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2,4-Dimethylthiophenol

    • Product Name 2,4-Dimethylthiophenol
    • Alias 2,4-Dimethylbenzenethiol
    • Einecs 210-499-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    947313

    Cas Number 13616-63-6
    Molecular Formula C8H10S
    Molecular Weight 138.23 g/mol
    Appearance Colorless to yellowish liquid
    Boiling Point 224-226 °C
    Melting Point -2 °C
    Density 1.030 g/mL at 25 °C
    Flash Point 108 °C
    Solubility In Water Insoluble
    Refractive Index 1.552 at 20 °C
    Synonyms 2,4-Dimethylbenzenethiol
    Odor Strong, unpleasant

    As an accredited 2,4-Dimethylthiophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 2,4-Dimethylthiophenol is packaged in a 25-gram amber glass bottle with a tightly sealed, chemical-resistant cap and labeling.
    Shipping **Shipping Description for 2,4-Dimethylthiophenol:** Ship in airtight, corrosion-resistant containers under cool, dry conditions. Clearly label as a flammable and toxic liquid. Avoid heat, sparks, and open flames. Handle in accordance with local, national, and international regulations. Ensure proper documentation and provide appropriate hazard warnings during transport. Handle spills and leaks with proper PPE.
    Storage 2,4-Dimethylthiophenol should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition, heat, and direct sunlight. Keep away from oxidizing agents, acids, and bases. Store under an inert atmosphere if possible to minimize oxidation and degradation. Ensure proper labeling and secure access, following all relevant safety regulations and guidelines.
    Application of 2,4-Dimethylthiophenol

    Applications of 2,4-Dimethylthiophenol in Industrial Manufacturing

    2,4-Dimethylthiophenol serves as a selective intermediate in several specialized chemical industries, supporting precision synthesis and performance optimization at various stages of downstream manufacturing. As a core producer, we enable secure integration of this compound into targeted processes, ensuring reliability and compliance across established applications.

    1. Pharmaceutical Intermediate for Thioether-Linked API Synthesis

    This material is widely adopted in pharmaceutical manufacturing as a thioether-forming intermediate, particularly for active pharmaceutical ingredients (APIs) containing aromatic-thioether motifs. Chemists leverage its unique reactivity to introduce controlled methyl-thiophenol functionalities during core structure assembly, enabling precise molecular modification while simplifying purification steps. Selection depends on the target molecule’s design and the desired profile of downstream intermediates.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Part 210/211 Current Good Manufacturing Practice
    • EU GMP Volume 4 Part II

    Typical usage ratio

    • 0.18–0.30 molar equivalents in stepwise thioetherification, adjusted per target residue yield and competing impurity profile

    Downstream process integration

    • Added during the key thioetherification stage in multi-step synthesis, with tight controls on reaction time and temperature to prevent by-product formation; utilization often follows aromatic halide activation or sulfonylation reactions

    Final product types

    • Pharmaceutical intermediates for anti-hypertensive drug substances
    • Sulfur-containing small molecule APIs for oncology therapeutics
    • Thioether analogues of established CNS agents

    2. Agrochemical Intermediate for Selective Herbicide Production

    Downstream agrochemical manufacturers employ this thiophenol derivative to synthesize sulfur-modified aromatic cores in selective herbicide formulations. Its electron-donating properties help optimize molecular reactivity during coupling reactions, supporting high-yield integration into key intermediates for advanced crop protection agents. Entry point and addition are tailored for the desired selectivity and S-content in the final molecule.

    Industry compliance standards

    • FAO/WHO Specification and Evaluations for Agricultural Pesticides
    • ISO 9001:2015 Quality Management Systems for Agrochemical Production
    • China National Standard GB 20811 for Pesticide Technical Material

    Typical usage ratio

    • 0.22–0.35 mole per mole of coupling partner, modulated for substrate reactivity and process control parameters in large-scale batches

    Downstream process integration

    • Introduced during the aromatic coupling or substitution step, following primary ring activation and before molecular condensation or chlorination; routine inclusion in the synthesis of S-aryl functional sites

    Final product types

    • Thioether-based post-emergent herbicide actives
    • Sulfur-modified pre-emergent weed control compounds
    • Intermediate stock solutions for pesticide formulation plants

