evolution and Research Support

    Being a direct manufacturer gives us the chance to respond swiftly to requests for specialized grades. For those in analytical chemistry, a higher-purity or ultra-low-water version is sometimes required. Whether by further drying, custom sieving, or targeted impurity removal, our teams validate these specialized lots in both the lab and in customers’ processes. We’ve grown by listening; requests from pharmaceutical researchers and electronics formulators led to new grades where ultra-trace metal or halogen content is controlled and documented.

    Researchers pushing the envelope of green chemistry have sought out modified routes or alternative feedstocks. In response to demand for drop-in replacements with improved environmental footprint, our chemists have trialed and implemented processes based on renewable-derived starting materials. While these require ongoing investment in sourcing, traceability, and alternative purification methods, results show that lower-impact options don’t need to sacrifice performance.

    Our network extends into academic consortia and industry groups debating new methods and upcoming regulations. We participate directly, using our hands-on data to guide discussions and deliver real-world perspectives. Whether sharing impurity profiles for consensus on standards, or reporting yield and purity trends for pilot-scale syntheses, our commitment to open knowledge supports shared progress.

    Ongoing Commitment to End User Success

    Every month brings new challenges from partners around the world—unexpected storage requirements, special packaging requests, or unique documentation for regulatory frameworks. With a large, experienced team, we match solutions to each challenge based on proven outcomes. Packaging, for example, has shifted from basic drums to advanced, protection-layered containers after perfumers in hot climates experienced melting and material loss. Documentation has grown from basic certificates to advanced batch genealogy and contaminant tracking, after electronics customers faced audit scrutiny. None of these advances happened in a vacuum; each mirrors a real need, met by direct production oversight and long-term improvement cycles.

    As global chemical regulation complexities increase, our direct communication with regulatory teams, customs officials, and end users serves as an early-warning and mitigation network. We don’t rely on generic answers; every inquiry runs through the same technical and regulatory rigor that produced the product in the first place. In practice, this approach saves our partners time, reduces material waste, and strengthens their trust in a volatile marketplace.

    Closing Thoughts on 2-(4-Tert-Butylphenyl)Ethanol’s Unique Role

    Years of manufacturer-side experience show that high-value intermediates like 2-(4-Tert-Butylphenyl)Ethanol command attention, not just for cost or technical performance, but for the blend of quality, reliability, and technical depth they represent. From fine fragrance and specialty coatings, through pharmaceutical innovation and advanced materials, this compound does more than fill a chemical role. It marks the intersection of precision process control, responsive customer service, and constant adaptation.

    Direct manufacturing experience provides ongoing insight into both what works and where improvement is due. By investing in talent, technologies, and open listening to end-user needs, 2-(4-Tert-Butylphenyl)Ethanol evolves to meet the ever-tightening standards of modern chemistry. Our team takes real pride in providing a bridge—a consistently pure, high-performing product supported by expertise, transparency, and unmatched stability.