    3. Polymer Additive Manufacturing for Heat-Resistant Resins

    Specialty plastic and advanced resin manufacturers utilize this material as an aromatic sulfur donor in engineered polymer systems, especially for applications requiring enhanced heat resistance and chemical durability. In specific formulations, it provides controlled functionalization at the backbone stage, imparting improved performance characteristics to finished polymers exposed to harsh operating environments.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 for chemical additives
    • UL 94 Flammability Tests for Polymeric Materials
    • ISO 9001:2015 for Quality Management in Polymer Compounding

    Typical usage ratio

    • 0.05–0.12% by weight of total polymer mass; determined by targeted property profiles and end-use application tolerances

    Downstream process integration

    • Dispersion occurs during the pre-polymer mixing and chain extension phase, followed by in situ crosslinking under controlled temperature and blending conditions to ensure uniform functional group inclusion

    Final product types

    • High-temperature-resistant epoxy and phenolic molding compounds
    • Industrial-grade specialty copolymers used in electronics encapsulation
    • Protective resin coatings for automotive underbody systems

    4. Fine Chemical Synthesis for Advanced Organic Building Blocks

    Producers of high-purity fine chemicals integrate this compound into processes aimed at constructing unique organosulfur building blocks, which serve as stepping stones for advanced dye, flavor, and specialty additive production. The reactivity profile supports formation of substituted thioethers, aiding precise modification in downstream synthesis routes that require stringent selectivity and minimal cross-contamination.

    Industry compliance standards

    • ISO 9001:2015 for Fine Chemical Manufacturing
    • OECD Guidelines for Testing of Chemicals (for downstream product registration)
    • Internal QC protocols for impurity profiling

    Typical usage ratio

    • 0.10–0.25 equivalents relative to parent aromatic substrate, optimized per individual route selectivity and desired final sulfur incorporation

    Downstream process integration

    • Charged at the stage of nucleophilic substitution or electrophilic aromatic substitution, carefully sequenced to prevent side reactions and maximize yield of the targeted intermediate for onward conversion

    Final product types

    • Functionalized aromatic building blocks for specialty dye synthesis
    • Organosulfur intermediates for fragrance and flavor ingredient production
    • Precision precursors for specialty antioxidants and fine additives
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    Certification & Compliance
    More Introduction

    Introducing 2,4-Dimethylthiophenol: A Manufacturer’s Perspective

    Understanding 2,4-Dimethylthiophenol from the Ground Up

    Crafting 2,4-dimethylthiophenol begins with a clear-eyed commitment to purity and reliability, forged over years of practical experience in fine chemical manufacturing. The unique character of this organosulfur compound draws interest from advanced synthesis labs, flavor and fragrance houses, specialty material developers, and pesticide researchers. Our production line focuses on delivering 2,4-dimethylthiophenol under the CAS number 1193-02-8, and the molecular formula C8H10S, with a consistent approach to quality control that addresses the very real challenges of working with thiophenol derivatives.

    Molecular Precision: Specifications and the Manufacturing Approach

    Our process for 2,4-dimethylthiophenol steers around catalytic impurities by using carefully selected raw materials and maintaining defined environmental conditions during synthesis. Each batch is distilled under reduced pressure and stored in airtight, inert-atmosphere containers to limit exposure to air and moisture, which can degrade the quality or introduce unpredictable byproducts. The product takes the form of a clear yellowish to pale liquid with a distinctive, pungent odor common to thiophenols. Sulfur-based chemistry can prove stubborn to control and often reveals the manufacturer’s craftsmanship. Typical assay levels exceed 99 percent (GC), and we closely monitor for trace contaminants such as o-, p-dimethyl isomers, toluene, and phenol, since they impact both odor and downstream reactivity in custom synthesis.

    The choice of packaging stems from years of practical handling. Glass bottles with PTFE seals or lined drums provide better resistance to permeation and reactivity compared to untreated plastic containers. Shipping involves temperature stabilization since unplanned heating encourages volatilization and loss of the characteristic thiol note. Rust and corrosion concerns led us to reject conventional steel vessels for this compound after witnessing premature quality degradation in earlier years.

    Distinctions Beyond the Catalog: Comparing to Other Thiophenols

    2,4-dimethylthiophenol’s two methyl groups on the aromatic ring set it apart from its relatives like 2-methylthiophenol, 4-methylthiophenol, or simple thiophenol. These subtle structural tweaks shape not just the strength and nuance of its odor but also its solubility in common organic solvents. Chemists regularly share feedback with us that our product’s lower impurity profile directly improves reproducibility in catalytic reactions and substitution chemistry.

    Other thiophenols often act as blunt tools in synthesis, but the methyl substitution at both ortho and para positions here tweaks electron density, affecting nucleophilicity and reaction selectivity. Customers exploring arylthioethers, custom ligands, or sulfur-based stabilizers enjoy these tailored properties—not just another interchangeable component. Similar isomers may cost less in the open market, yet consistent performance demands precision, and our data-driven oversight ensures that methyl shifts do not invite contamination from cresol siblings or thioanisole crossover.

    Practical Considerations: Handling, Safety, and Stewardship

    Working with strong-smelling thiols introduces strict process controls, not just for product integrity but for plant and lab safety. Each shipment includes guidelines translated into hands-on practice: protective equipment, careful transfer under fume hoods, and distinct odor minimization strategies. From decades on the shop floor, we know that even sealed bottles can emit odor trace if not double-contained, so our logistics team uses additional vapor barriers for both small and bulk lots.

    Environmental care guided many upgrades to our facility. Thiophenols demand scrubbing systems tailored to their chemistry—carbon filters, caustic scrubbers, and secondary containment that factors in vapor pressures, tank permeation rates, and mercaptan reactivity. Our waste streams undergo targeted treatment, neutralizing active sulfur with oxidants under controlled pH. We have worked alongside local regulatory bodies to minimize odor complaints and airborne exposure risk, sharing data and inspection results with stakeholders to build a reputation for responsible stewardship.

    Applications: How Value Emerges from Molecular Detail

    Flavor and fragrance formulators approach us seeking reliable, high-purity 2,4-dimethylthiophenol that will deliver robust, sulfurous base notes in specialty aromas. In the wrong hands, contaminants or isomeric impurities can produce off-odors, so we collaborate to ensure every bottle meets tight organoleptic requirements. This direct engagement helped us refine distillation protocols and train staff to recognize the subtle cues that separate premium product from “good enough.”

    For agrochemical synthesis, speed and purity rule all decisions. The introduction of methyl groups in 2,4-dimethylthiophenol offers a building block for sulfenylation of crop protection agents, allowing the creation of fungistatic or insecticidal compounds with custom reactivity. Our technical support team answers application-specific questions from research and production scientists, sharing batch records and impurity details to support scale-up decisions. Time after time, project managers relay that smoother reactions and fewer side-products with our material have kept their schedules on track.

    Polymer researchers also use this molecule in specialty stabilization chemistries or to introduce functional sulfur groups. In these applications, even minor contaminants risk downstream discoloration, mechanical failure, or batch variability. Our long-term partnerships with large materials companies evolved precisely because of our willingness to adapt purification strategies and share analytical data, reinforcing the direct impact of chemical quality on novel polymer performance.

    Data-Driven Reliability: Why Analytical Transparency Matters

    We take product verification seriously, running every lot through GC-MS and NMR to document that each batch matches the critical performance factors our end users expect. Early on, we encountered feedback where minor batch-to-batch differences stifled process optimization at our clients’ facilities. Our response—full certificates of analysis, returnable reference samples, and open data on impurity patterns—allowed us to align with even the most data-intensive pharmaceutical developers.

    That transparency extends beyond technical documentation. Clients visit our production areas and audit our protocols, observing firsthand the rigorous oversight that underpins quality. These relationships build resilience—should anything deviate from specification, direct communication means fast, transparent remediation. Laboratories gain reliability, scale-ups unfold with fewer surprises, and new methods can trust the foundation we lay with each consistently manufactured kilogram.

    Supply Chain Confidence: Manufacturing at Scale

    Significant demand swings have defined specialty chemical markets over the last decade. In some years, spikes in request volumes delayed access to niche intermediates. Our answer has been process intensification, reserve capacity, and modular production lines that support both pilot-scale and large-volume orders with minimal delay.

    We source our starting materials from accredited suppliers who meet our purity requirements, and all new material undergoes pre-acceptance testing by our QC team. Long-standing relationships with global shippers help us avoid common pitfalls—seasonal delays, cargo handling errors, or storage missteps. The learning curve has been steep; each disruption drove us to tighten logistics, invest in real-time tracking tech, and pre-empt paperwork tangles by working directly with customs and regulatory teams.

    Short lead times matter immensely for high-value R&D or critical-path production. Our reputation grew as partners realized we met ambitious delivery schedules with exacting consistency. The feedback loop continues: success at scale begins with hands-on diligence at every step, from raw material acceptance to final packaging.

    Working Together: Supporting End-User Innovation

    From the earliest conversations with R&D teams, our engagement remains collaborative rather than transactional. Chemists, perfumers, and materials scientists at our partner organizations often request custom documentation, process modifications, or additional purity data. Our teams respond with practical advice grounded in years of operational experience: renewal of SOPs for transferring or sampling, live troubleshooting with process chemists grappling with reactivity roadblocks, or deeper dives into the impacts of accidental exposure to light, trace oxygen, or incompatible solvents.

    We have hosted joint trials and application testing sessions at our site, inviting customers to run pilot syntheses using our 2,4-dimethylthiophenol drawn directly from active production lots. The data gathered from these sessions—reaction yields, side-product formation profiles, and downstream process results—feeds improvements on both sides. Building trust with direct, verifiable support has made us a go-to partner for researchers who cannot risk their results on unpredictable material sources.

    Troubleshooting and Real-World Solutions

    In past years, clients have reported challenges when using lower-grade or poorly stored 2,4-dimethylthiophenol from less rigorous sources: unplanned side-reactions, batch failures, and strong off-odors. After root-cause analysis, we introduced stricter storage parameters for our finished product, integrating advanced vapor-control and ambient monitoring tools. The adjustability of container sizes—ranging from small bottles for research labs to custom drums for industrial use—further streamlines integration into diverse workflows. Internal tracking systems log every batch movement within our facility, enabling full traceability and recall capacity, should it ever prove necessary.

    Direct feedback inspired upgrades to our analytical toolkit. Our lab now runs not only typical GC and HPLC but also low-level sulfur speciation methods, enabling detection of trace impurities that evade standard checks. This investment paid off during process transfer projects, where undetected contaminants in competitor’s material threatened to derail commercial launches. By maintaining this extra layer of vigilance, we help safeguard sensitive applications in which even the slightest deviation can cascade into large-scale delays or compliance headaches.

    Continuing Improvement: Learning from Every Batch

    No successful chemical operation stands still. Each year brings new advances in processing equipment, analytical detection limits, and regulatory expectations. Modernizing our distillation and containment systems stemmed as much from competitive drive as from requests by client QA auditors and plant operators. By holding open debriefs with end users, discussing which product attributes enabled their best results, our team identifies improvements that make a concrete difference at their site—be it in smoother pourability, lower peroxide content, or practical labeling tweaks to streamline inventory tracking.

    We train our production team rigorously, emphasizing both the importance of absolute purity and the safety risks tied to volatile organosulfur species. Operators are empowered to halt production if real or potential deviations threaten downstream quality, and we reward practical suggestions for process improvements. Our culture reflects a genuine commitment not only to making a consistently high-grade 2,4-dimethylthiophenol but supporting the innovation of our partners and the health of our workforce and communities.

    Future Outlook: Sustaining Leadership through Knowledge and Engagement

    As specialized industries push for ever-tighter chemical specifications and broader performance envelopes, we see our role not just as ingredient suppliers, but as partners who anticipate needs and deliver actionable solutions. Global trends—in green chemistry, stricter standards for trace contaminants, and calls for more transparent supply chains—inform our ongoing process and investment decisions.

    Researchers seek to minimize waste and energy, prompting us to reduce residual solvents, optimize reaction kinetics, and adopt closed-loop systems wherever possible. Our environmental team routinely audits waste handling and emission controls, cross-referencing both regulatory requirements and best-in-class industry benchmarks. As emerging industries demand new variations—custom isotopically labeled compounds, or specialty grades with tailored odor or reactivity profiles—our agile manufacturing philosophy accommodates new product lines without sacrificing existing reliability or compliance.

    In the end, success comes down to unbroken attention to each batch, a readiness to listen, and a hands-on commitment to practical excellence. Our clients move confidently knowing 2,4-dimethylthiophenol sourced here is not just another commodity molecule, but the result of decades of hard-fought experience, ongoing investment, and genuine engagement with the most demanding users in the field. This is how we keep the focus squarely on real-world outcomes, supporting both today’s innovations and tomorrow’s breakthroughs.